Q923K9 Q8CH55 Q8CH56 Q8CH57 Q8CH58 Q924K3 A1CF_RAT APOBEC1 complementation factor APOBEC1-stimulating protein A1cf Acf Asp Rattus norvegicus Rat Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Rattus NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) SUBCELLULAR LOCATION Sprague-Dawley Liver NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4) NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 295-594 (ISOFORM 3) NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 295-409 (ISOFORM 1) TISSUE SPECIFICITY Sprague-Dawley Liver NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) Sprague-Dawley PARTIAL PROTEIN SEQUENCE FUNCTION Liver Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity). Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2. Interacts with RBM47. Nucleus Endoplasmic reticulum Cytoplasm Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. Q923K9-1 1 ACF65 Q923K9-2 2 ACF64 Q923K9-3 3 ACF45 Q923K9-4 4 ACF43 Isoforms 1 and 2 are widely expressed while isoforms 3 and 4 are restricted to liver and small intestine. The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity (By similarity). Alternative splicing Cytoplasm Direct protein sequencing Endoplasmic reticulum mRNA processing Nucleus Phosphoprotein Reference proteome Repeat RNA-binding EIYMNVPVGAAGVRGLGGRGYLAYTG GCSRTPSIYLCFLTAVHAGVHHIHVQ EIYM GNIS T A G P MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDTTPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRNTMLQEYTYPLSHVYDPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKRQDKLYDLLPGMELTPMNTISLKPQGVKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFTPPKLSAYVDEAKRYAAEHTLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYTTYEVYPTFAVTTRGDGYGTF Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License