{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96A09","uniProtkbId":"TET5B_HUMAN","entryAudit":{"firstPublicDate":"2006-11-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-04-20","entryVersion":152,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Terminal nucleotidyltransferase 5B"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34048638"}],"value":"2.7.7.19"}]},"alternativeNames":[{"fullName":{"value":"Non-canonical poly(A) polymerase FAM46B"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:28273"}],"value":"TENT5B"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:28273"}],"value":"FAM46B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30532005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34048638"}],"value":"Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner (PubMed:32009146, PubMed:34048638). May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs (PubMed:32009146). Prefers RNA molecules that are adenosine-rich close to 3'-end (PubMed:32009146). In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1 (PubMed:30532005)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11332"},{"database":"Rhea","id":"RHEA-COMP:14527"},{"database":"Rhea","id":"RHEA-COMP:17347"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:140395"},{"database":"ChEBI","id":"CHEBI:173115"}],"ecNumber":"2.7.7.19","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34048638"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11333"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32009146"}]}]},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q03154","geneName":"ACY1","intActId":"EBI-742064"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9ULX6","geneName":"AKAP8L","intActId":"EBI-357530"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q6PJH3","geneName":"AKAP9","intActId":"EBI-11745576"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q86V38","geneName":"ATN1","intActId":"EBI-11954292"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P54253","geneName":"ATXN1","intActId":"EBI-930964"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"O14503","geneName":"BHLHE40","intActId":"EBI-711810"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q5SWW7","geneName":"C10orf55","intActId":"EBI-12809220"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q3SXR2","geneName":"C3orf36","intActId":"EBI-18036948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P55212","geneName":"CASP6","intActId":"EBI-718729"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q5T4B2","geneName":"CERCAM","intActId":"EBI-12261896"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P28329-3","geneName":"CHAT","intActId":"EBI-25837549"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"A8MTA8-2","geneName":"CIMIP2B","intActId":"EBI-12160437"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P02489","geneName":"CRYAA","intActId":"EBI-6875961"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"A8MQ03","geneName":"CYSRT1","intActId":"EBI-3867333"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q15038","geneName":"DAZAP2","intActId":"EBI-724310"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9H0I2","geneName":"ENKD1","intActId":"EBI-744099"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"A1KXE4-2","geneName":"FAM168B","intActId":"EBI-12193763"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P22607","geneName":"FGFR3","intActId":"EBI-348399"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P01100","geneName":"FOS","intActId":"EBI-852851"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P53539","geneName":"FOSB","intActId":"EBI-2806743"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q12951-2","geneName":"FOXI1","intActId":"EBI-12018822"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P06396","geneName":"GSN","intActId":"EBI-351506"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"O00291","geneName":"HIP1","intActId":"EBI-473886"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9UGU5","geneName":"HMGXB4","intActId":"EBI-7261162"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P52597","geneName":"HNRNPF","intActId":"EBI-352986"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P04792","geneName":"HSPB1","intActId":"EBI-352682"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"O60333-2","geneName":"KIF1B","intActId":"EBI-10975473"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q2WGJ6","geneName":"KLHL38","intActId":"EBI-6426443"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q92876","geneName":"KLK6","intActId":"EBI-2432309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"O76011","geneName":"KRT34","intActId":"EBI-1047093"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q3LI70","geneName":"KRTAP19-6","intActId":"EBI-12805508"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q3LI64","geneName":"KRTAP6-1","intActId":"EBI-12111050"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q3LI66","geneName":"KRTAP6-2","intActId":"EBI-11962084"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q13064","geneName":"MKRN3","intActId":"EBI-2340269"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q96HR8","geneName":"NAF1","intActId":"EBI-2515597"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9BSH3","geneName":"NICN1","intActId":"EBI-13324229"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q6NSM0","geneName":"NR1D2","intActId":"EBI-10250949"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P32243-2","geneName":"OTX2","intActId":"EBI-9087860"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"O00444","geneName":"PLK4","intActId":"EBI-746202"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q16633","geneName":"POU2AF1","intActId":"EBI-943588"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P78424","geneName":"POU6F2","intActId":"EBI-12029004"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"O75360","geneName":"PROP1","intActId":"EBI-9027467"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P60891","geneName":"PRPS1","intActId":"EBI-749195"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P28062-2","geneName":"PSMB8","intActId":"EBI-372312"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q92530","geneName":"PSMF1","intActId":"EBI-945916"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P62826","geneName":"RAN","intActId":"EBI-286642"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q6ZRY4","geneName":"RBPMS2","intActId":"EBI-11987469"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q8HWS3","geneName":"RFX6","intActId":"EBI-746118"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9BQY4","geneName":"RHOXF2","intActId":"EBI-372094"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9UFD9","geneName":"RIMBP3","intActId":"EBI-10182375"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9Y3C5","geneName":"RNF11","intActId":"EBI-396669"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9BVN2","geneName":"RUSC1","intActId":"EBI-6257312"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9NP31","geneName":"SH2D2A","intActId":"EBI-490630"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q16348","geneName":"SLC15A2","intActId":"EBI-12806032"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q6P1M0-2","geneName":"SLC27A4","intActId":"EBI-12898981"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q8WU79","geneName":"SMAP2","intActId":"EBI-2822515"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q5JUK2","geneName":"SOHLH1","intActId":"EBI-12288855"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P35711","geneName":"SOX5","intActId":"EBI-3505701"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q99932-2","geneName":"SPAG8","intActId":"EBI-11959123"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"O95947","geneName":"TBX6","intActId":"EBI-2824328"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q08117-2","geneName":"TLE5","intActId":"EBI-11741437"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q63HR2","geneName":"TNS2","intActId":"EBI-949753"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q15645","geneName":"TRIP13","intActId":"EBI-358993"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q5T6F2","geneName":"UBAP2","intActId":"EBI-2514383"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9UHD9","geneName":"UBQLN2","intActId":"EBI-947187"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q70EL1-9","geneName":"USP54","intActId":"EBI-11975223"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"O76024","geneName":"WFS1","intActId":"EBI-720609"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q8N680","geneName":"ZBTB2","intActId":"EBI-2515601"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q96K80","geneName":"ZC3H10","intActId":"EBI-742550"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q96F45","geneName":"ZNF503","intActId":"EBI-8832437"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q6ZNG0","geneName":"ZNF620","intActId":"EBI-4395669"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"P0C7X2","geneName":"ZNF688","intActId":"EBI-4395732"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96A09","intActId":"EBI-752030"},"interactantTwo":{"uniProtKBAccession":"Q9Y649","intActId":"EBI-25900580"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"value":"Uniquely and highly expressed in pre-implantation embryos and pluripotent stem cells, but sharply down-regulated following differentiation"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TENT family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"It is uncertain whether Met-1 or Met-2 is the initiator"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH12790.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH14160.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"Terminal nucleotidyltransferase 5B","featureId":"PRO_0000259931"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Mutagenesis","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Does not affect polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Reduces polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Substantially reduces polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Substantially reduces polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Substantially reduces polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Substantially reduces polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Does not affect polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Loss of polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Does not affect polyadenylation activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32009146"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"30532005","citationType":"journal article","authors":["Liang T.","Ye X.","Liu Y.","Qiu X.","Li Z.","Tian B.","Yan D."],"citationCrossReferences":[{"database":"PubMed","id":"30532005"},{"database":"DOI","id":"10.1038/s12276-018-0184-0"}],"title":"FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of beta-catenin.","publicationDate":"2018","journal":"Exp. Mol. Med.","firstPage":"1","lastPage":"12","volume":"50"},"referencePositions":["FUNCTION"]},{"referenceNumber":4,"citation":{"id":"32009146","citationType":"journal article","authors":["Hu J.L.","Liang H.","Zhang H.","Yang M.Z.","Sun W.","Zhang P.","Luo L.","Feng J.X.","Bai H.","Liu F.","Zhang T.","Yang J.Y.","Gao Q.","Long Y.","Ma X.Y.","Chen Y.","Zhong Q.","Yu B.","Liao S.","Wang Y.","Zhao Y.","Zeng M.S.","Cao N.","Wang J.","Chen W.","Yang H.T.","Gao S."],"citationCrossReferences":[{"database":"PubMed","id":"32009146"},{"database":"DOI","id":"10.1093/nar/gkaa049"}],"title":"FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.","publicationDate":"2020","journal":"Nucleic Acids Res.","firstPage":"2733","lastPage":"2748","volume":"48"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF GLY-108; SER-109; LYS-124; ASP-125; ASP-127; LYS-176; LYS-179; CYS-181; GLU-201; LYS-203; ARG-210; GLU-213; ILE-216; ARG-269; GLU-272; ARG-275; LYS-281; ARG-303; ARG-321; HIS-330 AND PHE-331","DEVELOPMENTAL STAGE","SUBCELLULAR LOCATION"]},{"referenceNumber":5,"citation":{"id":"34048638","citationType":"journal article","authors":["Zhang H.","Zhang S.H.","Hu J.L.","Wu Y.T.","Ma X.Y.","Chen Y.","Yu B.","Liao S.","Huang H.","Gao S."],"citationCrossReferences":[{"database":"PubMed","id":"34048638"},{"database":"DOI","id":"10.1002/cac2.12163"}],"title":"Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.","publicationDate":"2021","journal":"Cancer Commun. (Lond)","firstPage":"615","lastPage":"630","volume":"41"},"referencePositions":["CATALYTIC ACTIVITY","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL356390","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC012790","properties":[{"key":"ProteinId","value":"AAH12790.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC014160","properties":[{"key":"ProteinId","value":"AAH14160.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS294.2","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_443175.2","properties":[{"key":"NucleotideSequenceId","value":"NM_052943.4"}]},{"database":"AlphaFoldDB","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"125440","properties":[{"key":"Interactions","value":"69"}]},{"database":"FunCoup","id":"Q96A09","properties":[{"key":"Number of interactors","value":"1067"}]},{"database":"IntAct","id":"Q96A09","properties":[{"key":"Interactions","value":"78"}]},{"database":"STRING","id":"9606.ENSP00000289166","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q96A09","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FAM46B","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"294862433","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000289166","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"75890","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"69553","properties":[{"key":"antibodies","value":"31 antibodies from 8 providers"}]},{"database":"DNASU","id":"115572","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000289166.6","properties":[{"key":"ProteinId","value":"ENSP00000289166.5"},{"key":"GeneId","value":"ENSG00000158246.8"}]},{"database":"GeneID","id":"115572","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:115572","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000289166.6","properties":[{"key":"ProteinId","value":"ENSP00000289166.5"},{"key":"RefSeqNucleotideId","value":"NM_052943.4"},{"key":"RefSeqProteinId","value":"NP_443175.2"}]},{"database":"UCSC","id":"uc010ofj.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:28273","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134962922","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"115572","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"115572","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TENT5B","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:28273","properties":[{"key":"GeneName","value":"TENT5B"}]},{"database":"HPA","id":"ENSG00000158246","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (esophagus, skin)"}]},{"database":"MIM","id":"619069","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000158246","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000158246","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3852","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000160747","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_008115_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CVHSVRL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10065073at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96A09","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.7.7.19","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000158246","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"115572","properties":[{"key":"hits","value":"7 hits in 1156 CRISPR screens"}]},{"database":"ChiTaRS","id":"FAM46B","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"115572","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96A09","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q96A09","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q96A09","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000158246","properties":[{"key":"ExpressionPatterns","value":"Expressed in skin of leg and 116 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32009146"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32009146"}]},{"database":"GO","id":"GO:1990817","properties":[{"key":"GoTerm","value":"F:poly(A) RNA polymerase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32009146"}]},{"database":"GO","id":"GO:0048255","properties":[{"key":"GoTerm","value":"P:mRNA stabilization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"32009146"}]},{"database":"GO","id":"GO:0045786","properties":[{"key":"GoTerm","value":"P:negative regulation of cell cycle"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30532005"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30532005"}]},{"database":"GO","id":"GO:0045727","properties":[{"key":"GoTerm","value":"P:positive regulation of translation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"32009146"}]},{"database":"InterPro","id":"IPR012937","properties":[{"key":"EntryName","value":"TET5"}]},{"database":"PANTHER","id":"PTHR12974","properties":[{"key":"EntryName","value":"PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12974:SF46","properties":[{"key":"EntryName","value":"TERMINAL NUCLEOTIDYLTRANSFERASE 5B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07984","properties":[{"key":"EntryName","value":"NTP_transf_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01153","properties":[{"key":"EntryName","value":"DUF1693"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMPSESGAERRDRAAAQVGTAAATAVATAAPAGGGPDPEALSAFPGRHLSGLSWPQVKRLDALLSEPIPIHGRGNFPTLSVQPRQIVQVVRSTLEEQGLHVHSVRLHGSAASHVLHPESGLGYKDLDLVFRVDLRSEASFQLTKAVVLACLLDFLPAGVSRAKITPLTLKEAYVQKLVKVCTDSDRWSLISLSNKSGKNVELKFVDSVRRQFEFSIDSFQIILDSLLLFGQCSSTPMSEAFHPTVTGESLYGDFTEALEHLRHRVIATRSPEEIRGGGLLKYCHLLVRGFRPRPSTDVRALQRYMCSRFFIDFPDLVEQRRTLERYLEAHFGGADAARRYACLVTLHRVVNESTVCLMNHERRQTLDLIAALALQALAEQGPAATAALAWRPPGTDGVVPATVNYYVTPVQPLLAHAYPTWLPCN","length":425,"molWeight":46688,"crc64":"A0FD17359AF2C6DD","md5":"D8AB288014103D0B97C17357FAA9EB4C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"INTERACTION":74,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Mutagenesis":21},"uniParcId":"UPI0000374A6A"}}