{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8WXI2","secondaryAccessions":["B4DGR4","B7ZLJ1","B9EG83","E7ESA4","O94976","Q5JPK4","Q5JPN0","Q8WXI1"],"uniProtkbId":"CNKR2_HUMAN","entryAudit":{"firstPublicDate":"2004-07-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-01","entryVersion":194,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Connector enhancer of kinase suppressor of ras 2"},"shortNames":[{"value":"Connector enhancer of KSR 2"}]},"alternativeNames":[{"fullName":{"value":"CNK homolog protein 2"},"shortNames":[{"value":"CNK2"}]}]},"genes":[{"geneName":{"value":"CNKSR2"},"synonyms":[{"value":"CNK2"},{"value":"KIAA0902"},{"value":"KSR2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14597674"}],"value":"May function as an adapter protein or regulator of Ras signaling pathways"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14597674"}],"value":"Interacts with RAF1, RAB2L and RAL GTPase proteins"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q96NW7","geneName":"LRRC7","intActId":"EBI-524275"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WXI2","intActId":"EBI-1045119"},"interactantTwo":{"uniProtKBAccession":"Q8ML92","geneName":"ave","intActId":"EBI-2563975"},"numberOfExperiments":5,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}},{"location":{"value":"Membrane","id":"SL-0162"},"topology":{"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"CNK2A"},{"value":"KSR2A"}],"isoformIds":["Q8WXI2-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"CNK2B"},{"value":"KSR2B"}],"isoformIds":["Q8WXI2-2"],"sequenceIds":["VSP_010887"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8WXI2-4"],"sequenceIds":["VSP_043168","VSP_010887"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8WXI2-5"],"sequenceIds":["VSP_043169"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14597674"}],"value":"Phosphorylated on tyrosine"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Intellectual developmental disorder, X-linked, syndromic, Houge type","diseaseAccession":"DI-05156","acronym":"MRXSHG","description":"A disorder characterized by delayed development, intellectual disability, speech and language delay, and early-onset seizures. Carrier females may be mildly affected.","diseaseCrossReference":{"database":"MIM","id":"301008"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25223753"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28098945"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CNKSR family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","molecule":"Isoform 2","sequenceCautionType":"Frameshift","sequence":"BAA74925.2","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"Connector enhancer of kinase suppressor of ras 2","featureId":"PRO_0000089970"},{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"SAM","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00184"}]},{"type":"Domain","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"CRIC","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00621"}]},{"type":"Domain","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"PDZ","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00143"}]},{"type":"Domain","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"DUF1170"},{"type":"Domain","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00145"}]},{"type":"Region","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":682,"modifier":"EXACT"},"end":{"value":766,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":864,"modifier":"EXACT"},"end":{"value":905,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":875,"modifier":"EXACT"},"end":{"value":904,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":545,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":701,"modifier":"EXACT"},"end":{"value":714,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":740,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":875,"modifier":"EXACT"},"end":{"value":889,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":905,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80YA9"}]},{"type":"Modified residue","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80YA9"}]},{"type":"Modified residue","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80YA9"}]},{"type":"Modified residue","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":683,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80YA9"}]},{"type":"Modified residue","location":{"start":{"value":685,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80YA9"}]},{"type":"Modified residue","location":{"start":{"value":687,"modifier":"EXACT"},"end":{"value":687,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80YA9"}]},{"type":"Modified residue","location":{"start":{"value":756,"modifier":"EXACT"},"end":{"value":756,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z1T4"}]},{"type":"Modified residue","location":{"start":{"value":767,"modifier":"EXACT"},"end":{"value":767,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z1T4"}]},{"type":"Modified residue","location":{"start":{"value":908,"modifier":"EXACT"},"end":{"value":908,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Alternative sequence","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_043168","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":464,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_043169","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":899,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10048485"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14597674"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_010887","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"in a colorectal cancer sample; somatic mutation; dbSNP:rs771705122","featureCrossReferences":[{"database":"dbSNP","id":"rs771705122"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035681","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":712,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"in MRXSHG","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28098945"}],"featureId":"VAR_080600","alternativeSequence":{}},{"type":"Helix","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3BS5"}]},{"type":"Helix","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3BS5"}]},{"type":"Helix","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3BS5"}]},{"type":"Helix","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3BS5"}]},{"type":"Helix","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3BS5"}]},{"type":"Helix","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3BS5"}]},{"type":"Helix","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3BS5"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14597674","citationType":"journal article","authors":["Lanigan T.M.","Liu A.","Huang Y.Z.","Mei L.","Margolis B.","Guan K.-L."],"citationCrossReferences":[{"database":"PubMed","id":"14597674"},{"database":"DOI","id":"10.1096/fj.02-1096com"}],"title":"Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.","publicationDate":"2003","journal":"FASEB J.","firstPage":"2048","lastPage":"2060","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)","FUNCTION","INTERACTION WITH RAF1; RAB2L AND RAL GTPASE PROTEINS","PHOSPHORYLATION"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10048485","citationType":"journal article","authors":["Nagase T.","Ishikawa K.","Suyama M.","Kikuno R.","Hirosawa M.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"10048485"},{"database":"DOI","id":"10.1093/dnares/5.6.355"}],"title":"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"1998","journal":"DNA Res.","firstPage":"355","lastPage":"364","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15772651","citationType":"journal article","authors":["Ross M.T.","Grafham D.V.","Coffey A.J.","Scherer S.","McLay K.","Muzny D.","Platzer M.","Howell G.R.","Burrows C.","Bird C.P.","Frankish A.","Lovell F.L.","Howe K.L.","Ashurst J.L.","Fulton R.S.","Sudbrak R.","Wen G.","Jones M.C.","Hurles M.E.","Andrews T.D.","Scott C.E.","Searle S.","Ramser J.","Whittaker A.","Deadman R.","Carter N.P.","Hunt S.E.","Chen R.","Cree A.","Gunaratne P.","Havlak P.","Hodgson A.","Metzker M.L.","Richards S.","Scott G.","Steffen D.","Sodergren E.","Wheeler D.A.","Worley K.C.","Ainscough R.","Ambrose K.D.","Ansari-Lari M.A.","Aradhya S.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Ballabio A.","Banerjee R.","Barker G.E.","Barlow K.F.","Barrett I.P.","Bates K.N.","Beare D.M.","Beasley H.","Beasley O.","Beck A.","Bethel G.","Blechschmidt K.","Brady N.","Bray-Allen S.","Bridgeman A.M.","Brown A.J.","Brown M.J.","Bonnin D.","Bruford E.A.","Buhay C.","Burch P.","Burford D.","Burgess J.","Burrill W.","Burton J.","Bye J.M.","Carder C.","Carrel L.","Chako J.","Chapman J.C.","Chavez D.","Chen E.","Chen G.","Chen Y.","Chen Z.","Chinault C.","Ciccodicola A.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Clerc-Blankenburg K.","Clifford K.","Cobley V.","Cole C.G.","Conquer J.S.","Corby N.","Connor R.E.","David R.","Davies J.","Davis C.","Davis J.","Delgado O.","Deshazo D.","Dhami P.","Ding Y.","Dinh H.","Dodsworth S.","Draper H.","Dugan-Rocha S.","Dunham A.","Dunn M.","Durbin K.J.","Dutta I.","Eades T.","Ellwood M.","Emery-Cohen A.","Errington H.","Evans K.L.","Faulkner L.","Francis F.","Frankland J.","Fraser A.E.","Galgoczy P.","Gilbert J.","Gill R.","Gloeckner G.","Gregory S.G.","Gribble S.","Griffiths C.","Grocock R.","Gu Y.","Gwilliam R.","Hamilton C.","Hart E.A.","Hawes A.","Heath P.D.","Heitmann K.","Hennig S.","Hernandez J.","Hinzmann B.","Ho S.","Hoffs M.","Howden P.J.","Huckle E.J.","Hume J.","Hunt P.J.","Hunt A.R.","Isherwood J.","Jacob L.","Johnson D.","Jones S.","de Jong P.J.","Joseph S.S.","Keenan S.","Kelly S.","Kershaw J.K.","Khan Z.","Kioschis P.","Klages S.","Knights A.J.","Kosiura A.","Kovar-Smith C.","Laird G.K.","Langford C.","Lawlor S.","Leversha M.","Lewis L.","Liu W.","Lloyd C.","Lloyd D.M.","Loulseged H.","Loveland J.E.","Lovell J.D.","Lozado R.","Lu J.","Lyne R.","Ma J.","Maheshwari M.","Matthews L.H.","McDowall J.","McLaren S.","McMurray A.","Meidl P.","Meitinger T.","Milne S.","Miner G.","Mistry S.L.","Morgan M.","Morris S.","Mueller I.","Mullikin J.C.","Nguyen N.","Nordsiek G.","Nyakatura G.","O'dell C.N.","Okwuonu G.","Palmer S.","Pandian R.","Parker D.","Parrish J.","Pasternak S.","Patel D.","Pearce A.V.","Pearson D.M.","Pelan S.E.","Perez L.","Porter K.M.","Ramsey Y.","Reichwald K.","Rhodes S.","Ridler K.A.","Schlessinger D.","Schueler M.G.","Sehra H.K.","Shaw-Smith C.","Shen H.","Sheridan E.M.","Shownkeen R.","Skuce C.D.","Smith M.L.","Sotheran E.C.","Steingruber H.E.","Steward C.A.","Storey R.","Swann R.M.","Swarbreck D.","Tabor P.E.","Taudien S.","Taylor T.","Teague B.","Thomas K.","Thorpe A.","Timms K.","Tracey A.","Trevanion S.","Tromans A.C.","d'Urso M.","Verduzco D.","Villasana D.","Waldron L.","Wall M.","Wang Q.","Warren J.","Warry G.L.","Wei X.","West A.","Whitehead S.L.","Whiteley M.N.","Wilkinson J.E.","Willey D.L.","Williams G.","Williams L.","Williamson A.","Williamson H.","Wilming L.","Woodmansey R.L.","Wray P.W.","Yen J.","Zhang J.","Zhou J.","Zoghbi H.","Zorilla S.","Buck D.","Reinhardt R.","Poustka A.","Rosenthal A.","Lehrach H.","Meindl A.","Minx P.J.","Hillier L.W.","Willard H.F.","Wilson R.K.","Waterston R.H.","Rice C.M.","Vaudin M.","Coulson A.","Nelson D.L.","Weinstock G.","Sulston J.E.","Durbin R.M.","Hubbard T.","Gibbs R.A.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"15772651"},{"database":"DOI","id":"10.1038/nature03440"}],"title":"The DNA sequence of the human X chromosome.","publicationDate":"2005","journal":"Nature","firstPage":"325","lastPage":"337","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"CI-FNV8COQ01P1I6","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of the N-terminal SAM-domain of human KIAA0902 protein (connector enhancer of kinase suppressor of RAS 2).","publicationDate":"JUL-2007","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 8-79"]},{"referenceNumber":11,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] HIS-46"]},{"referenceNumber":12,"citation":{"id":"25223753","citationType":"journal article","authors":["Vaags A.K.","Bowdin S.","Smith M.L.","Gilbert-Dussardier B.","Brocke-Holmefjord K.S.","Sinopoli K.","Gilles C.","Haaland T.B.","Vincent-Delorme C.","Lagrue E.","Harbuz R.","Walker S.","Marshall C.R.","Houge G.","Kalscheuer V.M.","Scherer S.W.","Minassian B.A."],"citationCrossReferences":[{"database":"PubMed","id":"25223753"},{"database":"DOI","id":"10.1002/ana.24274"}],"title":"Absent CNKSR2 causes seizures and intellectual, attention, and language deficits.","publicationDate":"2014","journal":"Ann. Neurol.","firstPage":"758","lastPage":"764","volume":"76"},"referencePositions":["INVOLVEMENT IN MRXSHG"]},{"referenceNumber":13,"citation":{"id":"28098945","citationType":"journal article","authors":["Damiano J.A.","Burgess R.","Kivity S.","Lerman-Sagie T.","Afawi Z.","Scheffer I.E.","Berkovic S.F.","Hildebrand M.S."],"citationCrossReferences":[{"database":"PubMed","id":"28098945"},{"database":"DOI","id":"10.1111/epi.13666"}],"title":"Frequency of CNKSR2 mutation in the X-linked epilepsy-aphasia spectrum.","publicationDate":"2017","journal":"Epilepsia","firstPage":"E40","lastPage":"E43","volume":"58"},"referencePositions":["INVOLVEMENT IN MRXSHG","VARIANT MRXSHG 712-ARG--VAL-1034 DEL"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF418269","properties":[{"key":"ProteinId","value":"AAL60502.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF418270","properties":[{"key":"ProteinId","value":"AAL60503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB020709","properties":[{"key":"ProteinId","value":"BAA74925.2"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK294728","properties":[{"key":"ProteinId","value":"BAG57875.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL928874","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL807781","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL772392","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471074","properties":[{"key":"ProteinId","value":"EAW98977.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC126121","properties":[{"key":"ProteinId","value":"AAI26122.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC136289","properties":[{"key":"ProteinId","value":"AAI36290.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC143839","properties":[{"key":"ProteinId","value":"AAI43840.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS14198.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WXI2-1"},{"database":"CCDS","id":"CCDS55387.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WXI2-2"},{"database":"CCDS","id":"CCDS55388.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WXI2-5"},{"database":"CCDS","id":"CCDS55389.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WXI2-4"},{"database":"RefSeq","id":"NP_001162118.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001168647.3"}],"isoformId":"Q8WXI2-5"},{"database":"RefSeq","id":"NP_001162119.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001168648.3"}],"isoformId":"Q8WXI2-2"},{"database":"RefSeq","id":"NP_001162120.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001168649.3"}],"isoformId":"Q8WXI2-4"},{"database":"RefSeq","id":"NP_055742.2","properties":[{"key":"NucleotideSequenceId","value":"NM_014927.5"}],"isoformId":"Q8WXI2-1"},{"database":"PDB","id":"2EAN","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=8-77"}]},{"database":"PDB","id":"3BS5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B=5-84"}]},{"database":"PDBsum","id":"2EAN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3BS5","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116534","properties":[{"key":"Interactions","value":"20"}]},{"database":"DIP","id":"DIP-29736N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8WXI2","properties":[{"key":"Number of interactors","value":"615"}]},{"database":"IntAct","id":"Q8WXI2","properties":[{"key":"Interactions","value":"87"}]},{"database":"MINT","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000368824","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1938216","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8WXI2","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CNKSR2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"50400586","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000368824","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"75059","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WXI2-1"},{"database":"ProteomicsDB","id":"75060","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WXI2-2"},{"database":"ProteomicsDB","id":"75061","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WXI2-4"},{"database":"ProteomicsDB","id":"75062","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WXI2-5"},{"database":"Antibodypedia","id":"456","properties":[{"key":"antibodies","value":"110 antibodies from 20 providers"}]},{"database":"DNASU","id":"22866","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000379510.5","properties":[{"key":"ProteinId","value":"ENSP00000368824.3"},{"key":"GeneId","value":"ENSG00000149970.16"}],"isoformId":"Q8WXI2-1"},{"database":"Ensembl","id":"ENST00000425654.7","properties":[{"key":"ProteinId","value":"ENSP00000397906.2"},{"key":"GeneId","value":"ENSG00000149970.16"}],"isoformId":"Q8WXI2-5"},{"database":"Ensembl","id":"ENST00000543067.6","properties":[{"key":"ProteinId","value":"ENSP00000444633.1"},{"key":"GeneId","value":"ENSG00000149970.16"}],"isoformId":"Q8WXI2-4"},{"database":"Ensembl","id":"ENST00000642359.1","properties":[{"key":"ProteinId","value":"ENSP00000496709.1"},{"key":"GeneId","value":"ENSG00000149970.16"}],"isoformId":"Q8WXI2-2"},{"database":"GeneID","id":"22866","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:22866","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000379510.5","properties":[{"key":"ProteinId","value":"ENSP00000368824.3"},{"key":"RefSeqNucleotideId","value":"NM_014927.5"},{"key":"RefSeqProteinId","value":"NP_055742.2"}]},{"database":"UCSC","id":"uc004czw.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8WXI2-1"},{"database":"AGR","id":"HGNC:19701","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134867759","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"22866","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"22866","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CNKSR2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:19701","properties":[{"key":"GeneName","value":"CNKSR2"}]},{"database":"HPA","id":"ENSG00000149970","properties":[{"key":"ExpressionPatterns","value":"Group enriched (brain, retina)"}]},{"database":"MalaCards","id":"CNKSR2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"300724","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"301008","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000149970","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"442835","properties":[{"key":"Disease","value":"Non-specific early-onset epileptic encephalopathy"}]},{"database":"Orphanet","id":"777","properties":[{"key":"Disease","value":"X-linked non-syndromic intellectual disability"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149970","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1738","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156709","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_013414_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"XAREGEV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"74412at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8WXI2","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-5674135","properties":[{"key":"PathwayName","value":"MAP2K and MAPK activation"}]},{"database":"Reactome","id":"R-HSA-6802946","properties":[{"key":"PathwayName","value":"Signaling by moderate kinase activity BRAF mutants"}]},{"database":"Reactome","id":"R-HSA-6802948","properties":[{"key":"PathwayName","value":"Signaling by high-kinase activity BRAF mutants"}]},{"database":"Reactome","id":"R-HSA-6802952","properties":[{"key":"PathwayName","value":"Signaling by BRAF and RAF1 fusions"}]},{"database":"Reactome","id":"R-HSA-6802955","properties":[{"key":"PathwayName","value":"Paradoxical activation of RAF signaling by kinase inactive BRAF"}]},{"database":"Reactome","id":"R-HSA-9649948","properties":[{"key":"PathwayName","value":"Signaling downstream of RAS mutants"}]},{"database":"Reactome","id":"R-HSA-9656223","properties":[{"key":"PathwayName","value":"Signaling by RAF1 mutants"}]},{"database":"SignaLink","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000149970","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"22866","properties":[{"key":"hits","value":"18 hits in 767 CRISPR screens"}]},{"database":"ChiTaRS","id":"CNKSR2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CNKSR2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"22866","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8WXI2","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8WXI2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"RNAct","id":"Q8WXI2","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000149970","properties":[{"key":"ExpressionPatterns","value":"Expressed in Brodmann (1909) area 23 and 149 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8WXI2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0099147","properties":[{"key":"GoTerm","value":"C:extrinsic component of postsynaptic density membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14597674"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0019901","properties":[{"key":"GoTerm","value":"F:protein kinase binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14597674"}]},{"database":"GO","id":"GO:0030674","properties":[{"key":"GoTerm","value":"F:protein-macromolecule adaptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007167","properties":[{"key":"GoTerm","value":"P:enzyme-linked receptor protein signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14597674"}]},{"database":"GO","id":"GO:0099084","properties":[{"key":"GoTerm","value":"P:postsynaptic specialization organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0009966","properties":[{"key":"GoTerm","value":"P:regulation of signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd06748","properties":[{"key":"EntryName","value":"PDZ_CNK1_2_3-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01260","properties":[{"key":"EntryName","value":"PH_CNK_mammalian-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd09511","properties":[{"key":"EntryName","value":"SAM_CNK1_2_3-suppressor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.50:FF:000019","properties":[{"key":"EntryName","value":"Connector enhancer of kinase suppressor of Ras 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000092","properties":[{"key":"EntryName","value":"Connector enhancer of kinase suppressor of Ras 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.42.10:FF:000060","properties":[{"key":"EntryName","value":"Connector enhancer of kinase suppressor of Ras 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.42.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.50","properties":[{"key":"EntryName","value":"Transcription Factor, Ets-1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR049628","properties":[{"key":"EntryName","value":"CNK1-3_SAM"}]},{"database":"InterPro","id":"IPR010599","properties":[{"key":"EntryName","value":"CNK2/3_dom"}]},{"database":"InterPro","id":"IPR051566","properties":[{"key":"EntryName","value":"CNKSR"}]},{"database":"InterPro","id":"IPR063211","properties":[{"key":"EntryName","value":"CNKSR_C"}]},{"database":"InterPro","id":"IPR017874","properties":[{"key":"EntryName","value":"CRIC_domain"}]},{"database":"InterPro","id":"IPR001478","properties":[{"key":"EntryName","value":"PDZ"}]},{"database":"InterPro","id":"IPR036034","properties":[{"key":"EntryName","value":"PDZ_sf"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR001660","properties":[{"key":"EntryName","value":"SAM"}]},{"database":"InterPro","id":"IPR013761","properties":[{"key":"EntryName","value":"SAM/pointed_sf"}]},{"database":"PANTHER","id":"PTHR12844","properties":[{"key":"EntryName","value":"CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12844:SF21","properties":[{"key":"EntryName","value":"CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06663","properties":[{"key":"EntryName","value":"CNK2_3_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30894","properties":[{"key":"EntryName","value":"CNKSR_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10534","properties":[{"key":"EntryName","value":"CRIC_ras_sig"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00595","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00536","properties":[{"key":"EntryName","value":"SAM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00228","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00454","properties":[{"key":"EntryName","value":"SAM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50156","properties":[{"key":"EntryName","value":"PDZ domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47769","properties":[{"key":"EntryName","value":"SAM/Pointed domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51290","properties":[{"key":"EntryName","value":"CRIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50106","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50105","properties":[{"key":"EntryName","value":"SAM_DOMAIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV","length":1034,"molWeight":117535,"crc64":"E43DB0D8D72D954C","md5":"84D04A558F38076DA0E69E3436193491"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":24,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"PTM":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":5,"Region":5,"Coiled coil":1,"Compositional bias":7,"Modified residue":9,"Alternative sequence":3,"Natural variant":2,"Helix":7},"uniParcId":"UPI0000070D72"}}