{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q95RR8","uniProtkbId":"PAN3_DROME","entryAudit":{"firstPublicDate":"2014-04-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":193,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"PAN2-PAN3 deadenylation complex subunit PAN3"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"PAB1P-dependent poly(A)-specific ribonuclease"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"Poly(A)-nuclease deadenylation complex subunit 3"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"PAN deadenylation complex subunit 3"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"PAN3"},"orfNames":[{"value":"CG11486"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23172285"}],"value":"Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21981923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23172285"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23932717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31114929"}],"value":"Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein (via PABC domain), conferring substrate specificity of the enzyme complex (PubMed:23932717). Interacts with the GW182 family protein gw (PubMed:21981923, PubMed:23172285). Interacts with Gyf (PubMed:31114929)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q95RR8","intActId":"EBI-119468"},"interactantTwo":{"uniProtKBAccession":"A1Z7K9","geneName":"PAN2","intActId":"EBI-193297"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"Cytoplasm, P-body","id":"SL-0230"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"The N-terminal zinc finger binds to poly(A) RNA"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23932717"}],"value":"Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro (PubMed:23932717). The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"value":"Belongs to the protein kinase superfamily. PAN3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":790,"modifier":"EXACT"}},"description":"PAN2-PAN3 deadenylation complex subunit PAN3","featureId":"PRO_0000426721"},{"type":"Region","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":655,"modifier":"EXACT"}},"description":"Pseudokinase domain","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}]},{"type":"Region","location":{"start":{"value":695,"modifier":"EXACT"},"end":{"value":790,"modifier":"EXACT"}},"description":"Knob domain","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}]},{"type":"Coiled coil","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":694,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}]},{"type":"Compositional bias","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23932717"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23932717"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03181"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"10731132","citationType":"journal article","authors":["Adams M.D.","Celniker S.E.","Holt R.A.","Evans C.A.","Gocayne J.D.","Amanatides P.G.","Scherer S.E.","Li P.W.","Hoskins R.A.","Galle R.F.","George R.A.","Lewis S.E.","Richards S.","Ashburner M.","Henderson S.N.","Sutton G.G.","Wortman J.R.","Yandell M.D.","Zhang Q.","Chen L.X.","Brandon R.C.","Rogers Y.-H.C.","Blazej R.G.","Champe M.","Pfeiffer B.D.","Wan K.H.","Doyle C.","Baxter E.G.","Helt G.","Nelson C.R.","Miklos G.L.G.","Abril J.F.","Agbayani A.","An H.-J.","Andrews-Pfannkoch C.","Baldwin D.","Ballew R.M.","Basu A.","Baxendale J.","Bayraktaroglu L.","Beasley E.M.","Beeson K.Y.","Benos P.V.","Berman B.P.","Bhandari D.","Bolshakov S.","Borkova D.","Botchan M.R.","Bouck J.","Brokstein P.","Brottier P.","Burtis K.C.","Busam D.A.","Butler H.","Cadieu E.","Center A.","Chandra I.","Cherry J.M.","Cawley S.","Dahlke C.","Davenport L.B.","Davies P.","de Pablos B.","Delcher A.","Deng Z.","Mays A.D.","Dew I.","Dietz S.M.","Dodson K.","Doup L.E.","Downes M.","Dugan-Rocha S.","Dunkov B.C.","Dunn P.","Durbin K.J.","Evangelista C.C.","Ferraz C.","Ferriera S.","Fleischmann W.","Fosler C.","Gabrielian A.E.","Garg N.S.","Gelbart W.M.","Glasser K.","Glodek A.","Gong F.","Gorrell J.H.","Gu Z.","Guan P.","Harris M.","Harris N.L.","Harvey D.A.","Heiman T.J.","Hernandez J.R.","Houck J.","Hostin D.","Houston K.A.","Howland T.J.","Wei M.-H.","Ibegwam C.","Jalali M.","Kalush F.","Karpen G.H.","Ke Z.","Kennison J.A.","Ketchum K.A.","Kimmel B.E.","Kodira C.D.","Kraft C.L.","Kravitz S.","Kulp D.","Lai Z.","Lasko P.","Lei Y.","Levitsky A.A.","Li J.H.","Li Z.","Liang Y.","Lin X.","Liu X.","Mattei B.","McIntosh T.C.","McLeod M.P.","McPherson D.","Merkulov G.","Milshina N.V.","Mobarry C.","Morris J.","Moshrefi A.","Mount S.M.","Moy M.","Murphy B.","Murphy L.","Muzny D.M.","Nelson D.L.","Nelson D.R.","Nelson K.A.","Nixon K.","Nusskern D.R.","Pacleb J.M.","Palazzolo M.","Pittman G.S.","Pan S.","Pollard J.","Puri V.","Reese M.G.","Reinert K.","Remington K.","Saunders R.D.C.","Scheeler F.","Shen H.","Shue B.C.","Siden-Kiamos I.","Simpson M.","Skupski M.P.","Smith T.J.","Spier E.","Spradling A.C.","Stapleton M.","Strong R.","Sun E.","Svirskas R.","Tector C.","Turner R.","Venter E.","Wang A.H.","Wang X.","Wang Z.-Y.","Wassarman D.A.","Weinstock G.M.","Weissenbach J.","Williams S.M.","Woodage T.","Worley K.C.","Wu D.","Yang S.","Yao Q.A.","Ye J.","Yeh R.-F.","Zaveri J.S.","Zhan M.","Zhang G.","Zhao Q.","Zheng L.","Zheng X.H.","Zhong F.N.","Zhong W.","Zhou X.","Zhu S.C.","Zhu X.","Smith H.O.","Gibbs R.A.","Myers E.W.","Rubin G.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10731132"},{"database":"DOI","id":"10.1126/science.287.5461.2185"}],"title":"The genome sequence of Drosophila melanogaster.","publicationDate":"2000","journal":"Science","firstPage":"2185","lastPage":"2195","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"12537572","citationType":"journal article","authors":["Misra S.","Crosby M.A.","Mungall C.J.","Matthews B.B.","Campbell K.S.","Hradecky P.","Huang Y.","Kaminker J.S.","Millburn G.H.","Prochnik S.E.","Smith C.D.","Tupy J.L.","Whitfield E.J.","Bayraktaroglu L.","Berman B.P.","Bettencourt B.R.","Celniker S.E.","de Grey A.D.N.J.","Drysdale R.A.","Harris N.L.","Richter J.","Russo S.","Schroeder A.J.","Shu S.Q.","Stapleton M.","Yamada C.","Ashburner M.","Gelbart W.M.","Rubin G.M.","Lewis S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537572"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0083"}],"title":"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0083.1","lastPage":"RESEARCH0083.22","volume":"3"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"12537569","citationType":"journal article","authors":["Stapleton M.","Carlson J.W.","Brokstein P.","Yu C.","Champe M.","George R.A.","Guarin H.","Kronmiller B.","Pacleb J.M.","Park S.","Wan K.H.","Rubin G.M.","Celniker S.E."],"citationCrossReferences":[{"database":"PubMed","id":"12537569"},{"database":"DOI","id":"10.1186/gb-2002-3-12-research0080"}],"title":"A Drosophila full-length cDNA resource.","publicationDate":"2002","journal":"Genome Biol.","firstPage":"RESEARCH0080.1","lastPage":"RESEARCH0080.8","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Berkeley","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"21981923","citationType":"journal article","authors":["Braun J.E.","Huntzinger E.","Fauser M.","Izaurralde E."],"citationCrossReferences":[{"database":"PubMed","id":"21981923"},{"database":"DOI","id":"10.1016/j.molcel.2011.09.007"}],"title":"GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.","publicationDate":"2011","journal":"Mol. Cell","firstPage":"120","lastPage":"133","volume":"44"},"referencePositions":["INTERACTION WITH GW"]},{"referenceNumber":5,"citation":{"id":"23172285","citationType":"journal article","authors":["Huntzinger E.","Kuzuoglu-Ozturk D.","Braun J.E.","Eulalio A.","Wohlbold L.","Izaurralde E."],"citationCrossReferences":[{"database":"PubMed","id":"23172285"},{"database":"DOI","id":"10.1093/nar/gks1078"}],"title":"The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.","publicationDate":"2013","journal":"Nucleic Acids Res.","firstPage":"978","lastPage":"994","volume":"41"},"referencePositions":["FUNCTION","INTERACTION WITH GW"]},{"referenceNumber":6,"citation":{"id":"31114929","citationType":"journal article","authors":["Ruscica V.","Bawankar P.","Peter D.","Helms S.","Igreja C.","Izaurralde E."],"citationCrossReferences":[{"database":"PubMed","id":"31114929"},{"database":"DOI","id":"10.1093/nar/gkz429"}],"title":"Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression.","publicationDate":"2019","journal":"Nucleic Acids Res.","firstPage":"7035","lastPage":"7048","volume":"47"},"referencePositions":["INTERACTION WITH GYF"]},{"referenceNumber":7,"citation":{"id":"23932717","citationType":"journal article","authors":["Christie M.","Boland A.","Huntzinger E.","Weichenrieder O.","Izaurralde E."],"citationCrossReferences":[{"database":"PubMed","id":"23932717"},{"database":"DOI","id":"10.1016/j.molcel.2013.07.011"}],"title":"Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.","publicationDate":"2013","journal":"Mol. Cell","firstPage":"360","lastPage":"373","volume":"51"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS) OF 349-790 IN COMPLEX WITH AMP","INTERACTION WITH PAN2","SUBUNIT"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AE014296","properties":[{"key":"ProteinId","value":"AAN11527.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY061183","properties":[{"key":"ProteinId","value":"AAL28731.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_647767.1","properties":[{"key":"NucleotideSequenceId","value":"NM_139510.4"}]},{"database":"PDB","id":"4BWP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/B=349-790"}]},{"database":"PDBsum","id":"4BWP","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q95RR8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q95RR8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"63867","properties":[{"key":"Interactions","value":"81"}]},{"database":"DIP","id":"DIP-17364N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q95RR8","properties":[{"key":"Number of interactors","value":"1905"}]},{"database":"IntAct","id":"Q95RR8","properties":[{"key":"Interactions","value":"20"}]},{"database":"STRING","id":"7227.FBpp0072861","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q95RR8","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"PaxDb","id":"7227-FBpp0072861","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q95RR8","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"38369","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"FBtr0072991","properties":[{"key":"ProteinId","value":"FBpp0072861"},{"key":"GeneId","value":"FBgn0035397"}]},{"database":"GeneID","id":"38369","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dme:Dmel_CG11486","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"CG11486-RG","properties":[{"key":"OrganismName","value":"d. melanogaster"}]},{"database":"AGR","id":"FB:FBgn0035397","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"255967","properties":[{"key":"Description","value":"-"}]},{"database":"FlyBase","id":"FBgn0035397","properties":[{"key":"GeneName","value":"PAN3"}]},{"database":"VEuPathDB","id":"VectorBase:FBgn0035397","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3741","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q95RR8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ASHVINM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"204958at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q95RR8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-DME-429947","properties":[{"key":"PathwayName","value":"Deadenylation of mRNA"}]},{"database":"SignaLink","id":"Q95RR8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"38369","properties":[{"key":"hits","value":"0 hits in 3 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"Q95RR8","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"38369","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q95RR8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000803","properties":[{"key":"Component","value":"Chromosome 3L"}]},{"database":"Bgee","id":"FBgn0035397","properties":[{"key":"ExpressionPatterns","value":"Expressed in adult olfactory receptor neuron Or92a (Drosophila) in antenna and 284 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q95RR8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"HDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"25294944"}]},{"database":"GO","id":"GO:0000932","properties":[{"key":"GoTerm","value":"C:P-body"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031251","properties":[{"key":"GoTerm","value":"C:PAN complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008143","properties":[{"key":"GoTerm","value":"F:poly(A) binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000289","properties":[{"key":"GoTerm","value":"P:nuclear-transcribed mRNA poly(A) tail shortening"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0010606","properties":[{"key":"GoTerm","value":"P:positive regulation of cytoplasmic mRNA processing body assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"1.10.287.3700:FF:000001","properties":[{"key":"EntryName","value":"PAN2-PAN3 deadenylation complex subunit PAN3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000451","properties":[{"key":"EntryName","value":"PAN2-PAN3 deadenylation complex subunit PAN3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.5160:FF:000001","properties":[{"key":"EntryName","value":"PAN2-PAN3 deadenylation complex subunit PAN3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.3700","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.5160","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03181","properties":[{"key":"EntryName","value":"PAN3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR032050","properties":[{"key":"EntryName","value":"DUF4797"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR030844","properties":[{"key":"EntryName","value":"PAN3"}]},{"database":"InterPro","id":"IPR041332","properties":[{"key":"EntryName","value":"Pan3_CK"}]},{"database":"PANTHER","id":"PTHR12272","properties":[{"key":"EntryName","value":"DEADENYLATION COMPLEX SUBUNIT PAN3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12272:SF11","properties":[{"key":"EntryName","value":"PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16051","properties":[{"key":"EntryName","value":"DUF4797"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18101","properties":[{"key":"EntryName","value":"Pan3_CK"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MCSTYGLLSFEFSDTAAMDPIFFSPTNGIPSESKLATYMNRQNVATPSGYGLNNGFSLLNLDSPLNKKSQVTPQSPEFIPTRLGSTPNFYAPYHNAPMQLSNGLNGVNGLTAAAAAAAAAAAAAAAAVPSSTSSASSASVTISKTANGGASMLALQKTASIASVTIAQQQPQHPQKQQQHPPSVGGGAVSAASAPIAISGAPPNPAAAPFVSSMSAQTPLKGRGAMMRQESPTAAMISGAGPGEKSPPHGMTPHGASPIPSALPTSVHQENVGGTIYFYPTANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGVPAAMMYTGHVYPGPSSNVVTMQPKTLLESAFFMPDEMRAEVLARNEISNLIMDAAEAAQHALPLEVENYHALYPLEPPAQPLHAKLTFPATTYRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISDITQFDPNASNPLALVNMHQQDDLTALGRLVLALACRCLQSVQRDNVQSSIDMVTRNYSTDLRNFIVYLFTTNNRRSVTDLMPMIGARFYTQLDALQSKIDMQEDELAKEMENGRLYRILVKLNSINERPDFNLDCTWSETGDRYMLKLFRDYLFHSVTEDGRPWLDHAHIVQCLNKLDAGSIERVQLMSRDEQSVLIVSYAELKNCLENAFSELMSSAAN","length":790,"molWeight":85391,"crc64":"19555B56DAA43E21","md5":"FA30EAF35DF260A92AB846E07DBAF969"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"DOMAIN":3,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":4,"Coiled coil":1,"Compositional bias":1,"Binding site":3},"uniParcId":"UPI0000083BB8"}}