{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8WWF3","uniProtkbId":"SSMM1_HUMAN","entryAudit":{"firstPublicDate":"2007-01-09","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2002-03-01","entryVersion":132,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Serine-rich single-pass membrane protein 1"}}},"genes":[{"geneName":{"value":"SSMEM1"},"synonyms":[{"value":"C7orf45"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D9Y8"}],"value":"Essential for regulating the timely and localized migration of the Golgi apparatus during spermiogenesis, facilitating proper sperm head formation and motility, thus playing a crucial role in male fertility"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q92685","geneName":"ALG3","intActId":"EBI-2848814"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P02652","geneName":"APOA2","intActId":"EBI-1171525"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P29972","geneName":"AQP1","intActId":"EBI-745213"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96PS8","geneName":"AQP10","intActId":"EBI-12820279"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q92482","geneName":"AQP3","intActId":"EBI-2808854"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8WVX3-2","geneName":"ARLN","intActId":"EBI-12003442"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P27449","geneName":"ATP6V0C","intActId":"EBI-721179"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O15155","geneName":"BET1","intActId":"EBI-749204"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P62952","geneName":"BLCAP","intActId":"EBI-3895726"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96F05","geneName":"C11orf24","intActId":"EBI-2836238"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q86Z23","geneName":"C1QL4","intActId":"EBI-12062109"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P01031","geneName":"C5","intActId":"EBI-8558308"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8NHW4","geneName":"CCL4L2","intActId":"EBI-10271156"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O95674","geneName":"CDS2","intActId":"EBI-3913685"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"A0PK11","geneName":"CLRN2","intActId":"EBI-12813623"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96FZ5","geneName":"CMTM7","intActId":"EBI-2807956"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8N6G5","geneName":"CSGALNACT2","intActId":"EBI-10267100"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q07325","geneName":"CXCL9","intActId":"EBI-3911467"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P49447","geneName":"CYB561","intActId":"EBI-8646596"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9BQA9","geneName":"CYBC1","intActId":"EBI-2680384"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P81534","geneName":"DEFB103B","intActId":"EBI-12074168"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q5J5C9","geneName":"DEFB121","intActId":"EBI-10244198"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P52803","geneName":"EFNA5","intActId":"EBI-1753674"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q08426","geneName":"EHHADH","intActId":"EBI-2339219"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P50402","geneName":"EMD","intActId":"EBI-489887"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9UKR5","geneName":"ERG28","intActId":"EBI-711490"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q7Z2K6","geneName":"ERMP1","intActId":"EBI-10976398"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q92520","geneName":"FAM3C","intActId":"EBI-2876774"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q969F0","geneName":"FATE1","intActId":"EBI-743099"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P14324","geneName":"FDPS","intActId":"EBI-948245"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P25090","geneName":"FPR2","intActId":"EBI-17291771"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O43681","geneName":"GET3","intActId":"EBI-2515857"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P29033","geneName":"GJB2","intActId":"EBI-3905204"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q86YW7","geneName":"GPHB5","intActId":"EBI-11659720"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8TDV0","geneName":"GPR151","intActId":"EBI-11955647"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P30519","geneName":"HMOX2","intActId":"EBI-712096"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O43561-2","geneName":"LAT","intActId":"EBI-8070286"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O95214","geneName":"LEPROTL1","intActId":"EBI-750776"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9UIQ6-2","geneName":"LNPEP","intActId":"EBI-12133176"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9P0N8","geneName":"MARCHF2","intActId":"EBI-10317612"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96EZ8","geneName":"MCRS1","intActId":"EBI-348259"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q6NUT3-2","geneName":"MFSD12","intActId":"EBI-17295698"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q6N075","geneName":"MFSD5","intActId":"EBI-3920969"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q6ZSS7","geneName":"MFSD6","intActId":"EBI-2858252"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P30301","geneName":"MIP","intActId":"EBI-8449636"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8IY49-2","geneName":"MMD2","intActId":"EBI-13349813"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q5J8X5","geneName":"MS4A13","intActId":"EBI-12070086"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q0D2K0","geneName":"NIPAL4","intActId":"EBI-9550165"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8IXM6","geneName":"NRM","intActId":"EBI-10262547"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9UHJ9-5","geneName":"PGAP2","intActId":"EBI-12092917"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O14494","geneName":"PLPP1","intActId":"EBI-2865290"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q5VZY2","geneName":"PLPP4","intActId":"EBI-10485931"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8IY26","geneName":"PLPP6","intActId":"EBI-11721828"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96GM1","geneName":"PLPPR2","intActId":"EBI-12955265"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q59EV6","geneName":"PPGB","intActId":"EBI-14210385"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q02161-2","geneName":"RHD","intActId":"EBI-17249212"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q5QGT7","geneName":"RTP2","intActId":"EBI-10244780"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96GQ5","geneName":"RUSF1","intActId":"EBI-8636004"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9H228","geneName":"S1PR5","intActId":"EBI-2564169"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9Y6X1","geneName":"SERP1","intActId":"EBI-10329948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9BRI3","geneName":"SLC30A2","intActId":"EBI-8644112"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8IWU4","geneName":"SLC30A8","intActId":"EBI-10262251"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P78382","geneName":"SLC35A1","intActId":"EBI-12870360"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96G79","geneName":"SLC35A4","intActId":"EBI-12363689"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9NQQ7-3","geneName":"SLC35C2","intActId":"EBI-17295964"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q7Z769","geneName":"SLC35E3","intActId":"EBI-13389236"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9H2H9","geneName":"SLC38A1","intActId":"EBI-9978441"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9NVC3","geneName":"SLC38A7","intActId":"EBI-10314552"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9NP94","geneName":"SLC39A2","intActId":"EBI-12898013"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9NUM3","geneName":"SLC39A9","intActId":"EBI-2823239"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8IVJ1","geneName":"SLC41A1","intActId":"EBI-12266234"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96JW4","geneName":"SLC41A2","intActId":"EBI-10290130"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9UNK0","geneName":"STX8","intActId":"EBI-727240"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q03518","geneName":"TAP1","intActId":"EBI-747259"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9NYW0","geneName":"TAS2R10","intActId":"EBI-12963900"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96CP7","geneName":"TLCD1","intActId":"EBI-11337932"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9BZW4","geneName":"TM6SF2","intActId":"EBI-13082040"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q5BJH2-2","geneName":"TMEM128","intActId":"EBI-10694905"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q7Z5S9","geneName":"TMEM144","intActId":"EBI-12876358"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9Y6G1","geneName":"TMEM14A","intActId":"EBI-2800360"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9P0S9","geneName":"TMEM14C","intActId":"EBI-2339195"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q969S6","geneName":"TMEM203","intActId":"EBI-12274070"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"A2RU14","geneName":"TMEM218","intActId":"EBI-10173151"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9H0R3","geneName":"TMEM222","intActId":"EBI-347385"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8WW34-2","geneName":"TMEM239","intActId":"EBI-11528917"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9BU79","geneName":"TMEM243","intActId":"EBI-12887458"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9NWC5","geneName":"TMEM45A","intActId":"EBI-10823938"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9H2L4","geneName":"TMEM60","intActId":"EBI-2852148"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8N2M4","geneName":"TMEM86A","intActId":"EBI-12015604"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q8N661","geneName":"TMEM86B","intActId":"EBI-2548832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q5BJF2","geneName":"TMEM97","intActId":"EBI-12111910"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q6ZT21","geneName":"TMPPE","intActId":"EBI-11724433"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"P01375","geneName":"TNF","intActId":"EBI-359977"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"A5PKU2","geneName":"TUSC5","intActId":"EBI-11988865"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q9H1C4","geneName":"UNC93B1","intActId":"EBI-4401271"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O75841","geneName":"UPK1B","intActId":"EBI-12237619"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O75379","geneName":"VAMP4","intActId":"EBI-744953"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"Q96EC8","geneName":"YIPF6","intActId":"EBI-751210"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WWF3","intActId":"EBI-17280858"},"interactantTwo":{"uniProtKBAccession":"O95159","geneName":"ZFPL1","intActId":"EBI-718439"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32301969"}],"value":"Testis-specific"}],"commentType":"TISSUE SPECIFICITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Serine-rich single-pass membrane protein 1","featureId":"PRO_0000271354"},{"type":"Transmembrane","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Natural variant","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"in dbSNP:rs4728190","featureCrossReferences":[{"database":"dbSNP","id":"rs4728190"}],"featureId":"VAR_029873","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}}],"keywords":[{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0744","category":"Biological process","name":"Spermatogenesis"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"32301969","citationType":"journal article","authors":["Nozawa K.","Zhang Q.","Miyata H.","Devlin D.J.","Yu Z.","Oura S.","Koyano T.","Matsuyama M.","Ikawa M.","Matzuk M.M."],"citationCrossReferences":[{"database":"PubMed","id":"32301969"},{"database":"DOI","id":"10.1093/biolre/ioaa040"}],"title":"Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice.","publicationDate":"2020","journal":"Biol. Reprod.","firstPage":"244","lastPage":"253","volume":"103"},"referencePositions":["TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK097635","properties":[{"key":"ProteinId","value":"BAC05126.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC017587","properties":[{"key":"ProteinId","value":"AAH17587.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS5816.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_660311.1","properties":[{"key":"NucleotideSequenceId","value":"NM_145268.4"}]},{"database":"AlphaFoldDB","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"126451","properties":[{"key":"Interactions","value":"120"}]},{"database":"FunCoup","id":"Q8WWF3","properties":[{"key":"Number of interactors","value":"40"}]},{"database":"IntAct","id":"Q8WWF3","properties":[{"key":"Interactions","value":"145"}]},{"database":"STRING","id":"9606.ENSP00000297819","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SSMEM1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74730975","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000297819","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"74880","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"17943","properties":[{"key":"antibodies","value":"56 antibodies from 9 providers"}]},{"database":"DNASU","id":"136263","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000297819.4","properties":[{"key":"ProteinId","value":"ENSP00000297819.3"},{"key":"GeneId","value":"ENSG00000165120.5"}]},{"database":"GeneID","id":"136263","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:136263","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000297819.4","properties":[{"key":"ProteinId","value":"ENSP00000297819.3"},{"key":"RefSeqNucleotideId","value":"NM_145268.4"},{"key":"RefSeqProteinId","value":"NP_660311.1"}]},{"database":"UCSC","id":"uc003vpp.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:29580","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162380490","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"136263","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SSMEM1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:29580","properties":[{"key":"GeneName","value":"SSMEM1"}]},{"database":"HPA","id":"ENSG00000165120","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (testis)"}]},{"database":"MIM","id":"621366","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000165120","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000165120","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S512","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000015907","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_099475_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CQKDDSC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9367609at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8WWF3","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"136263","properties":[{"key":"hits","value":"15 hits in 1146 CRISPR screens"}]},{"database":"GenomeRNAi","id":"136263","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8WWF3","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8WWF3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q8WWF3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000165120","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 41 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8WWF3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0007283","properties":[{"key":"GoTerm","value":"P:spermatogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR027955","properties":[{"key":"EntryName","value":"DUF4636"}]},{"database":"PANTHER","id":"PTHR31822","properties":[{"key":"EntryName","value":"SERINE-RICH SINGLE-PASS MEMBRANE PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31822:SF1","properties":[{"key":"EntryName","value":"SERINE-RICH SINGLE-PASS MEMBRANE PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15468","properties":[{"key":"EntryName","value":"DUF4636"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGDLFSLFWEVDPPPIPVNCAIPNQDYECWKDDSCGTIGSFLLWYFVIVFVLMFFSRASVWMSEDKKDEGSGTSTSVRKASKETSCKRQSKDSAWDPSQTMKKPKQNQLTPVTNSEVALVNAYPEQRRARRQSQFNEVNQNQHDSDTTEYGSEESNSEASSWKESESEHHPSPDSIKRRKMAQRQRNLGSYQMSERHCLHCKALRTNEWLAHHSRQKPSVTPPMKRDSQEESSISDINKKFSKF","length":244,"molWeight":28167,"crc64":"14EB74E45FE0303D","md5":"30CFA5BB1D44670D9C359E1C5B0063F6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":99,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Region":3,"Compositional bias":4,"Natural variant":1},"uniParcId":"UPI00000706B0"}}