{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8VBW5","secondaryAccessions":["B8JK46","B8JK47","B8JK48","B8JK49","Q3TZK1","Q6NXY8","Q6PEU3","Q8BQJ7","Q8C7E0","Q8CDQ0","Q8CDV1","Q8VI48","Q8VI49","Q8VI50","Q9CS94"],"uniProtkbId":"BBX_MOUSE","entryAudit":{"firstPublicDate":"2006-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-04-18","entryVersion":156,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"HMG box transcription factor BBX"}},"alternativeNames":[{"fullName":{"value":"Bobby sox homolog"}},{"fullName":{"value":"HMG box-containing protein 2"}}]},"genes":[{"geneName":{"value":"Bbx"},"synonyms":[{"value":"Hbp2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11680820"}],"value":"Transcription factor that is necessary for cell cycle progression from G1 to S phase"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"BbxA"}],"isoformIds":["Q8VBW5-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8VBW5-2"],"sequenceIds":["VSP_018007","VSP_018008","VSP_018009"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8VBW5-3"],"sequenceIds":["VSP_018010"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8VBW5-4"],"sequenceIds":["VSP_018011","VSP_018012"],"isoformSequenceStatus":"Described"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAL68987.1","note":"Contaminating sequence. Potential poly-A sequence.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAL68988.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":907,"modifier":"EXACT"}},"description":"HMG box transcription factor BBX","featureId":"PRO_0000232886"},{"type":"DNA binding","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"HMG box","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00267"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":628,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":708,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":769,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":877,"modifier":"EXACT"},"end":{"value":907,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":457,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":591,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":668,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":723,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":772,"modifier":"EXACT"},"end":{"value":783,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":483,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8WY36"}]},{"type":"Modified residue","location":{"start":{"value":701,"modifier":"EXACT"},"end":{"value":701,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8WY36"}]},{"type":"Modified residue","location":{"start":{"value":789,"modifier":"EXACT"},"end":{"value":789,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8WY36"}]},{"type":"Modified residue","location":{"start":{"value":811,"modifier":"EXACT"},"end":{"value":811,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8WY36"}]},{"type":"Cross-link","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8WY36"}]},{"type":"Cross-link","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8WY36"}]},{"type":"Cross-link","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8WY36"}]},{"type":"Alternative sequence","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_018007","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_018008","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_018009","alternativeSequence":{"originalSequence":"S","alternativeSequences":["SKGPFQSQKKNLFHKIVSKYKHKKEKPNVPE"]}},{"type":"Alternative sequence","location":{"start":{"value":732,"modifier":"EXACT"},"end":{"value":751,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_018010","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":750,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_018011","alternativeSequence":{"originalSequence":"SGDKWSHKQFFLDAIHPT","alternativeSequences":["PFQSQKKNLFHKIVSKYK"]}},{"type":"Alternative sequence","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":907,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_018012","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in strain: C3H/He","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in strain: C3H/He","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"in Ref. 1; AAL58872/AAL58873 and 2; BAB30768","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"in Ref. 2; BAC34285","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"in Ref. 1; AAL58872/AAL58873","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Helix","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WZ6"}]},{"type":"Beta strand","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WZ6"}]},{"type":"Helix","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WZ6"}]},{"type":"Helix","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WZ6"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-424OJSKOHOR68","citationType":"submission","authors":["Lee C.-J.","Chan W.-I.","Appleby V.J.","Orme A.T.","Scotting P.J."],"title":"BBX is expressed in developing CNS and in neuronal tumours.","publicationDate":"DEC-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","VARIANTS LEU-30 AND HIS-281"],"referenceComments":[{"value":"C3H/He","type":"STRAIN"},{"value":"NMRI","type":"STRAIN"},{"value":"Mammary gland","type":"TISSUE"},{"value":"Mammary tumor","type":"TISSUE"},{"value":"Mesenchymal stem cell","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"11680820","citationType":"journal article","authors":["Sanchez-Diaz A.","Blanco M.A.","Jones N.","Moreno S."],"citationCrossReferences":[{"database":"PubMed","id":"11680820"},{"database":"DOI","id":"10.1007/s002940100241"}],"title":"HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.","publicationDate":"2001","journal":"Curr. Genet.","firstPage":"110","lastPage":"118","volume":"40"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-454","FUNCTION"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"19144319","citationType":"journal article","authors":["Trost M.","English L.","Lemieux S.","Courcelles M.","Desjardins M.","Thibault P."],"citationCrossReferences":[{"database":"PubMed","id":"19144319"},{"database":"DOI","id":"10.1016/j.immuni.2008.11.006"}],"title":"The phagosomal proteome in interferon-gamma-activated macrophages.","publicationDate":"2009","journal":"Immunity","firstPage":"143","lastPage":"154","volume":"30"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":7,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242 AND SER-476","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"CI-39SQ7253MEIJR","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of the HMG-box domain of murine bobby sox homolog.","publicationDate":"AUG-2005","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 80-148"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF454943","properties":[{"key":"ProteinId","value":"AAL58872.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF454944","properties":[{"key":"ProteinId","value":"AAL58873.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK017487","properties":[{"key":"ProteinId","value":"BAB30768.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK029532","properties":[{"key":"ProteinId","value":"BAC26500.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK029747","properties":[{"key":"ProteinId","value":"BAC26596.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK049516","properties":[{"key":"ProteinId","value":"BAC33788.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK050488","properties":[{"key":"ProteinId","value":"BAC34285.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK157813","properties":[{"key":"ProteinId","value":"BAE34207.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC109627","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CT571273","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC057869","properties":[{"key":"ProteinId","value":"AAH57869.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC066821","properties":[{"key":"ProteinId","value":"AAH66821.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF276950","properties":[{"key":"ProteinId","value":"AAL68986.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF276951","properties":[{"key":"ProteinId","value":"AAL68987.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF276952","properties":[{"key":"ProteinId","value":"AAL68988.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS37354.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VBW5-1"},{"database":"CCDS","id":"CCDS84241.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VBW5-3"},{"database":"RefSeq","id":"NP_001334169.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001347240.1"}],"isoformId":"Q8VBW5-3"},{"database":"RefSeq","id":"NP_081720.2","properties":[{"key":"NucleotideSequenceId","value":"NM_027444.3"}],"isoformId":"Q8VBW5-1"},{"database":"RefSeq","id":"XP_011244310.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011246008.4"}],"isoformId":"Q8VBW5-1"},{"database":"RefSeq","id":"XP_011244311.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011246009.3"}],"isoformId":"Q8VBW5-3"},{"database":"RefSeq","id":"XP_017172619.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017317130.3"}],"isoformId":"Q8VBW5-1"},{"database":"RefSeq","id":"XP_030105137.1","properties":[{"key":"NucleotideSequenceId","value":"XM_030249277.2"}],"isoformId":"Q8VBW5-1"},{"database":"RefSeq","id":"XP_036016018.1","properties":[{"key":"NucleotideSequenceId","value":"XM_036160125.1"}],"isoformId":"Q8VBW5-3"},{"database":"PDB","id":"1WZ6","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=80-148"}]},{"database":"PDBsum","id":"1WZ6","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"214101","properties":[{"key":"Interactions","value":"2"}]},{"database":"FunCoup","id":"Q8VBW5","properties":[{"key":"Number of interactors","value":"2863"}]},{"database":"STRING","id":"10090.ENSMUSP00000119238","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000119238","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"277183","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VBW5-1"},{"database":"ProteomicsDB","id":"277184","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VBW5-2"},{"database":"ProteomicsDB","id":"277185","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VBW5-3"},{"database":"ProteomicsDB","id":"277186","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8VBW5-4"},{"database":"Pumba","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"32337","properties":[{"key":"antibodies","value":"114 antibodies from 24 providers"}]},{"database":"DNASU","id":"70508","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000066037.13","properties":[{"key":"ProteinId","value":"ENSMUSP00000066384.7"},{"key":"GeneId","value":"ENSMUSG00000022641.16"}],"isoformId":"Q8VBW5-2"},{"database":"Ensembl","id":"ENSMUST00000089399.11","properties":[{"key":"ProteinId","value":"ENSMUSP00000086821.5"},{"key":"GeneId","value":"ENSMUSG00000022641.16"}],"isoformId":"Q8VBW5-4"},{"database":"Ensembl","id":"ENSMUST00000089404.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000086826.4"},{"key":"GeneId","value":"ENSMUSG00000022641.16"}],"isoformId":"Q8VBW5-3"},{"database":"Ensembl","id":"ENSMUST00000114488.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000110132.2"},{"key":"GeneId","value":"ENSMUSG00000022641.16"}],"isoformId":"Q8VBW5-1"},{"database":"Ensembl","id":"ENSMUST00000138166.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000119238.2"},{"key":"GeneId","value":"ENSMUSG00000022641.16"}],"isoformId":"Q8VBW5-1"},{"database":"GeneID","id":"70508","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:70508","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007zkn.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8VBW5-1"},{"database":"UCSC","id":"uc007zkp.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8VBW5-3"},{"database":"UCSC","id":"uc007zkq.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8VBW5-2"},{"database":"UCSC","id":"uc007zkr.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8VBW5-4"},{"database":"AGR","id":"MGI:1917758","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"56987","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1917758","properties":[{"key":"GeneName","value":"Bbx"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000022641","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2746","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158592","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_017230_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LAEAKMC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2377365at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"70508","properties":[{"key":"hits","value":"6 hits in 79 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q8VBW5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q8VBW5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000022641","properties":[{"key":"ExpressionPatterns","value":"Expressed in placenta labyrinth and 251 other cell types or tissues"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0060348","properties":[{"key":"GoTerm","value":"P:bone development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22876197"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd21989","properties":[{"key":"EntryName","value":"HMG-box_HBP2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.30.10:FF:000014","properties":[{"key":"EntryName","value":"HMG box transcription factor BBX"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.30.10","properties":[{"key":"EntryName","value":"High mobility group box domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR049523","properties":[{"key":"EntryName","value":"BBX_HMG-box"}]},{"database":"InterPro","id":"IPR052412","properties":[{"key":"EntryName","value":"CC-Dev_Transcription_Reg"}]},{"database":"InterPro","id":"IPR009071","properties":[{"key":"EntryName","value":"HMG_box_dom"}]},{"database":"InterPro","id":"IPR036910","properties":[{"key":"EntryName","value":"HMG_box_dom_sf"}]},{"database":"InterPro","id":"IPR019102","properties":[{"key":"EntryName","value":"TF_HMG_box_BBX_DUF2028"}]},{"database":"PANTHER","id":"PTHR13059:SF10","properties":[{"key":"EntryName","value":"HMG BOX TRANSCRIPTION FACTOR BBX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13059","properties":[{"key":"EntryName","value":"HMG-BOX TRANSCRIPTION FACTOR BBX"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09667","properties":[{"key":"EntryName","value":"DUF2028"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00505","properties":[{"key":"EntryName","value":"HMG_box"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00398","properties":[{"key":"EntryName","value":"HMG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47095","properties":[{"key":"EntryName","value":"HMG-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50118","properties":[{"key":"EntryName","value":"HMG_BOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKGSNRNKDHSTEGEGDGKRPKRKCLQWHPLLAKKLLDFSEEEEEDEEEEDIDKVQLLEADGLEQDVAETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYRWCPTTNKPVKSPTPTVNPRKKLWAFPPDSSRDLPTPKKAKTEVPQLNFGMADPTQMGGLSMLLLAGEHALGTPEASSGTCRPDISESPELRQKSPLFQFAEISSRTSHPDAPSKQCQASALFQFAEISSSTSQLGGTEPVKRCGNSALFQLAEMCLASEGVKMEDTKLIKSKESDGGRIEEIEKGKEERGTEVEKTTETSFQKEAEFGKSAKGNVRESKDLRDIEQLQMDNVMAIKVEDPKEIRKEPEDDQKYSHFPDFSYSASSKIIISGVPSRKDHMCHPHGIMIIEDPTTLNKPEKIKKKKKKNKLDRHGNDKSTPKKTCKKRQSSESDIESVMYTIEAVAKGDWGVDKLGETPRKKVRPSSSGKGGILDAKPPKKKVKSKEKKVSKEKCSDITKESRPPDFLSISASKSVPGEVPEGIKAEPLTPTEDALPPSLPGQAKPEDSDCHRKTETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWSEESWTFNQSGTSGSKKFKKKLREDSFLGSAKLDEEFEKKFNSLPQYSPITFDRKCVSTPRKKKKTGNMSSESTKTSKGSGDKWSHKQFFLDAIHPTEAIFSEDKSTTEPAFKVKNALSIPNTPEPTTMQEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLDDKPKEQLQRSLPKVPGTYCGDNCSHSTVEEPRSSTPDMPAVSAFFSLAALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ","length":907,"molWeight":100783,"crc64":"53E113D4B3DE4DAC","md5":"6CEF9F09DD1AAAFA1D6C84957DB32AD4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"DNA binding":1,"Region":10,"Compositional bias":12,"Modified residue":6,"Cross-link":3,"Alternative sequence":6,"Natural variant":2,"Sequence conflict":3,"Helix":3,"Beta strand":1},"uniParcId":"UPI00001EA8EA"}}