{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8WU39","secondaryAccessions":["D2IYS0","Q7Z6N2","Q96RL5","Q9P0T3"],"uniProtkbId":"MZB1_HUMAN","entryAudit":{"firstPublicDate":"2008-02-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-01","entryVersion":149,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Marginal zone B- and B1-cell-specific protein"}},"alternativeNames":[{"fullName":{"value":"Mesenteric estrogen-dependent adipose 7"},"shortNames":[{"value":"MEDA-7"}]},{"fullName":{"value":"Plasma cell-induced resident endoplasmic reticulum protein"},"shortNames":[{"value":"Plasma cell-induced resident ER protein"},{"value":"pERp1"}]},{"fullName":{"value":"Proapoptotic caspase adapter protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"MZB1"},"synonyms":[{"value":"MEDA7"},{"value":"PACAP"}],"orfNames":[{"value":"HSPC190"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11350957"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21688198"}],"value":"Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation"}],"commentType":"FUNCTION"},{"texts":[{"value":"Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8WU39","intActId":"EBI-7212043"},"interactantTwo":{"uniProtKBAccession":"Q99816","geneName":"TSG101","intActId":"EBI-346882"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}],"value":"Endoplasmic reticulum lumen","id":"SL-0096"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21688198"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","note":{"texts":[{"value":"Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11350957"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8WU39-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8WU39-2"],"sequenceIds":["VSP_031281"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8WU39-3"],"sequenceIds":["VSP_031280","VSP_038332"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8WU39-4"],"sequenceIds":["VSP_038333","VSP_038334"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q8WU39-5"],"sequenceIds":["VSP_039073","VSP_039074"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11350957"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12792799"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}],"value":"Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11350957"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21688198"}],"value":"Down-regulated in primary B-cells early after ligand-stimulated activation. Up-regulated in bacterial lipopolysaccharides (LPS)-stimulated peritoneal macrophages"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Forms an interchain disulfide bond with IgM monomers"}],"commentType":"PTM"},{"texts":[{"value":"Major"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MZB1 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous translation","sequence":"AAF36110.1","note":"Wrong choice of frame.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Marginal zone B- and B1-cell-specific protein","featureId":"PRO_0000318740"},{"type":"Motif","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Prevents secretion from ER","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10138"}]},{"type":"Disulfide bond","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_031280","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11350957"}],"featureId":"VSP_031281","alternativeSequence":{"originalSequence":"MWQNLAKAETKLHTSNSGGRRELSELVYTDVLDRSCSRNWQDYGVREVDQVKRLTGPGLSEGPEPSISVMVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQQGRGALEALLCGGPQGACSEKVSATREEL","alternativeSequences":["SLLVPDVAKSGKGRDQTSYLKLWGAAGAERVGLHGCPGPELLPELAGLRSSRSGPSETSHRPRT"]}},{"type":"Alternative sequence","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11042152"}],"featureId":"VSP_038333","alternativeSequence":{"originalSequence":"MWQNLAKAETKLHTSN","alternativeSequences":["RLCSYPPHLPLTEQQS"]}},{"type":"Alternative sequence","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_039073","alternativeSequence":{"originalSequence":"MWQ","alternativeSequences":["AHP"]}},{"type":"Alternative sequence","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_039074","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11042152"}],"featureId":"VSP_038334","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_038332","alternativeSequence":{"originalSequence":"RSCSRNWQD","alternativeSequences":["MPAELWLTS"]}},{"type":"Mutagenesis","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Does not affect activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"No significant activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"No significant activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"No significant activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"No significant activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Does not affect activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Helix","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Helix","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Helix","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Beta strand","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Beta strand","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Beta strand","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Helix","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Helix","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Helix","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]},{"type":"Helix","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AAH"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11350957","citationType":"journal article","authors":["Bonfoco E.","Li E.","Kolbinger F.","Cooper N.R."],"citationCrossReferences":[{"database":"PubMed","id":"11350957"},{"database":"DOI","id":"10.1074/jbc.m100684200"}],"title":"Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"29242","lastPage":"29250","volume":"276"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","INDUCTION","INTERACTION WITH CASP2 AND CASP9"]},{"referenceNumber":2,"citation":{"id":"11042152","citationType":"journal article","authors":["Zhang Q.-H.","Ye M.","Wu X.-Y.","Ren S.-X.","Zhao M.","Zhao C.-J.","Fu G.","Shen Y.","Fan H.-Y.","Lu G.","Zhong M.","Xu X.-R.","Han Z.-G.","Zhang J.-W.","Tao J.","Huang Q.-H.","Zhou J.","Hu G.-X.","Gu J.","Chen S.-J.","Chen Z."],"citationCrossReferences":[{"database":"PubMed","id":"11042152"},{"database":"DOI","id":"10.1101/gr.140200"}],"title":"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.","publicationDate":"2000","journal":"Genome Res.","firstPage":"1546","lastPage":"1560","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)"],"referenceComments":[{"value":"Umbilical cord blood","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"19805157","citationType":"journal article","authors":["Shimizu Y.","Meunier L.","Hendershot L.M."],"citationCrossReferences":[{"database":"PubMed","id":"19805157"},{"database":"DOI","id":"10.1073/pnas.0811591106"}],"title":"pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"17013","lastPage":"17018","volume":"106"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","MUTAGENESIS OF CYS-50; CYS-53; CYS-95; CYS-143; CYS-171 AND CYS-178"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)"]},{"referenceNumber":6,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.-F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)"],"referenceComments":[{"value":"B-cell","type":"TISSUE"},{"value":"Lymph","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"12792799","citationType":"journal article","authors":["Katoh M.","Katoh M."],"citationCrossReferences":[{"database":"PubMed","id":"12792799"},{"database":"DOI","id":"10.3892/ijo.23.1.235"}],"title":"MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues.","publicationDate":"2003","journal":"Int. J. Oncol.","firstPage":"235","lastPage":"241","volume":"23"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":9,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":10,"citation":{"id":"21688198","citationType":"journal article","authors":["Zhang H.","Chen X.","Sairam M.R."],"citationCrossReferences":[{"database":"PubMed","id":"21688198"},{"database":"DOI","id":"10.1007/s00125-011-2212-7"}],"title":"Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA-7: implications for obesity, insulin resistance and the metabolic syndrome.","publicationDate":"2011","journal":"Diabetologia","firstPage":"2368","lastPage":"2380","volume":"54"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF338109","properties":[{"key":"ProteinId","value":"AAK84085.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF151024","properties":[{"key":"ProteinId","value":"AAF36110.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BP366737","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"GQ477350","properties":[{"key":"ProteinId","value":"ACY74343.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK292706","properties":[{"key":"ProteinId","value":"BAF85395.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL698690","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC135457","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC009931","properties":[{"key":"ProteinId","value":"AAH09931.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC021275","properties":[{"key":"ProteinId","value":"AAH21275.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS47273.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WU39-1"},{"database":"RefSeq","id":"NP_057543.2","properties":[{"key":"NucleotideSequenceId","value":"NM_016459.4"}],"isoformId":"Q8WU39-1"},{"database":"PDB","id":"7AAH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=23-185"}]},{"database":"PDBsum","id":"7AAH","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"119399","properties":[{"key":"Interactions","value":"13"}]},{"database":"FunCoup","id":"Q8WU39","properties":[{"key":"Number of interactors","value":"52"}]},{"database":"IntAct","id":"Q8WU39","properties":[{"key":"Interactions","value":"10"}]},{"database":"MINT","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000303920","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8WU39","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (4 sites)"}]},{"database":"iPTMnet","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MZB1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74730663","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000303920","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"74625","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WU39-1"},{"database":"ProteomicsDB","id":"74626","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WU39-2"},{"database":"ProteomicsDB","id":"74627","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WU39-3"},{"database":"ProteomicsDB","id":"74628","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WU39-4"},{"database":"Antibodypedia","id":"26772","properties":[{"key":"antibodies","value":"130 antibodies from 26 providers"}]},{"database":"DNASU","id":"51237","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000302125.9","properties":[{"key":"ProteinId","value":"ENSP00000303920.8"},{"key":"GeneId","value":"ENSG00000170476.16"}],"isoformId":"Q8WU39-1"},{"database":"Ensembl","id":"ENST00000417694.6","properties":[{"key":"ProteinId","value":"ENSP00000415420.2"},{"key":"GeneId","value":"ENSG00000170476.16"}],"isoformId":"Q8WU39-4"},{"database":"Ensembl","id":"ENST00000503481.5","properties":[{"key":"ProteinId","value":"ENSP00000423205.1"},{"key":"GeneId","value":"ENSG00000170476.16"}],"isoformId":"Q8WU39-2"},{"database":"GeneID","id":"51237","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:51237","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000302125.9","properties":[{"key":"ProteinId","value":"ENSP00000303920.8"},{"key":"RefSeqNucleotideId","value":"NM_016459.4"},{"key":"RefSeqProteinId","value":"NP_057543.2"}]},{"database":"UCSC","id":"uc003lei.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8WU39-1"},{"database":"AGR","id":"HGNC:30125","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"51237","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"51237","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MZB1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:30125","properties":[{"key":"GeneName","value":"MZB1"}]},{"database":"HPA","id":"ENSG00000170476","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (intestine, lymphoid tissue)"}]},{"database":"MIM","id":"609447","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000170476","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000170476","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S4B7","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002716","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2014477_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QNWQDYG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"448621at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8WU39","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000170476","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"51237","properties":[{"key":"hits","value":"12 hits in 1141 CRISPR screens"}]},{"database":"ChiTaRS","id":"MZB1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"51237","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8WU39","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8WU39","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q8WU39","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000170476","properties":[{"key":"ExpressionPatterns","value":"Expressed in thymus and 135 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8WU39","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11350957"}]},{"database":"GO","id":"GO:0034663","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum chaperone complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005788","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum lumen"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19805157"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21688198"}]},{"database":"GO","id":"GO:0033622","properties":[{"key":"GoTerm","value":"P:integrin activation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0002639","properties":[{"key":"GoTerm","value":"P:positive regulation of immunoglobulin production"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030888","properties":[{"key":"GoTerm","value":"P:regulation of B cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042127","properties":[{"key":"GoTerm","value":"P:regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046626","properties":[{"key":"GoTerm","value":"P:regulation of insulin receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR021852","properties":[{"key":"EntryName","value":"DUF3456"}]},{"database":"InterPro","id":"IPR052682","properties":[{"key":"EntryName","value":"MZB1"}]},{"database":"PANTHER","id":"PTHR15881","properties":[{"key":"EntryName","value":"MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15881:SF2","properties":[{"key":"EntryName","value":"MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11938","properties":[{"key":"EntryName","value":"DUF3456"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00014","properties":[{"key":"EntryName","value":"ER_TARGET"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRLSLPLLLLLLGAWAIPGGLGDRAPLTATAPQLDDEEMYSAHMPAHLRCDACRAVAYQMWQNLAKAETKLHTSNSGGRRELSELVYTDVLDRSCSRNWQDYGVREVDQVKRLTGPGLSEGPEPSISVMVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQQGRGALEALLCGGPQGACSEKVSATREEL","length":189,"molWeight":20694,"crc64":"C71AED212D3393D3","md5":"0AB7234A328A230CD3EC17DDBBB7FDE2"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":2,"ALTERNATIVE PRODUCTS":5,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Motif":1,"Disulfide bond":3,"Alternative sequence":7,"Mutagenesis":6,"Helix":7,"Beta strand":3},"uniParcId":"UPI0000035F67"}}