{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q93DZ1","secondaryAccessions":["V6F515"],"uniProtkbId":"MAMO_MAGGM","entryAudit":{"firstPublicDate":"2019-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":103,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)","taxonId":431944,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Alphaproteobacteria","Rhodospirillales","Rhodospirillaceae","Magnetospirillum"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable membrane transporter protein MamO"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"13129949"}],"value":"mamO"},"orderedLocusNames":[{"value":"MGMSRv2__2373"}],"orfNames":[{"value":"mgI493"},{"value":"MGR_4097"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2W8Q2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20674739"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27286560"}],"value":"Plays 2 roles; promotes magnetite nucleation/formation and activates the MamE protease (By similarity) (PubMed:20674739). Despite its near conservation of a protease-like sequence, this is probably not a protease (By similarity). Required in conjunction with MamP for proteolysis of at least MamE, itself and MamP (By similarity). May transport a solute that controls MamE's protease activity. May place individual iron atoms into the magnetite lattice (By similarity). One of 7 genes (mamLQBIEMO) able to induce magnetosome membrane biogenesis; coexpression of mamLQRBIEMO in a deletion of the 17 gene mamAB operon restores magnetosome vesicle formation but not magnetite biosynthesis (PubMed:27286560)"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"a metal cation","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2W8Q2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:25213"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14766587"}],"value":"Magnetosome membrane","id":"SL-0512"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"13129949"}],"value":"Part of the probable 17 gene mamAB operon"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2W8Q2"}],"value":"The N-terminal region is an inactive protease, the C-terminal region may have transporter activity which could contribute to its function in proteolysis by MamE"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2W8Q2"}],"value":"Subject to proteolytic cleavage by MamE"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"13129949"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20674739"}],"value":"Single gene deletion, loss of magnetic response, about 30% iron content. Forms magnetosome chains without magnetosome crystals (PubMed:20674739). Deletion of approximately 80 kb of DNA, including this operon, leads to cells that are non-magnetic, lack internal membrane systems, grow poorly, have reduced mobility and take-up and accumulate iron poorly (PubMed:13129949)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}],"value":"Chains of magnetosomes (coated with carboxy-methyl-dextran) injected into mouse prostate tumors cause tumor disappearance after ultrasound treatment (6-10 applications of 1 W cm(-2), 1 MHz)"}],"commentType":"BIOTECHNOLOGY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11571158"}],"value":"This bacteria makes up to 60 cubo-octahedral magnetosomes of about 45 nm in diameter which contain membrane-bound crystals of magnetite (Fe(3)O(4))"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22043287"}],"value":"Expression of just the minimal mamAB gene cluster (MGMSRv2__2365 to MGMSRv2__2381), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"In the N-terminal section; belongs to the peptidase S1C family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"In the C-terminal section; belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"Probable membrane transporter protein MamO","featureId":"PRO_0000447780"},{"type":"Transmembrane","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Protease-like","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2W8Q2"}]},{"type":"Region","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"TSUP-like","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2W8Q2"}]},{"type":"Binding site","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2W8Q2"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}},{"type":"Binding site","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q2W8Q2"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}}],"keywords":[{"id":"KW-0091","category":"Biological process","name":"Biomineralization"},{"id":"KW-1281","category":"Cellular component","name":"Magnetosome"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11571158","citationType":"journal article","authors":["Grunberg K.","Wawer C.","Tebo B.M.","Schuler D."],"citationCrossReferences":[{"database":"PubMed","id":"11571158"},{"database":"DOI","id":"10.1128/aem.67.10.4573-4582.2001"}],"title":"A large gene cluster encoding several magnetosome proteins is conserved in different species of magnetotactic bacteria.","publicationDate":"2001","journal":"Appl. 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