{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q93KV9","uniProtkbId":"Q93KV9_STRVR","entryAudit":{"firstPublicDate":"2001-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":46,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Streptomyces viridochromogenes Tue57","taxonId":1160705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}],"value":"Putative methyltransferase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}],"value":"aviG6"}}],"features":[{"type":"Domain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Methyltransferase FkbM","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF05050"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}],"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"11410376","citationType":"journal article","authors":["Weitnauer G.","Muhlenweg A.","Trefzer A.","Hoffmeister D.","Sussmuth R.D.","Jung G.","Welzel K.","Vente A.","Girreser U.","Bechthold A."],"citationCrossReferences":[{"database":"PubMed","id":"11410376"},{"database":"DOI","id":"10.1016/S1074-5521(01)00040-0"}],"title":"Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics.","publicationDate":"2001","journal":"Chem. Biol.","firstPage":"569","lastPage":"581","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}],"value":"Tue57","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}]},{"referenceNumber":2,"citation":{"id":"15489167","citationType":"journal article","authors":["Weitnauer G.","Hauser G.","Hofmann C.","Linder U.","Boll R.","Pelz K.","Glaser S.J.","Bechthold A."],"citationCrossReferences":[{"database":"PubMed","id":"15489167"},{"database":"DOI","id":"10.1016/j.chembiol.2004.08.016"}],"title":"Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.","publicationDate":"2004","journal":"Chem. Biol.","firstPage":"1403","lastPage":"1411","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}],"value":"Tue57","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAK83186.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF333038","properties":[{"key":"ProteinId","value":"AAK83186.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_235192922.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_AMLP01000092.1"}]},{"database":"AlphaFoldDB","id":"Q93KV9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008171","properties":[{"key":"GoTerm","value":"F:O-methyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR053188","properties":[{"key":"EntryName","value":"FkbM_Methyltransferase"}]},{"database":"InterPro","id":"IPR006342","properties":[{"key":"EntryName","value":"FkbM_mtfrase"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"NCBIfam","id":"TIGR01444","properties":[{"key":"EntryName","value":"fkbM_fam"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36973:SF4","properties":[{"key":"EntryName","value":"NODULATION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36973","properties":[{"key":"EntryName","value":"SLL1456 PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05050","properties":[{"key":"EntryName","value":"Methyltransf_21"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPVPQLNDWYDQLTVEIIERVCAPDSGCLDIGAGGGEILTHMRRAAPRGRHFAVEPLPQYAEQLRRDFPEVTVWQAAAAATPGRDSFVHVVSNPGYSGLRRRPYDRADETLEEIAVDTVRLDDVVPEDARVDLVKVDVEGGEVGALRGAAELLRRQSPVVVFEHGGDHAMRDYGTTSDDLWALLVDDLGYTLYTLPGWLAAEPGLDRAALAAELRTQWYFVADRGPLSARSPRGEVHST","length":239,"molWeight":26314,"crc64":"A2FA056E54E31A60","md5":"D21482D8A745C7896FA898E9EF599226"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI000004F6BF"}}