{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q91YN0","secondaryAccessions":["Q3UVK4"],"uniProtkbId":"FERY3_MOUSE","entryAudit":{"firstPublicDate":"2005-07-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":135,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NQ89"}],"value":"FERRY endosomal RAB5 effector complex subunit 3"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NQ89"}],"value":"Ferry3"},"synonyms":[{"value":"D6Wsu163e"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D4A770"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NQ89"}],"value":"Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (By similarity). Plays a role in mast cell degranulation (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NQ89"}],"value":"Component of the FERRY complex composed of five subunits, TBCK, PPP1R21, FERRY3, CRYZL1 and GATD1 with a ratio of 1:2:1:2:4, respectively"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"D4A770"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NQ89"}],"value":"Early endosome","id":"SL-0094"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"FERRY endosomal RAB5 effector complex subunit 3","featureId":"PRO_0000089843"},{"type":"Modified residue","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Adipose tissue","type":"TISSUE"},{"value":"Corpora quadrigemina","type":"TISSUE"},{"value":"Urinary bladder","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Mammary tumor","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK045541","properties":[{"key":"ProteinId","value":"BAC32412.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK046707","properties":[{"key":"ProteinId","value":"BAC32841.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK137201","properties":[{"key":"ProteinId","value":"BAE23265.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC016429","properties":[{"key":"ProteinId","value":"AAH16429.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS20560.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_613060.1","properties":[{"key":"NucleotideSequenceId","value":"NM_138594.4"}]},{"database":"AlphaFoldDB","id":"Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"205730","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q91YN0","properties":[{"key":"Number of interactors","value":"3726"}]},{"database":"STRING","id":"10090.ENSMUSP00000032497","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q91YN0","properties":[{"key":"glycosylation","value":"2 sites, 2 N-linked glycans (2 sites)"}]},{"database":"iPTMnet","id":"Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000032497","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"279094","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"41818","properties":[{"key":"antibodies","value":"84 antibodies from 15 providers"}]},{"database":"Ensembl","id":"ENSMUST00000032497.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000032497.4"},{"key":"GeneId","value":"ENSMUSG00000030347.7"}]},{"database":"GeneID","id":"28040","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009dvm.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:107893","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"28040","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:107893","properties":[{"key":"GeneName","value":"D6Wsu163e"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000030347","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4506","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000010229","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_036084_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CKHKRSH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"415359at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"28040","properties":[{"key":"hits","value":"1 hit in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:Q91YN0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q91YN0","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000030347","properties":[{"key":"ExpressionPatterns","value":"Expressed in saccule of membranous labyrinth and 245 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q91YN0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043304","properties":[{"key":"GoTerm","value":"P:regulation of mast cell degranulation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR019311","properties":[{"key":"EntryName","value":"Fy-3"}]},{"database":"PANTHER","id":"PTHR16525","properties":[{"key":"EntryName","value":"PROTEIN C12ORF4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16525:SF0","properties":[{"key":"EntryName","value":"PROTEIN C12ORF4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10154","properties":[{"key":"EntryName","value":"Fy-3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKKNRERFCNKEREFVYKFQVGRERLELRVPLRFPVEENASHLHGRLMLLHSLPCFIESDLKDALSRFIEEESLRDHDSDAEACLEAVKSGEVDLHQLASAWAKAYAETTLEHARPEEPDWDEDFADVYHDLIHSPASETLLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAAQHFESQQDLENKWSNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQFRESADAAGRIYEEQRKLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRTHGSGVKLHRLQTALSLYSTSLCGLVLLVDNRINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVALYARTQRKSKCKEARDSGNQNGGSDDKSKNAERNYLNILPGEFYITRHSNLSEIHVAFHLCVDDNVKSGNITARDPAIMGLRNILKVCCTHDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGISRTVQFLVPQSISEEMFYQLSNMLPQIFRVSSTLTLTSKH","length":552,"molWeight":63644,"crc64":"79C9C39ECBA14BCE","md5":"73CA9417B2F53874D9B379544671DB20"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Modified residue":1},"uniParcId":"UPI00000296FF"}}