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Modulates peptidoglycan (PG) synthesis pathway committed-step enzyme MurA (PubMed:32469310). Positively modulates ClpCP-dependent proteolysis of MurA, thereby regulating PG synthesis and inhibiting intrinsic cephalosporin resistance (PubMed:32469310)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32469310"}],"value":"Interacts directly with IreB/ReoM; interaction may bridge the interaction of ClpCP with its substrate MurA (PubMed:32469310). Interacts with ClpC (PubMed:32469310). Interacts with ClpP (PubMed:32469310)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32469310"}],"value":"Thicker PG layers at the cell poles and more uneven PG layers along the lateral wall (PubMed:32469310). Salt-sensitive growth (PubMed:32469310). Deletion has no effect on growth, but completely suppresses the growth defects of a gpsB mutant at both 37 and 42 degrees Celsius (PubMed:32469310). Cell length is normal; similar phenotype in a gpsB mutant background (PubMed:32469310). Normal rod-shape, but partially bent in a gpsB mutant background (PubMed:32469310). MurA protein levels increase by at least eight-fold; expression level of MurA increases similarly in clpC, ireB/reoM or murZ/murA2 mutant backgrounds (PubMed:32469310). Increases resistance to cephalosporin antibiotic ceftriaxone about two- to three-fold (PubMed:32469310)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00760"},{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ReoY family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Peptidoglycan synthesis regulatory protein ReoY","featureId":"PRO_0000216102"},{"type":"Mutagenesis","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Completely suppresses the growth defects of a gpsB mutant at both 37 and 42 degrees 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