{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8W4K1","secondaryAccessions":["Q9S9V3"],"uniProtkbId":"TYW23_ARATH","entryAudit":{"firstPublicDate":"2007-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-01","entryVersion":148,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"tRNA wybutosine-synthesizing protein 2/3/4"}},"includes":[{"recommendedName":{"fullName":{"value":"tRNA wybutosine-synthesizing protein 3 homolog"},"shortNames":[{"value":"tRNA-yW-synthesizing protein 3"}],"ecNumbers":[{"value":"2.1.1.282"}]},"alternativeNames":[{"fullName":{"value":"tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase"}}]},{"recommendedName":{"fullName":{"value":"tRNA wybutosine-synthesizing protein 2 homolog"},"shortNames":[{"value":"tRNA-yW-synthesizing protein 2"}],"ecNumbers":[{"value":"2.5.1.114"}]},"alternativeNames":[{"fullName":{"value":"tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase"}}]}]},"genes":[{"orderedLocusNames":[{"value":"At4g04670"}],"orfNames":[{"value":"T19J18.2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36635"},{"database":"Rhea","id":"RHEA-COMP:10378"},{"database":"Rhea","id":"RHEA-COMP:10379"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:73543"},{"database":"ChEBI","id":"CHEBI:73550"}],"ecNumber":"2.1.1.282"}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36355"},{"database":"Rhea","id":"RHEA-COMP:10164"},{"database":"Rhea","id":"RHEA-COMP:10378"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17509"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:64315"},{"database":"ChEBI","id":"CHEBI:73550"}],"ecNumber":"2.5.1.114"}},{"texts":[{"value":"tRNA modification; wybutosine-tRNA(Phe) biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"In the C-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"In the N-terminal section; belongs to the TYW3 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"In plants, methylation steps 2, 3 and 4 of wybutosine biosynthesis are probably processed by the this multifunctional enzyme, while in other eukaryotes, these steps are mediated by 3 different proteins"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAD48952.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"CAB80832.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":995,"modifier":"EXACT"}},"description":"tRNA wybutosine-synthesizing protein 2/3/4","featureId":"PRO_0000281849"},{"type":"Repeat","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Kelch 1"},{"type":"Repeat","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"Kelch 2"},{"type":"Repeat","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"Kelch 3"},{"type":"Repeat","location":{"start":{"value":437,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"Kelch 4"},{"type":"Repeat","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":535,"modifier":"EXACT"}},"description":"Kelch 5"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"tRNA wybutosine-synthesizing protein 3 homolog"},{"type":"Region","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":995,"modifier":"EXACT"}},"description":"tRNA wybutosine-synthesizing protein 2 homolog"},{"type":"Binding site","location":{"start":{"value":828,"modifier":"EXACT"},"end":{"value":828,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01021"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":896,"modifier":"EXACT"},"end":{"value":897,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01021"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}}],"keywords":[{"id":"KW-0880","category":"Domain","name":"Kelch repeat"},{"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0819","category":"Biological process","name":"tRNA processing"}],"references":[{"referenceNumber":1,"citation":{"id":"10617198","citationType":"journal article","authors":["Mayer K.F.X.","Schueller C.","Wambutt R.","Murphy G.","Volckaert G.","Pohl T.","Duesterhoeft A.","Stiekema W.","Entian K.-D.","Terryn N.","Harris B.","Ansorge W.","Brandt P.","Grivell L.A.","Rieger M.","Weichselgartner M.","de Simone V.","Obermaier B.","Mache R.","Mueller M.","Kreis M.","Delseny M.","Puigdomenech P.","Watson M.","Schmidtheini T.","Reichert B.","Portetelle D.","Perez-Alonso M.","Boutry M.","Bancroft I.","Vos P.","Hoheisel J.","Zimmermann W.","Wedler H.","Ridley P.","Langham S.-A.","McCullagh B.","Bilham L.","Robben J.","van der Schueren J.","Grymonprez B.","Chuang Y.-J.","Vandenbussche F.","Braeken M.","Weltjens I.","Voet M.","Bastiaens I.","Aert R.","Defoor E.","Weitzenegger T.","Bothe G.","Ramsperger U.","Hilbert H.","Braun M.","Holzer E.","Brandt A.","Peters S.","van Staveren M.","Dirkse W.","Mooijman P.","Klein Lankhorst R.","Rose M.","Hauf J.","Koetter P.","Berneiser S.","Hempel S.","Feldpausch M.","Lamberth S.","Van den Daele H.","De Keyser A.","Buysshaert C.","Gielen J.","Villarroel R.","De Clercq R.","van Montagu M.","Rogers J.","Cronin A.","Quail M.A.","Bray-Allen S.","Clark L.","Doggett J.","Hall S.","Kay M.","Lennard N.","McLay K.","Mayes R.","Pettett A.","Rajandream M.A.","Lyne M.","Benes V.","Rechmann S.","Borkova D.","Bloecker H.","Scharfe M.","Grimm M.","Loehnert T.-H.","Dose S.","de Haan M.","Maarse A.C.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Fartmann B.","Granderath K.","Dauner D.","Herzl A.","Neumann S.","Argiriou A.","Vitale D.","Liguori R.","Piravandi E.","Massenet O.","Quigley F.","Clabauld G.","Muendlein A.","Felber R.","Schnabl S.","Hiller R.","Schmidt W.","Lecharny A.","Aubourg S.","Chefdor F.","Cooke R.","Berger C.","Monfort A.","Casacuberta E.","Gibbons T.","Weber N.","Vandenbol M.","Bargues M.","Terol J.","Torres A.","Perez-Perez A.","Purnelle B.","Bent E.","Johnson S.","Tacon D.","Jesse T.","Heijnen L.","Schwarz S.","Scholler P.","Heber S.","Francs P.","Bielke C.","Frishman D.","Haase D.","Lemcke K.","Mewes H.-W.","Stocker S.","Zaccaria P.","Bevan M.","Wilson R.K.","de la Bastide M.","Habermann K.","Parnell L.","Dedhia N.","Gnoj L.","Schutz K.","Huang E.","Spiegel L.","Sekhon M.","Murray J.","Sheet P.","Cordes M.","Abu-Threideh J.","Stoneking T.","Kalicki J.","Graves T.","Harmon G.","Edwards J.","Latreille P.","Courtney L.","Cloud J.","Abbott A.","Scott K.","Johnson D.","Minx P.","Bentley D.","Fulton B.","Miller N.","Greco T.","Kemp K.","Kramer J.","Fulton L.","Mardis E.","Dante M.","Pepin K.","Hillier L.W.","Nelson J.","Spieth J.","Ryan E.","Andrews S.","Geisel C.","Layman D.","Du H.","Ali J.","Berghoff A.","Jones K.","Drone K.","Cotton M.","Joshu C.","Antonoiu B.","Zidanic M.","Strong C.","Sun H.","Lamar B.","Yordan C.","Ma P.","Zhong J.","Preston R.","Vil D.","Shekher M.","Matero A.","Shah R.","Swaby I.K.","O'Shaughnessy A.","Rodriguez M.","Hoffman J.","Till S.","Granat S.","Shohdy N.","Hasegawa A.","Hameed A.","Lodhi M.","Johnson A.","Chen E.","Marra M.A.","Martienssen R.","McCombie W.R."],"citationCrossReferences":[{"database":"PubMed","id":"10617198"},{"database":"DOI","id":"10.1038/47134"}],"title":"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.","publicationDate":"1999","journal":"Nature","firstPage":"769","lastPage":"777","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF149414","properties":[{"key":"ProteinId","value":"AAD48952.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161501","properties":[{"key":"ProteinId","value":"CAB80832.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002687","properties":[{"key":"ProteinId","value":"AEE82410.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408686","properties":[{"key":"ProteinId","value":"CAO7046152.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY062510","properties":[{"key":"ProteinId","value":"AAL32588.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT008367","properties":[{"key":"ProteinId","value":"AAP37726.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"H85058","properties":[{"key":"EntryName","value":"H85058"}]},{"database":"RefSeq","id":"NP_567268.2","properties":[{"key":"NucleotideSequenceId","value":"NM_116705.5"}]},{"database":"AlphaFoldDB","id":"Q8W4K1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8W4K1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8W4K1","properties":[{"key":"Number of interactors","value":"1119"}]},{"database":"STRING","id":"3702.Q8W4K1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q8W4K1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"242603","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"825800","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT4G04670","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT4G04670","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT4G04670","properties":[{"key":"GeneName","value":"TRM5C"}]},{"database":"eggNOG","id":"KOG0379","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG1227","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG1228","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_006768_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8W4K1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AVECKDL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"Q8W4K1","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00375","properties":[{"key":"RectionId","value":"-"}]},{"database":"PRO","id":"PR:Q8W4K1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0102522","properties":[{"key":"GoTerm","value":"F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0031591","properties":[{"key":"GoTerm","value":"P:wybutosine biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"16642040"}]},{"database":"CDD","id":"cd02440","properties":[{"key":"EntryName","value":"AdoMet_MTases"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.120.10.80:FF:000128","properties":[{"key":"EntryName","value":"tRNA wybutosine-synthesizing protein 2/3/4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1960.10:FF:000002","properties":[{"key":"EntryName","value":"tRNA wybutosine-synthesizing protein 2/3/4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.300.110:FF:000003","properties":[{"key":"EntryName","value":"tRNA wybutosine-synthesizing protein 2/3/4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.150:FF:000131","properties":[{"key":"EntryName","value":"tRNA wybutosine-synthesizing protein 2/3/4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.120.10.80","properties":[{"key":"EntryName","value":"Kelch-type beta propeller"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.300.110","properties":[{"key":"EntryName","value":"Met-10+ protein-like domains"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1960.10","properties":[{"key":"EntryName","value":"tRNA wybutosine-synthesizing-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR015915","properties":[{"key":"EntryName","value":"Kelch-typ_b-propeller"}]},{"database":"InterPro","id":"IPR030382","properties":[{"key":"EntryName","value":"MeTrfase_TRM5/TYW2"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"InterPro","id":"IPR056743","properties":[{"key":"EntryName","value":"TRM5-TYW2-like_MTfase"}]},{"database":"InterPro","id":"IPR056744","properties":[{"key":"EntryName","value":"TRM5/TYW2-like_N"}]},{"database":"InterPro","id":"IPR003827","properties":[{"key":"EntryName","value":"tRNA_yW-synthesising"}]},{"database":"InterPro","id":"IPR036602","properties":[{"key":"EntryName","value":"tRNA_yW-synthesising-like_sf"}]},{"database":"PANTHER","id":"PTHR23245","properties":[{"key":"EntryName","value":"TRNA METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23245:SF25","properties":[{"key":"EntryName","value":"TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24681","properties":[{"key":"EntryName","value":"Kelch_KLHDC2_KLHL20_DRC7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02475","properties":[{"key":"EntryName","value":"TRM5-TYW2_MTfase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25133","properties":[{"key":"EntryName","value":"TYW2_N_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02676","properties":[{"key":"EntryName","value":"TYW3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF117281","properties":[{"key":"EntryName","value":"Kelch motif"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF111278","properties":[{"key":"EntryName","value":"SSo0622-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51684","properties":[{"key":"EntryName","value":"SAM_MT_TRM5_TYW2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDFEKRKAATLASIRSSVTDKSPKGFLDEPIIPLLETINHHPSYFTTSSCSGRISILSQPKPKSNDSTKKKARGGSWLYITHDPADSDLVISLLFPSKSNQIDPIDQPSELVFRFEPLIIAVECKDLGSAQFLVALAISAGFRESGITSCGDGKRVIIAIRCSIRMEVPIGDTEKLMVSPEYVKFLVDIANEKMDANRKRTDGFSVALASNGFKNPDENDVDEDDNYENLAANHDSSINNGNLYPGVQKELIPLEKLSIVGEPVEKLHLWGHSACTIDESDRKEVIVFGGFGGFGRHARRNESLLLNPSCGTLKLIAVNESPSARLGHTASMVGDFMFVIGGRADPLNILNDVWRLDISTGEWSSQRCVGSEFPPRHRHAAASVGTKVYIFGGLYNDKIVSSMHILDTKDLQWKEVEQQGQWPCARHSHAMVAYGSQSFMFGGYNGENVLNDLYSFDVQSCSWKLEVISGKWPHARFSHSMFVYKHTIGIIGGCPVSQNCQELTLLDLKHRLWRSVRLEFMNKELFVRSTASILGDDLIVIGGGAACYAFGTKFSEPVKINLVQSVTMSENHLPPQPEDVSLESNKNNADLKTETSLSQPWVIQLERKYAKFGKDILKSFGWLDLERKVYSNEKGLCICFPVTENFSELFHEKQLLGKDFERSEENNLTKGLSLKDISCSAALNLLKEHGAKKLINVAFEAKKVAKSPLQRMREDITSILKQKGLPEELLDELPQKWERLGDIVVVPATSFKDPTWSSINDEVWCAVSKSLSANRLARQGRVEPNGTRDSTLEILVGDNGWVNHRENGILYSFDATKCMFSWGNLSEKLRMGNMACENEVVVDLFAGIGYFVLPFLVRAKAKLVYACEWNPHAIEALRRNVEANSVSERCIILEGDNRITAPKGVADRVNLGLIPSSEGSWVTAIQALRPEGGILHVHGNVKDSDESSWGEHVTKTLSDIARAEGRSWEVTVEHIEKVKWYAPRIRHLVADVRCR","length":995,"molWeight":110856,"crc64":"DCB5824E8762A5B9","md5":"27DD9C05F62E3E96DF5F6BF58739E02C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"PATHWAY":1,"SIMILARITY":2,"CAUTION":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Repeat":5,"Region":2,"Binding site":2},"uniParcId":"UPI00000A0B85"}}