{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96BY6","secondaryAccessions":["B3FL70","O75178","Q68DA4","Q9NW06","Q9NXI8"],"uniProtkbId":"DOC10_HUMAN","entryAudit":{"firstPublicDate":"2003-07-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-05-03","entryVersion":195,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Dedicator of cytokinesis protein 10"}},"alternativeNames":[{"fullName":{"value":"Zizimin-3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:23479"}],"value":"DOCK10"},"synonyms":[{"value":"KIAA0694"},{"value":"ZIZ3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}],"value":"Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96BY6","intActId":"EBI-748520"},"interactantTwo":{"uniProtKBAccession":"Q68D86","geneName":"CCDC102B","intActId":"EBI-10171570"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96BY6","intActId":"EBI-748520"},"interactantTwo":{"uniProtKBAccession":"P43364","geneName":"MAGEA11","intActId":"EBI-739552"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96BY6","intActId":"EBI-748520"},"interactantTwo":{"uniProtKBAccession":"O75400-2","geneName":"PRPF40A","intActId":"EBI-5280197"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96BY6","intActId":"EBI-748520"},"interactantTwo":{"uniProtKBAccession":"Q9Y371","geneName":"SH3GLB1","intActId":"EBI-2623095"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96BY6-3","intActId":"EBI-10282566"},"interactantTwo":{"uniProtKBAccession":"P43364-2","geneName":"MAGEA11","intActId":"EBI-10178634"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18499258"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18499258"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"DOCK10.1"}],"isoformIds":["Q96BY6-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q96BY6-2"],"sequenceIds":["VSP_007716","VSP_007717"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"DOCK10.2"}],"isoformIds":["Q96BY6-3"],"sequenceIds":["VSP_047731"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18499258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21514340"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9734811"}],"value":"Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18499258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21514340"}],"value":"Isoforms 1 and 2 are up-regulated in response to IL4 in B-cells but not T-cells"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}],"value":"The DOCKER domain may mediate some GEF activity"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"'Zizim' means 'spike' in Hebrew"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00983"}],"value":"Belongs to the DOCK family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH15018.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA31669.2","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAA91022.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA91583.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAH18316.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2186,"modifier":"EXACT"}},"description":"Dedicator of cytokinesis protein 10","featureId":"PRO_0000190002"},{"type":"Domain","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00145"}]},{"type":"Domain","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"C2 DOCK-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00983"}]},{"type":"Domain","location":{"start":{"value":1690,"modifier":"EXACT"},"end":{"value":2150,"modifier":"EXACT"}},"description":"DOCKER","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00984"}]},{"type":"Region","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1290,"modifier":"EXACT"},"end":{"value":1313,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1302,"modifier":"EXACT"},"end":{"value":1313,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}]},{"type":"Modified residue","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}]},{"type":"Modified residue","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}]},{"type":"Modified residue","location":{"start":{"value":834,"modifier":"EXACT"},"end":{"value":834,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":877,"modifier":"EXACT"},"end":{"value":877,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}]},{"type":"Modified residue","location":{"start":{"value":1232,"modifier":"EXACT"},"end":{"value":1232,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":1257,"modifier":"EXACT"},"end":{"value":1257,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}]},{"type":"Modified residue","location":{"start":{"value":1292,"modifier":"EXACT"},"end":{"value":1292,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18088087"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":1295,"modifier":"EXACT"},"end":{"value":1295,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18088087"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":1318,"modifier":"EXACT"},"end":{"value":1318,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":1406,"modifier":"EXACT"},"end":{"value":1406,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BZN6"}]},{"type":"Modified residue","location":{"start":{"value":1440,"modifier":"EXACT"},"end":{"value":1440,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21514340"}],"featureId":"VSP_047731","alternativeSequence":{"originalSequence":"MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQR","alternativeSequences":["MSFRGKVFKREPSEFWKKRRTVRRVNQEEIHRFSS"]}},{"type":"Alternative sequence","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9734811"}],"featureId":"VSP_007716","alternativeSequence":{"originalSequence":"FKDNQGNVDRDSRFSPLFRQESSKISTED","alternativeSequences":["DSCSQQTRNTFNGGIGSFSFERFCVAYYF"]}},{"type":"Alternative sequence","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":2186,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9734811"}],"featureId":"VSP_007717","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":563,"modifier":"EXACT"}},"description":"in Ref. 1; BAA31669","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Sequence conflict","location":{"start":{"value":1833,"modifier":"EXACT"},"end":{"value":1833,"modifier":"EXACT"}},"description":"in Ref. 7; BAA91583","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":1966,"modifier":"EXACT"},"end":{"value":1966,"modifier":"EXACT"}},"description":"in Ref. 7; BAA91022","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":2062,"modifier":"EXACT"},"end":{"value":2062,"modifier":"EXACT"}},"description":"in Ref. 8; CAH18316","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":2093,"modifier":"EXACT"},"end":{"value":2093,"modifier":"EXACT"}},"description":"in Ref. 8; CAH18316","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":1696,"modifier":"EXACT"},"end":{"value":1713,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1716,"modifier":"EXACT"},"end":{"value":1736,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1773,"modifier":"EXACT"},"end":{"value":1775,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1777,"modifier":"EXACT"},"end":{"value":1780,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Turn","location":{"start":{"value":1781,"modifier":"EXACT"},"end":{"value":1783,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1785,"modifier":"EXACT"},"end":{"value":1791,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1806,"modifier":"EXACT"},"end":{"value":1822,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1826,"modifier":"EXACT"},"end":{"value":1828,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1829,"modifier":"EXACT"},"end":{"value":1843,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1846,"modifier":"EXACT"},"end":{"value":1864,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Turn","location":{"start":{"value":1865,"modifier":"EXACT"},"end":{"value":1868,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":1876,"modifier":"EXACT"},"end":{"value":1883,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Turn","location":{"start":{"value":1885,"modifier":"EXACT"},"end":{"value":1887,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Turn","location":{"start":{"value":1890,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":1895,"modifier":"EXACT"},"end":{"value":1901,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1906,"modifier":"EXACT"},"end":{"value":1921,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1923,"modifier":"EXACT"},"end":{"value":1925,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":1926,"modifier":"EXACT"},"end":{"value":1929,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1934,"modifier":"EXACT"},"end":{"value":1936,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKZ"}]},{"type":"Helix","location":{"start":{"value":1937,"modifier":"EXACT"},"end":{"value":1939,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":1944,"modifier":"EXACT"},"end":{"value":1954,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":1958,"modifier":"EXACT"},"end":{"value":1961,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Turn","location":{"start":{"value":1967,"modifier":"EXACT"},"end":{"value":1970,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":1971,"modifier":"EXACT"},"end":{"value":1983,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":1985,"modifier":"EXACT"},"end":{"value":1987,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Turn","location":{"start":{"value":1993,"modifier":"EXACT"},"end":{"value":1995,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":1997,"modifier":"EXACT"},"end":{"value":2010,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":2012,"modifier":"EXACT"},"end":{"value":2026,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":2028,"modifier":"EXACT"},"end":{"value":2048,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Beta strand","location":{"start":{"value":2049,"modifier":"EXACT"},"end":{"value":2051,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":2054,"modifier":"EXACT"},"end":{"value":2065,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":2077,"modifier":"EXACT"},"end":{"value":2081,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":2083,"modifier":"EXACT"},"end":{"value":2086,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":2091,"modifier":"EXACT"},"end":{"value":2116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":2121,"modifier":"EXACT"},"end":{"value":2123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]},{"type":"Helix","location":{"start":{"value":2124,"modifier":"EXACT"},"end":{"value":2145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TKY"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"}],"references":[{"referenceNumber":1,"citation":{"id":"9734811","citationType":"journal article","authors":["Ishikawa K.","Nagase T.","Suyama M.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"9734811"},{"database":"DOI","id":"10.1093/dnares/5.3.169"}],"title":"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.","publicationDate":"1998","journal":"DNA Res.","firstPage":"169","lastPage":"176","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"12168954","citationType":"journal article","authors":["Nakajima D.","Okazaki N.","Yamakawa H.","Kikuno R.","Ohara O.","Nagase T."],"citationCrossReferences":[{"database":"PubMed","id":"12168954"},{"database":"DOI","id":"10.1093/dnares/9.3.99"}],"title":"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.","publicationDate":"2002","journal":"DNA Res.","firstPage":"99","lastPage":"106","volume":"9"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":3,"citation":{"id":"18499258","citationType":"journal article","authors":["Yelo E.","Bernardo M.V.","Gimeno L.","Alcaraz-Garcia M.J.","Majado M.J.","Parrado A."],"citationCrossReferences":[{"database":"PubMed","id":"18499258"},{"database":"DOI","id":"10.1016/j.molimm.2008.04.003"}],"title":"Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.","publicationDate":"2008","journal":"Mol. Immunol.","firstPage":"3411","lastPage":"3418","volume":"45"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)","INDUCTION","TISSUE SPECIFICITY","SUBCELLULAR LOCATION"]},{"referenceNumber":4,"citation":{"id":"21514340","citationType":"journal article","authors":["Alcaraz-Garcia M.J.","Ruiz-Lafuente N.","Sebastian-Ruiz S.","Majado M.J.","Gonzalez-Garcia C.","Bernardo M.V.","Alvarez-Lopez M.R.","Parrado A."],"citationCrossReferences":[{"database":"PubMed","id":"21514340"},{"database":"DOI","id":"10.1016/j.humimm.2011.03.024"}],"title":"Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.","publicationDate":"2011","journal":"Hum. Immunol.","firstPage":"531","lastPage":"537","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)","INDUCTION","TISSUE SPECIFICITY"]},{"referenceNumber":5,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1599-2186 (ISOFORM 1)"],"referenceComments":[{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1599-2186 (ISOFORM 1)"],"referenceComments":[{"value":"Colon mucosa","type":"TISSUE"},{"value":"Teratocarcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"11230166","citationType":"journal article","authors":["Wiemann S.","Weil B.","Wellenreuther R.","Gassenhuber J.","Glassl S.","Ansorge W.","Boecher M.","Bloecker H.","Bauersachs S.","Blum H.","Lauber J.","Duesterhoeft A.","Beyer A.","Koehrer K.","Strack N.","Mewes H.-W.","Ottenwaelder B.","Obermaier B.","Tampe J.","Heubner D.","Wambutt R.","Korn B.","Klein M.","Poustka A."],"citationCrossReferences":[{"database":"PubMed","id":"11230166"},{"database":"DOI","id":"10.1101/gr.gr1547r"}],"title":"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.","publicationDate":"2001","journal":"Genome Res.","firstPage":"422","lastPage":"435","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 977-2186"],"referenceComments":[{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"12432077","citationType":"journal article","authors":["Cote J.-F.","Vuori K."],"citationCrossReferences":[{"database":"PubMed","id":"12432077"},{"database":"DOI","id":"10.1242/jcs.00219"}],"title":"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.","publicationDate":"2002","journal":"J. Cell Sci.","firstPage":"4901","lastPage":"4913","volume":"115"},"referencePositions":["NOMENCLATURE"]},{"referenceNumber":10,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1292; SER-1295 AND SER-1318","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"18088087","citationType":"journal article","authors":["Zahedi R.P.","Lewandrowski U.","Wiesner J.","Wortelkamp S.","Moebius J.","Schuetz C.","Walter U.","Gambaryan S.","Sickmann A."],"citationCrossReferences":[{"database":"PubMed","id":"18088087"},{"database":"DOI","id":"10.1021/pr0704130"}],"title":"Phosphoproteome of resting human platelets.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"526","lastPage":"534","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1292 AND SER-1295","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1232; SER-1292; SER-1295; SER-1318 AND THR-1440","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-834","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":14,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB014594","properties":[{"key":"ProteinId","value":"BAA31669.2"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EU236710","properties":[{"key":"ProteinId","value":"ABY70713.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC011739","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC017095","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC093806","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC015018","properties":[{"key":"ProteinId","value":"AAH15018.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK000227","properties":[{"key":"ProteinId","value":"BAA91022.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK001253","properties":[{"key":"ProteinId","value":"BAA91583.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR749492","properties":[{"key":"ProteinId","value":"CAH18316.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS46528.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96BY6-1"},{"database":"CCDS","id":"CCDS74661.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96BY6-3"},{"database":"RefSeq","id":"NP_001277192.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001290263.2"}],"isoformId":"Q96BY6-3"},{"database":"RefSeq","id":"NP_055504.2","properties":[{"key":"NucleotideSequenceId","value":"NM_014689.3"}],"isoformId":"Q96BY6-1"},{"database":"PDB","id":"6TKY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A=1694-2151, B=1694-2150"}]},{"database":"PDB","id":"6TKZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.64 A"},{"key":"Chains","value":"A/B=1694-2151"}]},{"database":"PDB","id":"6TM1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.71 A"},{"key":"Chains","value":"B=1694-2150, C=1694-2151"}]},{"database":"PDB","id":"7Q43","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D/F=146-170"}]},{"database":"PDBsum","id":"6TKY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TKZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TM1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7Q43","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"120758","properties":[{"key":"Interactions","value":"32"}]},{"database":"FunCoup","id":"Q96BY6","properties":[{"key":"Number of interactors","value":"2479"}]},{"database":"IntAct","id":"Q96BY6","properties":[{"key":"Interactions","value":"13"}]},{"database":"MINT","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-DOCK10","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000493664","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q96BY6","properties":[{"key":"glycosylation","value":"1 site, 1 glycan"}]},{"database":"GlyGen","id":"Q96BY6","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (4 sites)"}]},{"database":"iPTMnet","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DOCK10","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"332278210","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000493664","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"3476","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"76127","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96BY6-1"},{"database":"ProteomicsDB","id":"76128","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96BY6-2"},{"database":"Pumba","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34369","properties":[{"key":"antibodies","value":"57 antibodies from 16 providers"}]},{"database":"DNASU","id":"55619","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000258390.12","properties":[{"key":"ProteinId","value":"ENSP00000258390.7"},{"key":"GeneId","value":"ENSG00000135905.21"}],"isoformId":"Q96BY6-1"},{"database":"Ensembl","id":"ENST00000409592.7","properties":[{"key":"ProteinId","value":"ENSP00000386694.3"},{"key":"GeneId","value":"ENSG00000135905.21"}],"isoformId":"Q96BY6-3"},{"database":"GeneID","id":"55619","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:55619","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000258390.12","properties":[{"key":"ProteinId","value":"ENSP00000258390.7"},{"key":"RefSeqNucleotideId","value":"NM_014689.3"},{"key":"RefSeqProteinId","value":"NP_055504.2"}]},{"database":"UCSC","id":"uc002vob.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96BY6-1"},{"database":"AGR","id":"HGNC:23479","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134983197","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55619","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"55619","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DOCK10","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:23479","properties":[{"key":"GeneName","value":"DOCK10"}]},{"database":"HPA","id":"ENSG00000135905","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain, lymphoid tissue)"}]},{"database":"MIM","id":"611518","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000135905","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135905","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1997","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157469","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000624_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RACNTPP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"47328at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96BY6","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9013148","properties":[{"key":"PathwayName","value":"CDC42 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9013149","properties":[{"key":"PathwayName","value":"RAC1 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9013404","properties":[{"key":"PathwayName","value":"RAC2 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9013423","properties":[{"key":"PathwayName","value":"RAC3 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-983231","properties":[{"key":"PathwayName","value":"Factors involved in megakaryocyte development and platelet production"}]},{"database":"SignaLink","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000135905","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"55619","properties":[{"key":"hits","value":"23 hits in 1150 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"DOCK10","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Dock10","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"55619","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96BY6","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q96BY6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"Q96BY6","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000135905","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 164 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96BY6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18499258"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18499258"}]},{"database":"GO","id":"GO:0005085","properties":[{"key":"GoTerm","value":"F:guanyl-nucleotide exchange factor activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001782","properties":[{"key":"GoTerm","value":"P:B cell homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060997","properties":[{"key":"GoTerm","value":"P:dendritic spine morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0002315","properties":[{"key":"GoTerm","value":"P:marginal zone B cell differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043547","properties":[{"key":"GoTerm","value":"P:positive regulation of GTPase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030334","properties":[{"key":"GoTerm","value":"P:regulation of cell migration"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18835169"}]},{"database":"GO","id":"GO:0150052","properties":[{"key":"GoTerm","value":"P:regulation of postsynapse assembly"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035023","properties":[{"key":"GoTerm","value":"P:regulation of Rho protein signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007264","properties":[{"key":"GoTerm","value":"P:small GTPase-mediated signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd08697","properties":[{"key":"EntryName","value":"C2_Dock-D"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd11699","properties":[{"key":"EntryName","value":"DHR2_DOCK10"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13267","properties":[{"key":"EntryName","value":"PH_DOCK-D"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.740:FF:000001","properties":[{"key":"EntryName","value":"dedicator of cytokinesis protein 9 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000016","properties":[{"key":"EntryName","value":"dedicator of cytokinesis protein 9 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.150:FF:000015","properties":[{"key":"EntryName","value":"dedicator of cytokinesis protein 9 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.740","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.410","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.150","properties":[{"key":"EntryName","value":"C2 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037809","properties":[{"key":"EntryName","value":"C2_Dock-D"}]},{"database":"InterPro","id":"IPR027007","properties":[{"key":"EntryName","value":"C2_DOCK-type_domain"}]},{"database":"InterPro","id":"IPR035892","properties":[{"key":"EntryName","value":"C2_domain_sf"}]},{"database":"InterPro","id":"IPR026791","properties":[{"key":"EntryName","value":"DOCK"}]},{"database":"InterPro","id":"IPR021816","properties":[{"key":"EntryName","value":"DOCK_C/D_N"}]},{"database":"InterPro","id":"IPR043161","properties":[{"key":"EntryName","value":"DOCK_C_lobe_A"}]},{"database":"InterPro","id":"IPR043162","properties":[{"key":"EntryName","value":"DOCK_C_lobe_C"}]},{"database":"InterPro","id":"IPR027357","properties":[{"key":"EntryName","value":"DOCKER_dom"}]},{"database":"InterPro","id":"IPR046769","properties":[{"key":"EntryName","value":"DOCKER_Lobe_A"}]},{"database":"InterPro","id":"IPR046770","properties":[{"key":"EntryName","value":"DOCKER_Lobe_B"}]},{"database":"InterPro","id":"IPR046773","properties":[{"key":"EntryName","value":"DOCKER_Lobe_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR060065","properties":[{"key":"EntryName","value":"TPR_DOCK6-11"}]},{"database":"PANTHER","id":"PTHR23317","properties":[{"key":"EntryName","value":"DEDICATOR OF CYTOKINESIS DOCK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23317:SF71","properties":[{"key":"EntryName","value":"DEDICATOR OF CYTOKINESIS PROTEIN 10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06920","properties":[{"key":"EntryName","value":"DHR-2_Lobe_A"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF20422","properties":[{"key":"EntryName","value":"DHR-2_Lobe_B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20421","properties":[{"key":"EntryName","value":"DHR-2_Lobe_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14429","properties":[{"key":"EntryName","value":"DOCK-C2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11878","properties":[{"key":"EntryName","value":"DOCK_C-D_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF28208","properties":[{"key":"EntryName","value":"TPR_DOCK9"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51650","properties":[{"key":"EntryName","value":"C2_DOCK"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51651","properties":[{"key":"EntryName","value":"DOCKER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEELEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQWHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRRSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKYLTETEDTVKTTRNMERLNLFSLDPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDPITNIEPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASVALENGNIDTITPRQSEEPHIKGLPEEWLKFPKQAVFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLVSDYRRADRISKMQTIPGSLDIAVDNVPLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEEFVYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMSFLPIILNQLFKVLVQNEEDEITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKERTVHEELAKNVTGLLKSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPESYQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISMFSSGDLKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQTHQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSTVMNEQITGRDDLSKRGVDQTCTRVISKATPALPTVSISSSAEV","length":2186,"molWeight":249531,"crc64":"955ABC03DE2270AF","md5":"86728902C43EA786E11788BD89334B43"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":5,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":5},"countByFeatureType":{"Chain":1,"Domain":3,"Region":2,"Compositional bias":1,"Modified residue":12,"Alternative sequence":3,"Sequence conflict":5,"Helix":21,"Turn":6,"Beta strand":9},"uniParcId":"UPI000021D2A7"}}