{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q92830","secondaryAccessions":["Q8N1A2","Q9UCW1"],"uniProtkbId":"KAT2A_HUMAN","entryAudit":{"firstPublicDate":"2001-04-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-10-14","entryVersion":243,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Histone acetyltransferase KAT2A"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21131905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22465951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27377381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}],"value":"2.3.1.48"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JHD2"}],"value":"General control of amino acid synthesis protein 5-like 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8552087"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9611240"}],"value":"Histone acetyltransferase GCN5"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8552087"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9611240"}],"value":"hGCN5"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Histone glutaryltransferase KAT2A"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31542297"}],"value":"2.3.1.-"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Histone succinyltransferase KAT2A"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}],"value":"2.3.1.-"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Lysine acetyltransferase 2A"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"39561764"}],"value":"Protein lactyltransferase KAT2A"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}],"value":"2.3.1.-"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11564863"}],"value":"STAF97"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"27796307"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4201"}],"value":"KAT2A"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8552087"}],"value":"GCN5"},{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JHD2"}],"value":"GCN5L2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JHD2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16753578"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17301242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19103755"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21131905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22465951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23142079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27377381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27796307"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29174768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29973595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31542297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35995428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37040526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39694035"}],"value":"Protein lysine acyltransferase that catalyzes acetylation of histone and non-histone proteins using acetyl-CoA (PubMed:16753578, PubMed:17301242, PubMed:21131905, PubMed:22465951, PubMed:23142079, PubMed:27796307, PubMed:29174768, PubMed:31527837, PubMed:35995428, PubMed:38128537, PubMed:27377381, PubMed:29211711, PubMed:37040526, PubMed:39561764, PubMed:39694035). Also catalyzes acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA (PubMed:31542297, PubMed:29211711, PubMed:37040526, PubMed:39561764). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755, PubMed:21131905). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (PubMed:21131905). Also catalyzes acetylation of histone H1.4 (H1-4) at 'Lys-34' (H1.4K34ac), a modification enriched at promoters of active genes (PubMed:22465951). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, CGAS, MRE11, PPARGC1A, PLK4 and TBX5 (PubMed:16753578, PubMed:17301242, PubMed:27796307, PubMed:29174768, PubMed:38128537, PubMed:39694035). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A (PubMed:16753578, PubMed:23142079). Acts as a positive regulator of cGAS-STING signaling by mediating acetylation and activation of CGAS (PubMed:39694035). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). Catalyzes histone H3 lactylation at 'Lys-14' and 'Lys-18' in a lactyl-CoA-dependent manner (PubMed:39561764). Lactyl-CoA for this reaction can be generated by ACSS2 (PubMed:39561764)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11384967"}],"value":"(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21992"},{"database":"Rhea","id":"RHEA-COMP:9845"},{"database":"Rhea","id":"RHEA-COMP:11338"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"ecNumber":"2.3.1.48","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21131905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22465951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27377381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37040526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21993"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21131905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22465951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27377381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45948"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16753578"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17301242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23142079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27796307"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29174768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35995428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39694035"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"succinyl-CoA + L-lysyl-[protein] = N(6)-succinyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16261"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:11877"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57292"},{"database":"ChEBI","id":"CHEBI:87830"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37040526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16262"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"39561764"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glutaryl-CoA + L-lysyl-[protein] = N(6)-glutaryl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18009"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:11875"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57378"},{"database":"ChEBI","id":"CHEBI:87828"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31542297"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:18010"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31542297"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:61996"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:19466"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:231527"},{"database":"ChEBI","id":"CHEBI:231528"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:61997"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"39561764"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53908"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:13707"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57332"},{"database":"ChEBI","id":"CHEBI:137954"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53909"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"39561764"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"propanoyl-CoA + L-lysyl-[protein] = N(6)-propanoyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54020"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:13758"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57392"},{"database":"ChEBI","id":"CHEBI:138019"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37040526"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54021"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37040526"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"butanoyl-CoA + L-lysyl-[protein] = N(6)-butanoyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53912"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:13708"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57371"},{"database":"ChEBI","id":"CHEBI:137955"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37040526"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53913"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37040526"}]}]},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":1.6,"unit":"nmol/sec/mg","enzyme":"enzyme with acetyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]},{"velocity":2.94,"unit":"nmol/sec/mg","enzyme":"enzyme with lactyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]}],"michaelisConstants":[{"constant":0.83,"unit":"uM","substrate":"acetyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"}]},{"constant":0.91,"unit":"uM","substrate":"acetyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27377381"}]},{"constant":0.36,"unit":"uM","substrate":"succinyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"}]},{"constant":5.9,"unit":"uM","substrate":"acetyl-CoA (in the presence of H3K9 peptide)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35995428"}]},{"constant":45.1,"unit":"uM","substrate":"malonyl-CoA (in the presence of H3K9 peptide)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35995428"}]},{"constant":0.8408,"unit":"uM","substrate":"acetyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]},{"constant":0.3782,"unit":"uM","substrate":"succinyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]},{"constant":0.489,"unit":"uM","substrate":"lactyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]},{"constant":2.853,"unit":"uM","substrate":"crotonyl-CoA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39561764"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JHD2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10373431"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10611234"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11438666"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14767476"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17301242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18206972"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19103755"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27796307"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29174768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29211711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29973595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30109122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30894545"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31527837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39694035"}],"value":"Homooligomer; may form a tetramer of homodimers (PubMed:30109122). Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP (PubMed:10373431, PubMed:10611234, PubMed:11438666). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (PubMed:18206972). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT14, MBIP and WDR5 (PubMed:19103755). Interacts with PML (By similarity). Interacts with CEBPB (PubMed:17301242). Interacts with TACC1, TACC2 and TACC3 (PubMed:14767476). Interacts with RELA (By similarity). Interacts with NFATC2 (By similarity). Interacts with TBX5 (PubMed:29174768). Interacts with PLK4 (PubMed:27796307). Associates with the 2-oxoglutarate dehydrogenase complex (PubMed:29211711). Interacts with XPC; leading to KAT2A recruitment to promoters and subsequent acetylation of histones (PubMed:29973595, PubMed:31527837). Interacts with ERCC3/XPB; leading to KAT2A recruitment to promoters and subsequent acetylation of histones (PubMed:30894545). Interacts with ISL1. Interactions of ISL1 with MLIP1 or KAT2A may be mutually exclusive (By similarity). Interacts with MYO1F; promoting interaction between KAT2A and CGAS (PubMed:39694035)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11384967"}],"value":"(Microbial infection) Interacts with and acetylates HIV-1 Tat"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q92830","intActId":"EBI-477622"},"interactantTwo":{"uniProtKBAccession":"Q9NY61","geneName":"AATF","intActId":"EBI-372428"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92830","intActId":"EBI-477622"},"interactantTwo":{"uniProtKBAccession":"Q01094","geneName":"E2F1","intActId":"EBI-448924"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92830","intActId":"EBI-477622"},"interactantTwo":{"uniProtKBAccession":"O75478","geneName":"TADA2A","intActId":"EBI-742268"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92830","intActId":"EBI-477622"},"interactantTwo":{"uniProtKBAccession":"O75717","geneName":"WDHD1","intActId":"EBI-3951691"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92830","intActId":"EBI-477622"},"interactantTwo":{"uniProtKBAccession":"Q8IYH5","geneName":"ZZZ3","intActId":"EBI-2795524"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92830","intActId":"EBI-477622"},"interactantTwo":{"uniProtKBAccession":"P0DTC9","geneName":"N","intActId":"EBI-25475856"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q92830","intActId":"EBI-477622"},"interactantTwo":{"uniProtKBAccession":"P59595","geneName":"N","intActId":"EBI-7602718"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27796307"}],"value":"Mainly localizes to the nucleus (PubMed:27796307). Localizes to sites of DNA damage (PubMed:25593309). 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