{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8VCR3","secondaryAccessions":["Q8C2T2","Q8CEX9","Q9CYJ2","Q9D1H4"],"uniProtkbId":"TM242_MOUSE","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-01","entryVersion":123,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Transmembrane protein 242"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1917794"}],"value":"Tmem242"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NWH2"}],"value":"Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NWH2"}],"value":"Interacts with the core subunits NDUFAF1, ECSIT and ACAD9 of the MCIA complex. Interacts with ATP5MC3, NDUFC2, TMEM70, MT-ND2 AND MT-ND3"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NWH2"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NWH2"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8VCR3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8VCR3-2"],"sequenceIds":["VSP_027110"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8VCR3-3"],"sequenceIds":["VSP_027111","VSP_027112"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TMEM242 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAC25272.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Transmembrane protein 242","featureId":"PRO_0000295849"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NWH2"}]},{"type":"Transmembrane","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NWH2"}]},{"type":"Transmembrane","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NWH2"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NWH2"}]},{"type":"Alternative sequence","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_027110","alternativeSequence":{"originalSequence":"MKDFRSKMQSIFPPIPKNHESAEEWEEVLKWK","alternativeSequences":["VSTSPCESCLSTLCCLKFLVFKFAYILVPVF"]}},{"type":"Alternative sequence","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_027111","alternativeSequence":{"originalSequence":"MKDFRSKMQS","alternativeSequences":["ALFDCREETR"]}},{"type":"Alternative sequence","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_027112","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"in Ref. 1; BAC40103/BAE33193","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in Ref. 1; BAC40103/BAE33193","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"NOD","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"},{"value":"Inner ear","type":"TISSUE"},{"value":"Thymus","type":"TISSUE"},{"value":"Tongue","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK003559","properties":[{"key":"ProteinId","value":"BAB22856.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK009851","properties":[{"key":"ProteinId","value":"BAC25272.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK017626","properties":[{"key":"ProteinId","value":"BAB30845.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK088025","properties":[{"key":"ProteinId","value":"BAC40103.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK155326","properties":[{"key":"ProteinId","value":"BAE33193.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK158107","properties":[{"key":"ProteinId","value":"BAE34359.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC019420","properties":[{"key":"ProteinId","value":"AAH19420.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS49930.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VCR3-1"},{"database":"RefSeq","id":"NP_081733.3","properties":[{"key":"NucleotideSequenceId","value":"NM_027457.4"}],"isoformId":"Q8VCR3-1"},{"database":"AlphaFoldDB","id":"Q8VCR3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8VCR3","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8VCR3","properties":[{"key":"Number of interactors","value":"755"}]},{"database":"STRING","id":"10090.ENSMUSP00000005053","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8VCR3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000005053","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8VCR3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"259414","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VCR3-1"},{"database":"ProteomicsDB","id":"259415","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VCR3-2"},{"database":"ProteomicsDB","id":"259416","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VCR3-3"},{"database":"Pumba","id":"Q8VCR3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"49845","properties":[{"key":"antibodies","value":"39 antibodies from 8 providers"}]},{"database":"DNASU","id":"70544","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000005053.14","properties":[{"key":"ProteinId","value":"ENSMUSP00000005053.8"},{"key":"GeneId","value":"ENSMUSG00000004945.16"}],"isoformId":"Q8VCR3-1"},{"database":"Ensembl","id":"ENSMUST00000185896.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000139712.2"},{"key":"GeneId","value":"ENSMUSG00000004945.16"}],"isoformId":"Q8VCR3-2"},{"database":"Ensembl","id":"ENSMUST00000188282.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000139629.2"},{"key":"GeneId","value":"ENSMUSG00000004945.16"}],"isoformId":"Q8VCR3-3"},{"database":"GeneID","id":"70544","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:70544","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008afa.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8VCR3-1"},{"database":"UCSC","id":"uc008afc.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8VCR3-3"},{"database":"UCSC","id":"uc008afd.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8VCR3-2"},{"database":"AGR","id":"MGI:1917794","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"729515","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1917794","properties":[{"key":"GeneName","value":"Tmem242"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000004945","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S2GB","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000008642","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_115460_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8VCR3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RSPEWFN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2378895at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8VCR3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"70544","properties":[{"key":"hits","value":"10 hits in 79 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8VCR3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"Q8VCR3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000004945","properties":[{"key":"ExpressionPatterns","value":"Expressed in hindlimb stylopod muscle and 249 other cell types or tissues"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033615","properties":[{"key":"GoTerm","value":"P:mitochondrial proton-transporting ATP synthase complex assembly"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"InterPro","id":"IPR009792","properties":[{"key":"EntryName","value":"TMEM242"}]},{"database":"PANTHER","id":"PTHR13141","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 242"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13141:SF4","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 242"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07096","properties":[{"key":"EntryName","value":"DUF1358"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"METSGPGPGESSELEAPGSPDDRLFLVKGGIFLGSAAAAGMLAGFVTTLSLAKKKSPEWFNKGTMATAALPESGSSLALRALGWGSLYAWCGVGVISFAVWKALGVHSMKDFRSKMQSIFPPIPKNHESAEEWEEVLKWK","length":140,"molWeight":14916,"crc64":"AF42EC70C1AED3D8","md5":"359475C0DEBAA0A2655900D11B486364"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":2,"Region":1,"Modified residue":1,"Alternative sequence":3,"Sequence conflict":2},"uniParcId":"UPI0000020E51"}}