ID   UCMA_HUMAN              Reviewed;         138 AA.
AC   Q8WVF2;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   24-JAN-2024, entry version 135.
DE   RecName: Full=Unique cartilage matrix-associated protein;
DE   Contains:
DE     RecName: Full=Unique cartilage matrix-associated protein C-terminal fragment;
DE              Short=Ucma-C;
DE     AltName: Full=Gla-rich protein;
DE              Short=GRP;
DE   Flags: Precursor;
GN   Name=UCMA; Synonyms=C10orf49;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=16176871; DOI=10.1016/j.matbio.2005.08.002;
RA   Tagariello A., Schlaubitz S., Hankeln T., Mohrmann G., Stelzer C.,
RA   Schweizer A., Hermanns P., Lee B., Schmidt E.R., Winterpacht A., Zabel B.;
RT   "Expression profiling of human fetal growth plate cartilage by EST
RT   sequencing.";
RL   Matrix Biol. 24:530-538(2005).
CC   -!- FUNCTION: May be involved in the negative control of osteogenic
CC       differentiation of osteochondrogenic precursor cells in peripheral
CC       zones of fetal cartilage and at the cartilage-bone interface.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in resting chondrocytes.
CC       {ECO:0000269|PubMed:16176871}.
CC   -!- PTM: Proteolytically cleaved by a furin-like convertase to generate a
CC       persistent C-terminal fragment found in almost the entire cartilage
CC       matrix, and affecting osteoblast differentiation. {ECO:0000250}.
CC   -!- PTM: Sulfated on tyrosine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UCMA family. {ECO:0000305}.
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DR   EMBL; AL138764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC018068; AAH18068.2; -; mRNA.
DR   CCDS; CCDS31147.1; -.
DR   RefSeq; NP_001290047.1; NM_001303118.1.
DR   RefSeq; NP_001290048.1; NM_001303119.1.
DR   RefSeq; NP_660357.2; NM_145314.2.
DR   AlphaFoldDB; Q8WVF2; -.
DR   BioGRID; 128678; 1.
DR   STRING; 9606.ENSP00000367952; -.
DR   BioMuta; UCMA; -.
DR   DMDM; 68565241; -.
DR   PaxDb; 9606-ENSP00000367952; -.
DR   PeptideAtlas; Q8WVF2; -.
DR   Antibodypedia; 24782; 86 antibodies from 24 providers.
DR   DNASU; 221044; -.
DR   Ensembl; ENST00000378681.8; ENSP00000367952.3; ENSG00000165623.10.
DR   GeneID; 221044; -.
DR   KEGG; hsa:221044; -.
DR   MANE-Select; ENST00000378681.8; ENSP00000367952.3; NM_145314.3; NP_660357.2.
DR   UCSC; uc001imd.4; human.
DR   AGR; HGNC:25205; -.
DR   CTD; 221044; -.
DR   DisGeNET; 221044; -.
DR   GeneCards; UCMA; -.
DR   HGNC; HGNC:25205; UCMA.
DR   HPA; ENSG00000165623; Tissue enhanced (brain).
DR   neXtProt; NX_Q8WVF2; -.
DR   OpenTargets; ENSG00000165623; -.
DR   PharmGKB; PA164727494; -.
DR   VEuPathDB; HostDB:ENSG00000165623; -.
DR   eggNOG; ENOG502S1J9; Eukaryota.
DR   GeneTree; ENSGT00390000011492; -.
DR   InParanoid; Q8WVF2; -.
DR   OMA; TMLQEGT; -.
DR   OrthoDB; 4230712at2759; -.
DR   PhylomeDB; Q8WVF2; -.
DR   TreeFam; TF332568; -.
DR   PathwayCommons; Q8WVF2; -.
DR   Reactome; R-HSA-8940973; RUNX2 regulates osteoblast differentiation.
DR   SignaLink; Q8WVF2; -.
DR   BioGRID-ORCS; 221044; 17 hits in 1139 CRISPR screens.
DR   ChiTaRS; UCMA; human.
DR   GenomeRNAi; 221044; -.
DR   Pharos; Q8WVF2; Tbio.
DR   PRO; PR:Q8WVF2; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q8WVF2; Protein.
DR   Bgee; ENSG00000165623; Expressed in cartilage tissue and 43 other cell types or tissues.
DR   ExpressionAtlas; Q8WVF2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0036122; F:BMP binding; IDA:MGI.
DR   GO; GO:0048706; P:embryonic skeletal system development; IBA:GO_Central.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; IEA:Ensembl.
DR   GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR   InterPro; IPR031386; UCMA.
DR   PANTHER; PTHR28647; UNIQUE CARTILAGE MATRIX-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR28647:SF2; UNIQUE CARTILAGE MATRIX-ASSOCIATED PROTEIN; 1.
DR   Pfam; PF17085; UCMA; 1.
DR   Genevisible; Q8WVF2; HS.
PE   2: Evidence at transcript level;
KW   Coiled coil; Extracellular matrix; Reference proteome; Secreted; Signal;
KW   Sulfation.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..138
FT                   /note="Unique cartilage matrix-associated protein"
FT                   /id="PRO_0000019549"
FT   PROPEP          28..64
FT                   /note="Ucma-N"
FT                   /id="PRO_0000347063"
FT   CHAIN           65..138
FT                   /note="Unique cartilage matrix-associated protein C-
FT                   terminal fragment"
FT                   /id="PRO_0000347064"
FT   COILED          90..122
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   138 AA;  16563 MW;  DFCF8D3DA9B36F23 CRC64;
     MTWRQAVLLS CFSAVVLLSM LREGTSVSVG TMQMAGEEAS EDAKQKIFMQ ESDASNFLKR
     RGKRSPKSRD EVNVENRQKL RVDELRREYY EEQRNEFENF VEEQNDEQEE RSREAVEQWR
     QWHYDGLHPS YLYNRHHT
//