{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q92945","secondaryAccessions":["O00301","Q59EZ9","Q5U4P6","Q9UNT5","Q9UQH5"],"uniProtkbId":"FUBP2_HUMAN","entryAudit":{"firstPublicDate":"2003-09-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-11-30","entryVersion":221,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Far upstream element-binding protein 2"},"shortNames":[{"value":"FUSE-binding protein 2"}]},"alternativeNames":[{"fullName":{"value":"KH type-splicing regulatory protein"},"shortNames":[{"value":"KSRP"}]},{"fullName":{"value":"p75"}}]},"genes":[{"geneName":{"value":"KHSRP"},"synonyms":[{"value":"FUBP2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11003644"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8940189"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9136930"}],"value":"Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11003644"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15175153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21933836"}],"value":"Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1 (PubMed:11003644). Interacts with PARN (PubMed:15175153). Interacts with PQBP1 (PubMed:21933836)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q92945","intActId":"EBI-1049099"},"interactantTwo":{"uniProtKBAccession":"Q9UPY3-1","geneName":"DICER1","intActId":"EBI-15569571"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92945","intActId":"EBI-1049099"},"interactantTwo":{"uniProtKBAccession":"P63101","geneName":"Ywhaz","intActId":"EBI-354751"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19198587"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19198587"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"value":"Detected in neural and non-neural cell lines"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"KH domains KH 3 and KH 4 behave as independent binding modules and can interact with different regions of the AU-rich RNA targets of degradation"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19198587"}],"value":"Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the KHSRP family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAC50892.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAH85004.1","note":"Aberrant splicing.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":711,"modifier":"EXACT"}},"description":"Far upstream element-binding protein 2","featureId":"PRO_0000050137"},{"type":"Domain","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"KH 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00117"}]},{"type":"Domain","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"KH 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00117"}]},{"type":"Domain","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"KH 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00117"}]},{"type":"Domain","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"KH 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00117"}]},{"type":"Repeat","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"1"},{"type":"Repeat","location":{"start":{"value":617,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"2"},{"type":"Repeat","location":{"start":{"value":643,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"3"},{"type":"Repeat","location":{"start":{"value":673,"modifier":"EXACT"},"end":{"value":684,"modifier":"EXACT"}},"description":"4"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":569,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":684,"modifier":"EXACT"}},"description":"4 X 12 AA imperfect repeats"},{"type":"Region","location":{"start":{"value":583,"modifier":"EXACT"},"end":{"value":711,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":528,"modifier":"EXACT"},"end":{"value":542,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":587,"modifier":"EXACT"},"end":{"value":613,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3U0V1"}]},{"type":"Modified residue","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3U0V1"}]},{"type":"Modified residue","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19198587"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":415,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Cross-link","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25114211"}]},{"type":"Cross-link","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Sequence conflict","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"in Ref. 1; AAB53222 and 4; AAD29861","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Sequence conflict","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"in Ref. 5; AAC50892","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"in Ref. 5; AAC50892","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"MP","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"in Ref. 5; AAC50892","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":487,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"in Ref. 5; AAC50892","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"AK","alternativeSequences":["CR"]}},{"type":"Sequence conflict","location":{"start":{"value":694,"modifier":"EXACT"},"end":{"value":696,"modifier":"EXACT"}},"description":"in Ref. 5; AAC50892","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"GPG","alternativeSequences":["VP"]}},{"type":"Beta strand","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Helix","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Beta strand","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Helix","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Turn","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Helix","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Beta strand","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Beta strand","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Helix","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPU"}]},{"type":"Beta strand","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Turn","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPV"}]},{"type":"Helix","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Turn","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Helix","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Beta strand","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Beta strand","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OPV"}]},{"type":"Beta strand","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Beta strand","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Helix","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Beta strand","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JVZ"}]},{"type":"Turn","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4B8T"}]},{"type":"Beta strand","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH3"}]},{"type":"Turn","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH3"}]},{"type":"Helix","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH3"}]},{"type":"Turn","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH3"}]},{"type":"Helix","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH3"}]},{"type":"Beta strand","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH3"}]},{"type":"Beta strand","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH3"}]},{"type":"Helix","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH3"}]},{"type":"Beta strand","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4B8T"}]},{"type":"Turn","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4B8T"}]},{"type":"Beta strand","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Helix","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Turn","location":{"start":{"value":436,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Turn","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Helix","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Beta strand","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Helix","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Beta strand","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Helix","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]},{"type":"Helix","location":{"start":{"value":498,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HH2"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"id":"KW-0508","category":"Biological process","name":"mRNA splicing"},{"id":"KW-0509","category":"Biological process","name":"mRNA transport"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"9136930","citationType":"journal article","authors":["Min H.","Turck C.W.","Nikolic J.M.","Black D.L."],"citationCrossReferences":[{"database":"PubMed","id":"9136930"},{"database":"DOI","id":"10.1101/gad.11.8.1023"}],"title":"A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.","publicationDate":"1997","journal":"Genes Dev.","firstPage":"1023","lastPage":"1036","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","PROTEIN SEQUENCE OF 72-85; 123-128; 267-281; 283-291; 348-359; 474-488; 489-494; 621-627; 629-646 AND 647-653","FUNCTION"],"referenceComments":[{"value":"Neuroblastoma","type":"TISSUE"},{"value":"Retinoblastoma","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"10087204","citationType":"journal article","authors":["Ring H.Z.","Vameghi-Meyers V.","Nikolic J.M.","Min H.","Black D.L.","Francke U."],"citationCrossReferences":[{"database":"PubMed","id":"10087204"},{"database":"DOI","id":"10.1006/geno.1998.5725"}],"title":"Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17.","publicationDate":"1999","journal":"Genomics","firstPage":"350","lastPage":"352","volume":"56"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-115 AND 573-711"]},{"referenceNumber":5,"citation":{"id":"8940189","citationType":"journal article","authors":["Davis-Smyth T.","Duncan R.C.","Zheng T.","Michelotti G.","Levens D."],"citationCrossReferences":[{"database":"PubMed","id":"8940189"},{"database":"DOI","id":"10.1074/jbc.271.49.31679"}],"title":"The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"31679","lastPage":"31687","volume":"271"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 60-711","FUNCTION"],"referenceComments":[{"value":"B-cell lymphoma","type":"TISSUE"},{"value":"Skeletal muscle","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-652NQH91LIDA8","citationType":"submission","authors":["Lubec G.","Chen W.-Q.","Sun Y."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 151-162; 321-331 AND 385-394","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Fetal brain cortex","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"CI-6FM9UGIHPC7GG","citationType":"submission","authors":["Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S.","Ohara O.","Nagase T.","Kikuno R.F."],"publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 183-566"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"11003644","citationType":"journal article","authors":["Markovtsov V.","Nikolic J.M.","Goldman J.A.","Turck C.W.","Chou M.-Y.","Black D.L."],"citationCrossReferences":[{"database":"PubMed","id":"11003644"},{"database":"DOI","id":"10.1128/mcb.20.20.7463-7479.2000"}],"title":"Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.","publicationDate":"2000","journal":"Mol. Cell. Biol.","firstPage":"7463","lastPage":"7479","volume":"20"},"referencePositions":["FUNCTION","INTERACTION WITH PTBP1; PTBP2 AND HNRPH1"]},{"referenceNumber":9,"citation":{"id":"15175153","citationType":"journal article","authors":["Gherzi R.","Lee K.-Y.","Briata P.","Wegmueller D.","Moroni C.","Karin M.","Chen C.-Y."],"citationCrossReferences":[{"database":"PubMed","id":"15175153"},{"database":"DOI","id":"10.1016/j.molcel.2004.05.002"}],"title":"A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"571","lastPage":"583","volume":"14"},"referencePositions":["INTERACTION WITH PARN"]},{"referenceNumber":10,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-100; SER-181 AND SER-274","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":16,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":17,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181 AND SER-480","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"21933836","citationType":"journal article","authors":["Kunde S.A.","Musante L.","Grimme A.","Fischer U.","Mueller E.","Wanker E.E.","Kalscheuer V.M."],"citationCrossReferences":[{"database":"PubMed","id":"21933836"},{"database":"DOI","id":"10.1093/hmg/ddr430"}],"title":"The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.","publicationDate":"2011","journal":"Hum. Mol. Genet.","firstPage":"4916","lastPage":"4931","volume":"20"},"referencePositions":["INTERACTION WITH PQBP1"]},{"referenceNumber":21,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181; SER-274 AND SER-480","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":22,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.m111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":23,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":24,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99; SER-125; SER-129; SER-131; SER-181; SER-184; SER-193; SER-274 AND SER-480","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":25,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-411; ARG-413; ARG-415 AND ARG-442","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"25114211","citationType":"journal article","authors":["Impens F.","Radoshevich L.","Cossart P.","Ribet D."],"citationCrossReferences":[{"database":"PubMed","id":"25114211"},{"database":"DOI","id":"10.1073/pnas.1413825111"}],"title":"Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12432","lastPage":"12437","volume":"111"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-121","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":28,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-121","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":30,"citation":{"id":"17437720","citationType":"journal article","authors":["Garcia-Mayoral M.F.","Hollingworth D.","Masino L.","Diaz-Moreno I.","Kelly G.","Gherzi R.","Chou C.F.","Chen C.Y.","Ramos A."],"citationCrossReferences":[{"database":"PubMed","id":"17437720"},{"database":"DOI","id":"10.1016/j.str.2007.03.006"}],"title":"The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation.","publicationDate":"2007","journal":"Structure","firstPage":"485","lastPage":"498","volume":"15"},"referencePositions":["STRUCTURE BY NMR OF 218-418 AND 423-525"]},{"referenceNumber":31,"citation":{"id":"19198587","citationType":"journal article","authors":["Diaz-Moreno I.","Hollingworth D.","Frenkiel T.A.","Kelly G.","Martin S.","Howell S.","Garcia-Mayoral M.","Gherzi R.","Briata P.","Ramos A."],"citationCrossReferences":[{"database":"PubMed","id":"19198587"},{"database":"DOI","id":"10.1038/nsmb.1558"}],"title":"Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding.","publicationDate":"2009","journal":"Nat. Struct. Mol. Biol.","firstPage":"238","lastPage":"246","volume":"16"},"referencePositions":["STRUCTURE BY NMR OF 130-218 AND 221-305","PHOSPHORYLATION AT SER-193","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U94832","properties":[{"key":"ProteinId","value":"AAB53222.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC011491","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC011539","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC085004","properties":[{"key":"ProteinId","value":"AAH85004.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF093747","properties":[{"key":"ProteinId","value":"AAD29861.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF093745","properties":[{"key":"ProteinId","value":"AAD29861.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF093748","properties":[{"key":"ProteinId","value":"AAD29862.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U69126","properties":[{"key":"ProteinId","value":"AAC50892.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB209662","properties":[{"key":"ProteinId","value":"BAD92899.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS45936.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_003676.2","properties":[{"key":"NucleotideSequenceId","value":"NM_003685.3"}]},{"database":"PDB","id":"2HH2","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=423-525"}]},{"database":"PDB","id":"2HH3","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=318-418"}]},{"database":"PDB","id":"2JVZ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=233-396"}]},{"database":"PDB","id":"2OPU","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=130-218"}]},{"database":"PDB","id":"2OPV","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=221-305"}]},{"database":"PDB","id":"4B8T","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=317-418"}]},{"database":"PDBsum","id":"2HH2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2HH3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2JVZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OPU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OPV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4B8T","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114139","properties":[{"key":"Interactions","value":"330"}]},{"database":"CORUM","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-48484N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q92945","properties":[{"key":"Number of interactors","value":"4259"}]},{"database":"IntAct","id":"Q92945","properties":[{"key":"Interactions","value":"112"}]},{"database":"MINT","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-KHSRP","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000381216","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1795105","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB11638","properties":[{"key":"GenericName","value":"Artenimol"}]},{"database":"DrugBank","id":"DB02709","properties":[{"key":"GenericName","value":"Resveratrol"}]},{"database":"GlyCosmos","id":"Q92945","properties":[{"key":"glycosylation","value":"5 sites, 1 glycan"}]},{"database":"GlyGen","id":"Q92945","properties":[{"key":"glycosylation","value":"10 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (8 sites)"}]},{"database":"iPTMnet","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"KHSRP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"313104306","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000381216","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"75616","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"6316","properties":[{"key":"antibodies","value":"336 antibodies from 38 providers"}]},{"database":"DNASU","id":"8570","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000398148.7","properties":[{"key":"ProteinId","value":"ENSP00000381216.2"},{"key":"GeneId","value":"ENSG00000088247.19"}]},{"database":"GeneID","id":"8570","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:8570","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc002mer.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:6316","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30097","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"8570","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"8570","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"KHSRP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:6316","properties":[{"key":"GeneName","value":"KHSRP"}]},{"database":"HPA","id":"ENSG00000088247","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"603445","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000088247","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000088247","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1676","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156051","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_014285_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5204190at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q92945","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-380994","properties":[{"key":"PathwayName","value":"ATF4 activates genes in response to endoplasmic reticulum stress"}]},{"database":"Reactome","id":"R-HSA-450604","properties":[{"key":"PathwayName","value":"KSRP (KHSRP) binds and destabilizes mRNA"}]},{"database":"SignaLink","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000088247","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"8570","properties":[{"key":"hits","value":"79 hits in 1173 CRISPR screens"}]},{"database":"CD-CODE","id":"232F8A39","properties":[{"key":"EntryName","value":"P-body"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"F659AEC6","properties":[{"key":"EntryName","value":"Pericentriolar compartment"}]},{"database":"ChiTaRS","id":"KHSRP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"KHSRP","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"8570","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q92945","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q92945","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"Q92945","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000088247","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 213 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q92945","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0035925","properties":[{"key":"GoTerm","value":"F:mRNA 3'-UTR AU-rich region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16126846"}]},{"database":"GO","id":"GO:0003730","properties":[{"key":"GoTerm","value":"F:mRNA 3'-UTR binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0044183","properties":[{"key":"GoTerm","value":"F:protein folding chaperone"},{"key":"GoEvidenceType","value":"EXP:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19198587"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0061158","properties":[{"key":"GoTerm","value":"P:3'-UTR-mediated mRNA destabilization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16126846"}]},{"database":"GO","id":"GO:0071345","properties":[{"key":"GoTerm","value":"P:cellular response to cytokine stimulus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16126846"}]},{"database":"GO","id":"GO:0010586","properties":[{"key":"GoTerm","value":"P:miRNA metabolic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27478153"}]},{"database":"GO","id":"GO:0006397","properties":[{"key":"GoTerm","value":"P:mRNA processing"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9136930"}]},{"database":"GO","id":"GO:0010989","properties":[{"key":"GoTerm","value":"P:negative regulation of low-density lipoprotein particle clearance"},{"key":"GoEvidenceType","value":"IGI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"26523989"}]},{"database":"GO","id":"GO:0045019","properties":[{"key":"GoTerm","value":"P:negative regulation of nitric oxide biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16126846"}]},{"database":"GO","id":"GO:0061014","properties":[{"key":"GoTerm","value":"P:positive regulation of mRNA catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16126846"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0043488","properties":[{"key":"GoTerm","value":"P:regulation of mRNA stability"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16126846"}]},{"database":"GO","id":"GO:0008380","properties":[{"key":"GoTerm","value":"P:RNA splicing"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10911989"}]},{"database":"GO","id":"GO:0000375","properties":[{"key":"GoTerm","value":"P:RNA splicing, via transesterification reactions"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10911989"}]},{"database":"CDD","id":"cd22479","properties":[{"key":"EntryName","value":"KH-I_FUBP2_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd22482","properties":[{"key":"EntryName","value":"KH-I_FUBP2_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd22485","properties":[{"key":"EntryName","value":"KH-I_FUBP2_rpt3"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd22488","properties":[{"key":"EntryName","value":"KH-I_FUBP2_rpt4"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP01590","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"3.30.1370.10:FF:000007","properties":[{"key":"EntryName","value":"far upstream element-binding protein 1 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1370.10:FF:000008","properties":[{"key":"EntryName","value":"far upstream element-binding protein 1 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1370.10:FF:000010","properties":[{"key":"EntryName","value":"far upstream element-binding protein 1 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1370.10:FF:000049","properties":[{"key":"EntryName","value":"far upstream element-binding protein 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1370.10","properties":[{"key":"EntryName","value":"K Homology domain, type 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR015096","properties":[{"key":"EntryName","value":"FUBP_C"}]},{"database":"InterPro","id":"IPR047372","properties":[{"key":"EntryName","value":"KH-I_FUBP2_rpt1"}]},{"database":"InterPro","id":"IPR047369","properties":[{"key":"EntryName","value":"KH-I_FUBP2_rpt2"}]},{"database":"InterPro","id":"IPR047370","properties":[{"key":"EntryName","value":"KH-I_FUBP2_rpt3"}]},{"database":"InterPro","id":"IPR047371","properties":[{"key":"EntryName","value":"KH-I_FUBP2_rpt4"}]},{"database":"InterPro","id":"IPR004087","properties":[{"key":"EntryName","value":"KH_dom"}]},{"database":"InterPro","id":"IPR004088","properties":[{"key":"EntryName","value":"KH_dom_type_1"}]},{"database":"InterPro","id":"IPR036612","properties":[{"key":"EntryName","value":"KH_dom_type_1_sf"}]},{"database":"PANTHER","id":"PTHR10288","properties":[{"key":"EntryName","value":"KH DOMAIN CONTAINING RNA BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09005","properties":[{"key":"EntryName","value":"FUBP_C"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00013","properties":[{"key":"EntryName","value":"KH_1"},{"key":"MatchStatus","value":"4"}]},{"database":"SMART","id":"SM00322","properties":[{"key":"EntryName","value":"KH"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF54791","properties":[{"key":"EntryName","value":"Eukaryotic type KH-domain (KH-domain type I)"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50084","properties":[{"key":"EntryName","value":"KH_TYPE_1"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MSDYSTGGPPPGPPPPAGGGGGAGGAGGGPPPGPPGAGDRGGGGPGGGGPGGGSAGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGGDAATTVNNSTPDFGFGGQKRQLEDGDQPESKKLASQGDSISSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQISPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQNTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFIIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQWQPPAPHDPSKAAAAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEYYRQQAAYYGQTPGPGGPQPPPTQQGQQQAQ","length":711,"molWeight":73115,"crc64":"AB0B7C0B5B938114","md5":"256033C5A5842A7B8FF571BF382E01EE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":4,"Repeat":4,"Region":5,"Compositional bias":9,"Modified residue":17,"Cross-link":2,"Sequence conflict":6,"Beta strand":17,"Helix":15,"Turn":9},"uniParcId":"UPI000049DE96"}}