{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q949R9","uniProtkbId":"MPC1_ARATH","entryAudit":{"firstPublicDate":"2015-01-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":130,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAK93615.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Mitochondrial pyruvate carrier 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"AtMPC1"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"MPC1"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT5G20090"}],"value":"At5g20090"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AF296836"}],"value":"F28I16.240"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24842572"}],"value":"Mediates the uptake of pyruvate into mitochondria"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P53157"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q949R9-1"],"isoformSequenceStatus":"Displayed"}],"note":{"texts":[{"value":"A number of isoforms are produced. According to EST sequences."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Mitochondrial pyruvate carrier 1","featureId":"PRO_0000431615"},{"type":"Transmembrane","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11130714","citationType":"journal article","authors":["Tabata S.","Kaneko T.","Nakamura Y.","Kotani H.","Kato T.","Asamizu E.","Miyajima N.","Sasamoto S.","Kimura T.","Hosouchi T.","Kawashima K.","Kohara M.","Matsumoto M.","Matsuno A.","Muraki A.","Nakayama S.","Nakazaki N.","Naruo K.","Okumura S.","Shinpo S.","Takeuchi C.","Wada T.","Watanabe A.","Yamada M.","Yasuda M.","Sato S.","de la Bastide M.","Huang E.","Spiegel L.","Gnoj L.","O'Shaughnessy A.","Preston R.","Habermann K.","Murray J.","Johnson D.","Rohlfing T.","Nelson J.","Stoneking T.","Pepin K.","Spieth J.","Sekhon M.","Armstrong J.","Becker M.","Belter E.","Cordum H.","Cordes M.","Courtney L.","Courtney W.","Dante M.","Du H.","Edwards J.","Fryman J.","Haakensen B.","Lamar E.","Latreille P.","Leonard S.","Meyer R.","Mulvaney E.","Ozersky P.","Riley A.","Strowmatt C.","Wagner-McPherson C.","Wollam A.","Yoakum M.","Bell M.","Dedhia N.","Parnell L.","Shah R.","Rodriguez M.","Hoon See L.","Vil D.","Baker J.","Kirchoff K.","Toth K.","King L.","Bahret A.","Miller B.","Marra M.A.","Martienssen R.","McCombie W.R.","Wilson R.K.","Murphy G.","Bancroft I.","Volckaert G.","Wambutt R.","Duesterhoeft A.","Stiekema W.","Pohl T.","Entian K.-D.","Terryn N.","Hartley N.","Bent E.","Johnson S.","Langham S.-A.","McCullagh B.","Robben J.","Grymonprez B.","Zimmermann W.","Ramsperger U.","Wedler H.","Balke K.","Wedler E.","Peters S.","van Staveren M.","Dirkse W.","Mooijman P.","Klein Lankhorst R.","Weitzenegger T.","Bothe G.","Rose M.","Hauf J.","Berneiser S.","Hempel S.","Feldpausch M.","Lamberth S.","Villarroel R.","Gielen J.","Ardiles W.","Bents O.","Lemcke K.","Kolesov G.","Mayer K.F.X.","Rudd S.","Schoof H.","Schueller C.","Zaccaria P.","Mewes H.-W.","Bevan M.","Fransz P.F."],"citationCrossReferences":[{"database":"PubMed","id":"11130714"},{"database":"DOI","id":"10.1038/35048507"}],"title":"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"823","lastPage":"826","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-3TH3AFLAVIRO9","citationType":"submission","authors":["Brover V.V.","Troukhan M.E.","Alexandrov N.A.","Lu Y.-P.","Flavell R.B.","Feldmann K.A."],"title":"Full-length cDNA from Arabidopsis thaliana.","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"24842572","citationType":"journal article","authors":["Li C.L.","Wang M.","Ma X.Y.","Zhang W."],"citationCrossReferences":[{"database":"PubMed","id":"24842572"},{"database":"DOI","id":"10.1093/mp/ssu061"}],"title":"NRGA1, a putative mitochondrial pyruvate carrier, mediates ABA regulation of guard cell ion channels and drought stress responses in Arabidopsis.","publicationDate":"2014","journal":"Mol. Plant","firstPage":"1508","lastPage":"1521","volume":"7"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF296836","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED92792.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED92793.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"ANM68303.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"CAO7052946.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY050938","properties":[{"key":"ProteinId","value":"AAK93615.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY079418","properties":[{"key":"ProteinId","value":"AAL85149.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY085758","properties":[{"key":"ProteinId","value":"AAM62976.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001078606.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001085137.1"}],"isoformId":"Q949R9-1"},{"database":"RefSeq","id":"NP_001330067.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001343637.1"}],"isoformId":"Q949R9-1"},{"database":"RefSeq","id":"NP_197509.1","properties":[{"key":"NucleotideSequenceId","value":"NM_122016.3"}],"isoformId":"Q949R9-1"},{"database":"AlphaFoldDB","id":"Q949R9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q949R9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q949R9","properties":[{"key":"Number of interactors","value":"3425"}]},{"database":"STRING","id":"3702.Q949R9","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"2.A.105.1.4","properties":[{"key":"FamilyName","value":"the mitochondrial pyruvate carrier (mpc) family"}]},{"database":"PaxDb","id":"3702-Q949R9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"250883","properties":[{"key":"Description","value":"-"}],"isoformId":"Q949R9-1"},{"database":"DNASU","id":"832131","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"832131","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT5G20090","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT5G20090","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT5G20090","properties":[{"key":"GeneName","value":"MPC1"}]},{"database":"eggNOG","id":"KOG1590","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q949R9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FLQHFWG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1697690at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q949R9","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q949R9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"ExpressionAtlas","id":"Q949R9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"15276431"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22923678"}]},{"database":"GO","id":"GO:0000325","properties":[{"key":"GoTerm","value":"C:plant-type vacuole"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"17151019"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"17644812"}]},{"database":"GO","id":"GO:0009536","properties":[{"key":"GoTerm","value":"C:plastid"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"28887381"}]},{"database":"GO","id":"GO:0050833","properties":[{"key":"GoTerm","value":"F:pyruvate transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006850","properties":[{"key":"GoTerm","value":"P:pyruvate import into mitochondria"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24842572"}]},{"database":"GO","id":"GO:0010119","properties":[{"key":"GoTerm","value":"P:regulation of stomatal movement"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29166881"}]},{"database":"InterPro","id":"IPR005336","properties":[{"key":"EntryName","value":"MPC"}]},{"database":"PANTHER","id":"PTHR14154","properties":[{"key":"EntryName","value":"UPF0041 BRAIN PROTEIN 44-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03650","properties":[{"key":"EntryName","value":"MPC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MATSRFQAFLNSPIGPKTTHFWGPIANWGFVAAGLVDMQKPPEMISGNMSSAMCVYSALFMRFAWMVQPRNYLLLACHASNETVQLYQLSRWARAQGYLSSKKEEEKPSQ","length":110,"molWeight":12438,"crc64":"2FC4D3DB5674FC5E","md5":"915A03BD2956F0A168DD404958A8DE35"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":2},"uniParcId":"UPI00000A2244"}}