{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q93009","secondaryAccessions":["A6NMY8","B7Z815","H0Y3G8"],"uniProtkbId":"UBP7_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-04","entryVersion":250,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Ubiquitin C-terminal hydrolase 7"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11923872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12507430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16964248"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18716620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21745816"}],"value":"3.4.19.12"}]},"alternativeNames":[{"fullName":{"value":"Deubiquitinating enzyme 7"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9034339"}],"value":"Herpesvirus-associated ubiquitin-specific protease"}},{"fullName":{"value":"Ubiquitin thioesterase 7"}},{"fullName":{"value":"Ubiquitin-specific-processing protease 7"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12093161"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:12630"}],"value":"USP7"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9034339"}],"value":"HAUSP"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6A4J8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11923872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16845383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16964248"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18566590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18716620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20153724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20601937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21258371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21745816"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22411829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22466611"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22466612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22689415"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23973222"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25283148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25865756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25944111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26365382"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26786098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27123980"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28655758"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33544460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35216969"}],"value":"Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). Deubiquitinates H2AB1, H2BC4 and H2BC22 (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16160161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18590780"}],"value":"(Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20719947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24216761"}],"value":"(Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).","ecNumber":"3.4.19.12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11923872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12507430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16964248"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18716620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21745816"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25865756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28655758"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33544460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35216969"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506283"}],"value":"Inhibited by N-ethyl-maleimide (NEM) and divalent cations. Tolerates high concentrations of NaCl but is inhibited at concentrations of 195 mM and higher"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","phDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506283"}],"value":"Active from pH 7.0 to 9.5."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6A4J8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12093161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16845383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16964248"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18566590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18716620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20601937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21170034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21258371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21745816"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22411829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22466611"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22466612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22863774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25266658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25283148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25944111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26030138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26365382"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27123980"}],"value":"Monomer. Homodimer. Part of a complex with DAXX, MDM2, RASSF1 and USP7 (PubMed:18566590). Part of a complex with DAXX, MDM2 and USP7 (PubMed:16845383). Interacts with MDM2; the interaction is independent of p53/TP53. Interacts with DAXX; the interaction is direct and independent of MDM2 and p53/TP53 (PubMed:16845383). Component of a complex composed of KMT2E/MLL5 (isoform 3), OGT (isoform 1) and USP7; the complex stabilizes KMT2E/MLL5, preventing KMT2E/MLL5 ubiquitination and proteasomal-mediated degradation (PubMed:26678539). Interacts (via MATH domain) with KMT2E/MLL5 isoform 3 (PubMed:26678539). Interacts with OGT isoform 1 (PubMed:26678539). Interacts with FOXO4; the interaction is enhanced in presence of hydrogen peroxide and occurs independently of p53/TP53 (PubMed:16964248). Interacts with p53/TP53; the interaction is enhanced in response to DNA damage (PubMed:25283148). Interacts with TSPYL5; this impairs interaction with p53/TP53 (PubMed:21170034). Interacts with PTEN; the interaction is direct (PubMed:18716620). Interacts with ATXN1 and the strength of interaction is influenced by the length of the poly-Gln region in ATXN1 (PubMed:12093161). A weaker interaction seen with mutants having longer poly-Gln regions (PubMed:12093161). Interacts with KIAA1530/UVSSA (PubMed:22466611, PubMed:22466612). Interacts with ABRAXAS2; the interaction is direct (PubMed:25283148). Identified in a complex with TP53/p53 and ABRAXAS2 (PubMed:25283148). Interacts with MEX3C and antagonizes its ability to degrade mRNA (PubMed:22863774). Interacts with DNMT1 and UHRF1 (PubMed:21745816, PubMed:22411829). Interacts with FOXP3 (PubMed:23973222). Interacts (via MATH domain) with RNF220. Associated component of the Polycomb group (PcG) multiprotein PRC1-like complex (PubMed:20601937). Interacts with EPOP (By similarity). Interacts with OTUD4 and USP9X; the interaction is direct (PubMed:25944111). Interacts with CRY2 (PubMed:27123980). Interacts with REST (PubMed:21258371). Interacts with ERCC6 (PubMed:26030138). Part of a complex consisting of USP7, MAGEL2 and TRIM27; directly interacts with MAGEL2; directly interacts with TRIM27 (PubMed:26365382). Interacts with FAM170A; this interaction promotes USP7 nuclear translocation and deubiquitinating activity (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16160161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18590780"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9034339"}],"value":"(Microbial infection) Isoform 1 and isoform 2 interact with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 (PubMed:14506283, PubMed:16160161, PubMed:18590780, PubMed:9034339). Binding to ICP0/VMW110 may modulate the substrate specificity or activity of USP7 to stabilize viral proteins"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14506283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24216761"}],"value":"(Microbial infection) Interacts with Epstein-Barr virus EBNA1; the interaction is independent and simultaneous to EBNA1 interaction with USP7 as well as necessary for PML nuclear bodies disruption by EBNA1 (PubMed:14506283, PubMed:24216761). EBNA1, USP7 and CSNK2B form a ternary complex. EBNA1 shows a 10-fold higher affinity than p53/TP53 and can compete with it for USP7 binding (PubMed:14506283)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22072767"}],"value":"(Microbial infection) Interacts with human cytomegalovirus proteins UL35 and UL35A; these interactions inhibit the ability of USP7 to form nuclear bodies"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29343584"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31666375"}],"value":"(Microbial infection) Interacts with herpes virus 8/HHV-8 proteins vIRF-1 and vIRF-3; these interactions may disrupt TP53 signaling pathway during viral infection by decreasing the availability of USP7 for deubiquitinating and stabilizing TP53"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31666375"}],"value":"(Microbial infection) Interacts with herpes virus 8/HHV-8 protein vIRF-2; this interaction modulates antiviral signaling via disruption of USP7 interactions with innate immune signaling proteins TRAF3 and TRAF6 thus affecting their ubiquitination"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q49AR9","geneName":"ANKS1A","intActId":"EBI-11954519"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q6W2J9","geneName":"BCOR","intActId":"EBI-950027"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P35226","geneName":"BMI1","intActId":"EBI-2341576"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q9HC52","geneName":"CBX8","intActId":"EBI-712912"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"O96017","geneName":"CHEK2","intActId":"EBI-1180783"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q9UER7","geneName":"DAXX","intActId":"EBI-77321"},"numberOfExperiments":16,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q9HCI5","geneName":"MAGEE1","intActId":"EBI-949966"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q9UJ55","geneName":"MAGEL2","intActId":"EBI-5668174"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P21145","geneName":"MAL","intActId":"EBI-3932027"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q00987","geneName":"MDM2","intActId":"EBI-389668"},"numberOfExperiments":34,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"O15151","geneName":"MDM4","intActId":"EBI-398437"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q5U5Q3","geneName":"MEX3C","intActId":"EBI-2864451"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q99836","geneName":"MYD88","intActId":"EBI-447677"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P06748","geneName":"NPM1","intActId":"EBI-78579"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P35227","geneName":"PCGF2","intActId":"EBI-2129767"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q9GZU2","geneName":"PEG3","intActId":"EBI-1015078"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P60484","geneName":"PTEN","intActId":"EBI-696162"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P60484-1","geneName":"PTEN","intActId":"EBI-15722967"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P06400","geneName":"RB1","intActId":"EBI-491274"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q06587","geneName":"RING1","intActId":"EBI-752313"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q99496","geneName":"RNF2","intActId":"EBI-722416"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P84022","geneName":"SMAD3","intActId":"EBI-347161"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P48431","geneName":"SOX2","intActId":"EBI-6124081"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q99426","geneName":"TBCB","intActId":"EBI-764356"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P14373","geneName":"TRIM27","intActId":"EBI-719493"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q86VY4","geneName":"TSPYL5","intActId":"EBI-3436472"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P36508","geneName":"ZNF76","intActId":"EBI-7254550"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"P03211","geneName":"EBNA1","intActId":"EBI-996522"},"numberOfExperiments":5,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"Q77UV9","geneName":"KIE-2","intActId":"EBI-2608731"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"O35618","geneName":"Mdm4","intActId":"EBI-2603376"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q93009","intActId":"EBI-302474"},"interactantTwo":{"uniProtKBAccession":"F5H9D8","geneName":"vIRF-4","intActId":"EBI-15951580"},"numberOfExperiments":13,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6A4J8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12093161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16845383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18716620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9034339"}],"value":"Present in a minority of ND10 nuclear bodies (PubMed:9034339). Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10 (PubMed:9034339). Colocalizes with ATXN1 in the nucleus (PubMed:12093161). Colocalized with DAXX in speckled structures (PubMed:16845383). Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies (PubMed:18716620). Interaction with FAM170A promotes its nuclear translocation (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21258371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23973222"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25283148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26678539"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25283148"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9034339"}],"value":"Nucleus, PML body","id":"SL-0465"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20601937"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q93009-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"USP7 beta"}],"isoformIds":["Q93009-2"],"isoformSequenceStatus":"Not described"},{"name":{"value":"3"},"isoformIds":["Q93009-3"],"sequenceIds":["VSP_054884"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18716620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21258371"}],"value":"Expressed in neural progenitor cells (at protein level) (PubMed:21258371). 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