{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96E40","secondaryAccessions":["Q9UGQ0"],"uniProtkbId":"SACA9_HUMAN","entryAudit":{"firstPublicDate":"2005-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":161,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Sperm acrosome-associated protein 9"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1367"}],"value":"SPACA9"},"synonyms":[{"value":"C9orf9"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TPM5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36191189"}],"value":"Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa (PubMed:36191189). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8P4"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TPM5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36191189"}],"value":"Microtubule inner protein component of sperm flagellar doublet microtubules (PubMed:36191189). Interacts with CABP1 and CALR (By similarity). Interacts with INCA1 (By similarity). Interacts with microtubules (By similarity) (PubMed:36191189)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96E40","intActId":"EBI-722584"},"interactantTwo":{"uniProtKBAccession":"O95967","geneName":"EFEMP2","intActId":"EBI-743414"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96E40","intActId":"EBI-722584"},"interactantTwo":{"uniProtKBAccession":"O00471","geneName":"EXOC5","intActId":"EBI-949824"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96E40","intActId":"EBI-722584"},"interactantTwo":{"uniProtKBAccession":"Q07627","geneName":"KRTAP1-1","intActId":"EBI-11959885"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96E40","intActId":"EBI-722584"},"interactantTwo":{"uniProtKBAccession":"P60370","geneName":"KRTAP10-5","intActId":"EBI-10172150"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96E40","intActId":"EBI-722584"},"interactantTwo":{"uniProtKBAccession":"P60409","geneName":"KRTAP10-7","intActId":"EBI-10172290"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96E40","intActId":"EBI-722584"},"interactantTwo":{"uniProtKBAccession":"P60410","geneName":"KRTAP10-8","intActId":"EBI-10171774"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96E40","intActId":"EBI-722584"},"interactantTwo":{"uniProtKBAccession":"P60411","geneName":"KRTAP10-9","intActId":"EBI-10172052"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TPM5"}],"value":"In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TPM5"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TPM5"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome","id":"SL-0007"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TPM5"}],"value":"Cytoplasm, cytoskeleton, cilium basal body","id":"SL-0087"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TPM5"}],"value":"Cytoplasm, cytoskeleton, flagellum axoneme","id":"SL-0114"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28282151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36191189"}],"value":"Cytoplasm, cytoskeleton, cilium axoneme","id":"SL-0304"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8P4"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q96E40-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q96E40-2"],"sequenceIds":["VSP_014456","VSP_014457"],"isoformSequenceStatus":"Described"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Sperm acrosome-associated protein 9","featureId":"PRO_0000089673"},{"type":"Region","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Essential for interaction with INCA1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8P4"}]},{"type":"Site","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Essential for interaction with INCA1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8P4"}]},{"type":"Alternative sequence","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_014456","alternativeSequence":{"originalSequence":"VSE","alternativeSequences":["GTT"]}},{"type":"Alternative sequence","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_014457","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"in dbSNP:rs2231406","featureCrossReferences":[{"database":"dbSNP","id":"rs2231406"}],"featureId":"VAR_056817","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0282","category":"Cellular component","name":"Flagellum"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-1T0DVGOT36F1B","citationType":"submission","authors":["Young J.M.","Woodward K.J.","Aziz S.","Burley M.","Kwiatkowski D.J.","Povey S."],"title":"Cloning of a sugar transporter gene, a G-beta subunit like gene and three novel genes in human chromosome 9q34.","publicationDate":"SEP-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Thyroid","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"]},{"referenceNumber":4,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.S.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.R.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.I.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.M.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"28282151","citationType":"journal article","authors":["Blackburn K.","Bustamante-Marin X.","Yin W.","Goshe M.B.","Ostrowski L.E."],"citationCrossReferences":[{"database":"PubMed","id":"28282151"},{"database":"DOI","id":"10.1021/acs.jproteome.6b00972"}],"title":"Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance.","publicationDate":"2017","journal":"J. Proteome Res.","firstPage":"1579","lastPage":"1592","volume":"16"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":7,"citation":{"id":"36191189","citationType":"journal article","authors":["Gui M.","Croft J.T.","Zabeo D.","Acharya V.","Kollman J.M.","Burgoyne T.","Hoog J.L.","Brown A."],"citationCrossReferences":[{"database":"PubMed","id":"36191189"},{"database":"DOI","id":"10.1073/pnas.2207605119"}],"title":"SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.","publicationDate":"2022","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2207605119","lastPage":"e2207605119","volume":"119"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS) IN ASSOCIATION WITH MICROTUBULES","SUBCELLULAR LOCATION","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UNG"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ011375","properties":[{"key":"ProteinId","value":"CAB66158.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK075259","properties":[{"key":"ProteinId","value":"BAC11503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR457210","properties":[{"key":"ProteinId","value":"CAG33491.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL445645","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC012940","properties":[{"key":"ProteinId","value":"AAH12940.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6955.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96E40-2"},{"database":"CCDS","id":"CCDS83434.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96E40-1"},{"database":"RefSeq","id":"NP_001303826.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001316897.2"}],"isoformId":"Q96E40-1"},{"database":"RefSeq","id":"NP_001303827.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001316898.2"}],"isoformId":"Q96E40-1"},{"database":"RefSeq","id":"NP_001303829.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001316900.2"}]},{"database":"RefSeq","id":"NP_061829.3","properties":[{"key":"NucleotideSequenceId","value":"NM_018956.5"}],"isoformId":"Q96E40-2"},{"database":"RefSeq","id":"XP_024303164.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024447396.2"}],"isoformId":"Q96E40-1"},{"database":"RefSeq","id":"XP_024303165.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024447397.2"}],"isoformId":"Q96E40-2"},{"database":"RefSeq","id":"XP_047278653.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047422697.1"}],"isoformId":"Q96E40-2"},{"database":"RefSeq","id":"XP_054217829.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054361854.1"}],"isoformId":"Q96E40-1"},{"database":"RefSeq","id":"XP_054217831.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054361856.1"}],"isoformId":"Q96E40-2"},{"database":"RefSeq","id":"XP_054217832.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054361857.1"}],"isoformId":"Q96E40-2"},{"database":"PDB","id":"7UN1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/d/e/f/g/h/i=1-222"}]},{"database":"PDB","id":"7UNG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"F0/F1/F2/F3/F4/F5/F6/F7/F8/G0/G1/G2/G3/G4/G5/G6/G7/G8/H0/H1/H2=1-222"}]},{"database":"PDB","id":"8J07","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.10 A"},{"key":"Chains","value":"6A/6C/6E/6G/6I/6K/6L/6N/6O/6Q/6R/6T/6V=1-222"}]},{"database":"PDBsum","id":"7UN1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UNG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8J07","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26611","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26624","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35888","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116273","properties":[{"key":"Interactions","value":"21"}]},{"database":"FunCoup","id":"Q96E40","properties":[{"key":"Number of interactors","value":"56"}]},{"database":"IntAct","id":"Q96E40","properties":[{"key":"Interactions","value":"18"}]},{"database":"MINT","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000361209","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SPACA9","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"68565255","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000361209","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"76371","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96E40-1"},{"database":"ProteomicsDB","id":"76372","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96E40-2"},{"database":"Antibodypedia","id":"18219","properties":[{"key":"antibodies","value":"54 antibodies from 14 providers"}]},{"database":"DNASU","id":"11092","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000350499.6","properties":[{"key":"ProteinId","value":"ENSP00000298546.7"},{"key":"GeneId","value":"ENSG00000165698.17"}],"isoformId":"Q96E40-2"},{"database":"Ensembl","id":"ENST00000356311.10","properties":[{"key":"ProteinId","value":"ENSP00000348659.5"},{"key":"GeneId","value":"ENSG00000165698.17"}],"isoformId":"Q96E40-1"},{"database":"Ensembl","id":"ENST00000372136.7","properties":[{"key":"ProteinId","value":"ENSP00000361209.3"},{"key":"GeneId","value":"ENSG00000165698.17"}],"isoformId":"Q96E40-1"},{"database":"Ensembl","id":"ENST00000855798.1","properties":[{"key":"ProteinId","value":"ENSP00000525857.1"},{"key":"GeneId","value":"ENSG00000165698.17"}],"isoformId":"Q96E40-1"},{"database":"Ensembl","id":"ENST00000944246.1","properties":[{"key":"ProteinId","value":"ENSP00000614305.1"},{"key":"GeneId","value":"ENSG00000165698.17"}],"isoformId":"Q96E40-1"},{"database":"Ensembl","id":"ENST00000944247.1","properties":[{"key":"ProteinId","value":"ENSP00000614306.1"},{"key":"GeneId","value":"ENSG00000165698.17"}],"isoformId":"Q96E40-1"},{"database":"GeneID","id":"11092","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:11092","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000356311.10","properties":[{"key":"ProteinId","value":"ENSP00000348659.5"},{"key":"RefSeqNucleotideId","value":"NM_001316897.2"},{"key":"RefSeqProteinId","value":"NP_001303826.1"}]},{"database":"UCSC","id":"uc004cbx.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96E40-1"},{"database":"AGR","id":"HGNC:1367","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25983","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"11092","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"11092","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SPACA9","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1367","properties":[{"key":"GeneName","value":"SPACA9"}]},{"database":"HPA","id":"ENSG00000165698","properties":[{"key":"ExpressionPatterns","value":"Group enriched (epididymis, fallopian tube, testis)"}]},{"database":"MIM","id":"618552","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000165698","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000165698","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QQV9","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000007746","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_100443_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EHHCYNS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9999829at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96E40","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000165698","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"11092","properties":[{"key":"hits","value":"17 hits in 1131 CRISPR screens"}]},{"database":"ChiTaRS","id":"SPACA9","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"11092","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96E40","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q96E40","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"Q96E40","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000165698","properties":[{"key":"ExpressionPatterns","value":"Expressed in left testis and 162 other cell types or tissues"}]},{"database":"GO","id":"GO:0001669","properties":[{"key":"GoTerm","value":"C:acrosomal vesicle"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005879","properties":[{"key":"GoTerm","value":"C:axonemal microtubule"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36191189"}]},{"database":"GO","id":"GO:0160110","properties":[{"key":"GoTerm","value":"C:axonemal microtubule doublet inner sheath"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005930","properties":[{"key":"GoTerm","value":"C:axoneme"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28282151"}]},{"database":"GO","id":"GO:0036064","properties":[{"key":"GoTerm","value":"C:ciliary basal body"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0097546","properties":[{"key":"GoTerm","value":"C:ciliary base"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005881","properties":[{"key":"GoTerm","value":"C:cytoplasmic microtubule"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23264731"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0097229","properties":[{"key":"GoTerm","value":"C:sperm end piece"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0036126","properties":[{"key":"GoTerm","value":"C:sperm flagellum"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048306","properties":[{"key":"GoTerm","value":"F:calcium-dependent protein binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36191189"}]},{"database":"GO","id":"GO:0035082","properties":[{"key":"GoTerm","value":"P:axoneme assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36191189"}]},{"database":"GO","id":"GO:0030317","properties":[{"key":"GoTerm","value":"P:flagellated sperm motility"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"InterPro","id":"IPR027818","properties":[{"key":"EntryName","value":"SPACA9"}]},{"database":"PANTHER","id":"PTHR32455","properties":[{"key":"EntryName","value":"SPERM ACROSOME-ASSOCIATED PROTEIN 9"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR32455:SF1","properties":[{"key":"EntryName","value":"SPERM ACROSOME-ASSOCIATED PROTEIN 9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15120","properties":[{"key":"EntryName","value":"SPACA9"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNEVKESLRSIEQKYKLFQQQQLTFTAALEHCRENAHDKIRPISSIGQVQSYMEHYCNSSTDRRVLLMFLDICSELNKLCQHFEAVHSGTPVTNNLLEKCKTLVSQSNDLSSLRAKYPHDVVNHLSCDEARNHYGGVVSLIPLILDLMKEWIAHSEKLPRKVLQHVSEPQAHQESTRGAARPAQAIGTQPRATKHKCRQLTKASLKPRGCSKPPWRPPGGKL","length":222,"molWeight":25166,"crc64":"F052332EB5E6EC96","md5":"0DF1BD918E024AC5AB6C9A3B7DD9CC21"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":7,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2},"countByFeatureType":{"Chain":1,"Region":1,"Site":2,"Alternative sequence":2,"Natural variant":1},"uniParcId":"UPI0000073F8B"}}