{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96EB1","secondaryAccessions":["B4E3W0","E7EPZ6","Q9H4E8","Q9NX11"],"uniProtkbId":"ELP4_HUMAN","entryAudit":{"firstPublicDate":"2007-04-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-04-17","entryVersion":167,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Elongator complex protein 4"},"shortNames":[{"value":"hELP4"}]},"alternativeNames":[{"fullName":{"value":"PAX6 neighbor gene protein"}}]},"genes":[{"geneName":{"value":"ELP4"},"synonyms":[{"value":"C11orf19"},{"value":"PAXNEB"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29332244"}],"value":"Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29332244"}],"value":"tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11714725"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22854966"}],"value":"Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6 (PubMed:11714725, PubMed:22854966)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96EB1","intActId":"EBI-3951755"},"interactantTwo":{"uniProtKBAccession":"Q8TE02","geneName":"ELP5","intActId":"EBI-946189"},"numberOfExperiments":6,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11818576"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11889558"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22854966"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11889558"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q96EB1-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q96EB1-2"],"sequenceIds":["VSP_024409"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q96EB1-3"],"sequenceIds":["VSP_054128","VSP_054129"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11889558"}],"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Aniridia 2","diseaseAccession":"DI-04858","acronym":"AN2","description":"A form of aniridia, a congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time.","diseaseCrossReference":{"database":"MIM","id":"617141"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24290376"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24290376"}],"value":"The disease is caused by variants affecting the gene represented in this entry. A disease-causing mutation is located in intron 9 of ELP4. The mutation does not alter normal ELP4 expression and function, but disrupts a long-range cis-regulatory element of PAX6 expression, known as SIMO. SIMO is contained within ELP4 intron 9 and located 150 kb downstream of PAX6"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ELP4 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11714725"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11818576"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16713582"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29332244"}],"value":"The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"Elongator complex protein 4","featureId":"PRO_0000284004"},{"type":"Alternative sequence","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054128","alternativeSequence":{"originalSequence":"E","alternativeSequences":["EQ"]}},{"type":"Alternative sequence","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_024409","alternativeSequence":{"originalSequence":"RLHLPPDLSDTVSRSSKMDLAESAKRLGPGCGMMAGGKKHLDF","alternativeSequences":["AGVQWHDLGSRRPRLLGSGGSPASASLVAGITGAHHHAQLIFVFLVEMGFHHVGQAGLELLTSGDSSASASQSAGIAGMSYRARPRALYFKENKSKVGARQLLETREEHLSSRLLILTQAERLCMGRRFFTAFHIFNELPCKGDCICLQTCQTQ"]}},{"type":"Alternative sequence","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054129","alternativeSequence":{"originalSequence":"RLHLPPDLSDTVSRSSKMDLAESAKRLGPGCGMMAGGKKHLDF","alternativeSequences":["WVQDNYLRQERNIYPPGFSYLLKQKDSAWGEGSLQHSTFLMSFLAKATAFASRLVRHSEPLKQNGSGRIRQAAGPRLWHDGRRQEAPGLLGIPP"]}},{"type":"Natural variant","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"in dbSNP:rs34804357","featureCrossReferences":[{"database":"dbSNP","id":"rs34804357"}],"featureId":"VAR_053881","alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0819","category":"Biological process","name":"tRNA processing"}],"references":[{"referenceNumber":1,"citation":{"id":"11230166","citationType":"journal article","authors":["Wiemann S.","Weil B.","Wellenreuther R.","Gassenhuber J.","Glassl S.","Ansorge W.","Boecher M.","Bloecker H.","Bauersachs S.","Blum H.","Lauber J.","Duesterhoeft A.","Beyer A.","Koehrer K.","Strack N.","Mewes H.-W.","Ottenwaelder B.","Obermaier B.","Tampe J.","Heubner D.","Wambutt R.","Korn B.","Klein M.","Poustka A."],"citationCrossReferences":[{"database":"PubMed","id":"11230166"},{"database":"DOI","id":"10.1101/gr.gr1547r"}],"title":"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.","publicationDate":"2001","journal":"Genome Res.","firstPage":"422","lastPage":"435","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)"]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.-W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.-S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"11889558","citationType":"journal article","authors":["Kleinjan D.A.","Seawright A.","Elgar G.","van Heyningen V."],"citationCrossReferences":[{"database":"PubMed","id":"11889558"},{"database":"DOI","id":"10.1007/s00335-001-3058-y"}],"title":"Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance.","publicationDate":"2002","journal":"Mamm. Genome","firstPage":"102","lastPage":"107","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":6,"citation":{"id":"11714725","citationType":"journal article","authors":["Hawkes N.A.","Otero G.","Winkler G.S.","Marshall N.","Dahmus M.E.","Krappmann D.","Scheidereit C.","Thomas C.L.","Schiavo G.","Erdjument-Bromage H.","Tempst P.","Svejstrup J.Q."],"citationCrossReferences":[{"database":"PubMed","id":"11714725"},{"database":"DOI","id":"10.1074/jbc.m110445200"}],"title":"Purification and characterization of the human elongator complex.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"3047","lastPage":"3052","volume":"277"},"referencePositions":["IDENTIFICATION IN THE ELONGATOR COMPLEX","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":7,"citation":{"id":"11818576","citationType":"journal article","authors":["Kim J.H.","Lane W.S.","Reinberg D."],"citationCrossReferences":[{"database":"PubMed","id":"11818576"},{"database":"DOI","id":"10.1073/pnas.251672198"}],"title":"Human Elongator facilitates RNA polymerase II transcription through chromatin.","publicationDate":"2002","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1241","lastPage":"1246","volume":"99"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":8,"citation":{"id":"16713582","citationType":"journal article","authors":["Close P.","Hawkes N.","Cornez I.","Creppe C.","Lambert C.A.","Rogister B.","Siebenlist U.","Merville M.P.","Slaugenhaupt S.A.","Bours V.","Svejstrup J.Q.","Chariot A."],"citationCrossReferences":[{"database":"PubMed","id":"16713582"},{"database":"DOI","id":"10.1016/j.molcel.2006.04.017"}],"title":"Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia.","publicationDate":"2006","journal":"Mol. Cell","firstPage":"521","lastPage":"531","volume":"22"},"referencePositions":["DISPUTED FUNCTION IN HISTONE ACETYLATION"]},{"referenceNumber":9,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":10,"citation":{"id":"22854966","citationType":"journal article","authors":["Close P.","Gillard M.","Ladang A.","Jiang Z.","Papuga J.","Hawkes N.","Nguyen L.","Chapelle J.P.","Bouillenne F.","Svejstrup J.","Fillet M.","Chariot A."],"citationCrossReferences":[{"database":"PubMed","id":"22854966"},{"database":"DOI","id":"10.1074/jbc.m112.402727"}],"title":"DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"32535","lastPage":"32545","volume":"287"},"referencePositions":["IDENTIFICATION IN THE ELONGATOR COMPLEX","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"24290376","citationType":"journal article","authors":["Bhatia S.","Bengani H.","Fish M.","Brown A.","Divizia M.T.","de Marco R.","Damante G.","Grainger R.","van Heyningen V.","Kleinjan D.A."],"citationCrossReferences":[{"database":"PubMed","id":"24290376"},{"database":"DOI","id":"10.1016/j.ajhg.2013.10.028"}],"title":"Disruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.","publicationDate":"2013","journal":"Am. J. Hum. Genet.","firstPage":"1126","lastPage":"1134","volume":"93"},"referencePositions":["INVOLVEMENT IN AN2"]},{"referenceNumber":12,"citation":{"id":"29332244","citationType":"journal article","authors":["Dalwadi U.","Yip C.K."],"citationCrossReferences":[{"database":"PubMed","id":"29332244"},{"database":"DOI","id":"10.1007/s00018-018-2747-6"}],"title":"Structural insights into the function of Elongator.","publicationDate":"2018","journal":"Cell. Mol. Life Sci.","firstPage":"1613","lastPage":"1622","volume":"75"},"referencePositions":["REVIEW"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136677","properties":[{"key":"ProteinId","value":"CAB66612.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK000505","properties":[{"key":"ProteinId","value":"BAA91212.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK304885","properties":[{"key":"ProteinId","value":"BAG65622.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC108456","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC131571","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z83001","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z83306","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z83307","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC012514","properties":[{"key":"ProteinId","value":"AAH12514.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ276005","properties":[{"key":"ProteinId","value":"CAC08200.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS73271.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96EB1-3"},{"database":"CCDS","id":"CCDS73272.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96EB1-2"},{"database":"CCDS","id":"CCDS7875.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96EB1-1"},{"database":"RefSeq","id":"NP_001275654.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001288725.2"}],"isoformId":"Q96EB1-3"},{"database":"RefSeq","id":"NP_001275655.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001288726.2"}]},{"database":"RefSeq","id":"NP_061913.3","properties":[{"key":"NucleotideSequenceId","value":"NM_019040.5"}],"isoformId":"Q96EB1-1"},{"database":"AlphaFoldDB","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"117764","properties":[{"key":"Interactions","value":"73"}]},{"database":"ComplexPortal","id":"CPX-1949","properties":[{"key":"EntryName","value":"Elongator holoenzyme complex"}]},{"database":"CORUM","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q96EB1","properties":[{"key":"Number of interactors","value":"2869"}]},{"database":"IntAct","id":"Q96EB1","properties":[{"key":"Interactions","value":"25"}]},{"database":"MINT","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ELP4","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000379267","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q96EB1","properties":[{"key":"glycosylation","value":"3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ELP4","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"145558903","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000379267","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"5926","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"76391","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96EB1-1"},{"database":"ProteomicsDB","id":"76392","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96EB1-2"},{"database":"Pumba","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"25549","properties":[{"key":"antibodies","value":"161 antibodies from 27 providers"}]},{"database":"DNASU","id":"26610","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000379163.10","properties":[{"key":"ProteinId","value":"ENSP00000368461.5"},{"key":"GeneId","value":"ENSG00000109911.20"}],"isoformId":"Q96EB1-3"},{"database":"Ensembl","id":"ENST00000640961.2","properties":[{"key":"ProteinId","value":"ENSP00000492152.1"},{"key":"GeneId","value":"ENSG00000109911.20"}],"isoformId":"Q96EB1-1"},{"database":"GeneID","id":"26610","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:26610","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000640961.2","properties":[{"key":"ProteinId","value":"ENSP00000492152.1"},{"key":"RefSeqNucleotideId","value":"NM_019040.5"},{"key":"RefSeqProteinId","value":"NP_061913.3"}]},{"database":"UCSC","id":"uc001mtb.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96EB1-1"},{"database":"AGR","id":"HGNC:1171","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27764","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"26610","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"26610","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ELP4","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1171","properties":[{"key":"GeneName","value":"ELP4"}]},{"database":"HPA","id":"ENSG00000109911","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"ELP4","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"606985","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"617141","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000109911","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000109911","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3949","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000001443","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_031345_3_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"289162at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96EB1","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:ENSG00000109911-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-3214847","properties":[{"key":"PathwayName","value":"HATs acetylate histones"}]},{"database":"SignaLink","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00988","properties":[{"key":"RectionId","value":"-"}]},{"database":"Agora","id":"ENSG00000109911","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"26610","properties":[{"key":"hits","value":"485 hits in 1172 CRISPR screens"}]},{"database":"ChiTaRS","id":"ELP4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"ELP4","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"26610","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96EB1","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q96EB1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q96EB1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000109911","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 169 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96EB1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11818576"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22854966"}]},{"database":"GO","id":"GO:0033588","properties":[{"key":"GoTerm","value":"C:elongator holoenzyme complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22854966"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11889558"}]},{"database":"GO","id":"GO:0008023","properties":[{"key":"GoTerm","value":"C:transcription elongation factor complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11818576"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11818576"}]},{"database":"GO","id":"GO:0006417","properties":[{"key":"GoTerm","value":"P:regulation of translation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22854966"}]},{"database":"GO","id":"GO:0002098","properties":[{"key":"GoTerm","value":"P:tRNA wobble uridine modification"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd19494","properties":[{"key":"EntryName","value":"Elp4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000623","properties":[{"key":"EntryName","value":"Elongator acetyltransferase complex subunit 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008728","properties":[{"key":"EntryName","value":"Elongator_complex_protein_4"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR12896:SF1","properties":[{"key":"EntryName","value":"ELONGATOR COMPLEX PROTEIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12896","properties":[{"key":"EntryName","value":"PAX6 NEIGHBOR PROTEIN PAXNEB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05625","properties":[{"key":"EntryName","value":"PAXNEB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAVATCGSVAASTGSAVATASKSNVTSFQRRGPRASVTNDSGPRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNLICDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSSKMDLAESAKRLGPGCGMMAGGKKHLDF","length":424,"molWeight":46588,"crc64":"A044C964F7C91E73","md5":"59BD2079BFBFA216E5F207267483173D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"PATHWAY":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Chain":1,"Alternative sequence":3,"Natural variant":1},"uniParcId":"UPI0000074047"}}