{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96FL8","secondaryAccessions":["Q53HF5","Q6PD77","Q86VL4","Q9NVA3"],"uniProtkbId":"S47A1_HUMAN","entryAudit":{"firstPublicDate":"2007-12-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":172,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16330770"}],"value":"Multidrug and toxin extrusion protein 1"},"shortNames":[{"value":"MATE-1"},{"value":"hMATE-1"}]},"alternativeNames":[{"fullName":{"value":"Solute carrier family 47 member 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25588"}],"value":"SLC47A1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16330770"}],"value":"MATE1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17495125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17582384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24961373"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35307651"}],"value":"Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"thiamine(out) + H(+)(in) = thiamine(in) + H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71271"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:18385"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24961373"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"estrone 3-sulfate(in) + H(+)(out) = estrone 3-sulfate(out) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72139"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:60050"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72183"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16737"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72127"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58145"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:72128"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21128598"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:72129"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21128598"}]}]},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":0.192,"unit":"nmol/min/mg","enzyme":"enzyme toward agmatine (at pH 8.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"velocity":2.94,"unit":"nmol/min/mg","enzyme":"enzyme toward thiamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24961373"}]},{"velocity":1.185,"unit":"nmol/min/mg","enzyme":"enzyme toward TEA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":0.81,"unit":"nmol/min/mg","enzyme":"enzyme toward TEA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}]},{"velocity":0.735,"unit":"nmol/min/mg","enzyme":"enzyme toward MPP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":0.135,"unit":"nmol/min/mg","enzyme":"enzyme toward cimetidine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":0.104,"unit":"nmol/min/mg","enzyme":"enzyme toward cimetidine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}]},{"velocity":2.23,"unit":"nmol/min/mg","enzyme":"enzyme toward metformin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":0.89,"unit":"nmol/min/mg","enzyme":"enzyme toward guanidine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":3.78,"unit":"nmol/min/mg","enzyme":"enzyme toward procainamide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":0.21,"unit":"nmol/min/mg","enzyme":"enzyme toward topotecan","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":0.265,"unit":"nmol/min/mg","enzyme":"enzyme toward estrone sulfate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":0.62,"unit":"nmol/min/mg","enzyme":"enzyme toward acyclovir","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"velocity":1.08,"unit":"nmol/min/mg","enzyme":"enzyme toward ganciclovir","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]}],"michaelisConstants":[{"constant":0.38,"unit":"mM","substrate":"TEA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":0.58,"unit":"mM","substrate":"TEA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}]},{"constant":0.1,"unit":"mM","substrate":"MPP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":0.17,"unit":"mM","substrate":"cimetidine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":7.4,"unit":"uM","substrate":"cimetidine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}]},{"constant":0.78,"unit":"mM","substrate":"metformin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":2.1,"unit":"mM","substrate":"guanidine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":1.23,"unit":"mM","substrate":"procainamide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":0.07,"unit":"mM","substrate":"topotecan","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":0.47,"unit":"mM","substrate":"estrone sulfate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":2.64,"unit":"mM","substrate":"acyclovir","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]},{"constant":240.0,"unit":"uM","substrate":"agmatine (at pH 8.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}]},{"constant":830.0,"unit":"uM","substrate":"thiamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24961373"}]},{"constant":5.12,"unit":"mM","substrate":"ganciclovir","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"}]}]},"phDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"}],"value":"Optimum pH is 8.0 for agmatine uptake (PubMed:21128598). Optimum pH is 8.5. Active from pH 6 to 8.5."}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96FL8","intActId":"EBI-12887226"},"interactantTwo":{"uniProtKBAccession":"Q9H0Q3","geneName":"FXYD6","intActId":"EBI-713304"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"}],"value":"Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16641166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158817"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"}],"value":"Apical cell membrane","id":"SL-0015"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q96FL8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q96FL8-2"],"sequenceIds":["VSP_029903","VSP_029904"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q96FL8-3"],"sequenceIds":["VSP_029905"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35307651"}],"value":"Widely expressed. The highest expression is found in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney. In testis, primarily localized throughout the adluminal compartment of the seminiferous tubules with expression at the peritubular myoid cells and Leydig cells (PubMed:35307651)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16914559"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17495125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17509534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17582384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21128598"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26979622"}],"value":"Mediates the efflux of cationic compounds such as the model cations, tetraethylammonium (TEA), the neurotoxin 1-methyl-4-phenylpyridinium (MPP), the platinum-based drugs cisplatin and oxaliplatin, the drugs procainamide, acyclovir and topotecan, or weak bases that are positively charged at physiological pH, such as cimetidine or the antidiabetic drug metformin"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH50592.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"Multidrug and toxin extrusion protein 1","featureId":"PRO_0000312845"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Alternative sequence","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_029903","alternativeSequence":{"originalSequence":"ILGMV","alternativeSequences":["LYEDG"]}},{"type":"Alternative sequence","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_029904","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_029905","alternativeSequence":{"originalSequence":"VGILVRFYVRIQ","alternativeSequences":["AGVRWCDHSSLQPRTLGLQAILLCQPPE"]}},{"type":"Natural variant","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"does not affect plasma membrane expression; does not affect TEA and metformin transport; dbSNP:rs555657341","featureCrossReferences":[{"database":"dbSNP","id":"rs555657341"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158817"}],"featureId":"VAR_087027","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"found in a patient with renal disease; uncertain significance; decreases plasma membrane expression; transport of TEA and metformin are reduced by at least 90%; dbSNP:rs77630697","featureCrossReferences":[{"database":"dbSNP","id":"rs77630697"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158817"}],"featureId":"VAR_087028","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"found in a patient with renal disease; uncertain significance; does not affect plasma membrane expression; decreases TEA and metformin transport; Vmax value for TEA transport is decreased; Km value for TEA is increased; dbSNP:rs1322335818","featureCrossReferences":[{"database":"dbSNP","id":"rs1322335818"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158817"}],"featureId":"VAR_087029","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"found in a patient with renal disease; uncertain significance; decreases plasma membrane expression; decreases TEA and metformin transport; Vmax value for TEA transport is decreased; dbSNP:rs149774861","featureCrossReferences":[{"database":"dbSNP","id":"rs149774861"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158817"}],"featureId":"VAR_087030","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"in dbSNP:rs35790011","featureCrossReferences":[{"database":"dbSNP","id":"rs35790011"}],"featureId":"VAR_037587","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"found in a patient with renal disease; uncertain significance; does not affect plasma membrane localization; decreases TEA transport; Km value for TEA is increased; does not affect metformin transport; dbSNP:rs1480708114","featureCrossReferences":[{"database":"dbSNP","id":"rs1480708114"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158817"}],"featureId":"VAR_087031","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Abolishes membrane subcellular location. Abolishes TEA transport.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Does not affect membrane subcellular location. Decreases TEA transport. Higher affinity for cimetidine and reduced affinity to TEA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"No change in subcellular location and abolition of MATE1-dependent TEA transport activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16330770"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Does not affect membrane subcellular location. Abolishes TEA transport.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Does not affect membrane subcellular location. Decreases TEA transport.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"Decreased TEA and metformin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26979622"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Does not affect membrane subcellular location. Decreases TEA transport.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A","D"]}},{"type":"Mutagenesis","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Does not affect membrane subcellular location. Decreases TEA transport.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18305230"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A","D"]}},{"type":"Sequence conflict","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"in Ref. 2; BAD96345","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"in Ref. 1; BAA91852","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"in Ref. 2; BAD96345","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":507,"modifier":"EXACT"},"end":{"value":507,"modifier":"EXACT"}},"description":"in Ref. 2; BAD96345","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0050","category":"Biological process","name":"Antiport"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"CI-5AVBODINQ93DF","citationType":"submission","authors":["Suzuki Y.","Sugano S.","Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S."],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"Colon","type":"TISSUE"},{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"16330770","citationType":"journal article","authors":["Otsuka M.","Matsumoto T.","Morimoto R.","Arioka S.","Omote H.","Moriyama Y."],"citationCrossReferences":[{"database":"PubMed","id":"16330770"},{"database":"DOI","id":"10.1073/pnas.0506483102"}],"title":"A human transporter protein that mediates the final excretion step for toxic organic cations.","publicationDate":"2005","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"17923","lastPage":"17928","volume":"102"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","MUTAGENESIS OF GLU-273","TISSUE SPECIFICITY","SUBCELLULAR LOCATION","BIOPHYSICOCHEMICAL PROPERTIES","MISCELLANEOUS"]},{"referenceNumber":6,"citation":{"id":"16641166","citationType":"journal article","authors":["Hiasa M.","Matsumoto T.","Komatsu T.","Moriyama Y."],"citationCrossReferences":[{"database":"PubMed","id":"16641166"},{"database":"DOI","id":"10.1152/ajpcell.00090.2006"}],"title":"Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations.","publicationDate":"2006","journal":"Am. J. Physiol.","firstPage":"C678","lastPage":"C686","volume":"291"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":7,"citation":{"id":"16914559","citationType":"journal article","authors":["Yonezawa A.","Masuda S.","Yokoo S.","Katsura T.","Inui K."],"citationCrossReferences":[{"database":"PubMed","id":"16914559"},{"database":"DOI","id":"10.1124/jpet.106.110346"}],"title":"Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).","publicationDate":"2006","journal":"J. Pharmacol. Exp. Ther.","firstPage":"879","lastPage":"886","volume":"319"},"referencePositions":["MISCELLANEOUS"]},{"referenceNumber":8,"citation":{"id":"17509534","citationType":"journal article","authors":["Tanihara Y.","Masuda S.","Sato T.","Katsura T.","Ogawa O.","Inui K."],"citationCrossReferences":[{"database":"PubMed","id":"17509534"},{"database":"DOI","id":"10.1016/j.bcp.2007.04.010"}],"title":"Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.","publicationDate":"2007","journal":"Biochem. Pharmacol.","firstPage":"359","lastPage":"371","volume":"74"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","BIOPHYSICOCHEMICAL PROPERTIES","TISSUE SPECIFICITY","SUBSTRATE SPECIFICITY","MISCELLANEOUS"]},{"referenceNumber":9,"citation":{"id":"17582384","citationType":"journal article","authors":["Yokoo S.","Yonezawa A.","Masuda S.","Fukatsu A.","Katsura T.","Inui K."],"citationCrossReferences":[{"database":"PubMed","id":"17582384"},{"database":"DOI","id":"10.1016/j.bcp.2007.03.004"}],"title":"Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.","publicationDate":"2007","journal":"Biochem. Pharmacol.","firstPage":"477","lastPage":"487","volume":"74"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","MISCELLANEOUS"]},{"referenceNumber":10,"citation":{"id":"17495125","citationType":"journal article","authors":["Chen Y.","Zhang S.","Sorani M.","Giacomini K.M."],"citationCrossReferences":[{"database":"PubMed","id":"17495125"},{"database":"DOI","id":"10.1124/jpet.107.123554"}],"title":"Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.","publicationDate":"2007","journal":"J. Pharmacol. Exp. Ther.","firstPage":"695","lastPage":"700","volume":"322"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","MISCELLANEOUS"]},{"referenceNumber":11,"citation":{"id":"18305230","citationType":"journal article","authors":["Matsumoto T.","Kanamoto T.","Otsuka M.","Omote H.","Moriyama Y."],"citationCrossReferences":[{"database":"PubMed","id":"18305230"},{"database":"DOI","id":"10.1152/ajpcell.00504.2007"}],"title":"Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter.","publicationDate":"2008","journal":"Am. J. Physiol.","firstPage":"C1074","lastPage":"C1078","volume":"294"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION","MISCELLANEOUS","MUTAGENESIS OF GLU-273; GLU-278; GLU-300 AND GLU-389"]},{"referenceNumber":12,"citation":{"id":"19158817","citationType":"journal article","authors":["Kajiwara M.","Terada T.","Ogasawara K.","Iwano J.","Katsura T.","Fukatsu A.","Doi T.","Inui K."],"citationCrossReferences":[{"database":"PubMed","id":"19158817"},{"database":"DOI","id":"10.1038/jhg.2008.1"}],"title":"Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.","publicationDate":"2009","journal":"J. Hum. Genet.","firstPage":"40","lastPage":"46","volume":"54"},"referencePositions":["VARIANTS LEU-10; ASP-64; VAL-310; ALA-328 AND SER-474","CHARACTERIZATION OF VARIANTS LEU-10; ASP-64; VAL-310; ALA-328 AND SER-474","FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION","MISCELLANEOUS"]},{"referenceNumber":13,"citation":{"id":"21128598","citationType":"journal article","authors":["Winter T.N.","Elmquist W.F.","Fairbanks C.A."],"citationCrossReferences":[{"database":"PubMed","id":"21128598"},{"database":"DOI","id":"10.1021/mp100180a"}],"title":"OCT2 and MATE1 provide bidirectional agmatine transport.","publicationDate":"2011","journal":"Mol. Pharm.","firstPage":"133","lastPage":"142","volume":"8"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","BIOPHYSICOCHEMICAL PROPERTIES","MISCELLANEOUS"]},{"referenceNumber":14,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"24961373","citationType":"journal article","authors":["Chen L.","Shu Y.","Liang X.","Chen E.C.","Yee S.W.","Zur A.A.","Li S.","Xu L.","Keshari K.R.","Lin M.J.","Chien H.C.","Zhang Y.","Morrissey K.M.","Liu J.","Ostrem J.","Younger N.S.","Kurhanewicz J.","Shokat K.M.","Ashrafi K.","Giacomini K.M."],"citationCrossReferences":[{"database":"PubMed","id":"24961373"},{"database":"DOI","id":"10.1073/pnas.1314939111"}],"title":"OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9983","lastPage":"9988","volume":"111"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY"]},{"referenceNumber":16,"citation":{"id":"26979622","citationType":"journal article","authors":["Sprowl J.A.","Ong S.S.","Gibson A.A.","Hu S.","Du G.","Lin W.","Li L.","Bharill S.","Ness R.A.","Stecula A.","Offer S.M.","Diasio R.B.","Nies A.T.","Schwab M.","Cavaletti G.","Schlatter E.","Ciarimboli G.","Schellens J.H.M.","Isacoff E.Y.","Sali A.","Chen T.","Baker S.D.","Sparreboom A.","Pabla N."],"citationCrossReferences":[{"database":"PubMed","id":"26979622"},{"database":"DOI","id":"10.1038/ncomms10880"}],"title":"A phosphotyrosine switch regulates organic cation transporters.","publicationDate":"2016","journal":"Nat. Commun.","firstPage":"10880","lastPage":"10880","volume":"7"},"referencePositions":["MUTAGENESIS OF TYR-299","MISCELLANEOUS"]},{"referenceNumber":17,"citation":{"id":"35307651","citationType":"journal article","authors":["Hau R.K.","Klein R.R.","Wright S.H.","Cherrington N.J."],"citationCrossReferences":[{"database":"PubMed","id":"35307651"},{"database":"DOI","id":"10.1124/dmd.121.000748"}],"title":"Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.","publicationDate":"2022","journal":"Drug Metab. Dispos.","firstPage":"770","lastPage":"780","volume":"50"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK001709","properties":[{"key":"ProteinId","value":"BAA91852.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK222625","properties":[{"key":"ProteinId","value":"BAD96345.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471212","properties":[{"key":"ProteinId","value":"EAW50893.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471212","properties":[{"key":"ProteinId","value":"EAW50894.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC010661","properties":[{"key":"ProteinId","value":"AAH10661.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC050592","properties":[{"key":"ProteinId","value":"AAH50592.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC058882","properties":[{"key":"ProteinId","value":"AAH58882.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS11209.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96FL8-1"},{"database":"RefSeq","id":"NP_060712.2","properties":[{"key":"NucleotideSequenceId","value":"NM_018242.3"}],"isoformId":"Q96FL8-1"},{"database":"PDB","id":"9R10","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A=1-570"}]},{"database":"PDB","id":"9R1E","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-570"}]},{"database":"PDB","id":"9R1F","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.31 A"},{"key":"Chains","value":"A=1-570"}]},{"database":"PDB","id":"9R1G","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"A=1-570"}]},{"database":"PDBsum","id":"9R10","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R1E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R1F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R1G","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53489","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53506","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53507","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53508","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"120535","properties":[{"key":"Interactions","value":"93"}]},{"database":"FunCoup","id":"Q96FL8","properties":[{"key":"Number of interactors","value":"693"}]},{"database":"IntAct","id":"Q96FL8","properties":[{"key":"Interactions","value":"86"}]},{"database":"NDEx","id":"IQUERY-CP-SLC47A1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000270570","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1743126","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB12001","properties":[{"key":"GenericName","value":"Abemaciclib"}]},{"database":"DrugBank","id":"DB00787","properties":[{"key":"GenericName","value":"Acyclovir"}]},{"database":"DrugBank","id":"DB16640","properties":[{"key":"GenericName","value":"Almonertinib"}]},{"database":"DrugBank","id":"DB06288","properties":[{"key":"GenericName","value":"Amisulpride"}]},{"database":"DrugBank","id":"DB11901","properties":[{"key":"GenericName","value":"Apalutamide"}]},{"database":"DrugBank","id":"DB05025","properties":[{"key":"GenericName","value":"Arimoclomol"}]},{"database":"DrugBank","id":"DB16098","properties":[{"key":"GenericName","value":"Atogepant"}]},{"database":"DrugBank","id":"DB15233","properties":[{"key":"GenericName","value":"Avapritinib"}]},{"database":"DrugBank","id":"DB11799","properties":[{"key":"GenericName","value":"Bictegravir"}]},{"database":"DrugBank","id":"DB15638","properties":[{"key":"GenericName","value":"Brensocatib"}]},{"database":"DrugBank","id":"DB12267","properties":[{"key":"GenericName","value":"Brigatinib"}]},{"database":"DrugBank","id":"DB12218","properties":[{"key":"GenericName","value":"Capivasertib"}]},{"database":"DrugBank","id":"DB11791","properties":[{"key":"GenericName","value":"Capmatinib"}]},{"database":"DrugBank","id":"DB01333","properties":[{"key":"GenericName","value":"Cefradine"}]},{"database":"DrugBank","id":"DB00567","properties":[{"key":"GenericName","value":"Cephalexin"}]},{"database":"DrugBank","id":"DB00501","properties":[{"key":"GenericName","value":"Cimetidine"}]},{"database":"DrugBank","id":"DB00537","properties":[{"key":"GenericName","value":"Ciprofloxacin"}]},{"database":"DrugBank","id":"DB08930","properties":[{"key":"GenericName","value":"Dolutegravir"}]},{"database":"DrugBank","id":"DB14844","properties":[{"key":"GenericName","value":"Dordaviprone"}]},{"database":"DrugBank","id":"DB11981","properties":[{"key":"GenericName","value":"Elamipretide"}]},{"database":"DrugBank","id":"DB00879","properties":[{"key":"GenericName","value":"Emtricitabine"}]},{"database":"DrugBank","id":"DB04574","properties":[{"key":"GenericName","value":"Estrone sulfate"}]},{"database":"DrugBank","id":"DB12605","properties":[{"key":"GenericName","value":"Etripamil"}]},{"database":"DrugBank","id":"DB00927","properties":[{"key":"GenericName","value":"Famotidine"}]},{"database":"DrugBank","id":"DB12500","properties":[{"key":"GenericName","value":"Fedratinib"}]},{"database":"DrugBank","id":"DB12265","properties":[{"key":"GenericName","value":"Fexinidazole"}]},{"database":"DrugBank","id":"DB01195","properties":[{"key":"GenericName","value":"Flecainide"}]},{"database":"DrugBank","id":"DB16628","properties":[{"key":"GenericName","value":"Fosdenopterin"}]},{"database":"DrugBank","id":"DB01004","properties":[{"key":"GenericName","value":"Ganciclovir"}]},{"database":"DrugBank","id":"DB15097","properties":[{"key":"GenericName","value":"Gefapixant"}]},{"database":"DrugBank","id":"DB12134","properties":[{"key":"GenericName","value":"Gepotidacin"}]},{"database":"DrugBank","id":"DB12141","properties":[{"key":"GenericName","value":"Gilteritinib"}]},{"database":"DrugBank","id":"DB11978","properties":[{"key":"GenericName","value":"Glasdegib"}]},{"database":"DrugBank","id":"DB00986","properties":[{"key":"GenericName","value":"Glycopyrronium"}]},{"database":"DrugBank","id":"DB01018","properties":[{"key":"GenericName","value":"Guanfacine"}]},{"database":"DrugBank","id":"DB00536","properties":[{"key":"GenericName","value":"Guanidine"}]},{"database":"DrugBank","id":"DB11886","properties":[{"key":"GenericName","value":"Infigratinib"}]},{"database":"DrugBank","id":"DB11757","properties":[{"key":"GenericName","value":"Istradefylline"}]},{"database":"DrugBank","id":"DB11732","properties":[{"key":"GenericName","value":"Lasmiditan"}]},{"database":"DrugBank","id":"DB01137","properties":[{"key":"GenericName","value":"Levofloxacin"}]},{"database":"DrugBank","id":"DB05667","properties":[{"key":"GenericName","value":"Levoketoconazole"}]},{"database":"DrugBank","id":"DB04948","properties":[{"key":"GenericName","value":"Lofexidine"}]},{"database":"DrugBank","id":"DB05501","properties":[{"key":"GenericName","value":"Mavorixafor"}]},{"database":"DrugBank","id":"DB01043","properties":[{"key":"GenericName","value":"Memantine"}]},{"database":"DrugBank","id":"DB00331","properties":[{"key":"GenericName","value":"Metformin"}]},{"database":"DrugBank","id":"DB09241","properties":[{"key":"GenericName","value":"Methylene blue"}]},{"database":"DrugBank","id":"DB08840","properties":[{"key":"GenericName","value":"N-methylnicotinamide"}]},{"database":"DrugBank","id":"DB01203","properties":[{"key":"GenericName","value":"Nadolol"}]},{"database":"DrugBank","id":"DB18237","properties":[{"key":"GenericName","value":"Nerandomilast"}]},{"database":"DrugBank","id":"DB11793","properties":[{"key":"GenericName","value":"Niraparib"}]},{"database":"DrugBank","id":"DB16267","properties":[{"key":"GenericName","value":"Olutasidenib"}]},{"database":"DrugBank","id":"DB11837","properties":[{"key":"GenericName","value":"Osilodrostat"}]},{"database":"DrugBank","id":"DB16277","properties":[{"key":"GenericName","value":"Paltusotine"}]},{"database":"DrugBank","id":"DB15102","properties":[{"key":"GenericName","value":"Pemigatinib"}]},{"database":"DrugBank","id":"DB12978","properties":[{"key":"GenericName","value":"Pexidartinib"}]},{"database":"DrugBank","id":"DB12615","properties":[{"key":"GenericName","value":"Plazomicin"}]},{"database":"DrugBank","id":"DB15822","properties":[{"key":"GenericName","value":"Pralsetinib"}]},{"database":"DrugBank","id":"DB01035","properties":[{"key":"GenericName","value":"Procainamide"}]},{"database":"DrugBank","id":"DB00205","properties":[{"key":"GenericName","value":"Pyrimethamine"}]},{"database":"DrugBank","id":"DB00243","properties":[{"key":"GenericName","value":"Ranolazine"}]},{"database":"DrugBank","id":"DB12377","properties":[{"key":"GenericName","value":"Relebactam"}]},{"database":"DrugBank","id":"DB14761","properties":[{"key":"GenericName","value":"Remdesivir"}]},{"database":"DrugBank","id":"DB16852","properties":[{"key":"GenericName","value":"Remibrutinib"}]},{"database":"DrugBank","id":"DB18515","properties":[{"key":"GenericName","value":"Revumenib"}]},{"database":"DrugBank","id":"DB11753","properties":[{"key":"GenericName","value":"Rifamycin"}]},{"database":"DrugBank","id":"DB12457","properties":[{"key":"GenericName","value":"Rimegepant"}]},{"database":"DrugBank","id":"DB14840","properties":[{"key":"GenericName","value":"Ripretinib"}]},{"database":"DrugBank","id":"DB15305","properties":[{"key":"GenericName","value":"Risdiplam"}]},{"database":"DrugBank","id":"DB12332","properties":[{"key":"GenericName","value":"Rucaparib"}]},{"database":"DrugBank","id":"DB18305","properties":[{"key":"GenericName","value":"Sebetralstat"}]},{"database":"DrugBank","id":"DB15685","properties":[{"key":"GenericName","value":"Selpercatinib"}]},{"database":"DrugBank","id":"DB21667","properties":[{"key":"GenericName","value":"Sevabertinib"}]},{"database":"DrugBank","id":"DB00877","properties":[{"key":"GenericName","value":"Sirolimus"}]},{"database":"DrugBank","id":"DB19325","properties":[{"key":"GenericName","value":"Sofpironium"}]},{"database":"DrugBank","id":"DB14754","properties":[{"key":"GenericName","value":"Solriamfetol"}]},{"database":"DrugBank","id":"DB00391","properties":[{"key":"GenericName","value":"Sulpiride"}]},{"database":"DrugBank","id":"DB06608","properties":[{"key":"GenericName","value":"Tafenoquine"}]},{"database":"DrugBank","id":"DB18711","properties":[{"key":"GenericName","value":"Taletrectinib"}]},{"database":"DrugBank","id":"DB12887","properties":[{"key":"GenericName","value":"Tazemetostat"}]},{"database":"DrugBank","id":"DB15133","properties":[{"key":"GenericName","value":"Tepotinib"}]},{"database":"DrugBank","id":"DB13946","properties":[{"key":"GenericName","value":"Testosterone undecanoate"}]},{"database":"DrugBank","id":"DB08837","properties":[{"key":"GenericName","value":"Tetraethylammonium"}]},{"database":"DrugBank","id":"DB09343","properties":[{"key":"GenericName","value":"Tipiracil"}]},{"database":"DrugBank","id":"DB06137","properties":[{"key":"GenericName","value":"Tirbanibulin"}]},{"database":"DrugBank","id":"DB01030","properties":[{"key":"GenericName","value":"Topotecan"}]},{"database":"DrugBank","id":"DB15442","properties":[{"key":"GenericName","value":"Trilaciclib"}]},{"database":"DrugBank","id":"DB00440","properties":[{"key":"GenericName","value":"Trimethoprim"}]},{"database":"DrugBank","id":"DB11652","properties":[{"key":"GenericName","value":"Tucatinib"}]},{"database":"DrugBank","id":"DB00661","properties":[{"key":"GenericName","value":"Verapamil"}]},{"database":"DrugBank","id":"DB09185","properties":[{"key":"GenericName","value":"Viloxazine"}]},{"database":"DrugBank","id":"DB17520","properties":[{"key":"GenericName","value":"Vimseltinib"}]},{"database":"DrugBank","id":"DB15688","properties":[{"key":"GenericName","value":"Zavegepant"}]},{"database":"DrugCentral","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"1216","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"2.A.66.1.14","properties":[{"key":"FamilyName","value":"the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily"}]},{"database":"iPTMnet","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SLC47A1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74731723","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000270570","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"76538","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96FL8-1"},{"database":"ProteomicsDB","id":"76539","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96FL8-2"},{"database":"ProteomicsDB","id":"76540","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96FL8-3"},{"database":"Pumba","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"13691","properties":[{"key":"antibodies","value":"143 antibodies from 30 providers"}]},{"database":"DNASU","id":"55244","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000270570.8","properties":[{"key":"ProteinId","value":"ENSP00000270570.4"},{"key":"GeneId","value":"ENSG00000142494.14"}],"isoformId":"Q96FL8-1"},{"database":"Ensembl","id":"ENST00000395585.5","properties":[{"key":"ProteinId","value":"ENSP00000378951.1"},{"key":"GeneId","value":"ENSG00000142494.14"}],"isoformId":"Q96FL8-3"},{"database":"GeneID","id":"55244","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:55244","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000270570.8","properties":[{"key":"ProteinId","value":"ENSP00000270570.4"},{"key":"RefSeqNucleotideId","value":"NM_018242.3"},{"key":"RefSeqProteinId","value":"NP_060712.2"}]},{"database":"UCSC","id":"uc002gvx.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96FL8-1"},{"database":"AGR","id":"HGNC:25588","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162403808","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55244","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"55244","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SLC47A1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:25588","properties":[{"key":"GeneName","value":"SLC47A1"}]},{"database":"HPA","id":"ENSG00000142494","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (adrenal gland, kidney, liver)"}]},{"database":"MIM","id":"609832","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000142494","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000142494","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1347","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000161644","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WFFVWKL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2126698at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96FL8","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-549127","properties":[{"key":"PathwayName","value":"SLC-mediated transport of organic cations"}]},{"database":"SABIO-RK","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000142494","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"55244","properties":[{"key":"hits","value":"13 hits in 1150 CRISPR screens"}]},{"database":"ChiTaRS","id":"SLC47A1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"SLC47A1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"55244","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96FL8","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q96FL8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"Q96FL8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000142494","properties":[{"key":"ExpressionPatterns","value":"Expressed in right adrenal gland cortex and 152 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96FL8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016324","properties":[{"key":"GoTerm","value":"C:apical plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16330770"}]},{"database":"GO","id":"GO:0016323","properties":[{"key":"GoTerm","value":"C:basolateral plasma membrane"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31791063"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28112518"}]},{"database":"GO","id":"GO:0015297","properties":[{"key":"GoTerm","value":"F:antiporter activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17509534"}]},{"database":"GO","id":"GO:0015179","properties":[{"key":"GoTerm","value":"F:L-amino acid transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23864433"}]},{"database":"GO","id":"GO:0061459","properties":[{"key":"GoTerm","value":"F:L-arginine transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23864433"}]},{"database":"GO","id":"GO:0140968","properties":[{"key":"GoTerm","value":"F:polyspecific organic cation:proton antiporter activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17509534"}]},{"database":"GO","id":"GO:0015489","properties":[{"key":"GoTerm","value":"F:putrescine transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21128598"}]},{"database":"GO","id":"GO:0015234","properties":[{"key":"GoTerm","value":"F:thiamine transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24961373"}]},{"database":"GO","id":"GO:0022857","properties":[{"key":"GoTerm","value":"F:transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17509534"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21128598"}]},{"database":"GO","id":"GO:0042910","properties":[{"key":"GoTerm","value":"F:xenobiotic transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17509534"}]},{"database":"GO","id":"GO:0015837","properties":[{"key":"GoTerm","value":"P:amine transport"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0089718","properties":[{"key":"GoTerm","value":"P:amino acid import across plasma membrane"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23864433"}]},{"database":"GO","id":"GO:1902475","properties":[{"key":"GoTerm","value":"P:L-alpha-amino acid transmembrane transport"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23864433"}]},{"database":"GO","id":"GO:0097638","properties":[{"key":"GoTerm","value":"P:L-arginine import across plasma membrane"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23864433"}]},{"database":"GO","id":"GO:0015847","properties":[{"key":"GoTerm","value":"P:putrescine transport"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21128598"}]},{"database":"GO","id":"GO:0055085","properties":[{"key":"GoTerm","value":"P:transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16330770"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17509534"}]},{"database":"GO","id":"GO:1990961","properties":[{"key":"GoTerm","value":"P:xenobiotic detoxification by transmembrane export across the plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16330770"}]},{"database":"GO","id":"GO:0006855","properties":[{"key":"GoTerm","value":"P:xenobiotic transmembrane transport"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042908","properties":[{"key":"GoTerm","value":"P:xenobiotic transport"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23864433"}]},{"database":"CDD","id":"cd13132","properties":[{"key":"EntryName","value":"MATE_eukaryotic"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045069","properties":[{"key":"EntryName","value":"MATE_euk"}]},{"database":"InterPro","id":"IPR002528","properties":[{"key":"EntryName","value":"MATE_fam"}]},{"database":"NCBIfam","id":"TIGR00797","properties":[{"key":"EntryName","value":"matE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11206","properties":[{"key":"EntryName","value":"MULTIDRUG RESISTANCE PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01554","properties":[{"key":"EntryName","value":"MatE"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ","length":570,"molWeight":61922,"crc64":"CA940CBC2F6F5CC4","md5":"FECEA745D25B923A0353F1E152715177"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":4,"BIOPHYSICOCHEMICAL PROPERTIES":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Topological domain":14,"Transmembrane":13,"Region":1,"Compositional bias":1,"Modified residue":1,"Alternative sequence":3,"Natural variant":6,"Mutagenesis":8,"Sequence conflict":4},"uniParcId":"UPI0000071042"}}