ID UCMA_HUMAN Reviewed; 138 AA. AC Q8WVF2; DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 11-OCT-2004, sequence version 2. DT 27-NOV-2024, entry version 139. DE RecName: Full=Unique cartilage matrix-associated protein; DE Contains: DE RecName: Full=Unique cartilage matrix-associated protein C-terminal fragment; DE Short=Ucma-C; DE AltName: Full=Gla-rich protein; DE Short=GRP; DE Flags: Precursor; GN Name=UCMA; Synonyms=C10orf49; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Hypothalamus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP TISSUE SPECIFICITY. RX PubMed=16176871; DOI=10.1016/j.matbio.2005.08.002; RA Tagariello A., Schlaubitz S., Hankeln T., Mohrmann G., Stelzer C., RA Schweizer A., Hermanns P., Lee B., Schmidt E.R., Winterpacht A., Zabel B.; RT "Expression profiling of human fetal growth plate cartilage by EST RT sequencing."; RL Matrix Biol. 24:530-538(2005). CC -!- FUNCTION: May be involved in the negative control of osteogenic CC differentiation of osteochondrogenic precursor cells in peripheral CC zones of fetal cartilage and at the cartilage-bone interface. CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Predominantly expressed in resting chondrocytes. CC {ECO:0000269|PubMed:16176871}. CC -!- PTM: Proteolytically cleaved by a furin-like convertase to generate a CC persistent C-terminal fragment found in almost the entire cartilage CC matrix, and affecting osteoblast differentiation. {ECO:0000250}. CC -!- PTM: Sulfated on tyrosine residues. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the UCMA family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL138764; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC018068; AAH18068.2; -; mRNA. DR CCDS; CCDS31147.1; -. DR RefSeq; NP_001290047.1; NM_001303118.1. DR RefSeq; NP_001290048.1; NM_001303119.1. DR RefSeq; NP_660357.2; NM_145314.2. DR AlphaFoldDB; Q8WVF2; -. DR BioGRID; 128678; 1. DR STRING; 9606.ENSP00000367952; -. DR BioMuta; UCMA; -. DR DMDM; 68565241; -. DR PaxDb; 9606-ENSP00000367952; -. DR PeptideAtlas; Q8WVF2; -. DR Antibodypedia; 24782; 77 antibodies from 23 providers. DR DNASU; 221044; -. DR Ensembl; ENST00000378681.8; ENSP00000367952.3; ENSG00000165623.10. DR GeneID; 221044; -. DR KEGG; hsa:221044; -. DR MANE-Select; ENST00000378681.8; ENSP00000367952.3; NM_145314.3; NP_660357.2. DR UCSC; uc001imd.4; human. DR AGR; HGNC:25205; -. DR CTD; 221044; -. DR DisGeNET; 221044; -. DR GeneCards; UCMA; -. DR HGNC; HGNC:25205; UCMA. DR HPA; ENSG00000165623; Tissue enhanced (brain). DR neXtProt; NX_Q8WVF2; -. DR OpenTargets; ENSG00000165623; -. DR PharmGKB; PA164727494; -. DR VEuPathDB; HostDB:ENSG00000165623; -. DR eggNOG; ENOG502S1J9; Eukaryota. DR GeneTree; ENSGT00390000011492; -. DR InParanoid; Q8WVF2; -. DR OMA; TMLQEGT; -. DR OrthoDB; 4230712at2759; -. DR PhylomeDB; Q8WVF2; -. DR TreeFam; TF332568; -. DR PathwayCommons; Q8WVF2; -. DR Reactome; R-HSA-8940973; RUNX2 regulates osteoblast differentiation. DR SignaLink; Q8WVF2; -. DR BioGRID-ORCS; 221044; 17 hits in 1139 CRISPR screens. DR ChiTaRS; UCMA; human. DR GenomeRNAi; 221044; -. DR Pharos; Q8WVF2; Tbio. DR PRO; PR:Q8WVF2; -. DR Proteomes; UP000005640; Chromosome 10. DR RNAct; Q8WVF2; protein. DR Bgee; ENSG00000165623; Expressed in cartilage tissue and 43 other cell types or tissues. DR ExpressionAtlas; Q8WVF2; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0036122; F:BMP binding; IDA:MGI. DR GO; GO:0048706; P:embryonic skeletal system development; IBA:GO_Central. DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl. DR GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; IEA:Ensembl. DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl. DR InterPro; IPR031386; UCMA. DR PANTHER; PTHR28647; UNIQUE CARTILAGE MATRIX-ASSOCIATED PROTEIN; 1. DR PANTHER; PTHR28647:SF2; UNIQUE CARTILAGE MATRIX-ASSOCIATED PROTEIN; 1. DR Pfam; PF17085; UCMA; 1. PE 1: Evidence at protein level; KW Coiled coil; Extracellular matrix; Proteomics identification; KW Reference proteome; Secreted; Signal; Sulfation. FT SIGNAL 1..26 FT /evidence="ECO:0000255" FT CHAIN 27..138 FT /note="Unique cartilage matrix-associated protein" FT /id="PRO_0000019549" FT PROPEP 28..64 FT /note="Ucma-N" FT /id="PRO_0000347063" FT CHAIN 65..138 FT /note="Unique cartilage matrix-associated protein C- FT terminal fragment" FT /id="PRO_0000347064" FT COILED 90..122 FT /evidence="ECO:0000255" SQ SEQUENCE 138 AA; 16563 MW; DFCF8D3DA9B36F23 CRC64; MTWRQAVLLS CFSAVVLLSM LREGTSVSVG TMQMAGEEAS EDAKQKIFMQ ESDASNFLKR RGKRSPKSRD EVNVENRQKL RVDELRREYY EEQRNEFENF VEEQNDEQEE RSREAVEQWR QWHYDGLHPS YLYNRHHT //