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May play an important role in BCR-induced B-cell apoptosis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16912232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18369315"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21930792"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9341187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9697839"}],"value":"Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2. Interacts through its SH2 domain with CD79A. Interacts (via SH2 domain) with SYK; phosphorylated and activated by SYK. Interacts (via SH2 domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-131' (PubMed:21930792)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8WV28","intActId":"EBI-2623522"},"interactantTwo":{"uniProtKBAccession":"P10275","geneName":"AR","intActId":"EBI-608057"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WV28","intActId":"EBI-2623522"},"interactantTwo":{"uniProtKBAccession":"Q06187","geneName":"BTK","intActId":"EBI-624835"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WV28","intActId":"EBI-2623522"},"interactantTwo":{"uniProtKBAccession":"Q9Y5K6","geneName":"CD2AP","intActId":"EBI-298152"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WV28","intActId":"EBI-2623522"},"interactantTwo":{"uniProtKBAccession":"P62993","geneName":"GRB2","intActId":"EBI-401755"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WV28","intActId":"EBI-2623522"},"interactantTwo":{"uniProtKBAccession":"P10721","geneName":"KIT","intActId":"EBI-1379503"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8WV28","intActId":"EBI-2623522"},"interactantTwo":{"uniProtKBAccession":"Q5ZMQ7","geneName":"RCJMB04_1g20","intActId":"EBI-7061433"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"BCR activation results in the translocation to membrane fraction"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9697839"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9697839"}],"value":"Cell membrane","id":"SL-0039"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8WV28-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8WV28-2"],"sequenceIds":["VSP_016178"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8WV28-3"],"sequenceIds":["VSP_045324"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Expressed in B-cell lineage and fibroblast cell lines (at protein level). 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