{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96A25","secondaryAccessions":["A8K2X2","B7Z698"],"uniProtkbId":"T106A_HUMAN","entryAudit":{"firstPublicDate":"2006-06-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":158,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transmembrane protein 106A"}}},"genes":[{"geneName":{"value":"TMEM106A"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VC04"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29131025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30456879"}],"value":"Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:29131025, PubMed:30456879)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"O75355-2","geneName":"ENTPD3","intActId":"EBI-12279764"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"Q9UKR5","geneName":"ERG28","intActId":"EBI-711490"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"P29033","geneName":"GJB2","intActId":"EBI-3905204"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"O14653","geneName":"GOSR2","intActId":"EBI-4401517"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"P24593","geneName":"IGFBP5","intActId":"EBI-720480"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"Q9BVX2","geneName":"TMEM106C","intActId":"EBI-2821497"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"Q6UX40","geneName":"TMEM107","intActId":"EBI-12845616"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"Q5BJH2-2","geneName":"TMEM128","intActId":"EBI-10694905"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"Q8N661","geneName":"TMEM86B","intActId":"EBI-2548832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"Q9H2S6-2","geneName":"TNMD","intActId":"EBI-12003398"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A25","intActId":"EBI-3915978"},"interactantTwo":{"uniProtKBAccession":"O14817","geneName":"TSPAN4","intActId":"EBI-8652667"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VC04"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q96A25-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q96A25-2"],"sequenceIds":["VSP_056642"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29131025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30456879"}],"value":"Expressed in renal cells (at protein level) (PubMed:29131025). Expressed in epithelial cells (PubMed:30456879)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TMEM106 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Transmembrane protein 106A","featureId":"PRO_0000242137"},{"type":"Transmembrane","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_056642","alternativeSequence":{"originalSequence":"MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCE","alternativeSequences":["M"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Umbilical cord blood","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Kidney","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"29131025","citationType":"journal article","authors":["Wu C.","Xu J.","Wang H.","Zhang J.","Zhong J.","Zou X.","Chen Y.","Yang G.","Zhong Y.","Lai D.","Li X.","Tang A."],"citationCrossReferences":[{"database":"PubMed","id":"29131025"},{"database":"DOI","id":"10.1159/000484495"}],"title":"TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer.","publicationDate":"2017","journal":"Kidney Blood Press. Res.","firstPage":"853","lastPage":"864","volume":"42"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":6,"citation":{"id":"30456879","citationType":"journal article","authors":["Liu J.","Zhu H."],"citationCrossReferences":[{"database":"PubMed","id":"30456879"},{"database":"DOI","id":"10.1002/jcb.28057"}],"title":"TMEM106A inhibits cell proliferation, migration, and induces apoptosis of lung cancer cells.","publicationDate":"2018","journal":"J. Cell. Biochem.","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK056132","properties":[{"key":"ProteinId","value":"BAB71101.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK290387","properties":[{"key":"ProteinId","value":"BAF83076.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK299974","properties":[{"key":"ProteinId","value":"BAH13184.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC012139","properties":[{"key":"ProteinId","value":"AAH12139.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC146974","properties":[{"key":"ProteinId","value":"AAI46975.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC146976","properties":[{"key":"ProteinId","value":"AAI46977.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC147023","properties":[{"key":"ProteinId","value":"AAI47024.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC087365","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC109326","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471152","properties":[{"key":"ProteinId","value":"EAW60954.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC157892","properties":[{"key":"ProteinId","value":"AAI57893.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS11462.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96A25-1"},{"database":"CCDS","id":"CCDS74073.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96A25-2"},{"database":"RefSeq","id":"NP_001278515.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001291586.2"}],"isoformId":"Q96A25-1"},{"database":"RefSeq","id":"NP_001278516.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001291587.2"}],"isoformId":"Q96A25-2"},{"database":"RefSeq","id":"NP_659478.1","properties":[{"key":"NucleotideSequenceId","value":"NM_145041.4"}],"isoformId":"Q96A25-1"},{"database":"AlphaFoldDB","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"125240","properties":[{"key":"Interactions","value":"242"}]},{"database":"FunCoup","id":"Q96A25","properties":[{"key":"Number of interactors","value":"384"}]},{"database":"IntAct","id":"Q96A25","properties":[{"key":"Interactions","value":"222"}]},{"database":"NDEx","id":"IQUERY-CP-TMEM106A","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000483246","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.B.23.1.5","properties":[{"key":"FamilyName","value":"the tmem106 (tmem106) family"}]},{"database":"iPTMnet","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TMEM106A","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74731081","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000483246","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"6760","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"75896","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96A25-1"},{"database":"Antibodypedia","id":"61733","properties":[{"key":"antibodies","value":"57 antibodies from 18 providers"}]},{"database":"DNASU","id":"113277","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000541594.5","properties":[{"key":"ProteinId","value":"ENSP00000439844.1"},{"key":"GeneId","value":"ENSG00000184988.9"}],"isoformId":"Q96A25-2"},{"database":"Ensembl","id":"ENST00000588659.5","properties":[{"key":"ProteinId","value":"ENSP00000466820.1"},{"key":"GeneId","value":"ENSG00000184988.9"}],"isoformId":"Q96A25-1"},{"database":"Ensembl","id":"ENST00000612339.4","properties":[{"key":"ProteinId","value":"ENSP00000483246.1"},{"key":"GeneId","value":"ENSG00000184988.9"}],"isoformId":"Q96A25-1"},{"database":"Ensembl","id":"ENST00000876775.1","properties":[{"key":"ProteinId","value":"ENSP00000546834.1"},{"key":"GeneId","value":"ENSG00000184988.9"}],"isoformId":"Q96A25-1"},{"database":"Ensembl","id":"ENST00000876777.1","properties":[{"key":"ProteinId","value":"ENSP00000546836.1"},{"key":"GeneId","value":"ENSG00000184988.9"}],"isoformId":"Q96A25-1"},{"database":"Ensembl","id":"ENST00000876778.1","properties":[{"key":"ProteinId","value":"ENSP00000546837.1"},{"key":"GeneId","value":"ENSG00000184988.9"}],"isoformId":"Q96A25-1"},{"database":"Ensembl","id":"ENST00000959742.1","properties":[{"key":"ProteinId","value":"ENSP00000629801.1"},{"key":"GeneId","value":"ENSG00000184988.9"}],"isoformId":"Q96A25-1"},{"database":"GeneID","id":"113277","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:113277","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000612339.4","properties":[{"key":"ProteinId","value":"ENSP00000483246.1"},{"key":"RefSeqNucleotideId","value":"NM_145041.4"},{"key":"RefSeqProteinId","value":"NP_659478.1"}]},{"database":"UCSC","id":"uc002idn.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96A25-1"},{"database":"AGR","id":"HGNC:28288","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142670755","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"113277","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"113277","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TMEM106A","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:28288","properties":[{"key":"GeneName","value":"TMEM106A"}]},{"database":"HPA","id":"ENSG00000184988","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (kidney)"}]},{"database":"OpenTargets","id":"ENSG00000184988","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184988","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RY0I","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000161546","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_089337_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CSYLCHS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"508875at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96A25","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000184988","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"113277","properties":[{"key":"hits","value":"32 hits in 1159 CRISPR screens"}]},{"database":"GeneWiki","id":"TMEM106A","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"113277","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96A25","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q96A25","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"Q96A25","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000184988","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 169 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96A25","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042116","properties":[{"key":"GoTerm","value":"P:macrophage activation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"Gene3D","id":"6.20.20.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009790","properties":[{"key":"EntryName","value":"TMEM106"}]},{"database":"InterPro","id":"IPR048509","properties":[{"key":"EntryName","value":"TMEM106_C"}]},{"database":"InterPro","id":"IPR048511","properties":[{"key":"EntryName","value":"TMEM106_N"}]},{"database":"PANTHER","id":"PTHR28556:SF3","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 106A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28556","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 106B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07092","properties":[{"key":"EntryName","value":"TMEM106"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21002","properties":[{"key":"EntryName","value":"TMEM106_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLNSSTVAFDEADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLLLHIGPLASEQMFYAVATKIRDENTYKICTWLEIKVHHVLLHIQGTLTCSYLSHSEQLVFQSYEYVDCRGNASVPHQLTPHPP","length":262,"molWeight":28920,"crc64":"306433230D5E8D8B","md5":"7215EEAA8031656802046522B219077A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":11,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Alternative sequence":1},"uniParcId":"UPI0000037780"}}