{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8VY49","secondaryAccessions":["Q9SL68"],"uniProtkbId":"LCV1_ARATH","entryAudit":{"firstPublicDate":"2015-02-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-01","entryVersion":135,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAL62439.1"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12668628"}],"value":"Protein LIKE COV 1"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12668628"}],"value":"LCV1"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT2G20130"}],"value":"At2g20130"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAD24400.2"}],"value":"T2G17.7"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12668628"}],"value":"Expressed at low levels in flowers, stems, roots and leaves"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the plant COV1 protein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Protein LIKE COV 1","featureId":"PRO_0000431899"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10617197","citationType":"journal article","authors":["Lin X.","Kaul S.","Rounsley S.D.","Shea T.P.","Benito M.-I.","Town C.D.","Fujii C.Y.","Mason T.M.","Bowman C.L.","Barnstead M.E.","Feldblyum T.V.","Buell C.R.","Ketchum K.A.","Lee J.J.","Ronning C.M.","Koo H.L.","Moffat K.S.","Cronin L.A.","Shen M.","Pai G.","Van Aken S.","Umayam L.","Tallon L.J.","Gill J.E.","Adams M.D.","Carrera A.J.","Creasy T.H.","Goodman H.M.","Somerville C.R.","Copenhaver G.P.","Preuss D.","Nierman W.C.","White O.","Eisen J.A.","Salzberg S.L.","Fraser C.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10617197"},{"database":"DOI","id":"10.1038/45471"}],"title":"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.","publicationDate":"1999","journal":"Nature","firstPage":"761","lastPage":"768","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-3TH3AFLAVIRO9","citationType":"submission","authors":["Brover V.V.","Troukhan M.E.","Alexandrov N.A.","Lu Y.-P.","Flavell R.B.","Feldmann K.A."],"title":"Full-length cDNA from Arabidopsis thaliana.","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"12668628","citationType":"journal article","authors":["Parker G.","Schofield R.","Sundberg B.","Turner S."],"citationCrossReferences":[{"database":"PubMed","id":"12668628"},{"database":"DOI","id":"10.1242/dev.00441"}],"title":"Isolation of COV1, a gene involved in the regulation of vascular patterning in the stem of Arabidopsis.","publicationDate":"2003","journal":"Development","firstPage":"2139","lastPage":"2148","volume":"130"},"referencePositions":["TISSUE SPECIFICITY","GENE FAMILY","NOMENCLATURE"],"referenceComments":[{"value":"cv. Landsberg erecta","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC006081","properties":[{"key":"ProteinId","value":"AAD24400.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002685","properties":[{"key":"ProteinId","value":"AEC06969.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408684","properties":[{"key":"ProteinId","value":"CAO7035625.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY072447","properties":[{"key":"ProteinId","value":"AAL62439.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY128911","properties":[{"key":"ProteinId","value":"AAM91311.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY084942","properties":[{"key":"ProteinId","value":"AAM61503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"D84585","properties":[{"key":"EntryName","value":"D84585"}]},{"database":"RefSeq","id":"NP_565465.1","properties":[{"key":"NucleotideSequenceId","value":"NM_127571.3"}]},{"database":"AlphaFoldDB","id":"Q8VY49","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8VY49","properties":[{"key":"Number of interactors","value":"41"}]},{"database":"IntAct","id":"Q8VY49","properties":[{"key":"Interactions","value":"23"}]},{"database":"STRING","id":"3702.Q8VY49","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q8VY49","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"238411","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"816532","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT2G20130","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT2G20130","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT2G20130","properties":[{"key":"GeneName","value":"LCV1"}]},{"database":"eggNOG","id":"ENOG502QPUG","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_068050_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8VY49","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TTGWYTL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"534431at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8VY49","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q8VY49","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"ExpressionAtlas","id":"Q8VY49","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22430844"}]},{"database":"GO","id":"GO:0000137","properties":[{"key":"GoTerm","value":"C:Golgi cis cisterna"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"31266899"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0010222","properties":[{"key":"GoTerm","value":"P:stem vascular tissue pattern formation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR007462","properties":[{"key":"EntryName","value":"COV1-like"}]},{"database":"PANTHER","id":"PTHR31876","properties":[{"key":"EntryName","value":"COV-LIKE PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31876:SF19","properties":[{"key":"EntryName","value":"PROTEIN CONTINUOUS VASCULAR RING 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04367","properties":[{"key":"EntryName","value":"DUF502"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANRERDRELLIPVADFGDKDDGSSSKPSSSSSASSSHQSGHETLSLFIRGWASKKFMTGCVILLPIAVTFYTTWWFIHFVDGFFSPIYALLGINIFGFGFLTSIAFIFLVGVFMSSWLGASVLNLGEWFIKRMPFVRHIYNASKQISTAISPDQNTQAFKEVAIIRHPRVGEYAFGFITSTVVLQNYPTEEELCCVYVPTNHLYIGDILLVNSNDVIRPNLSVREGIEIVVSGGMSMPQILSTLDKPLASIGNES","length":256,"molWeight":28379,"crc64":"4A4BD808A297F44C","md5":"6D9B9D481021CA5686C46BDA9D49D93B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":2,"Region":1,"Compositional bias":2},"uniParcId":"UPI000009DCF9"}}