{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q933I7","uniProtkbId":"OMCBI_CHLTH","entryAudit":{"firstPublicDate":"2006-09-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":65,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Chlamydia trachomatis","taxonId":813,"lineage":["Bacteria","Pseudomonadati","Chlamydiota","Chlamydiia","Chlamydiales","Chlamydiaceae","Chlamydia/Chlamydophila group","Chlamydia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Large cysteine-rich periplasmic protein OmcB, serovars I/J"},"shortNames":[{"value":"Large-CRP"}]},"alternativeNames":[{"fullName":{"value":"60 kDa CRP"}},{"fullName":{"value":"60 kDa outer membrane protein"}},{"fullName":{"value":"Cysteine-rich outer membrane protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"omcB"},"synonyms":[{"value":"ompA"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan. It is present but the disulfide bonds are reduced in reticulate bodies (RBs) (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Periplasm","id":"SL-0200"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl; however based on experiments in C.psittaci it is likely to be periplasmic"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000248875"},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"Large cysteine-rich periplasmic protein OmcB, serovars I/J","featureId":"PRO_0000248876"},{"type":"Region","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0133","category":"Biological process","name":"Cell shape"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11567000","citationType":"journal article","authors":["Millman K.L.","Tavare S.","Dean D."],"citationCrossReferences":[{"database":"PubMed","id":"11567000"},{"database":"DOI","id":"10.1128/jb.183.20.5997-6008.2001"}],"title":"Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism.","publicationDate":"2001","journal":"J. Bacteriol.","firstPage":"5997","lastPage":"6008","volume":"183"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"I/UW-12","type":"STRAIN"},{"value":"J/UW-36","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF304330","properties":[{"key":"ProteinId","value":"AAL14100.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF304329","properties":[{"key":"ProteinId","value":"AAL14099.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q933I7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0042597","properties":[{"key":"GoTerm","value":"C:periplasmic space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003506","properties":[{"key":"EntryName","value":"Chlam_OMP6"}]},{"database":"InterPro","id":"IPR051172","properties":[{"key":"EntryName","value":"Chlamydia_OmcB"}]},{"database":"InterPro","id":"IPR047589","properties":[{"key":"EntryName","value":"DUF11_rpt"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR001434","properties":[{"key":"EntryName","value":"OmcB-like_DUF11"}]},{"database":"NCBIfam","id":"TIGR01451","properties":[{"key":"EntryName","value":"B_ant_repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34819:SF4","properties":[{"key":"EntryName","value":"LARGE CYSTEINE-RICH PERIPLASMIC PROTEIN OMCB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03504","properties":[{"key":"EntryName","value":"Chlam_OMP6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01345","properties":[{"key":"EntryName","value":"CLIPPER"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR01336","properties":[{"key":"EntryName","value":"CHLAMIDIAOM6"}]}],"sequence":{"value":"MNKLIRRAVTIFAVTSVASLFASGVLETSMAESLSTNVISLADTKAKDNTSHKSKKARKNHSKETPVDRKEVAPVHESKATGPKQDSCFGRMYTVKVNDDRNVEITQAVPEYATVGSPYPIEITATGKRDCVDVIITQQLPCEAEFVRSDPATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAATVCACPEIRSVTKCGQPAICVKQEGPENACLRCPVVYKINVVNQGTATARNVVVENPVPDGYAHSSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGCATNIATVSYCGGHKNTASVTTVINEPCVQVSIAGADWSYVCKPVEYVISVSNPGDLVLRDVVVEDTLSPGVTVLEAAGAQISCNKVVWTVKELNPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWKGVAATHMCVVDTCDPVCVGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGTITGNTVVFDSLPRLGSKETVEFSVTLKAVSAGDARGEAILSSDTLTVPVSDTENTHIY","length":547,"molWeight":58627,"crc64":"817BA3000FEA6A71","md5":"C681A3F13F78C9CE6AB93D51951B7172"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Region":1,"Compositional bias":2},"uniParcId":"UPI00000B1E46"}}