{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q91YP6","secondaryAccessions":["Q3TNV2"],"uniProtkbId":"ELMD3_MOUSE","entryAudit":{"firstPublicDate":"2007-02-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":147,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"ELMO domain-containing protein 3"}},"alternativeNames":[{"fullName":{"value":"RNA-binding motif and ELMO domain-containing protein 1"}}]},"genes":[{"geneName":{"value":"Elmod3"},"synonyms":[{"value":"Rbed1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Also present in the cuticular plate of auditory hair cells. In the organ of Corti, in inner hair cells, expressed along the length of the stereocilia, but excluded from the very tip. Colocalizes with F-actin cytoskeleton"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24039609"}],"value":"Cell projection, stereocilium","id":"SL-0302"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24039609"}],"value":"Cell projection, kinocilium","id":"SL-0460"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24039609"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"b/c"}],"isoformIds":["Q91YP6-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"a"}],"isoformIds":["Q91YP6-2"],"sequenceIds":["VSP_022925","VSP_022926"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24039609"}],"value":"Both isoform 1 and isoform 2 are widely expressed"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24039609"}],"value":"Both isoform 1 and isoform 2 are expressed postnatally in the inner ear. 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