{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8VCD5","secondaryAccessions":["Q8BYS6","Q99KQ1"],"uniProtkbId":"MED17_MOUSE","entryAudit":{"firstPublicDate":"2007-09-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-03-01","entryVersion":154,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Mediator of RNA polymerase II transcription subunit 17"}},"alternativeNames":[{"fullName":{"value":"Cofactor required for Sp1 transcriptional activation subunit 6"},"shortNames":[{"value":"CRSP complex subunit 6"}]},{"fullName":{"value":"Mediator complex subunit 17"}},{"fullName":{"value":"Thyroid hormone receptor-associated protein complex 80 kDa component"}}]},"genes":[{"geneName":{"value":"Med17"},"synonyms":[{"value":"Crsp6"},{"value":"Trap80"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12037571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17132730"}],"value":"Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2 (By similarity). Interacts with GATA1 and PPARG"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8VCD5","intActId":"EBI-5744951"},"interactantTwo":{"uniProtKBAccession":"Q04207","geneName":"Rela","intActId":"EBI-644400"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Mediator complex subunit 17 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":649,"modifier":"EXACT"}},"description":"Mediator of RNA polymerase II transcription subunit 17","featureId":"PRO_0000304700"},{"type":"Region","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"in Ref. 1; BAC30005","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Bone marrow","type":"TISSUE"},{"value":"Hypothalamus","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Czech II","type":"STRAIN"},{"value":"Eye","type":"TISSUE"},{"value":"Mammary tumor","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"12037571","citationType":"journal article","authors":["Ge K.","Guermah M.","Yuan C.-X.","Ito M.","Wallberg A.E.","Spiegelman B.M.","Roeder R.G."],"citationCrossReferences":[{"database":"PubMed","id":"12037571"},{"database":"DOI","id":"10.1038/417563a"}],"title":"Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.","publicationDate":"2002","journal":"Nature","firstPage":"563","lastPage":"567","volume":"417"},"referencePositions":["INTERACTION WITH PPARG"]},{"referenceNumber":4,"citation":{"id":"17132730","citationType":"journal article","authors":["Stumpf M.","Waskow C.","Kroetschel M.","van Essen D.","Rodriguez P.","Zhang X.","Guyot B.","Roeder R.G.","Borggrefe T."],"citationCrossReferences":[{"database":"PubMed","id":"17132730"},{"database":"DOI","id":"10.1073/pnas.0604494103"}],"title":"The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"18504","lastPage":"18509","volume":"103"},"referencePositions":["INTERACTION WITH GATA1","ASSOCIATION WITH PROMOTER REGIONS"]},{"referenceNumber":5,"citation":{"id":"CI-8E5P0C3ALNCK3","citationType":"journal article","authors":["Stumpf M.","Waskow C.","Kroetschel M.","van Essen D.","Rodriguez P.","Zhang X.","Guyot B.","Roeder R.G.","Borggrefe T."],"publicationDate":"2007","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1442","lastPage":"1442","volume":"104"},"referencePositions":["ERRATUM OF PUBMED:17132730"]},{"referenceNumber":6,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK033151","properties":[{"key":"ProteinId","value":"BAC28172.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK038451","properties":[{"key":"ProteinId","value":"BAC30005.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK049112","properties":[{"key":"ProteinId","value":"BAC33548.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK151377","properties":[{"key":"ProteinId","value":"BAE30349.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC004062","properties":[{"key":"ProteinId","value":"AAH04062.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC020185","properties":[{"key":"ProteinId","value":"AAH20185.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS22834.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_659182.1","properties":[{"key":"NucleotideSequenceId","value":"NM_144933.2"}]},{"database":"PDB","id":"6W1S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.02 A"},{"key":"Chains","value":"L=15-645"}]},{"database":"PDB","id":"8T1I","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.68 A"},{"key":"Chains","value":"L=1-649"}]},{"database":"PDB","id":"8T1L","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.83 A"},{"key":"Chains","value":"L=1-649"}]},{"database":"PDBsum","id":"6W1S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8T1I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8T1L","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21514","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40968","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40971","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"231602","properties":[{"key":"Interactions","value":"5"}]},{"database":"ComplexPortal","id":"CPX-3264","properties":[{"key":"EntryName","value":"Core mediator complex"}]},{"database":"CORUM","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-48407N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8VCD5","properties":[{"key":"Number of interactors","value":"4141"}]},{"database":"IntAct","id":"Q8VCD5","properties":[{"key":"Interactions","value":"11"}]},{"database":"MINT","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000034411","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000034411","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"295988","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"234959","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000034411.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000034411.9"},{"key":"GeneId","value":"ENSMUSG00000031935.10"}]},{"database":"GeneID","id":"234959","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:234959","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009ofl.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:2182585","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"9440","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2182585","properties":[{"key":"GeneName","value":"Med17"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000031935","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4512","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000011810","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_028003_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HMSYEPQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10058398at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"234959","properties":[{"key":"hits","value":"24 hits in 81 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8VCD5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"Q8VCD5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000031935","properties":[{"key":"ExpressionPatterns","value":"Expressed in primary oocyte and 247 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8VCD5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0070847","properties":[{"key":"GoTerm","value":"C:core mediator complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016592","properties":[{"key":"GoTerm","value":"C:mediator complex"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15340084"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"ISO:MGI"}]},{"database":"GO","id":"GO:0000151","properties":[{"key":"GoTerm","value":"C:ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0046966","properties":[{"key":"GoTerm","value":"F:nuclear thyroid hormone receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003713","properties":[{"key":"GoTerm","value":"F:transcription coactivator activity"},{"key":"GoEvidenceType","value":"ISO:MGI"}]},{"database":"GO","id":"GO:0003712","properties":[{"key":"GoTerm","value":"F:transcription coregulator activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:MGI"}]},{"database":"GO","id":"GO:0032968","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription elongation by RNA polymerase II"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11559591"}]},{"database":"GO","id":"GO:0060261","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription initiation by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:MGI"}]},{"database":"GO","id":"GO:0051123","properties":[{"key":"GoTerm","value":"P:RNA polymerase II preinitiation complex assembly"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11559591"}]},{"database":"GO","id":"GO:0019827","properties":[{"key":"GoTerm","value":"P:stem cell population maintenance"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20720539"}]},{"database":"InterPro","id":"IPR063235","properties":[{"key":"EntryName","value":"Med17_C"}]},{"database":"InterPro","id":"IPR061954","properties":[{"key":"EntryName","value":"Med17_M"}]},{"database":"InterPro","id":"IPR063477","properties":[{"key":"EntryName","value":"Med17_N"}]},{"database":"InterPro","id":"IPR019313","properties":[{"key":"EntryName","value":"Mediator_Med17"}]},{"database":"PANTHER","id":"PTHR13114","properties":[{"key":"EntryName","value":"MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13114:SF7","properties":[{"key":"EntryName","value":"MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10156","properties":[{"key":"EntryName","value":"Med17"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30532","properties":[{"key":"EntryName","value":"Med17_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30534","properties":[{"key":"EntryName","value":"Med17_M"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGPDGDAPDWGGAGADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVAENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSDDKKSQKCAAEKPGQEDHLYVLEHNLHLLIREFHKQTLSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVIMLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL","length":649,"molWeight":72462,"crc64":"924D5C2D4150B4B5","md5":"F90586F0161EAC6DCBC26C88929B60A5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Sequence conflict":1},"uniParcId":"UPI0000023918"}}