{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q92793","secondaryAccessions":["D3DUC9","O00147","Q16376","Q4LE28"],"uniProtkbId":"CBP_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-17","entryVersion":271,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"CREB-binding protein"}},"alternativeNames":[{"fullName":{"value":"Histone lysine acetyltransferase CREBBP"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21131905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"value":"2.3.1.48"}]},{"fullName":{"value":"Protein lactyltransferas CREBBP"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"}],"value":"2.3.1.-"}]},{"fullName":{"value":"Protein-lysine acetyltransferase CREBBP"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154691"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12738767"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24207024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24939902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28790157"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30540930"}],"value":"2.3.1.-"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2348"}],"value":"CREBBP"},"synonyms":[{"value":"CBP"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10490106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154691"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12738767"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12929931"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14645221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21131905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24207024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24939902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25514493"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28790157"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30540930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35675826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9707565"}],"value":"Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21992"},{"database":"Rhea","id":"RHEA-COMP:9845"},{"database":"Rhea","id":"RHEA-COMP:11338"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"ecNumber":"2.3.1.48","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21131905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21993"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21131905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45948"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154691"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12738767"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24207024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24939902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30540930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35675826"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45949"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154691"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12738767"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24207024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24939902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28790157"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30540930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35675826"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:61996"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:19466"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:231527"},{"database":"ChEBI","id":"CHEBI:231528"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:61997"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10077561"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10347196"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10722728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10866662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11154691"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11349124"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11481323"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11514544"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11568182"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11744733"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11864910"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11959977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11971985"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12730195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12738767"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14645221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14716005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15075319"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15126506"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15220471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18316612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23651431"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24939902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25514493"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26951377"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27302953"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28128295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8684459"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8917528"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9707565"}],"value":"Found in a complex containing NCOA2; NCOA3; IKKA; IKKB and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with GATA1; the interaction results in acetylation and enhancement of transcriptional activity of GATA1. Interacts with MAF and ZCCHC12. Interacts with DAXX; the interaction is dependent on CBP sumoylation and results in suppression of the transcriptional activity via recruitment of HDAC2 to DAXX (By similarity). Interacts with phosphorylated CREB1. Interacts with CITED4 (C-terminal region). Interacts (via the TAZ-type 1 domain) with HIF1A. Interacts with SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, DDX5, DDX17, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with KLF1; the interaction results in acetylation of KLF1 and enhancement of its transcriptional activity. Interacts with MTDH. Interacts with NFATC4. Interacts with MAFG; the interaction acetylates MAFG in the basic region and stimulates NFE2 transcriptional activity through increasing its DNA-binding activity. Interacts with IRF2; the interaction acetylates IRF2 and regulates its activity on the H4 promoter. Interacts with IRF3 (when phosphorylated); forming the dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I interferon genes (PubMed:27302953). Interacts (via N-terminus) with SS18L1/CREST (via C-terminus). Interacts with MECOM. Interacts with CITED1 (via C-terminus). Interacts with FOXO1; the interaction acetylates FOXO1 and inhibits its transcriptional activity. Interacts with NPAS2, CLOCK and BMAL1. Interacts with ASF1A and ASF1B; this promotes histone acetylation. Interacts with acetylated TP53/p53 and with the acetylated histones H3 and H4. Interacts (via transactivation domain and C-terminus) with PCNA; the interaction occurs on chromatin in UV-irradiated damaged cells (PubMed:24939902). Interacts with DHX9 (via N-terminus); this interaction mediates association with RNA polymerase II holoenzyme and stimulates CREB-dependent transcriptional activation (PubMed:9323138). Interacts with SMAD4; negatively regulated by ZBTB7A (PubMed:25514493). Interacts with DUX4 (via C-terminus) (PubMed:26951377). Forms a complex with KMT2A and CREB1 (PubMed:23651431). Interacts with DDX3X; this interaction may facilitate HNF4A acetylation (PubMed:28128295). Interacts with MSX1; the interaction may inhibit MSX1 autoinactivation (By similarity). Interacts with ACSS2 (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11463834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11559821"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9528808"}],"value":"(Microbial infection) Interacts with HTLV-1 Tax, p30II and HBZ"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11314014"}],"value":"(Microbial infection) Interacts with human herpes virus 8/HHV-8 protein vIRF-1; this interaction inhibits CREBBP binding to IRF3"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14744133"}],"value":"(Microbial infection) Interacts with HIV-1 Tat"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P31749","geneName":"AKT1","intActId":"EBI-296087"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"O96018","geneName":"APBA3","intActId":"EBI-6115839"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P10275","geneName":"AR","intActId":"EBI-608057"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P61201","geneName":"COPS2","intActId":"EBI-1050386"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P16220","geneName":"CREB1","intActId":"EBI-711855"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q9UER7","geneName":"DAXX","intActId":"EBI-77321"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q12778","geneName":"FOXO1","intActId":"EBI-1108782"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"O43524","geneName":"FOXO3","intActId":"EBI-1644164"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P23769","geneName":"GATA2","intActId":"EBI-2806671"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P62805","geneName":"H4C9","intActId":"EBI-302023"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q16665","geneName":"HIF1A","intActId":"EBI-447269"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P48551","geneName":"IFNAR2","intActId":"EBI-958408"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q14653","geneName":"IRF3","intActId":"EBI-2650369"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q13568","geneName":"IRF5","intActId":"EBI-3931258"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q92831","geneName":"KAT2B","intActId":"EBI-477430"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q13351","geneName":"KLF1","intActId":"EBI-8284732"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"O00629","geneName":"KPNA4","intActId":"EBI-396343"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q96QZ7","geneName":"MAGI1","intActId":"EBI-924464"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q86UE4","geneName":"MTDH","intActId":"EBI-1046588"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P55209","geneName":"NAP1L1","intActId":"EBI-356392"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q14686","geneName":"NCOA6","intActId":"EBI-78670"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"O14745","geneName":"NHERF1","intActId":"EBI-349787"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q04206","geneName":"RELA","intActId":"EBI-73886"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P36956-1","geneName":"SREBF1","intActId":"EBI-948328"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P36956-3","geneName":"SREBF1","intActId":"EBI-948338"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q12772","geneName":"SREBF2","intActId":"EBI-465059"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q9UL17","geneName":"TBX21","intActId":"EBI-3922312"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"O95049","geneName":"TJP3","intActId":"EBI-1171427"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P0DTC9","geneName":"N","intActId":"EBI-25475856"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P04608","geneName":"tat","intActId":"EBI-6164389"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P03070","intActId":"EBI-617698"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P03255","intActId":"EBI-2603114"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P03259","intActId":"EBI-6947456"},"numberOfExperiments":5,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q92793","intActId":"EBI-81215"},"interactantTwo":{"uniProtKBAccession":"P03259-2","intActId":"EBI-7225021"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12929931"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15023334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15488321"}],"value":"Recruited to nuclear bodies by SS18L1/CREST (PubMed:15488321). In the presence of ALX1 relocalizes from the cytoplasm to the nucleus (PubMed:12929931). Relocalizes from the nucleus to the cytoplasm following UV cell damage (PubMed:15023334)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12929931"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15023334"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12929931"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15023334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15488321"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25593309"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q92793-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q92793-2"],"sequenceIds":["VSP_045700"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"The KIX domain mediates binding to HIV-1 Tat"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"value":"Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17434128"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"}],"value":"Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386; these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B (PubMed:17434128). Phosphorylated by _ at Ser-124 in response to DNA damage, promoting interaction with MRE11 and lactylation of MRE11 (PubMed:38128537)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"value":"Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35675826"}],"value":"Autoacetylation is required for binding to protein substrates, such as acetylated histones and acetylated TP53/p53 (PubMed:24616510). Autoacetylation is induced by glucose and fatty acids (PubMed:35675826)"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"value":"Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with KMT2A/MLL1; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Rubinstein-Taybi syndrome 1","diseaseAccession":"DI-02730","acronym":"RSTS1","description":"A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, intellectual disability and a propensity for development of malignancies.","diseaseCrossReference":{"database":"MIM","id":"180849"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11331617"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12114483"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12566391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15706485"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20684013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Menke-Hennekam syndrome 1","diseaseAccession":"DI-05487","acronym":"MKHK1","description":"A form of Menke-Hennekam syndrome, a congenital autosomal dominant disease characterized by developmental delay, growth retardation, and craniofacial dysmorphism. Patients have intellectual disability of variable severity, speech delay, autistic behavior, short stature and microcephaly. Main facial characteristics include short palpebral fissures, telecanthi, depressed nasal ridge, short nose, anteverted nares, short columella and long philtrum.","diseaseCrossReference":{"database":"MIM","id":"618332"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30737887"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAE06125.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42/crebbp","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/P300/CBP","ftp":false,"note":"P300/CBP entry"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2442,"modifier":"EXACT"}},"description":"CREB-binding protein","featureId":"PRO_0000211190"},{"type":"Domain","location":{"start":{"value":587,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"KIX","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00311"}]},{"type":"Domain","location":{"start":{"value":1085,"modifier":"EXACT"},"end":{"value":1192,"modifier":"EXACT"}},"description":"Bromo","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00035"}]},{"type":"Domain","location":{"start":{"value":1323,"modifier":"EXACT"},"end":{"value":1700,"modifier":"EXACT"}},"description":"CBP/p300-type HAT","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01065"}]},{"type":"Zinc finger","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"TAZ-type 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00203"}]},{"type":"Zinc finger","location":{"start":{"value":1702,"modifier":"EXACT"},"end":{"value":1750,"modifier":"EXACT"}},"description":"ZZ-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}]},{"type":"Zinc finger","location":{"start":{"value":1765,"modifier":"EXACT"},"end":{"value":1846,"modifier":"EXACT"}},"description":"TAZ-type 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00203"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Interaction with SRCAP","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10347196"}]},{"type":"Region","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":794,"modifier":"EXACT"},"end":{"value":1083,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1124,"modifier":"EXACT"},"end":{"value":1170,"modifier":"EXACT"}},"description":"Interaction with histone","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24361270"}]},{"type":"Region","location":{"start":{"value":1162,"modifier":"EXACT"},"end":{"value":1180,"modifier":"EXACT"}},"description":"Interaction with ASF1A","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}]},{"type":"Region","location":{"start":{"value":1433,"modifier":"EXACT"},"end":{"value":1435,"modifier":"EXACT"}},"description":"Interaction with histone","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q09472"}]},{"type":"Region","location":{"start":{"value":1460,"modifier":"EXACT"},"end":{"value":1891,"modifier":"EXACT"}},"description":"Interaction with TRERF1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11349124"}]},{"type":"Region","location":{"start":{"value":1556,"modifier":"EXACT"},"end":{"value":1615,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1874,"modifier":"EXACT"},"end":{"value":1959,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1977,"modifier":"EXACT"},"end":{"value":2028,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2112,"modifier":"EXACT"},"end":{"value":2263,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2294,"modifier":"EXACT"},"end":{"value":2433,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":794,"modifier":"EXACT"},"end":{"value":805,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":814,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":844,"modifier":"EXACT"},"end":{"value":860,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":876,"modifier":"EXACT"},"end":{"value":885,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":886,"modifier":"EXACT"},"end":{"value":929,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":937,"modifier":"EXACT"},"end":{"value":952,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":973,"modifier":"EXACT"},"end":{"value":988,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1011,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1032,"modifier":"EXACT"},"end":{"value":1059,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1066,"modifier":"EXACT"},"end":{"value":1078,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1556,"modifier":"EXACT"},"end":{"value":1568,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1585,"modifier":"EXACT"},"end":{"value":1595,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1900,"modifier":"EXACT"},"end":{"value":1912,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1925,"modifier":"EXACT"},"end":{"value":1940,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1943,"modifier":"EXACT"},"end":{"value":1954,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2018,"modifier":"EXACT"},"end":{"value":2027,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2112,"modifier":"EXACT"},"end":{"value":2137,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2146,"modifier":"EXACT"},"end":{"value":2160,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2196,"modifier":"EXACT"},"end":{"value":2219,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2228,"modifier":"EXACT"},"end":{"value":2263,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2294,"modifier":"EXACT"},"end":{"value":2305,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2315,"modifier":"EXACT"},"end":{"value":2327,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2334,"modifier":"EXACT"},"end":{"value":2343,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2349,"modifier":"EXACT"},"end":{"value":2372,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2411,"modifier":"EXACT"},"end":{"value":2424,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":1434,"modifier":"EXACT"},"end":{"value":1436,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57288"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q09472"}],"ligand":{"name":"acetyl-CoA","id":"ChEBI:CHEBI:57288"}},{"type":"Binding site","location":{"start":{"value":1446,"modifier":"EXACT"},"end":{"value":1447,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57288"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q09472"}],"ligand":{"name":"acetyl-CoA","id":"ChEBI:CHEBI:57288"}},{"type":"Binding site","location":{"start":{"value":1493,"modifier":"EXACT"},"end":{"value":1493,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57288"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q09472"}],"ligand":{"name":"acetyl-CoA","id":"ChEBI:CHEBI:57288"}},{"type":"Binding site","location":{"start":{"value":1498,"modifier":"EXACT"},"end":{"value":1498,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57288"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q09472"}],"ligand":{"name":"acetyl-CoA","id":"ChEBI:CHEBI:57288"}},{"type":"Binding site","location":{"start":{"value":1502,"modifier":"EXACT"},"end":{"value":1502,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57288"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q09472"}],"ligand":{"name":"acetyl-CoA","id":"ChEBI:CHEBI:57288"}},{"type":"Binding site","location":{"start":{"value":1707,"modifier":"EXACT"},"end":{"value":1707,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1710,"modifier":"EXACT"},"end":{"value":1710,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1720,"modifier":"EXACT"},"end":{"value":1720,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1723,"modifier":"EXACT"},"end":{"value":1723,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1729,"modifier":"EXACT"},"end":{"value":1729,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1732,"modifier":"EXACT"},"end":{"value":1732,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1738,"modifier":"EXACT"},"end":{"value":1738,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1740,"modifier":"EXACT"},"end":{"value":1740,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00228"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Site","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form KAT6B-CREBBP"},{"type":"Site","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form KAT6A-CREBBP"},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Phosphoserine; by ATM","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"}]},{"type":"Modified residue","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":601,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}]},{"type":"Modified residue","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":625,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}]},{"type":"Modified residue","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}]},{"type":"Modified residue","location":{"start":{"value":1014,"modifier":"EXACT"},"end":{"value":1014,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1030,"modifier":"EXACT"},"end":{"value":1030,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17525332"}]},{"type":"Modified residue","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1076,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1216,"modifier":"EXACT"},"end":{"value":1216,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1382,"modifier":"EXACT"},"end":{"value":1382,"modifier":"EXACT"}},"description":"Phosphoserine; by IKKA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17434128"}]},{"type":"Modified residue","location":{"start":{"value":1386,"modifier":"EXACT"},"end":{"value":1386,"modifier":"EXACT"}},"description":"Phosphoserine; by IKKA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17434128"}]},{"type":"Modified residue","location":{"start":{"value":1583,"modifier":"EXACT"},"end":{"value":1583,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1591,"modifier":"EXACT"},"end":{"value":1591,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1592,"modifier":"EXACT"},"end":{"value":1592,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1595,"modifier":"EXACT"},"end":{"value":1595,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1597,"modifier":"EXACT"},"end":{"value":1597,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1741,"modifier":"EXACT"},"end":{"value":1741,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1744,"modifier":"EXACT"},"end":{"value":1744,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1763,"modifier":"EXACT"},"end":{"value":1763,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":2063,"modifier":"EXACT"},"end":{"value":2063,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":2076,"modifier":"EXACT"},"end":{"value":2076,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":2079,"modifier":"EXACT"},"end":{"value":2079,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":2351,"modifier":"EXACT"},"end":{"value":2351,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}]},{"type":"Cross-link","location":{"start":{"value":998,"modifier":"EXACT"},"end":{"value":998,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}]},{"type":"Cross-link","location":{"start":{"value":1033,"modifier":"EXACT"},"end":{"value":1033,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}]},{"type":"Cross-link","location":{"start":{"value":1056,"modifier":"EXACT"},"end":{"value":1056,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P45481"}]},{"type":"Alternative sequence","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_045700","alternativeSequence":{"originalSequence":"VAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQT","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":503,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"in dbSNP:rs748447855","featureCrossReferences":[{"database":"dbSNP","id":"rs748447855"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072912","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":532,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"in dbSNP:rs902901184","featureCrossReferences":[{"database":"dbSNP","id":"rs902901184"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072913","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":546,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"in dbSNP:rs2141247569","featureCrossReferences":[{"database":"dbSNP","id":"rs2141247569"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072914","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":650,"modifier":"EXACT"}},"description":"in RSTS1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072915","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":789,"modifier":"EXACT"},"end":{"value":789,"modifier":"EXACT"}},"description":"in RSTS1; dbSNP:rs746728741","featureCrossReferences":[{"database":"dbSNP","id":"rs746728741"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072916","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":910,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"in RSTS1; incomplete; dbSNP:rs143247685","featureCrossReferences":[{"database":"dbSNP","id":"rs143247685"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20684013"}],"featureId":"VAR_072917","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1175,"modifier":"EXACT"},"end":{"value":1175,"modifier":"EXACT"}},"description":"in RSTS1; mild form; impairs binding to ASF1A and acetylated histone H3; dbSNP:rs28937315","featureCrossReferences":[{"database":"dbSNP","id":"rs28937315"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12114483"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_037305","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":1278,"modifier":"EXACT"},"end":{"value":1278,"modifier":"EXACT"}},"description":"in RSTS1; dbSNP:rs2151368021","featureCrossReferences":[{"database":"dbSNP","id":"rs2151368021"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072918","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1278,"modifier":"EXACT"},"end":{"value":1278,"modifier":"EXACT"}},"description":"in RSTS1; abolishes acetyltransferase activity; dbSNP:rs267606752","featureCrossReferences":[{"database":"dbSNP","id":"rs267606752"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12566391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15706485"}],"featureId":"VAR_035080","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":1378,"modifier":"EXACT"},"end":{"value":1378,"modifier":"EXACT"}},"description":"in RSTS1; abolishes acetyltransferase activity and the ability of transactivate CREB; dbSNP:rs121434626","featureCrossReferences":[{"database":"dbSNP","id":"rs121434626"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11331617"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_015578","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":1406,"modifier":"EXACT"},"end":{"value":1406,"modifier":"EXACT"}},"description":"in RSTS1; dbSNP:rs2052153254","featureCrossReferences":[{"database":"dbSNP","id":"rs2052153254"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072919","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":1414,"modifier":"EXACT"},"end":{"value":1414,"modifier":"EXACT"}},"description":"in dbSNP:rs130015","featureCrossReferences":[{"database":"dbSNP","id":"rs130015"}],"featureId":"VAR_027953","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":1415,"modifier":"EXACT"},"end":{"value":1415,"modifier":"EXACT"}},"description":"in RSTS1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072920","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":1447,"modifier":"EXACT"},"end":{"value":1447,"modifier":"EXACT"}},"description":"in RSTS1; dbSNP:rs2151334254","featureCrossReferences":[{"database":"dbSNP","id":"rs2151334254"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15706485"}],"featureId":"VAR_035081","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":1450,"modifier":"EXACT"},"end":{"value":1450,"modifier":"EXACT"}},"description":"in RSTS1; dbSNP:rs1555473499","featureCrossReferences":[{"database":"dbSNP","id":"rs1555473499"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15706485"}],"featureId":"VAR_035082","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1470,"modifier":"EXACT"},"end":{"value":1470,"modifier":"EXACT"}},"description":"in RSTS1; dbSNP:rs797044860","featureCrossReferences":[{"database":"dbSNP","id":"rs797044860"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15706485"}],"featureId":"VAR_035083","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1475,"modifier":"EXACT"},"end":{"value":1475,"modifier":"EXACT"}},"description":"in RSTS1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072921","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":1503,"modifier":"EXACT"},"end":{"value":1503,"modifier":"EXACT"}},"description":"in RSTS1; dbSNP:rs587783497","featureCrossReferences":[{"database":"dbSNP","id":"rs587783497"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072922","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":1507,"modifier":"EXACT"},"end":{"value":1507,"modifier":"EXACT"}},"description":"in RSTS1; dbSNP:rs1057520191","featureCrossReferences":[{"database":"dbSNP","id":"rs1057520191"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072923","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":1543,"modifier":"EXACT"},"end":{"value":1543,"modifier":"EXACT"}},"description":"in RSTS1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25388907"}],"featureId":"VAR_072924","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":1664,"modifier":"EXACT"},"end":{"value":1664,"modifier":"EXACT"}},"description":"in RSTS1; abolishes acetyltransferase activity; dbSNP:rs1596791996","featureCrossReferences":[{"database":"dbSNP","id":"rs1596791996"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12566391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15706485"}],"featureId":"VAR_035084","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1710,"modifier":"EXACT"},"end":{"value":1710,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs1567265203","featureCrossReferences":[{"database":"dbSNP","id":"rs1567265203"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"}],"featureId":"VAR_078557","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1719,"modifier":"EXACT"},"end":{"value":1719,"modifier":"EXACT"}},"description":"in MKHK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_081979","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":1724,"modifier":"EXACT"},"end":{"value":1724,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs1567265131","featureCrossReferences":[{"database":"dbSNP","id":"rs1567265131"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30737887"}],"featureId":"VAR_081980","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":1747,"modifier":"EXACT"},"end":{"value":1747,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs2151312325","featureCrossReferences":[{"database":"dbSNP","id":"rs2151312325"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"}],"featureId":"VAR_078558","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1782,"modifier":"EXACT"},"end":{"value":1782,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs2051858361","featureCrossReferences":[{"database":"dbSNP","id":"rs2051858361"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_081981","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":1786,"modifier":"EXACT"},"end":{"value":1786,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs988251457","featureCrossReferences":[{"database":"dbSNP","id":"rs988251457"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"}],"featureId":"VAR_078559","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":1819,"modifier":"EXACT"},"end":{"value":1819,"modifier":"EXACT"}},"description":"in MKHK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"}],"featureId":"VAR_078560","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":1826,"modifier":"EXACT"},"end":{"value":1826,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs2151310481","featureCrossReferences":[{"database":"dbSNP","id":"rs2151310481"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"}],"featureId":"VAR_078561","alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":1829,"modifier":"EXACT"},"end":{"value":1829,"modifier":"EXACT"}},"description":"in MKHK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_081982","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":1838,"modifier":"EXACT"},"end":{"value":1838,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs1596787407","featureCrossReferences":[{"database":"dbSNP","id":"rs1596787407"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"}],"featureId":"VAR_078562","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":1865,"modifier":"EXACT"},"end":{"value":1866,"modifier":"EXACT"}},"description":"in MKHK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_081983","alternativeSequence":{"originalSequence":"MR","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":1867,"modifier":"EXACT"},"end":{"value":1867,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs1131691326","featureCrossReferences":[{"database":"dbSNP","id":"rs1131691326"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_078563","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":1867,"modifier":"EXACT"},"end":{"value":1867,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs398124148","featureCrossReferences":[{"database":"dbSNP","id":"rs398124148"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"}],"featureId":"VAR_078564","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":1868,"modifier":"EXACT"},"end":{"value":1868,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs1567263168","featureCrossReferences":[{"database":"dbSNP","id":"rs1567263168"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_081984","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":1868,"modifier":"EXACT"},"end":{"value":1868,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs886039491","featureCrossReferences":[{"database":"dbSNP","id":"rs886039491"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_078565","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":1870,"modifier":"EXACT"},"end":{"value":1870,"modifier":"EXACT"}},"description":"in MKHK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_081985","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":1872,"modifier":"EXACT"},"end":{"value":1872,"modifier":"EXACT"}},"description":"in MKHK1; dbSNP:rs797045037","featureCrossReferences":[{"database":"dbSNP","id":"rs797045037"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27311832"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29460469"}],"featureId":"VAR_078566","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Decreased phosphorylation and lactylation of MRE11.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38128537"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":1116,"modifier":"EXACT"},"end":{"value":1116,"modifier":"EXACT"}},"description":"Impairs binding to acetylated histones.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":1126,"modifier":"EXACT"},"end":{"value":1126,"modifier":"EXACT"}},"description":"Impairs binding to acetylated histones.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":1162,"modifier":"EXACT"},"end":{"value":1162,"modifier":"EXACT"}},"description":"Abolishes interaction with ASF1A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["E","R"]}},{"type":"Mutagenesis","location":{"start":{"value":1165,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Abolishes interaction with ASF1A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":1170,"modifier":"EXACT"},"end":{"value":1170,"modifier":"EXACT"}},"description":"Impairs binding to acetylated histones.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":1179,"modifier":"EXACT"},"end":{"value":1179,"modifier":"EXACT"}},"description":"Impairs interaction with ASF1A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Mutagenesis","location":{"start":{"value":1180,"modifier":"EXACT"},"end":{"value":1180,"modifier":"EXACT"}},"description":"Abolishes interaction with ASF1A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":1183,"modifier":"EXACT"},"end":{"value":1183,"modifier":"EXACT"}},"description":"Abolishes interaction with ASF1A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24616510"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":1511,"modifier":"EXACT"},"end":{"value":1513,"modifier":"EXACT"}},"description":"in Ref. 2; AAC51340","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"FAE","alternativeSequences":["NSG"]}},{"type":"Sequence conflict","location":{"start":{"value":1724,"modifier":"EXACT"},"end":{"value":1725,"modifier":"EXACT"}},"description":"in Ref. 2; AAC51340","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"ED","alternativeSequences":["VV"]}},{"type":"Sequence conflict","location":{"start":{"value":1770,"modifier":"EXACT"},"end":{"value":1770,"modifier":"EXACT"}},"description":"in Ref. 1; AAC51770","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":1789,"modifier":"EXACT"},"end":{"value":1789,"modifier":"EXACT"}},"description":"in Ref. 2; AAC51340","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":1812,"modifier":"EXACT"},"end":{"value":1812,"modifier":"EXACT"}},"description":"in Ref. 2; AAC51340","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Helix","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9IWL"}]},{"type":"Helix","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9IWL"}]},{"type":"Helix","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LIQ"}]},{"type":"Turn","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LIQ"}]},{"type":"Helix","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LIQ"}]},{"type":"Helix","location":{"start":{"value":592,"modifier":"EXACT"},"end":{"value":595,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5SVH"}]},{"type":"Helix","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5SVH"}]},{"type":"Helix","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5SVH"}]},{"type":"Helix","location":{"start":{"value":624,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5SVH"}]},{"type":"Helix","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5SVH"}]},{"type":"Helix","location":{"start":{"value":1082,"modifier":"EXACT"},"end":{"value":1084,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5J0D"}]},{"type":"Helix","location":{"start":{"value":1087,"modifier":"EXACT"},"end":{"value":1102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I86"}]},{"type":"Turn","location":{"start":{"value":1105,"modifier":"EXACT"},"end":{"value":1108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I86"}]},{"type":"Helix","location":{"start":{"value":1109,"modifier":"EXACT"},"end":{"value":1111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I86"}]},{"type":"Helix","location":{"start":{"value":1117,"modifier":"EXACT"},"end":{"value":1120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I86"}]},{"type":"Helix","location":{"start":{"value":1125,"modifier":"EXACT"},"end":{"value":1128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I86"}]},{"type":"Helix","location":{"start":{"value":1135,"modifier":"EXACT"},"end":{"value":1143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I86"}]},{"type":"Beta strand","location":{"start":{"value":1146,"modifier":"EXACT"},"end":{"value":1149,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2L85"}]},{"type":"Helix","location":{"start":{"value":1150,"modifier":"EXACT"},"end":{"value":1167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I86"}]},{"type":"Turn","location":{"start":{"value":1169,"modifier":"EXACT"},"end":{"value":1171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JSP"}]},{"type":"Helix","location":{"start":{"value":1173,"modifier":"EXACT"},"end":{"value":1195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I86"}]},{"type":"Helix","location":{"start":{"value":1208,"modifier":"EXACT"},"end":{"value":1210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Beta strand","location":{"start":{"value":1214,"modifier":"EXACT"},"end":{"value":1218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Beta strand","location":{"start":{"value":1226,"modifier":"EXACT"},"end":{"value":1230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Turn","location":{"start":{"value":1231,"modifier":"EXACT"},"end":{"value":1233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Beta strand","location":{"start":{"value":1234,"modifier":"EXACT"},"end":{"value":1237,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Turn","location":{"start":{"value":1238,"modifier":"EXACT"},"end":{"value":1240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Beta strand","location":{"start":{"value":1266,"modifier":"EXACT"},"end":{"value":1272,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Helix","location":{"start":{"value":1274,"modifier":"EXACT"},"end":{"value":1276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Beta strand","location":{"start":{"value":1280,"modifier":"EXACT"},"end":{"value":1282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Turn","location":{"start":{"value":1284,"modifier":"EXACT"},"end":{"value":1286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Beta strand","location":{"start":{"value":1289,"modifier":"EXACT"},"end":{"value":1291,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Helix","location":{"start":{"value":1292,"modifier":"EXACT"},"end":{"value":1295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Turn","location":{"start":{"value":1309,"modifier":"EXACT"},"end":{"value":1311,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5I8G"}]},{"type":"Turn","location":{"start":{"value":1708,"modifier":"EXACT"},"end":{"value":1710,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N1A"}]},{"type":"Beta strand","location":{"start":{"value":1714,"modifier":"EXACT"},"end":{"value":1716,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N1A"}]},{"type":"Beta strand","location":{"start":{"value":1718,"modifier":"EXACT"},"end":{"value":1721,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N1A"}]},{"type":"Beta strand","location":{"start":{"value":1725,"modifier":"EXACT"},"end":{"value":1728,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N1A"}]},{"type":"Helix","location":{"start":{"value":1733,"modifier":"EXACT"},"end":{"value":1737,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N1A"}]},{"type":"Beta strand","location":{"start":{"value":1742,"modifier":"EXACT"},"end":{"value":1744,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N1A"}]},{"type":"Helix","location":{"start":{"value":1765,"modifier":"EXACT"},"end":{"value":1784,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KJE"}]},{"type":"Helix","location":{"start":{"value":1793,"modifier":"EXACT"},"end":{"value":1805,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KJE"}]},{"type":"Helix","location":{"start":{"value":1811,"modifier":"EXACT"},"end":{"value":1814,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KJE"}]},{"type":"Helix","location":{"start":{"value":1817,"modifier":"EXACT"},"end":{"value":1832,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KJE"}]},{"type":"Helix","location":{"start":{"value":1841,"modifier":"EXACT"},"end":{"value":1853,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KJE"}]},{"type":"Helix","location":{"start":{"value":1953,"modifier":"EXACT"},"end":{"value":1967,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6M64"}]},{"type":"Turn","location":{"start":{"value":2063,"modifier":"EXACT"},"end":{"value":2065,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ES5"}]},{"type":"Helix","location":{"start":{"value":2068,"modifier":"EXACT"},"end":{"value":2070,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JFM"}]},{"type":"Helix","location":{"start":{"value":2071,"modifier":"EXACT"},"end":{"value":2073,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JFL"}]},{"type":"Helix","location":{"start":{"value":2077,"modifier":"EXACT"},"end":{"value":2079,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JFM"}]},{"type":"Helix","location":{"start":{"value":2080,"modifier":"EXACT"},"end":{"value":2092,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JFL"}]},{"type":"Helix","location":{"start":{"value":2094,"modifier":"EXACT"},"end":{"value":2103,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JFL"}]},{"type":"Turn","location":{"start":{"value":2104,"modifier":"EXACT"},"end":{"value":2106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZOQ"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-0103","category":"Domain","name":"Bromodomain"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"9238046","citationType":"journal article","authors":["Sobulo O.M.","Borrow J.","Tomek R.","Reshimi S.","Harden A.","Schlegelberger B.","Housman D.","Doggett N.A.","Rowley J.D.","Zeleznik-Le N.J."],"citationCrossReferences":[{"database":"PubMed","id":"9238046"},{"database":"DOI","id":"10.1073/pnas.94.16.8732"}],"title":"MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).","publicationDate":"1997","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"8732","lastPage":"8737","volume":"94"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"9177780","citationType":"journal article","authors":["Giles R.H.","Petrij F.","Dauwerse H.G.","den Hollander A.I.","Lushnikova T.","van Ommen G.J.B.","Goodman R.H.","Deaven L.L.","Doggett N.A.","Peters D.J.M.","Breuning M.H."],"citationCrossReferences":[{"database":"PubMed","id":"9177780"},{"database":"DOI","id":"10.1006/geno.1997.4699"}],"title":"Construction of a 1.2-Mb contig surrounding, and molecular analysis of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome 16p13.3.","publicationDate":"1997","journal":"Genomics","firstPage":"96","lastPage":"114","volume":"42"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"CI-3O8ERROQBQ55O","citationType":"submission","authors":["Petrij F.","den Hollander A.I.","Chrivia J.C."],"publicationDate":"MAR-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION TO 1724-1725; 1789 AND 1812"]},{"referenceNumber":4,"citation":{"id":"CI-1DVUKGU9SI55Q","citationType":"submission","authors":["Nakajima D.","Saito K.","Yamakawa H.","Kikuno R.F.","Nakayama M.","Ohara R.","Okazaki N.","Koga H.","Nagase T.","Ohara O."],"title":"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method.","publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"8782817","citationType":"journal article","authors":["Borrow J.","Stanton V.P. Jr.","Andresen J.M.","Becher R.","Behm F.G.","Chaganti R.S.K.","Civin C.I.","Disteche C.","Dube I.","Frischauf A.M.","Horsman D.","Mitelman F.","Volinia S.","Watmore A.E.","Housman D.E."],"citationCrossReferences":[{"database":"PubMed","id":"8782817"},{"database":"DOI","id":"10.1038/ng0996-33"}],"title":"The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein.","publicationDate":"1996","journal":"Nat. Genet.","firstPage":"33","lastPage":"41","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-405","CHROMOSOMAL TRANSLOCATION WITH KAT6A"]},{"referenceNumber":7,"citation":{"id":"11157802","citationType":"journal article","authors":["Panagopoulos I.","Fioretos T.","Isaksson M.","Samuelsson U.","Billstroem R.","Stroembeck B.","Mitelman F.","Johansson B."],"citationCrossReferences":[{"database":"PubMed","id":"11157802"},{"database":"DOI","id":"10.1093/hmg/10.4.395"}],"title":"Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).","publicationDate":"2001","journal":"Hum. Mol. Genet.","firstPage":"395","lastPage":"404","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-83","CHROMOSOMAL TRANSLOCATION WITH KAT6B"]},{"referenceNumber":8,"citation":{"id":"8684459","citationType":"journal article","authors":["Yang X.-J.","Ogryzko V.V.","Nishikawa J.","Howard B.H.","Nakatani Y."],"citationCrossReferences":[{"database":"PubMed","id":"8684459"},{"database":"DOI","id":"10.1038/382319a0"}],"title":"A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.","publicationDate":"1996","journal":"Nature","firstPage":"319","lastPage":"324","volume":"382"},"referencePositions":["INTERACTION WITH PCAF"]},{"referenceNumber":9,"citation":{"id":"8917528","citationType":"journal article","authors":["Arany Z.","Huang L.E.","Eckner R.","Bhattacharya S.","Jiang C.","Goldberg M.A.","Bunn H.F.","Livingston D.M."],"citationCrossReferences":[{"database":"PubMed","id":"8917528"},{"database":"DOI","id":"10.1073/pnas.93.23.12969"}],"title":"An essential role for p300/CBP in the cellular response to hypoxia.","publicationDate":"1996","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12969","lastPage":"12973","volume":"93"},"referencePositions":["INTERACTION WITH HIF1A AND EP300"]},{"referenceNumber":10,"citation":{"id":"9323138","citationType":"journal article","authors":["Nakajima T.","Uchida C.","Anderson S.F.","Lee C.-G.","Hurwitz J.","Parvin J.D.","Montminy M."],"citationCrossReferences":[{"database":"PubMed","id":"9323138"},{"database":"DOI","id":"10.1016/s0092-8674(00)80376-1"}],"title":"RNA helicase A mediates association of CBP with RNA polymerase II.","publicationDate":"1997","journal":"Cell","firstPage":"1107","lastPage":"1112","volume":"90"},"referencePositions":["INTERACTION WITH DHX9"]},{"referenceNumber":11,"citation":{"id":"9528808","citationType":"journal article","authors":["Bex F.","Yin M.-J.","Burny A.","Gaynor R.B."],"citationCrossReferences":[{"database":"PubMed","id":"9528808"},{"database":"DOI","id":"10.1128/mcb.18.4.2392"}],"title":"Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.","publicationDate":"1998","journal":"Mol. Cell. Biol.","firstPage":"2392","lastPage":"2405","volume":"18"},"referencePositions":["INTERACTION WITH HTLV-1 TAX (MICROBIAL INFECTION)"]},{"referenceNumber":12,"citation":{"id":"9707565","citationType":"journal article","authors":["Zhang W.","Bieker J.J."],"citationCrossReferences":[{"database":"PubMed","id":"9707565"},{"database":"DOI","id":"10.1073/pnas.95.17.9855"}],"title":"Acetylation and modulation of erythroid Krueppel-like factor (EKLF) activity by interaction with histone acetyltransferases.","publicationDate":"1998","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9855","lastPage":"9860","volume":"95"},"referencePositions":["INTERACTION WITH KLF1","FUNCTION"]},{"referenceNumber":13,"citation":{"id":"10347196","citationType":"journal article","authors":["Johnston H.","Kneer J.","Chackalaparampil I.","Yaciuk P.","Chrivia J."],"citationCrossReferences":[{"database":"PubMed","id":"10347196"},{"database":"DOI","id":"10.1074/jbc.274.23.16370"}],"title":"Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"16370","lastPage":"16376","volume":"274"},"referencePositions":["INTERACTION WITH SRCAP"]},{"referenceNumber":14,"citation":{"id":"10077561","citationType":"journal article","authors":["Doucas V.","Tini M.","Egan D.A.","Evans R.M."],"citationCrossReferences":[{"database":"PubMed","id":"10077561"},{"database":"DOI","id":"10.1073/pnas.96.6.2627"}],"title":"Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling.","publicationDate":"1999","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2627","lastPage":"2632","volume":"96"},"referencePositions":["INTERACTION WITH PML"]},{"referenceNumber":15,"citation":{"id":"10490106","citationType":"journal article","authors":["Chen H.","Lin R.J.","Xie W.","Wilpitz D.","Evans R.M."],"citationCrossReferences":[{"database":"PubMed","id":"10490106"},{"database":"DOI","id":"10.1016/s0092-8674(00)80054-9"}],"title":"Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.","publicationDate":"1999","journal":"Cell","firstPage":"675","lastPage":"686","volume":"98"},"referencePositions":["ACETYLATION OF NCOA3"]},{"referenceNumber":16,"citation":{"id":"10722728","citationType":"journal article","authors":["Yahata T.","de Caestecker M.P.","Lechleider R.J.","Andriole S.","Roberts A.B.","Isselbacher K.J.","Shioda T."],"citationCrossReferences":[{"database":"PubMed","id":"10722728"},{"database":"DOI","id":"10.1074/jbc.275.12.8825"}],"title":"The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"8825","lastPage":"8834","volume":"275"},"referencePositions":["INTERACTION WITH CITED1"]},{"referenceNumber":17,"citation":{"id":"10866662","citationType":"journal article","authors":["Mahajan M.A.","Samuels H.H."],"citationCrossReferences":[{"database":"PubMed","id":"10866662"},{"database":"DOI","id":"10.1128/mcb.20.14.5048-5063.2000"}],"title":"A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.","publicationDate":"2000","journal":"Mol. Cell. Biol.","firstPage":"5048","lastPage":"5063","volume":"20"},"referencePositions":["INTERACTION WITH NCOA6"]},{"referenceNumber":18,"citation":{"id":"11154691","citationType":"journal article","authors":["Hung H.-L.","Kim A.Y.","Hong W.","Rakowski C.","Blobel G.A."],"citationCrossReferences":[{"database":"PubMed","id":"11154691"},{"database":"DOI","id":"10.1074/jbc.m007846200"}],"title":"Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"10715","lastPage":"10721","volume":"276"},"referencePositions":["INTERACTION WITH MAFG","FUNCTION IN ACETYLATION OF MAFG"]},{"referenceNumber":19,"citation":{"id":"11514544","citationType":"journal article","authors":["Yang T.T.C.","Davis R.J.","Chow C.-W."],"citationCrossReferences":[{"database":"PubMed","id":"11514544"},{"database":"DOI","id":"10.1074/jbc.m102961200"}],"title":"Requirement of two NFATc4 transactivation domains for CBP potentiation.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"39569","lastPage":"39576","volume":"276"},"referencePositions":["INTERACTION WITH NFATC4"]},{"referenceNumber":20,"citation":{"id":"11568182","citationType":"journal article","authors":["Chakraborty S.","Senyuk V.","Sitailo S.","Chi Y.","Nucifora G."],"citationCrossReferences":[{"database":"PubMed","id":"11568182"},{"database":"DOI","id":"10.1074/jbc.m106733200"}],"title":"Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"44936","lastPage":"44943","volume":"276"},"referencePositions":["INTERACTION WITH MECOM"]},{"referenceNumber":21,"citation":{"id":"11463834","citationType":"journal article","authors":["Scoggin K.E.S.","Ulloa A.","Nyborg J.K."],"citationCrossReferences":[{"database":"PubMed","id":"11463834"},{"database":"DOI","id":"10.1128/mcb.21.16.5520-5530.2001"}],"title":"The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation.","publicationDate":"2001","journal":"Mol. Cell. Biol.","firstPage":"5520","lastPage":"5530","volume":"21"},"referencePositions":["INTERACTION WITH HTLV-1 TAX (MICROBIAL INFECTION)"]},{"referenceNumber":22,"citation":{"id":"11559821","citationType":"journal article","authors":["Zhang W.","Nisbet J.W.","Albrecht B.","Ding W.","Kashanchi F.","Bartoe J.T.","Lairmore M.D."],"citationCrossReferences":[{"database":"PubMed","id":"11559821"},{"database":"DOI","id":"10.1128/jvi.75.20.9885-9895.2001"}],"title":"Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.","publicationDate":"2001","journal":"J. Virol.","firstPage":"9885","lastPage":"9895","volume":"75"},"referencePositions":["INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P30II (MICROBIAL INFECTION)"]},{"referenceNumber":23,"citation":{"id":"11349124","citationType":"journal article","authors":["Gizard F.","Lavallee B.","DeWitte F.","Hum D.W."],"citationCrossReferences":[{"database":"PubMed","id":"11349124"},{"database":"DOI","id":"10.1074/jbc.m100113200"}],"title":"A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"33881","lastPage":"33892","volume":"276"},"referencePositions":["INTERACTION WITH TRERF1"]},{"referenceNumber":24,"citation":{"id":"11481323","citationType":"journal article","authors":["Vadlamudi R.K.","Wang R.-A.","Mazumdar A.","Kim Y.-S.","Shin J.","Sahin A.","Kumar R."],"citationCrossReferences":[{"database":"PubMed","id":"11481323"},{"database":"DOI","id":"10.1074/jbc.m103783200"}],"title":"Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"38272","lastPage":"38279","volume":"276"},"referencePositions":["INTERACTION WITH PELP1"]},{"referenceNumber":25,"citation":{"id":"11314014","citationType":"journal article","authors":["Lin R.","Genin P.","Mamane Y.","Sgarbanti M.","Battistini A.","Harrington W.J. Jr.","Barber G.N.","Hiscott J."],"citationCrossReferences":[{"database":"PubMed","id":"11314014"},{"database":"DOI","id":"10.1038/sj.onc.1204163"}],"title":"HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators.","publicationDate":"2001","journal":"Oncogene","firstPage":"800","lastPage":"811","volume":"20"},"referencePositions":["INTERACTION WITH HHV-8 PROTEIN VIRF1 (MICROBIAL INFECTION)"]},{"referenceNumber":26,"citation":{"id":"11864910","citationType":"journal article","authors":["Yamamoto H.","Kihara-Negishi F.","Yamada T.","Suzuki M.","Nakano T.","Oikawa T."],"citationCrossReferences":[{"database":"PubMed","id":"11864910"}],"title":"Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb.","publicationDate":"2002","journal":"Cell Growth Differ.","firstPage":"69","lastPage":"75","volume":"13"},"referencePositions":["INTERACTION WITH SPIB"]},{"referenceNumber":27,"citation":{"id":"11744733","citationType":"journal article","authors":["Braganca J.","Swingler T.","Marques F.I.R.","Jones T.","Eloranta J.J.","Hurst H.C.","Shioda T.","Bhattacharya S."],"citationCrossReferences":[{"database":"PubMed","id":"11744733"},{"database":"DOI","id":"10.1074/jbc.m110850200"}],"title":"Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"8559","lastPage":"8565","volume":"277"},"referencePositions":["INTERACTION WITH CITED4"]},{"referenceNumber":28,"citation":{"id":"11971985","citationType":"journal article","authors":["Wu R.-C.","Qin J.","Hashimoto Y.","Wong J.","Xu J.","Tsai S.Y.","Tsai M.-J.","O'Malley B.W."],"citationCrossReferences":[{"database":"PubMed","id":"11971985"},{"database":"DOI","id":"10.1128/mcb.22.10.3549-3561.2002"}],"title":"Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.","publicationDate":"2002","journal":"Mol. Cell. Biol.","firstPage":"3549","lastPage":"3561","volume":"22"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH NCOA2; NCOA3; IKKA; IKKB AND IKBKG"]},{"referenceNumber":29,"citation":{"id":"12738767","citationType":"journal article","authors":["Masumi A.","Yamakawa Y.","Fukazawa H.","Ozato K.","Komuro K."],"citationCrossReferences":[{"database":"PubMed","id":"12738767"},{"database":"DOI","id":"10.1074/jbc.m213037200"}],"title":"Interferon regulatory factor-2 regulates cell growth through its acetylation.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"25401","lastPage":"25407","volume":"278"},"referencePositions":["INTERACTION WITH IRF2","FUNCTION IN ACETYLATION OF IRF2"]},{"referenceNumber":30,"citation":{"id":"12730195","citationType":"journal article","authors":["Watanabe N.","Wachi S.","Fujita T."],"citationCrossReferences":[{"database":"PubMed","id":"12730195"},{"database":"DOI","id":"10.1074/jbc.m303518200"}],"title":"Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"26102","lastPage":"26110","volume":"278"},"referencePositions":["INTERACTION WITH N4BP2"]},{"referenceNumber":31,"citation":{"id":"12929931","citationType":"journal article","authors":["Iioka T.","Furukawa K.","Yamaguchi A.","Shindo H.","Yamashita S.","Tsukazaki T."],"citationCrossReferences":[{"database":"PubMed","id":"12929931"},{"database":"DOI","id":"10.1359/jbmr.2003.18.8.1419"}],"title":"P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.","publicationDate":"2003","journal":"J. Bone Miner. Res.","firstPage":"1419","lastPage":"1429","volume":"18"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":32,"citation":{"id":"14645221","citationType":"journal article","authors":["Curtis A.M.","Seo S.B.","Westgate E.J.","Rudic R.D.","Smyth E.M.","Chakravarti D.","FitzGerald G.A.","McNamara P."],"citationCrossReferences":[{"database":"PubMed","id":"14645221"},{"database":"DOI","id":"10.1074/jbc.m311973200"}],"title":"Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"7091","lastPage":"7097","volume":"279"},"referencePositions":["FUNCTION","INTERACTION WITH NPAS2 AND CLOCK"]},{"referenceNumber":33,"citation":{"id":"15075319","citationType":"journal article","authors":["Wang H.","Fang R.","Cho J.-Y.","Libermann T.A.","Oettgen P."],"citationCrossReferences":[{"database":"PubMed","id":"15075319"},{"database":"DOI","id":"10.1074/jbc.m401356200"}],"title":"Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"25241","lastPage":"25250","volume":"279"},"referencePositions":["INTERACTION WITH ELF3"]},{"referenceNumber":34,"citation":{"id":"15126506","citationType":"journal article","authors":["van der Horst A.","Tertoolen L.G.J.","de Vries-Smits L.M.M.","Frye R.A.","Medema R.H.","Burgering B.M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15126506"},{"database":"DOI","id":"10.1074/jbc.m401138200"}],"title":"FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"28873","lastPage":"28879","volume":"279"},"referencePositions":["INTERACTION WITH MLLT7"]},{"referenceNumber":35,"citation":{"id":"15488321","citationType":"journal article","authors":["Pradhan A.","Liu Y."],"citationCrossReferences":[{"database":"PubMed","id":"15488321"},{"database":"DOI","id":"10.1016/j.neulet.2004.08.062"}],"title":"The calcium-responsive transactivator recruits CREB binding protein to nuclear bodies.","publicationDate":"2004","journal":"Neurosci. Lett.","firstPage":"191","lastPage":"195","volume":"370"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":36,"citation":{"id":"15220471","citationType":"journal article","authors":["Daitoku H.","Hatta M.","Matsuzaki H.","Aratani S.","Ohshima T.","Miyagishi M.","Nakajima T.","Fukamizu A."],"citationCrossReferences":[{"database":"PubMed","id":"15220471"},{"database":"DOI","id":"10.1073/pnas.0400593101"}],"title":"Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10042","lastPage":"10047","volume":"101"},"referencePositions":["INTERACTION WITH FOXO1"]},{"referenceNumber":37,"citation":{"id":"14716005","citationType":"journal article","authors":["Aizawa H.","Hu S.-C.","Bobb K.","Balakrishnan K.","Ince G.","Gurevich I.","Cowan M.","Ghosh A."],"citationCrossReferences":[{"database":"PubMed","id":"14716005"},{"database":"DOI","id":"10.1126/science.1089845"}],"title":"Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.","publicationDate":"2004","journal":"Science","firstPage":"197","lastPage":"202","volume":"303"},"referencePositions":["INTERACTION WITH SS18L1/CREST"]},{"referenceNumber":38,"citation":{"id":"17434128","citationType":"journal article","authors":["Huang W.C.","Ju T.K.","Hung M.C.","Chen C.C."],"citationCrossReferences":[{"database":"PubMed","id":"17434128"},{"database":"DOI","id":"10.1016/j.molcel.2007.02.019"}],"title":"Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.","publicationDate":"2007","journal":"Mol. Cell","firstPage":"75","lastPage":"87","volume":"26"},"referencePositions":["PHOSPHORYLATION AT SER-1382 AND SER-1386 BY CHUK/IKKA"]},{"referenceNumber":39,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1030","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":40,"citation":{"id":"18316612","citationType":"journal article","authors":["Sarkar D.","Park E.S.","Emdad L.","Lee S.-G.","Su Z.-Z.","Fisher P.B."],"citationCrossReferences":[{"database":"PubMed","id":"18316612"},{"database":"DOI","id":"10.1158/0008-5472.can-07-6164"}],"title":"Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1.","publicationDate":"2008","journal":"Cancer Res.","firstPage":"1478","lastPage":"1484","volume":"68"},"referencePositions":["INTERACTION WITH MTDH"]},{"referenceNumber":41,"citation":{"id":"18599479","citationType":"journal article","authors":["Clerc I.","Polakowski N.","Andre-Arpin C.","Cook P.","Barbeau B.","Mesnard J.M.","Lemasson I."],"citationCrossReferences":[{"database":"PubMed","id":"18599479"},{"database":"DOI","id":"10.1074/jbc.m803116200"}],"title":"An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"23903","lastPage":"23913","volume":"283"},"referencePositions":["INTERACTION WITH HUMAN T-CELL LEUKEMIA VIRUS 1/HTLV-1 PROTEIN HBZ"]},{"referenceNumber":42,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-2063; SER-2076 AND SER-2079","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":43,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":44,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2063","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":45,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1014; LYS-1216; LYS-1583; LYS-1591; LYS-1592; LYS-1595; LYS-1597; LYS-1741 AND LYS-1744","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":46,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":47,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":48,"citation":{"id":"21131905","citationType":"journal article","authors":["Jin Q.","Yu L.R.","Wang L.","Zhang Z.","Kasper L.H.","Lee J.E.","Wang C.","Brindle P.K.","Dent S.Y.","Ge K."],"citationCrossReferences":[{"database":"PubMed","id":"21131905"},{"database":"DOI","id":"10.1038/emboj.2010.318"}],"title":"Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.","publicationDate":"2011","journal":"EMBO J.","firstPage":"249","lastPage":"262","volume":"30"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":49,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":50,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1076; SER-1763 AND SER-2063","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":51,"citation":{"id":"24207024","citationType":"journal article","authors":["Chen S.","Seiler J.","Santiago-Reichelt M.","Felbel K.","Grummt I.","Voit R."],"citationCrossReferences":[{"database":"PubMed","id":"24207024"},{"database":"DOI","id":"10.1016/j.molcel.2013.10.010"}],"title":"Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.","publicationDate":"2013","journal":"Mol. Cell","firstPage":"303","lastPage":"313","volume":"52"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":52,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":53,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-220","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":54,"citation":{"id":"24939902","citationType":"journal article","authors":["Cazzalini O.","Sommatis S.","Tillhon M.","Dutto I.","Bachi A.","Rapp A.","Nardo T.","Scovassi A.I.","Necchi D.","Cardoso M.C.","Stivala L.A.","Prosperi E."],"citationCrossReferences":[{"database":"PubMed","id":"24939902"},{"database":"DOI","id":"10.1093/nar/gku533"}],"title":"CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.","publicationDate":"2014","journal":"Nucleic Acids Res.","firstPage":"8433","lastPage":"8448","volume":"42"},"referencePositions":["FUNCTION AS ACETYLTRANSFERASE OF PCNA","INTERACTION WITH PCNA"]},{"referenceNumber":55,"citation":{"id":"25514493","citationType":"journal article","authors":["Yang Y.","Cui J.","Xue F.","Zhang C.","Mei Z.","Wang Y.","Bi M.","Shan D.","Meredith A.","Li H.","Xu Z.Q."],"citationCrossReferences":[{"database":"PubMed","id":"25514493"},{"database":"DOI","id":"10.1016/j.bbagrm.2014.12.008"}],"title":"Pokemon (FBI-1) interacts with Smad4 to repress TGF-beta-induced transcriptional responses.","publicationDate":"2015","journal":"Biochim. Biophys. Acta","firstPage":"270","lastPage":"281","volume":"1849"},"referencePositions":["FUNCTION","INTERACTION WITH SMAD4"]},{"referenceNumber":56,"citation":{"id":"25593309","citationType":"journal article","authors":["Gong F.","Chiu L.Y.","Cox B.","Aymard F.","Clouaire T.","Leung J.W.","Cammarata M.","Perez M.","Agarwal P.","Brodbelt J.S.","Legube G.","Miller K.M."],"citationCrossReferences":[{"database":"PubMed","id":"25593309"},{"database":"DOI","id":"10.1101/gad.252189.114"}],"title":"Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.","publicationDate":"2015","journal":"Genes Dev.","firstPage":"197","lastPage":"211","volume":"29"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":57,"citation":{"id":"26951377","citationType":"journal article","authors":["Choi S.H.","Gearhart M.D.","Cui Z.","Bosnakovski D.","Kim M.","Schennum N.","Kyba M."],"citationCrossReferences":[{"database":"PubMed","id":"26951377"},{"database":"DOI","id":"10.1093/nar/gkw141"}],"title":"DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.","publicationDate":"2016","journal":"Nucleic Acids Res.","firstPage":"5161","lastPage":"5173","volume":"44"},"referencePositions":["INTERACTION WITH DUX4"]},{"referenceNumber":58,"citation":{"id":"28790157","citationType":"journal article","authors":["Song C.","Hotz-Wagenblatt A.","Voit R.","Grummt I."],"citationCrossReferences":[{"database":"PubMed","id":"28790157"},{"database":"DOI","id":"10.1101/gad.300624.117"}],"title":"SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.","publicationDate":"2017","journal":"Genes Dev.","firstPage":"1370","lastPage":"1381","volume":"31"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":59,"citation":{"id":"28128295","citationType":"journal article","authors":["Tsai T.Y.","Wang W.T.","Li H.K.","Chen W.J.","Tsai Y.H.","Chao C.H.","Wu Lee Y.H."],"citationCrossReferences":[{"database":"PubMed","id":"28128295"},{"database":"DOI","id":"10.1038/srep41452"}],"title":"RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.","publicationDate":"2017","journal":"Sci. Rep.","firstPage":"41452","lastPage":"41452","volume":"7"},"referencePositions":["INTERACTION WITH DDX3X"]},{"referenceNumber":60,"citation":{"id":"30540930","citationType":"journal article","authors":["Iyer-Bierhoff A.","Krogh N.","Tessarz P.","Ruppert T.","Nielsen H.","Grummt I."],"citationCrossReferences":[{"database":"PubMed","id":"30540930"},{"database":"DOI","id":"10.1016/j.celrep.2018.11.051"}],"title":"SIRT7-dependent deacetylation of fibrillarin controls histone H2A methylation and rRNA synthesis during the cell cycle.","publicationDate":"2018","journal":"Cell Rep.","firstPage":"2946","lastPage":"2954","volume":"25"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":61,"citation":{"id":"35675826","citationType":"journal article","authors":["Zhou N.","Qi H.","Liu J.","Zhang G.","Liu J.","Liu N.","Zhu M.","Zhao X.","Song C.","Zhou Z.","Gong J.","Li R.","Bai X.","Jin Y.","Song Y.","Yin Y."],"citationCrossReferences":[{"database":"PubMed","id":"35675826"},{"database":"DOI","id":"10.1016/j.cmet.2022.05.005"}],"title":"Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.","publicationDate":"2022","journal":"Cell Metab.","firstPage":"1023","lastPage":"1041.e8","volume":"34"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","ACETYLATION"]},{"referenceNumber":62,"citation":{"id":"38128537","citationType":"journal article","authors":["Chen Y.","Wu J.","Zhai L.","Zhang T.","Yin H.","Gao H.","Zhao F.","Wang Z.","Yang X.","Jin M.","Huang B.","Ding X.","Li R.","Yang J.","He Y.","Wang Q.","Wang W.","Kloeber J.A.","Li Y.","Hao B.","Zhang Y.","Wang J.","Tan M.","Li K.","Wang P.","Lou Z.","Yuan J."],"citationCrossReferences":[{"database":"PubMed","id":"38128537"},{"database":"DOI","id":"10.1016/j.cell.2023.11.022"}],"title":"Metabolic regulation of homologous recombination repair by MRE11 lactylation.","publicationDate":"2024","journal":"Cell","firstPage":"294","lastPage":"311","volume":"187"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","PHOSPHORYLATION AT SER-124","MUTAGENESIS OF SER-124"]},{"referenceNumber":63,"citation":{"id":"11959977","citationType":"journal article","authors":["Dames S.A.","Martinez-Yamout M.","De Guzman R.N.","Dyson H.J.","Wright P.E."],"citationCrossReferences":[{"database":"PubMed","id":"11959977"},{"database":"DOI","id":"10.1073/pnas.082121399"}],"title":"Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.","publicationDate":"2002","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"5271","lastPage":"5276","volume":"99"},"referencePositions":["STRUCTURE BY NMR OF 345-439 IN COMPLEX WITH 776-826 OF HIF1A"]},{"referenceNumber":64,"citation":{"id":"11742995","citationType":"journal article","authors":["Kitabayashi I.","Aikawa Y.","Nguyen L.A.","Yokoyama A.","Ohki M."],"citationCrossReferences":[{"database":"PubMed","id":"11742995"},{"database":"DOI","id":"10.1093/emboj/20.24.7184"}],"title":"Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.","publicationDate":"2001","journal":"EMBO J.","firstPage":"7184","lastPage":"7196","volume":"20"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH KAT6A"]},{"referenceNumber":65,"citation":{"id":"14744133","citationType":"journal article","authors":["Vendel A.C.","Lumb K.J."],"citationCrossReferences":[{"database":"PubMed","id":"14744133"},{"database":"DOI","id":"10.1021/bi035612l"}],"title":"NMR mapping of the HIV-1 Tat interaction surface of the KIX domain of the human coactivator CBP.","publicationDate":"2004","journal":"Biochemistry","firstPage":"904","lastPage":"908","volume":"43"},"referencePositions":["STRUCTURE BY NMR OF 589-679 IN COMPLEX WITH HIV-1 TAT (MICROBIAL INFECTION)"]},{"referenceNumber":66,"citation":{"id":"22464331","citationType":"journal article","authors":["Filippakopoulos P.","Picaud S.","Mangos M.","Keates T.","Lambert J.P.","Barsyte-Lovejoy D.","Felletar I.","Volkmer R.","Muller S.","Pawson T.","Gingras A.C.","Arrowsmith C.H.","Knapp S."],"citationCrossReferences":[{"database":"PubMed","id":"22464331"},{"database":"DOI","id":"10.1016/j.cell.2012.02.013"}],"title":"Histone recognition and large-scale structural analysis of the human bromodomain family.","publicationDate":"2012","journal":"Cell","firstPage":"214","lastPage":"231","volume":"149"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1081-1197"]},{"referenceNumber":67,"citation":{"id":"23651431","citationType":"journal article","authors":["Bruschweiler S.","Konrat R.","Tollinger M."],"citationCrossReferences":[{"database":"PubMed","id":"23651431"},{"database":"DOI","id":"10.1021/cb4002188"}],"title":"Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core.","publicationDate":"2013","journal":"ACS Chem. Biol.","firstPage":"1600","lastPage":"1610","volume":"8"},"referencePositions":["STRUCTURE BY NMR OF 587-673 IN COMPLEX WITH KMT2A AND CREB1"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2LXS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2LXT"}]},{"referenceNumber":68,"citation":{"id":"24616510","citationType":"journal article","authors":["Das C.","Roy S.","Namjoshi S.","Malarkey C.S.","Jones D.N.","Kutateladze T.G.","Churchill M.E.","Tyler J.K."],"citationCrossReferences":[{"database":"PubMed","id":"24616510"},{"database":"DOI","id":"10.1073/pnas.1319122111"}],"title":"Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E1072","lastPage":"E1081","volume":"111"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 1082-1197","FUNCTION","INTERACTION WITH ASF1A; ASF1B; ACETYLATED HISTONES AND TP53","MUTAGENESIS OF ASP-1116; PHE-1126; ASN-1162; TRP-1165; LYS-1170; SER-1179; LYS-1180 AND GLU-1183","CHARACTERIZATION OF VARIANT RSTS1 CYS-1175","CATALYTIC ACTIVITY","AUTOACETYLATION"]},{"referenceNumber":69,"citation":{"id":"24361270","citationType":"journal article","authors":["Plotnikov A.N.","Yang S.","Zhou T.J.","Rusinova E.","Frasca A.","Zhou M.M."],"citationCrossReferences":[{"database":"PubMed","id":"24361270"},{"database":"DOI","id":"10.1016/j.str.2013.10.021"}],"title":"Structural insights into acetylated-histone H4 recognition by the bromodomain-PHD finger module of human transcriptional coactivator CBP.","publicationDate":"2014","journal":"Structure","firstPage":"353","lastPage":"360","volume":"22"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 1080-1316 IN COMPLEX WITH ZINC"]},{"referenceNumber":70,"citation":{"id":"27302953","citationType":"journal article","authors":["Zhao B.","Shu C.","Gao X.","Sankaran B.","Du F.","Shelton C.L.","Herr A.B.","Ji J.Y.","Li P."],"citationCrossReferences":[{"database":"PubMed","id":"27302953"},{"database":"DOI","id":"10.1073/pnas.1603269113"}],"title":"Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"E3403","lastPage":"E3412","volume":"113"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2111 IN COMPLEX WITH IRF3"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5JEM"}]},{"referenceNumber":71,"citation":{"id":"11331617","citationType":"journal article","authors":["Murata T.","Kurokawa R.","Krones A.","Tatsumi K.","Ishii M.","Taki T.","Masuno M.","Ohashi H.","Yanagisawa M.","Rosenfeld M.G.","Glass C.K.","Hayashi Y."],"citationCrossReferences":[{"database":"PubMed","id":"11331617"},{"database":"DOI","id":"10.1093/hmg/10.10.1071"}],"title":"Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome.","publicationDate":"2001","journal":"Hum. Mol. Genet.","firstPage":"1071","lastPage":"1076","volume":"10"},"referencePositions":["VARIANT RSTS1 PRO-1378"]},{"referenceNumber":72,"citation":{"id":"12114483","citationType":"journal article","authors":["Bartsch O.","Locher K.","Meinecke P.","Kress W.","Seemanova E.","Wagner A.","Ostermann K.","Roedel G."],"citationCrossReferences":[{"database":"PubMed","id":"12114483"},{"database":"DOI","id":"10.1136/jmg.39.7.496"}],"title":"Molecular studies in 10 cases of Rubinstein-Taybi syndrome, including a mild variant showing a missense mutation in codon 1175 of CREBBP.","publicationDate":"2002","journal":"J. Med. Genet.","firstPage":"496","lastPage":"501","volume":"39"},"referencePositions":["VARIANT RSTS1 CYS-1175"]},{"referenceNumber":73,"citation":{"id":"12566391","citationType":"journal article","authors":["Kalkhoven E.","Roelfsema J.H.","Teunissen H.","den Boer A.","Ariyuerek Y.","Zantema A.","Breuning M.H.","Hennekam R.C.M.","Peters D.J.M."],"citationCrossReferences":[{"database":"PubMed","id":"12566391"},{"database":"DOI","id":"10.1093/hmg/ddg039"}],"title":"Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome.","publicationDate":"2003","journal":"Hum. Mol. Genet.","firstPage":"441","lastPage":"450","volume":"12"},"referencePositions":["VARIANTS RSTS1 LYS-1278 AND HIS-1664","CHARACTERIZATION OF VARIANTS RSTS1 LYS-1278 AND HIS-1664"]},{"referenceNumber":74,"citation":{"id":"15706485","citationType":"journal article","authors":["Roelfsema J.H.","White S.J.","Ariyuerek Y.","Bartholdi D.","Niedrist D.","Papadia F.","Bacino C.A.","den Dunnen J.T.","van Ommen G.-J.B.","Breuning M.H.","Hennekam R.C.","Peters D.J.M."],"citationCrossReferences":[{"database":"PubMed","id":"15706485"},{"database":"DOI","id":"10.1086/429130"}],"title":"Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.","publicationDate":"2005","journal":"Am. J. Hum. Genet.","firstPage":"572","lastPage":"580","volume":"76"},"referencePositions":["VARIANTS RSTS1 LYS-1278; ILE-1447; HIS-1450; ARG-1470 AND HIS-1664"]},{"referenceNumber":75,"citation":{"id":"20684013","citationType":"journal article","authors":["Bartsch O.","Kress W.","Kempf O.","Lechno S.","Haaf T.","Zechner U."],"citationCrossReferences":[{"database":"PubMed","id":"20684013"},{"database":"DOI","id":"10.1002/ajmg.a.33598"}],"title":"Inheritance and variable expression in Rubinstein-Taybi syndrome.","publicationDate":"2010","journal":"Am. J. Med. Genet. A","firstPage":"2254","lastPage":"2261","volume":"152A"},"referencePositions":["VARIANT RSTS1 ALA-910"]},{"referenceNumber":76,"citation":{"id":"25388907","citationType":"journal article","authors":["Spena S.","Milani D.","Rusconi D.","Negri G.","Colapietro P.","Elcioglu N.","Bedeschi F.","Pilotta A.","Spaccini L.","Ficcadenti A.","Magnani C.","Scarano G.","Selicorni A.","Larizza L.","Gervasini C."],"citationCrossReferences":[{"database":"PubMed","id":"25388907"},{"database":"DOI","id":"10.1111/cge.12537"}],"title":"Insights into genotype-phenotype correlations from CREBBP point mutation screening in a cohort of 46 Rubinstein-Taybi syndrome patients.","publicationDate":"2015","journal":"Clin. Genet.","firstPage":"431","lastPage":"440","volume":"88"},"referencePositions":["VARIANTS HIS-503; THR-532 AND ASN-546","VARIANTS RSTS1 PHE-650; THR-789; CYS-1175; ALA-1278; PRO-1378; TYR-1406; PRO-1415; THR-1475; PHE-1503; PRO-1507 AND ASN-1543"]},{"referenceNumber":77,"citation":{"id":"27311832","citationType":"journal article","authoringGroup":["DDD Study"],"authors":["Menke L.A.","van Belzen M.J.","Alders M.","Cristofoli F.","Ehmke N.","Fergelot P.","Foster A.","Gerkes E.H.","Hoffer M.J.","Horn D.","Kant S.G.","Lacombe D.","Leon E.","Maas S.M.","Melis D.","Muto V.","Park S.M.","Peeters H.","Peters D.J.","Pfundt R.","van Ravenswaaij-Arts C.M.","Tartaglia M.","Hennekam R.C."],"citationCrossReferences":[{"database":"PubMed","id":"27311832"},{"database":"DOI","id":"10.1002/ajmg.a.37800"}],"title":"CREBBP mutations in individuals without Rubinstein-Taybi syndrome phenotype.","publicationDate":"2016","journal":"Am. J. Med. Genet. A","firstPage":"2681","lastPage":"2693","volume":"170"},"referencePositions":["VARIANTS MKHK1 ARG-1710; ARG-1747; PRO-1786; PHE-1819; TRP-1826; TYR-1838; GLN-1867; TRP-1867; TRP-1868 AND VAL-1872","INVOLVEMENT IN MKHK1"]},{"referenceNumber":78,"citation":{"id":"29460469","citationType":"journal article","authoringGroup":["DDD study"],"authors":["Menke L.A.","Gardeitchik T.","Hammond P.","Heimdal K.R.","Houge G.","Hufnagel S.B.","Ji J.","Johansson S.","Kant S.G.","Kinning E.","Leon E.L.","Newbury-Ecob R.","Paolacci S.","Pfundt R.","Ragge N.K.","Rinne T.","Ruivenkamp C.","Saitta S.C.","Sun Y.","Tartaglia M.","Terhal P.A.","van Essen A.J.","Vigeland M.D.","Xiao B.","Hennekam R.C."],"citationCrossReferences":[{"database":"PubMed","id":"29460469"},{"database":"DOI","id":"10.1002/ajmg.a.38626"}],"title":"Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.","publicationDate":"2018","journal":"Am. J. Med. Genet. A","firstPage":"862","lastPage":"876","volume":"176"},"referencePositions":["VARIANTS MKHK1 ASP-1719; VAL-1782; ASP-1829; 1865-MET-ARG-1866 DELINS ILE; GLN-1867; GLN-1868; TRP-1868; PRO-1870 AND VAL-1872","INVOLVEMENT IN MKHK1"]},{"referenceNumber":79,"citation":{"id":"30737887","citationType":"journal article","authors":["Angius A.","Uva P.","Oppo M.","Persico I.","Onano S.","Olla S.","Pes V.","Perria C.","Cuccuru G.","Atzeni R.","Serra G.","Cucca F.","Sotgiu S.","Hennekam R.C.","Crisponi L."],"citationCrossReferences":[{"database":"PubMed","id":"30737887"},{"database":"DOI","id":"10.1002/ajmg.a.61052"}],"title":"Confirmation of a new phenotype in an individual with a variant in the last part of exon 30 of CREBBP.","publicationDate":"2019","journal":"Am. J. Med. Genet. A","firstPage":"634","lastPage":"638","volume":"179"},"referencePositions":["VARIANT MKHK1 LYS-1724"]},{"referenceNumber":80,"citation":{"id":"15023334","citationType":"journal article","authors":["Cohen H.Y.","Lavu S.","Bitterman K.J.","Hekking B.","Imahiyerobo T.A.","Miller C.","Frye R.","Ploegh H.","Kessler B.M.","Sinclair D.A."],"citationCrossReferences":[{"database":"PubMed","id":"15023334"},{"database":"DOI","id":"10.1016/s1097-2765(04)00094-2"}],"title":"Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"627","lastPage":"638","volume":"13"},"referencePositions":["SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U85962","properties":[{"key":"ProteinId","value":"AAC51331.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U89354","properties":[{"key":"ProteinId","value":"AAC51339.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U89355","properties":[{"key":"ProteinId","value":"AAC51340.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U47741","properties":[{"key":"ProteinId","value":"AAC51770.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB210043","properties":[{"key":"ProteinId","value":"BAE06125.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471112","properties":[{"key":"ProteinId","value":"EAW85335.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471112","properties":[{"key":"ProteinId","value":"EAW85336.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471112","properties":[{"key":"ProteinId","value":"EAW85337.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS10509.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q92793-1"},{"database":"CCDS","id":"CCDS45399.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q92793-2"},{"database":"PIR","id":"S39162","properties":[{"key":"EntryName","value":"S39162"}]},{"database":"RefSeq","id":"NP_001073315.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001079846.1"}],"isoformId":"Q92793-2"},{"database":"RefSeq","id":"NP_004371.2","properties":[{"key":"NucleotideSequenceId","value":"NM_004380.3"}],"isoformId":"Q92793-1"},{"database":"PDB","id":"1JSP","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=1081-1197"}]},{"database":"PDB","id":"1LIQ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=376-402"}]},{"database":"PDB","id":"1RDT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"E=58-80"}]},{"database":"PDB","id":"1WO3","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=376-400"}]},{"database":"PDB","id":"1WO4","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=376-400"}]},{"database":"PDB","id":"1WO5","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=376-400"}]},{"database":"PDB","id":"1WO6","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=376-400"}]},{"database":"PDB","id":"1WO7","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=376-400"}]},{"database":"PDB","id":"1ZOQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.37 A"},{"key":"Chains","value":"C/D=2065-2111"}]},{"database":"PDB","id":"2D82","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"2KJE","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1763-1854"}]},{"database":"PDB","id":"2KWF","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=587-673"}]},{"database":"PDB","id":"2L84","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"2L85","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"2LXS","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=587-673"}]},{"database":"PDB","id":"2LXT","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=587-673"}]},{"database":"PDB","id":"2N1A","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=1699-1751"}]},{"database":"PDB","id":"2RNY","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"3DWY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.98 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"3P1C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"3P1D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"3P1E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"3P1F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.63 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"3SVH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"4A9K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.81 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"4N3W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1080-1316"}]},{"database":"PDB","id":"4N4F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.83 A"},{"key":"Chains","value":"A=1080-1316"}]},{"database":"PDB","id":"4NR4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"4NR5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"4NR6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"4NR7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.20 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"4NYV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.83 A"},{"key":"Chains","value":"A/B/C/D=1081-1197"}]},{"database":"PDB","id":"4NYW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.43 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"4NYX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.10 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"4OUF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"4TQN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"4TS8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"4WHU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.11 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"4YK0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/B/C/D=1083-1196"}]},{"database":"PDB","id":"5CGP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.96 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5DBM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A/B/C=1082-1197"}]},{"database":"PDB","id":"5EIC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"5ENG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5EP7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.20 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5GH9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A=1081-1196"}]},{"database":"PDB","id":"5H85","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5I83","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A=1082-1197"}]},{"database":"PDB","id":"5I86","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.05 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"5I89","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.07 A"},{"key":"Chains","value":"A=1082-1197"}]},{"database":"PDB","id":"5I8B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A=1081-1312"}]},{"database":"PDB","id":"5I8G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.41 A"},{"key":"Chains","value":"A=1081-1312"}]},{"database":"PDB","id":"5J0D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.05 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5JEM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"C/D/F/H=2065-2111"}]},{"database":"PDB","id":"5KTU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"5KTW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.09 A"},{"key":"Chains","value":"A/B/C=1085-1196"}]},{"database":"PDB","id":"5KTX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.27 A"},{"key":"Chains","value":"A=1085-1196"}]},{"database":"PDB","id":"5LPJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5LPL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5MME","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"5MMG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.23 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5MPK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"5MPN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.23 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5MPZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5MQE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"5MQG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"5MQK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"5NLK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5NRW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5NU3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5OWK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5SVH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=587-673"}]},{"database":"PDB","id":"5TB6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"5W0E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.41 A"},{"key":"Chains","value":"A=1082-1197"}]},{"database":"PDB","id":"5W0F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1082-1197"}]},{"database":"PDB","id":"5W0L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"5W0Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1082-1197"}]},{"database":"PDB","id":"5XXH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.62 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"6ALB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=1081-1312"}]},{"database":"PDB","id":"6ALC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.39 A"},{"key":"Chains","value":"A/B=1085-1196"}]},{"database":"PDB","id":"6AXQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A/B/C/D=1085-1196"}]},{"database":"PDB","id":"6AY3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.39 A"},{"key":"Chains","value":"A/B=1083-1197"}]},{"database":"PDB","id":"6AY5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.44 A"},{"key":"Chains","value":"A=1083-1197"}]},{"database":"PDB","id":"6DMK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=1083-1195"}]},{"database":"PDB","id":"6ES5","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=2061-2105"}]},{"database":"PDB","id":"6ES6","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=2061-2108"}]},{"database":"PDB","id":"6ES7","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=2061-2109"}]},{"database":"PDB","id":"6FQO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.35 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"6FQT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"6FQU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.43 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"6FR0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"6FRF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=1081-1197"}]},{"database":"PDB","id":"6LQX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.46 A"},{"key":"Chains","value":"A/B/C/D=1082-1196"}]},{"database":"PDB","id":"6M64","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"B/D/F=1951-1973"}]},{"database":"PDB","id":"6QST","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D=1081-1197"}]},{"database":"PDB","id":"6SQC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.28 A"},{"key":"Chains","value":"A=2046-2049, A=2061-2112"}]},{"database":"PDB","id":"6SQE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.51 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"6SQF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"6SQM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C=1081-1197"}]},{"database":"PDB","id":"6SXX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"6YIJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D/E/F/G=1081-1197"}]},{"database":"PDB","id":"6YIK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C=1081-1197"}]},{"database":"PDB","id":"6YIL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.22 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"6YIM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.23 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"7CO1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"B/D/F=1951-1973"}]},{"database":"PDB","id":"7EVJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.57 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"7JFL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.68 A"},{"key":"Chains","value":"C/D=2065-2111"}]},{"database":"PDB","id":"7JFM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.23 A"},{"key":"Chains","value":"C/D=2065-2111"}]},{"database":"PDB","id":"7JUO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=1082-1197"}]},{"database":"PDB","id":"7KPY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"7RLE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/D=57-80"}]},{"database":"PDB","id":"7TB3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.57 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=587-668"}]},{"database":"PDB","id":"7TBH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=587-668"}]},{"database":"PDB","id":"7UGE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"7UGL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"7WX2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.24 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"7XH6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"7XHE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"7XI0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.62 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"7XIJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"7XM7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.36 A"},{"key":"Chains","value":"A/B/C/D=1081-1197"}]},{"database":"PDB","id":"7XNE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.17 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"7XNG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"8FUP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"8FV2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.87 A"},{"key":"Chains","value":"A/B/C/D=1082-1197"}]},{"database":"PDB","id":"8FXA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/B=1082-1197"}]},{"database":"PDB","id":"8FXE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"8FXN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1082-1197"}]},{"database":"PDB","id":"8FXO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A=1082-1197"}]},{"database":"PDB","id":"8G6T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B/C/D=1082-1197"}]},{"database":"PDB","id":"8GA2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B/C/D=1082-1197"}]},{"database":"PDB","id":"8HAL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.40 A"},{"key":"Chains","value":"K=1084-1873"}]},{"database":"PDB","id":"8HAM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"K=1084-1873"}]},{"database":"PDB","id":"8HAN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.20 A"},{"key":"Chains","value":"K=1084-1873"}]},{"database":"PDB","id":"9GEJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.84 A"},{"key":"Chains","value":"A/B/C/D/E/F/G=1081-1197"}]},{"database":"PDB","id":"9GET","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.29 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"9GEU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"9GEW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.47 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"9GEY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"A/B=1081-1197"}]},{"database":"PDB","id":"9H02","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A=1322-1555, A=1618-1700"}]},{"database":"PDB","id":"9H0K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=1322-1555, A/B=1618-1700"}]},{"database":"PDB","id":"9IWL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"B=62-80"}]},{"database":"PDB","id":"9J6O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.67 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"9JUU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.48 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDB","id":"9JUY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.42 A"},{"key":"Chains","value":"A=1081-1197"}]},{"database":"PDBsum","id":"1JSP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1LIQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1RDT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1WO3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1WO4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1WO5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1WO6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1WO7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1ZOQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2D82","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2KJE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2KWF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L84","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L85","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LXS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LXT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2N1A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2RNY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3DWY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3P1C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3P1D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3P1E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3P1F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3SVH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4A9K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N3W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N4F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NR4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NR5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NR6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NR7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NYV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NYW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NYX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OUF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4TQN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4TS8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4WHU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4YK0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CGP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DBM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5EIC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ENG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5EP7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5GH9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5H85","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5I83","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5I86","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5I89","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5I8B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5I8G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5J0D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JEM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5KTU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5KTW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5KTX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5LPJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5LPL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MME","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MMG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MPK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MPN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MPZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MQE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MQG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5MQK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5NLK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5NRW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5NU3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5OWK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5SVH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5TB6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5W0E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5W0F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5W0L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5W0Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5XXH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ALB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ALC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6AXQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6AY3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6AY5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6DMK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ES5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ES6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ES7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FQO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FQT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FQU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FR0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FRF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6LQX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M64","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6QST","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SQC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SQE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SQF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SQM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SXX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6YIJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6YIK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6YIL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6YIM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7CO1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EVJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JFL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JFM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JUO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KPY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RLE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7TB3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7TBH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UGE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UGL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WX2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XH6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XHE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XI0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XIJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XM7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XNE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XNG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FUP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FV2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FXA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FXE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FXN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FXO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8G6T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GA2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HAL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HAM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HAN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9GEJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9GET","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9GEU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9GEW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9GEY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9H02","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9H0K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9IWL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9J6O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JUU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JUY","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34595","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34596","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34597","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107777","properties":[{"key":"Interactions","value":"561"}]},{"database":"CORUM","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-952N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q92793","properties":[{"key":"Number of interactors","value":"3989"}]},{"database":"IntAct","id":"Q92793","properties":[{"key":"Interactions","value":"229"}]},{"database":"MINT","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CREBBP","properties":[{"key":"Evidences","value":"54 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000262367","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5747","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB08655","properties":[{"key":"GenericName","value":"9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE"}]},{"database":"DrugBank","id":"DB02587","properties":[{"key":"GenericName","value":"Colforsin"}]},{"database":"DrugBank","id":"DB15034","properties":[{"key":"GenericName","value":"Foscenvivint"}]},{"database":"DrugBank","id":"DB17514","properties":[{"key":"GenericName","value":"Inobrodib"}]},{"database":"GuidetoPHARMACOLOGY","id":"2734","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q92793","properties":[{"key":"glycosylation","value":"12 sites, 1 glycan"}]},{"database":"GlyGen","id":"Q92793","properties":[{"key":"glycosylation","value":"34 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (30 sites)"}]},{"database":"iPTMnet","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CREBBP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"116241283","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000262367","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"62237","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"75472","properties":[{"key":"Description","value":"-"}],"isoformId":"Q92793-1"},{"database":"Pumba","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3781","properties":[{"key":"antibodies","value":"743 antibodies from 44 providers"}]},{"database":"DNASU","id":"1387","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000262367.10","properties":[{"key":"ProteinId","value":"ENSP00000262367.5"},{"key":"GeneId","value":"ENSG00000005339.15"}],"isoformId":"Q92793-1"},{"database":"Ensembl","id":"ENST00000382070.7","properties":[{"key":"ProteinId","value":"ENSP00000371502.3"},{"key":"GeneId","value":"ENSG00000005339.15"}],"isoformId":"Q92793-2"},{"database":"GeneID","id":"1387","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1387","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000262367.10","properties":[{"key":"ProteinId","value":"ENSP00000262367.5"},{"key":"RefSeqNucleotideId","value":"NM_004380.3"},{"key":"RefSeqProteinId","value":"NP_004371.2"}]},{"database":"UCSC","id":"uc002cvv.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q92793-1"},{"database":"AGR","id":"HGNC:2348","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"1387","properties":[{"key":"Number of evidences","value":"5 evidence items across 4 molecular profiles"}]},{"database":"ClinPGx","id":"PA26866","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1387","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1387","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CREBBP","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"CREBBP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:2348","properties":[{"key":"GeneName","value":"CREBBP"}]},{"database":"HPA","id":"ENSG00000005339","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"CREBBP","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"180849","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"600140","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618332","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000005339","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"370026","properties":[{"key":"Disease","value":"Acute myeloid leukemia with t(8;16)(p11;p13) translocation"}]},{"database":"Orphanet","id":"592574","properties":[{"key":"Disease","value":"Menke-Hennekam syndrome"}]},{"database":"Orphanet","id":"353281","properties":[{"key":"Disease","value":"Rubinstein-Taybi syndrome due to 16p13.3 microdeletion"}]},{"database":"Orphanet","id":"353277","properties":[{"key":"Disease","value":"Rubinstein-Taybi syndrome due to CREBBP mutations"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000005339","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1778","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155364","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000162_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QPPGTPX","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"899at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q92793","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.3.1.48","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1234158","properties":[{"key":"PathwayName","value":"Regulation of gene expression by Hypoxia-inducible Factor"}]},{"database":"Reactome","id":"R-HSA-1368108","properties":[{"key":"PathwayName","value":"BMAL1:CLOCK,NPAS2 activates circadian expression"}]},{"database":"Reactome","id":"R-HSA-1912408","properties":[{"key":"PathwayName","value":"Pre-NOTCH Transcription and Translation"}]},{"database":"Reactome","id":"R-HSA-1989781","properties":[{"key":"PathwayName","value":"PPARA activates gene expression"}]},{"database":"Reactome","id":"R-HSA-201722","properties":[{"key":"PathwayName","value":"Formation of the beta-catenin:TCF transactivating complex"}]},{"database":"Reactome","id":"R-HSA-210744","properties":[{"key":"PathwayName","value":"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"}]},{"database":"Reactome","id":"R-HSA-2122947","properties":[{"key":"PathwayName","value":"NOTCH1 Intracellular Domain Regulates Transcription"}]},{"database":"Reactome","id":"R-HSA-2151201","properties":[{"key":"PathwayName","value":"Transcriptional activation of mitochondrial biogenesis"}]},{"database":"Reactome","id":"R-HSA-2426168","properties":[{"key":"PathwayName","value":"Activation of gene expression by SREBF (SREBP)"}]},{"database":"Reactome","id":"R-HSA-2644606","properties":[{"key":"PathwayName","value":"Constitutive Signaling by NOTCH1 PEST Domain Mutants"}]},{"database":"Reactome","id":"R-HSA-2894862","properties":[{"key":"PathwayName","value":"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"}]},{"database":"Reactome","id":"R-HSA-3134973","properties":[{"key":"PathwayName","value":"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"}]},{"database":"Reactome","id":"R-HSA-3214847","properties":[{"key":"PathwayName","value":"HATs acetylate histones"}]},{"database":"Reactome","id":"R-HSA-3371568","properties":[{"key":"PathwayName","value":"Attenuation phase"}]},{"database":"Reactome","id":"R-HSA-350054","properties":[{"key":"PathwayName","value":"Notch-HLH transcription pathway"}]},{"database":"Reactome","id":"R-HSA-381340","properties":[{"key":"PathwayName","value":"Transcriptional regulation of white adipocyte differentiation"}]},{"database":"Reactome","id":"R-HSA-3899300","properties":[{"key":"PathwayName","value":"SUMOylation of transcription cofactors"}]},{"database":"Reactome","id":"R-HSA-400206","properties":[{"key":"PathwayName","value":"Regulation of lipid metabolism by PPARalpha"}]},{"database":"Reactome","id":"R-HSA-5617472","properties":[{"key":"PathwayName","value":"Activation of anterior HOX genes in hindbrain development during early embryogenesis"}]},{"database":"Reactome","id":"R-HSA-5621575","properties":[{"key":"PathwayName","value":"CD209 (DC-SIGN) signaling"}]},{"database":"Reactome","id":"R-HSA-6803204","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"}]},{"database":"Reactome","id":"R-HSA-8866907","properties":[{"key":"PathwayName","value":"Activation of the TFAP2 (AP-2) family of transcription factors"}]},{"database":"Reactome","id":"R-HSA-8939246","properties":[{"key":"PathwayName","value":"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"}]},{"database":"Reactome","id":"R-HSA-8941856","properties":[{"key":"PathwayName","value":"RUNX3 regulates NOTCH signaling"}]},{"database":"Reactome","id":"R-HSA-9013508","properties":[{"key":"PathwayName","value":"NOTCH3 Intracellular Domain Regulates Transcription"}]},{"database":"Reactome","id":"R-HSA-9013695","properties":[{"key":"PathwayName","value":"NOTCH4 Intracellular Domain Regulates Transcription"}]},{"database":"Reactome","id":"R-HSA-9018519","properties":[{"key":"PathwayName","value":"Estrogen-dependent gene expression"}]},{"database":"Reactome","id":"R-HSA-918233","properties":[{"key":"PathwayName","value":"TRAF3-dependent IRF activation pathway"}]},{"database":"Reactome","id":"R-HSA-933541","properties":[{"key":"PathwayName","value":"TRAF6 mediated IRF7 activation"}]},{"database":"Reactome","id":"R-HSA-9614657","properties":[{"key":"PathwayName","value":"FOXO-mediated transcription of cell death genes"}]},{"database":"Reactome","id":"R-HSA-9617629","properties":[{"key":"PathwayName","value":"Regulation of FOXO transcriptional activity by acetylation"}]},{"database":"Reactome","id":"R-HSA-9705671","properties":[{"key":"PathwayName","value":"SARS-CoV-2 activates/modulates innate and adaptive immune responses"}]},{"database":"Reactome","id":"R-HSA-9707564","properties":[{"key":"PathwayName","value":"Cytoprotection by HMOX1"}]},{"database":"Reactome","id":"R-HSA-9707616","properties":[{"key":"PathwayName","value":"Heme signaling"}]},{"database":"Reactome","id":"R-HSA-9759194","properties":[{"key":"PathwayName","value":"Nuclear events mediated by NFE2L2"}]},{"database":"Reactome","id":"R-HSA-9768919","properties":[{"key":"PathwayName","value":"NPAS4 regulates expression of target genes"}]},{"database":"Reactome","id":"R-HSA-9793380","properties":[{"key":"PathwayName","value":"Formation of paraxial mesoderm"}]},{"database":"Reactome","id":"R-HSA-9818026","properties":[{"key":"PathwayName","value":"NFE2L2 regulating inflammation associated genes"}]},{"database":"Reactome","id":"R-HSA-9818027","properties":[{"key":"PathwayName","value":"NFE2L2 regulating anti-oxidant/detoxification enzymes"}]},{"database":"Reactome","id":"R-HSA-9818028","properties":[{"key":"PathwayName","value":"NFE2L2 regulates pentose phosphate pathway genes"}]},{"database":"Reactome","id":"R-HSA-9818030","properties":[{"key":"PathwayName","value":"NFE2L2 regulating tumorigenic genes"}]},{"database":"Reactome","id":"R-HSA-9818032","properties":[{"key":"PathwayName","value":"NFE2L2 regulating MDR associated enzymes"}]},{"database":"Reactome","id":"R-HSA-9818035","properties":[{"key":"PathwayName","value":"NFE2L2 regulating ER-stress associated genes"}]},{"database":"Reactome","id":"R-HSA-9818749","properties":[{"key":"PathwayName","value":"Regulation of NFE2L2 gene expression"}]},{"database":"Reactome","id":"R-HSA-9819196","properties":[{"key":"PathwayName","value":"Zygotic genome activation (ZGA)"}]},{"database":"Reactome","id":"R-HSA-9833109","properties":[{"key":"PathwayName","value":"Evasion by RSV of host interferon responses"}]},{"database":"Reactome","id":"R-HSA-9841922","properties":[{"key":"PathwayName","value":"MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"}]},{"database":"Reactome","id":"R-HSA-9856649","properties":[{"key":"PathwayName","value":"Transcriptional and post-translational regulation of MITF-M expression and activity"}]},{"database":"Reactome","id":"R-HSA-9909649","properties":[{"key":"PathwayName","value":"Regulation of PD-L1(CD274) transcription"}]},{"database":"Reactome","id":"R-HSA-9931509","properties":[{"key":"PathwayName","value":"Expression of BMAL (ARNTL), CLOCK, and NPAS2"}]},{"database":"Reactome","id":"R-HSA-9931510","properties":[{"key":"PathwayName","value":"Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes"}]},{"database":"Reactome","id":"R-HSA-9931512","properties":[{"key":"PathwayName","value":"Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters"}]},{"database":"Reactome","id":"R-HSA-9931521","properties":[{"key":"PathwayName","value":"The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex"}]},{"database":"Reactome","id":"R-HSA-9933387","properties":[{"key":"PathwayName","value":"RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression"}]},{"database":"Reactome","id":"R-HSA-9943962","properties":[{"key":"PathwayName","value":"CHD6, CHD7, CHD8, CHD9 subfamily"}]},{"database":"Reactome","id":"R-HSA-9976102","properties":[{"key":"PathwayName","value":"Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)"}]},{"database":"SignaLink","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000005339","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1387","properties":[{"key":"hits","value":"137 hits in 1212 CRISPR screens"}]},{"database":"CD-CODE","id":"6F24707C","properties":[{"key":"EntryName","value":"Cajal body"}]},{"database":"CD-CODE","id":"9E21F925","properties":[{"key":"EntryName","value":"Synthetic Condensate 000351"}]},{"database":"CD-CODE","id":"B5B9A610","properties":[{"key":"EntryName","value":"PML body"}]},{"database":"ChiTaRS","id":"CREBBP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CREB-binding_protein","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1387","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q92793","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q92793","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q92793","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000005339","properties":[{"key":"ExpressionPatterns","value":"Expressed in sural nerve and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q92793","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21539536"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12929931"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0000123","properties":[{"key":"GoTerm","value":"C:histone acetyltransferase complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016604","properties":[{"key":"GoTerm","value":"C:nuclear body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15488321"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12929931"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25593309"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016407","properties":[{"key":"GoTerm","value":"F:acetyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15273251"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24939902"}]},{"database":"GO","id":"GO:0031490","properties":[{"key":"GoTerm","value":"F:chromatin DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003684","properties":[{"key":"GoTerm","value":"F:damaged DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24939902"}]},{"database":"GO","id":"GO:0140297","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15509593"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15674325"}]},{"database":"GO","id":"GO:0004402","properties":[{"key":"GoTerm","value":"F:histone acetyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11742995"}]},{"database":"GO","id":"GO:0043993","properties":[{"key":"GoTerm","value":"F:histone H3K18 acetyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21131905"}]},{"database":"GO","id":"GO:0044017","properties":[{"key":"GoTerm","value":"F:histone H3K27 acetyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21131905"}]},{"database":"GO","id":"GO:0043426","properties":[{"key":"GoTerm","value":"F:MRF binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8621548"}]},{"database":"GO","id":"GO:0002039","properties":[{"key":"GoTerm","value":"F:p53 binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"9194565"}]},{"database":"GO","id":"GO:0120300","properties":[{"key":"GoTerm","value":"F:peptide lactyltransferase (CoA-dependent) activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38128537"}]},{"database":"GO","id":"GO:0061733","properties":[{"key":"GoTerm","value":"F:protein-lysine-acetyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12435739"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15273251"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24207024"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24939902"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28790157"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30540930"}]},{"database":"GO","id":"GO:0061629","properties":[{"key":"GoTerm","value":"F:RNA polymerase II-specific DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16043483"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21539536"}]},{"database":"GO","id":"GO:0048156","properties":[{"key":"GoTerm","value":"F:tau protein binding"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"28386764"}]},{"database":"GO","id":"GO:0003713","properties":[{"key":"GoTerm","value":"F:transcription coactivator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12586840"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12929931"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14645221"}]},{"database":"GO","id":"GO:0001223","properties":[{"key":"GoTerm","value":"F:transcription coactivator binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11349124"}]},{"database":"GO","id":"GO:0003714","properties":[{"key":"GoTerm","value":"F:transcription corepressor activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21539536"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0141156","properties":[{"key":"GoTerm","value":"P:cAMP/PKA signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11522779"}]},{"database":"GO","id":"GO:0007249","properties":[{"key":"GoTerm","value":"P:canonical NF-kappaB signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16135789"}]},{"database":"GO","id":"GO:0031669","properties":[{"key":"GoTerm","value":"P:cellular response to nutrient levels"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35675826"}]},{"database":"GO","id":"GO:0034644","properties":[{"key":"GoTerm","value":"P:cellular response to UV"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0042733","properties":[{"key":"GoTerm","value":"P:embryonic digit morphogenesis"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"11001584"}]},{"database":"GO","id":"GO:0016479","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase I"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30540930"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21539536"}]},{"database":"GO","id":"GO:1901837","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription of nucleolar large rRNA by RNA polymerase I"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24207024"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11742995"}]},{"database":"GO","id":"GO:1905168","properties":[{"key":"GoTerm","value":"P:positive regulation of double-strand break repair via homologous recombination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38128537"}]},{"database":"GO","id":"GO:1900182","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35675826"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12435739"}]},{"database":"GO","id":"GO:0030511","properties":[{"key":"GoTerm","value":"P:positive regulation of transforming growth factor beta receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25514493"}]},{"database":"GO","id":"GO:0031648","properties":[{"key":"GoTerm","value":"P:protein destabilization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0065003","properties":[{"key":"GoTerm","value":"P:protein-containing complex assembly"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7913207"}]},{"database":"GO","id":"GO:1900034","properties":[{"key":"GoTerm","value":"P:regulation of cellular response to heat"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"15261140"}]},{"database":"GO","id":"GO:2000819","properties":[{"key":"GoTerm","value":"P:regulation of nucleotide-excision repair"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24939902"}]},{"database":"GO","id":"GO:0008589","properties":[{"key":"GoTerm","value":"P:regulation of smoothened signaling pathway"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"11001584"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0002223","properties":[{"key":"GoTerm","value":"P:stimulatory C-type lectin receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"CDD","id":"cd05495","properties":[{"key":"EntryName","value":"Bromo_cbp_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd20910","properties":[{"key":"EntryName","value":"NCBD_CREBBP-p300_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd15557","properties":[{"key":"EntryName","value":"PHD_CBP_p300"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd15802","properties":[{"key":"EntryName","value":"RING_CBP-p300"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd02337","properties":[{"key":"EntryName","value":"ZZ_CBP"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP02004","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"1.10.246.20:FF:000001","properties":[{"key":"EntryName","value":"E1A binding protein p300"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1020.10:FF:000001","properties":[{"key":"EntryName","value":"E1A binding protein p300"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1020.10:FF:000002","properties":[{"key":"EntryName","value":"E1A binding protein p300"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.110.40:FF:000001","properties":[{"key":"EntryName","value":"E1A binding protein p300"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.60.90:FF:000003","properties":[{"key":"EntryName","value":"E1A binding protein p300"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.920.10:FF:000001","properties":[{"key":"EntryName","value":"Histone acetyltransferase p300"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000034","properties":[{"key":"EntryName","value":"Histone acetyltransferase p300"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.110.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.60.90","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.920.10","properties":[{"key":"EntryName","value":"Bromodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.246.20","properties":[{"key":"EntryName","value":"Coactivator CBP, KIX domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.1630.10","properties":[{"key":"EntryName","value":"Nuclear receptor coactivator, CREB-bp-like, interlocking domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1020.10","properties":[{"key":"EntryName","value":"TAZ domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00092","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR001487","properties":[{"key":"EntryName","value":"Bromodomain"}]},{"database":"InterPro","id":"IPR036427","properties":[{"key":"EntryName","value":"Bromodomain-like_sf"}]},{"database":"InterPro","id":"IPR018359","properties":[{"key":"EntryName","value":"Bromodomain_CS"}]},{"database":"InterPro","id":"IPR064044","properties":[{"key":"EntryName","value":"CBP/p300/RT109_HAT"}]},{"database":"InterPro","id":"IPR031162","properties":[{"key":"EntryName","value":"CBP_P300_HAT"}]},{"database":"InterPro","id":"IPR013178","properties":[{"key":"EntryName","value":"Histone_AcTrfase_CBP/p300"}]},{"database":"InterPro","id":"IPR003101","properties":[{"key":"EntryName","value":"KIX_dom"}]},{"database":"InterPro","id":"IPR036529","properties":[{"key":"EntryName","value":"KIX_dom_sf"}]},{"database":"InterPro","id":"IPR009110","properties":[{"key":"EntryName","value":"Nuc_rcpt_coact"}]},{"database":"InterPro","id":"IPR014744","properties":[{"key":"EntryName","value":"Nuc_rcpt_coact_CREBbp"}]},{"database":"InterPro","id":"IPR037073","properties":[{"key":"EntryName","value":"Nuc_rcpt_coact_CREBbp_sf"}]},{"database":"InterPro","id":"IPR056484","properties":[{"key":"EntryName","value":"PHD_P300"}]},{"database":"InterPro","id":"IPR010303","properties":[{"key":"EntryName","value":"RING_CBP-p300"}]},{"database":"InterPro","id":"IPR038547","properties":[{"key":"EntryName","value":"RING_CBP-p300_sf"}]},{"database":"InterPro","id":"IPR035898","properties":[{"key":"EntryName","value":"TAZ_dom_sf"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR000197","properties":[{"key":"EntryName","value":"Znf_TAZ"}]},{"database":"InterPro","id":"IPR000433","properties":[{"key":"EntryName","value":"Znf_ZZ"}]},{"database":"InterPro","id":"IPR043145","properties":[{"key":"EntryName","value":"Znf_ZZ_sf"}]},{"database":"PANTHER","id":"PTHR13808","properties":[{"key":"EntryName","value":"CBP/P300-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13808:SF34","properties":[{"key":"EntryName","value":"CREB-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00439","properties":[{"key":"EntryName","value":"Bromodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09030","properties":[{"key":"EntryName","value":"Creb_binding"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF29847","properties":[{"key":"EntryName","value":"KAT3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02172","properties":[{"key":"EntryName","value":"KIX"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23570","properties":[{"key":"EntryName","value":"PHD_P300"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06001","properties":[{"key":"EntryName","value":"RING_CBP-p300"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02135","properties":[{"key":"EntryName","value":"zf-TAZ"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00569","properties":[{"key":"EntryName","value":"ZZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00503","properties":[{"key":"EntryName","value":"BROMODOMAIN"}]},{"database":"SMART","id":"SM00297","properties":[{"key":"EntryName","value":"BROMO"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01250","properties":[{"key":"EntryName","value":"KAT11"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00551","properties":[{"key":"EntryName","value":"ZnF_TAZ"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00291","properties":[{"key":"EntryName","value":"ZnF_ZZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47370","properties":[{"key":"EntryName","value":"Bromodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47040","properties":[{"key":"EntryName","value":"Kix domain of CBP (creb binding protein)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF69125","properties":[{"key":"EntryName","value":"Nuclear receptor coactivator interlocking domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57933","properties":[{"key":"EntryName","value":"TAZ domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00633","properties":[{"key":"EntryName","value":"BROMODOMAIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50014","properties":[{"key":"EntryName","value":"BROMODOMAIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51727","properties":[{"key":"EntryName","value":"CBP_P300_HAT"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50952","properties":[{"key":"EntryName","value":"KIX"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50134","properties":[{"key":"EntryName","value":"ZF_TAZ"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS01357","properties":[{"key":"EntryName","value":"ZF_ZZ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50135","properties":[{"key":"EntryName","value":"ZF_ZZ_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL","length":2442,"molWeight":265351,"crc64":"3BEA9B8558BA1A5E","md5":"7369E7DB94F24EDB1C0954D6E97CD9CE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"SUBUNIT":4,"INTERACTION":58,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DOMAIN":1,"PTM":4,"DISEASE":3,"SEQUENCE CAUTION":1,"WEB RESOURCE":2},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":3,"Zinc finger":3,"Region":14,"Compositional bias":31,"Binding site":25,"Site":2,"Modified residue":25,"Cross-link":3,"Alternative sequence":1,"Natural variant":38,"Mutagenesis":9,"Sequence conflict":5,"Helix":32,"Turn":10,"Beta strand":11},"uniParcId":"UPI0000000620"}}