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N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"9878773"}],"value":"Protein modification; protein glycosylation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15886282"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16096345"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16297388"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29301962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8175708"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9405463"}],"value":"Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:15886282, PubMed:16096345, PubMed:16297388, PubMed:29301962, PubMed:8175708, PubMed:9405463). 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