{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8VZF6","secondaryAccessions":["Q9FH45"],"uniProtkbId":"EDR2L_ARATH","entryAudit":{"firstPublicDate":"2014-05-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-01","entryVersion":139,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein ENHANCED DISEASE RESISTANCE 2-like"}}},"genes":[{"geneName":{"value":"EDR2L"},"orderedLocusNames":[{"value":"At5g45560"}],"orfNames":[{"value":"MFC19.23"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Binds to phosphatidylinositol-4-phosphate (PtdIns(4)P). May regulate the salicylic acid- (SA-) mediated resistance to pathogens (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Endosome membrane","id":"SL-0100"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The pleckstrin homology domain (3-110) binds to phosphatidylinositol-4-phosphate (PtdIns(4)P)"}],"commentType":"DOMAIN"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"BAB11194.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":719,"modifier":"EXACT"}},"description":"Protein ENHANCED DISEASE RESISTANCE 2-like","featureId":"PRO_0000428906"},{"type":"Transmembrane","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00145"}]},{"type":"Domain","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"START","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00197"}]},{"type":"Region","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0611","category":"Biological process","name":"Plant defense"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10718197","citationType":"journal article","authors":["Sato S.","Nakamura Y.","Kaneko T.","Katoh T.","Asamizu E.","Kotani H.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"10718197"},{"database":"DOI","id":"10.1093/dnares/7.1.31"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.","publicationDate":"2000","journal":"DNA Res.","firstPage":"31","lastPage":"63","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"10470850","citationType":"journal article","authors":["Kaneko T.","Katoh T.","Sato S.","Nakamura Y.","Asamizu E.","Kotani H.","Miyajima N.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"10470850"},{"database":"DOI","id":"10.1093/dnares/6.3.183"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence features of the regions of 1,011,550 bp covered by seventeen P1 and TAC clones.","publicationDate":"1999","journal":"DNA Res.","firstPage":"183","lastPage":"195","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB022213","properties":[{"key":"ProteinId","value":"BAB11194.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB018113","properties":[{"key":"ProteinId","value":"BAB11194.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED95268.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"CAO7055318.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY064989","properties":[{"key":"ProteinId","value":"AAL57642.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_199369.2","properties":[{"key":"NucleotideSequenceId","value":"NM_123924.3"}]},{"database":"AlphaFoldDB","id":"Q8VZF6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8VZF6","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8VZF6","properties":[{"key":"Number of interactors","value":"589"}]},{"database":"STRING","id":"3702.Q8VZF6","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8VZF6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q8VZF6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"224739","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"834592","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT5G45560","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT5G45560","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT5G45560","properties":[{"key":"GeneName","value":"-"}]},{"database":"eggNOG","id":"ENOG502QS0N","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_018946_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8VZF6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FRAKHEN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"Q8VZF6","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q8VZF6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"ExpressionAtlas","id":"Q8VZF6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0010008","properties":[{"key":"GoTerm","value":"C:endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008289","properties":[{"key":"GoTerm","value":"F:lipid binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00821","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00177","properties":[{"key":"EntryName","value":"START"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.530.20:FF:000035","properties":[{"key":"EntryName","value":"ENHANCED DISEASE RESISTANCE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000359","properties":[{"key":"EntryName","value":"Protein ENHANCED DISEASE RESISTANCE 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.530.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045096","properties":[{"key":"EntryName","value":"EDR2-like"}]},{"database":"InterPro","id":"IPR009769","properties":[{"key":"EntryName","value":"EDR2_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR023393","properties":[{"key":"EntryName","value":"START-like_dom_sf"}]},{"database":"InterPro","id":"IPR002913","properties":[{"key":"EntryName","value":"START_lipid-bd_dom"}]},{"database":"PANTHER","id":"PTHR12136","properties":[{"key":"EntryName","value":"ENHANCED DISEASE RESISTANCE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12136:SF100","properties":[{"key":"EntryName","value":"PROTEIN ENHANCED DISEASE RESISTANCE 2-LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07059","properties":[{"key":"EntryName","value":"EDR2_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01852","properties":[{"key":"EntryName","value":"START"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00234","properties":[{"key":"EntryName","value":"START"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55961","properties":[{"key":"EntryName","value":"Bet v1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50848","properties":[{"key":"EntryName","value":"START"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKVVYEGWMVRYGRRKIGRSYIHMRYFVLEPRLLAYYKKKPQDNQLPIKTMVIDGNCRVEDRGLKTHHGHMVYVLSIYNKKEKHHRITMAAFNIQEALMWKEKIECVIDQHQDSLVPSGQQYVSFEYKPGMDAGRTASSSDHESPFSALEDENDSQRDLLRRTTIGNGPPESILDWTKEFDAELSNQSSSNQAFSRKHWRLLQCQNGLRIFEELLEVDYLPRSCSRAMKAVGVVEATCEEIFELVMSMDGTRYEWDCSFHNGRLVEEVDGHTAILYHRLLLDWFPMVVWPRDLCYVRYWRRNDDGSYVVLFRSREHENCGPQPGFVRAHLESGGFNIAPLKPRNGRPRTQVQHLIQIDLKGWGSGYLPAFQQHCLLQMLNSVSGLREWFSQTDDRGQPIRIPVMVNMASSSLALGKGGKHHHKSSLSIDQTNGASRNSVLMDEDSDDDDEFQIPDSEPEPETSKQDQETDAKKTEEPALNIDLSCFSGNLRHDDNENARNCWRISDGNNFKVRGKSFCDDKRKIPAGKHLMDLVAVDWFKDTKRMDHVVRRKGCAAQVAAEKGLFSTVVNVQVPGSTHYSMVFYFVTKELVPGSLFQRFVDGDDEFRNSRLKLIPLVPKGSWIVRQSVGSTPCLLGKAVDCNYIRGPTYLEIDVDIGSSTVANGVLGLVIGVITSLVVEMAFLVQANTPEELPERLIGAVRVSHVELSSAIVPNLDSD","length":719,"molWeight":81725,"crc64":"240A36A041D69E34","md5":"3BC3450AF782E60F5EBC99C7FED54527"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Domain":2,"Region":2,"Compositional bias":3},"uniParcId":"UPI00000A5924"}}