{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8TEW8","secondaryAccessions":["E9PE87","Q8IUC7","Q8IUC9","Q96DK9","Q96N09","Q96NX6","Q96NX7","Q96Q29"],"uniProtkbId":"PAR3L_HUMAN","entryAudit":{"firstPublicDate":"2003-05-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-05-16","entryVersion":197,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Partitioning defective 3 homolog B"}},"alternativeNames":[{"fullName":{"value":"Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein"}},{"fullName":{"value":"PAR3-beta"}},{"fullName":{"value":"Partitioning defective 3-like protein"},"shortNames":[{"value":"PAR3-L protein"}]}]},"genes":[{"geneName":{"value":"PARD3B"},"synonyms":[{"value":"ALS2CR19"},{"value":"PAR3B"},{"value":"PAR3L"}]}],"comments":[{"texts":[{"value":"Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12234671"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16458856"}],"value":"Interacts with PARD6B. Interacts with INSC/inscuteable"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"O15439","geneName":"ABCC4","intActId":"EBI-4319622"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q5VV41","geneName":"ARHGEF16","intActId":"EBI-1057448"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q9UHC3","geneName":"ASIC3","intActId":"EBI-66903811"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"P23634","geneName":"ATP2B4","intActId":"EBI-1174388"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"O75838","geneName":"CIB2","intActId":"EBI-25770403"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q9NS75","geneName":"CYSLTR2","intActId":"EBI-3843579"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q5KSL6","geneName":"DGKK","intActId":"EBI-4401920"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q13574","geneName":"DGKZ","intActId":"EBI-715507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q8N1I0","geneName":"DOCK4","intActId":"EBI-1059186"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q14CM0","geneName":"FRMPD4","intActId":"EBI-311279"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"O75084","geneName":"FZD7","intActId":"EBI-746917"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"P22460","geneName":"KCNA5","intActId":"EBI-6426121"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q8N743","geneName":"KIR3DL3","intActId":"EBI-17272405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"P36507","geneName":"MAP2K2","intActId":"EBI-1056930"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q96KB5","geneName":"PBK","intActId":"EBI-536853"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"P60484","geneName":"PTEN","intActId":"EBI-696162"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q6ZTQ3","geneName":"RASSF6","intActId":"EBI-2933412"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q15418","geneName":"RPS6KA1","intActId":"EBI-963034"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"A6NIM6","geneName":"SLC15A5","intActId":"EBI-11792220"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q9NYB5","geneName":"SLCO1C1","intActId":"EBI-11792007"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q7Z6J2","geneName":"TAMALIN","intActId":"EBI-2806496"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q9UDY2","geneName":"TJP2","intActId":"EBI-1042602"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"P0DTC3","geneName":"3a","intActId":"EBI-25475894"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"P26554","geneName":"E6","intActId":"EBI-11793986"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"P36809","geneName":"E6","intActId":"EBI-63979783"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q9IR59","geneName":"E6","intActId":"EBI-64093585"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q9Q6P4","geneName":"GP1","intActId":"EBI-66910636"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"Q81964","geneName":"ORF putative E6","intActId":"EBI-64093422"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q8TEW8","intActId":"EBI-2861929"},"interactantTwo":{"uniProtKBAccession":"P03409","geneName":"Tax","intActId":"EBI-5236464"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions"}]},"subcellularLocations":[{"location":{"value":"Endomembrane system","id":"SL-0147"}},{"location":{"value":"Cell junction","id":"SL-0038"}},{"location":{"value":"Cell junction, tight junction","id":"SL-0265"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Par3La"},{"value":"a"}],"isoformIds":["Q8TEW8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Par3Lb"},{"value":"b"}],"isoformIds":["Q8TEW8-2"],"sequenceIds":["VSP_007478"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"Par3Lc"},{"value":"c"}],"isoformIds":["Q8TEW8-3"],"sequenceIds":["VSP_007479"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8TEW8-4"],"sequenceIds":["VSP_007476","VSP_007477"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q8TEW8-5"],"sequenceIds":["VSP_007543"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"isoformIds":["Q8TEW8-6"],"sequenceIds":["VSP_054048"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The N-terminal part (1-351) part blocks the association of the tight junction marker TJP1 with the cell-cell boundary when it is overexpressed"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PAR3 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAB71106.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB71623.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1205,"modifier":"EXACT"}},"description":"Partitioning defective 3 homolog B","featureId":"PRO_0000185072"},{"type":"Domain","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"PDZ 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00143"}]},{"type":"Domain","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"PDZ 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00143"}]},{"type":"Domain","location":{"start":{"value":498,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"PDZ 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00143"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":707,"modifier":"EXACT"},"end":{"value":743,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":784,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1111,"modifier":"EXACT"},"end":{"value":1205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":806,"modifier":"EXACT"},"end":{"value":822,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":838,"modifier":"EXACT"},"end":{"value":865,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":881,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CSB4"}]},{"type":"Modified residue","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":635,"modifier":"EXACT"},"end":{"value":635,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CSB4"}]},{"type":"Modified residue","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CSB4"}]},{"type":"Modified residue","location":{"start":{"value":728,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CSB4"}]},{"type":"Modified residue","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CSB4"}]},{"type":"Modified residue","location":{"start":{"value":746,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":749,"modifier":"EXACT"},"end":{"value":749,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CSB4"}]},{"type":"Modified residue","location":{"start":{"value":801,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":1184,"modifier":"EXACT"},"end":{"value":1184,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Alternative sequence","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11586298"}],"featureId":"VSP_007476","alternativeSequence":{"originalSequence":"GPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVF","alternativeSequences":["VSAARRSGARLQPRHLPGSWLLGEDSSLRIYRWRNPGSR"]}},{"type":"Alternative sequence","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":1205,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11586298"}],"featureId":"VSP_007477","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":479,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12234671"}],"featureId":"VSP_007478","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":729,"modifier":"EXACT"},"end":{"value":797,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_054048","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":798,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12234671"}],"featureId":"VSP_007479","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":914,"modifier":"EXACT"},"end":{"value":1014,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12459187"}],"featureId":"VSP_007543","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in dbSNP:rs1510765","featureCrossReferences":[{"database":"dbSNP","id":"rs1510765"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12459187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_015664","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in dbSNP:rs2289025","featureCrossReferences":[{"database":"dbSNP","id":"rs2289025"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_015665","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"in dbSNP:rs1061522","featureCrossReferences":[{"database":"dbSNP","id":"rs1061522"}],"featureId":"VAR_015666","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"in dbSNP:rs34751010","featureCrossReferences":[{"database":"dbSNP","id":"rs34751010"}],"featureId":"VAR_056642","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":901,"modifier":"EXACT"}},"description":"in Ref. 5; BAB71623","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"GTLKHGGLR","alternativeSequences":["WLINFVLIW"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0796","category":"Cellular component","name":"Tight junction"}],"references":[{"referenceNumber":1,"citation":{"id":"11586298","citationType":"journal article","authors":["Hadano S.","Hand C.K.","Osuga H.","Yanagisawa Y.","Otomo A.","Devon R.S.","Miyamoto N.","Showguchi-Miyata J.","Okada Y.","Singaraja R.","Figlewicz D.A.","Kwiatkowski T.","Hosler B.A.","Sagie T.","Skaug J.","Nasir J.","Brown R.H. Jr.","Scherer S.W.","Rouleau G.A.","Hayden M.R.","Ikeda J.-E."],"citationCrossReferences":[{"database":"PubMed","id":"11586298"},{"database":"DOI","id":"10.1038/ng1001-166"}],"title":"A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.","publicationDate":"2001","journal":"Nat. Genet.","firstPage":"166","lastPage":"173","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)"]},{"referenceNumber":2,"citation":{"id":"12459187","citationType":"journal article","authors":["Kohjima M.","Noda Y.","Takeya R.","Saito N.","Takeuchi K.","Sumimoto H."],"citationCrossReferences":[{"database":"PubMed","id":"12459187"},{"database":"DOI","id":"10.1016/s0006-291x(02)02698-0"}],"title":"PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.","publicationDate":"2002","journal":"Biochem. Biophys. Res. Commun.","firstPage":"641","lastPage":"646","volume":"299"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5)","VARIANT PRO-165"]},{"referenceNumber":3,"citation":{"id":"12234671","citationType":"journal article","authors":["Gao L.","Macara I.G.","Joberty G."],"citationCrossReferences":[{"database":"PubMed","id":"12234671"},{"database":"DOI","id":"10.1016/s0378-1119(02)00681-9"}],"title":"Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties.","publicationDate":"2002","journal":"Gene","firstPage":"99","lastPage":"107","volume":"294"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)","CHARACTERIZATION","INTERACTION WITH PARD6B"]},{"referenceNumber":4,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-901 (ISOFORM 1)","VARIANTS PRO-165 AND LYS-192"],"referenceComments":[{"value":"Gastric mucosa","type":"TISSUE"},{"value":"Neuron","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"16458856","citationType":"journal article","authors":["Izaki T.","Kamakura S.","Kohjima M.","Sumimoto H."],"citationCrossReferences":[{"database":"PubMed","id":"16458856"},{"database":"DOI","id":"10.1016/j.bbrc.2006.01.050"}],"title":"Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.","publicationDate":"2006","journal":"Biochem. Biophys. Res. Commun.","firstPage":"1001","lastPage":"1006","volume":"341"},"referencePositions":["INTERACTION WITH INSC"]},{"referenceNumber":7,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-746 AND SER-801","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-368 AND SER-746","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100 AND SER-1184","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB053321","properties":[{"key":"ProteinId","value":"BAB69028.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB073472","properties":[{"key":"ProteinId","value":"BAC54035.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB092439","properties":[{"key":"ProteinId","value":"BAC54285.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF428250","properties":[{"key":"ProteinId","value":"AAL30664.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF428251","properties":[{"key":"ProteinId","value":"AAL30665.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF466152","properties":[{"key":"ProteinId","value":"AAL79827.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC007385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC007465","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC007736","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC007746","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC008168","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC008171","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC009316","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC011750","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC016903","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC108468","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK056157","properties":[{"key":"ProteinId","value":"BAB71106.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK057965","properties":[{"key":"ProteinId","value":"BAB71623.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS42804.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-5"},{"database":"CCDS","id":"CCDS42805.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-6"},{"database":"CCDS","id":"CCDS42806.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-2"},{"database":"CCDS","id":"CCDS77511.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-1"},{"database":"RefSeq","id":"NP_001289698.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001302769.2"}],"isoformId":"Q8TEW8-1"},{"database":"RefSeq","id":"NP_476518.4","properties":[{"key":"NucleotideSequenceId","value":"NM_057177.7"}],"isoformId":"Q8TEW8-6"},{"database":"RefSeq","id":"NP_689739.4","properties":[{"key":"NucleotideSequenceId","value":"NM_152526.6"}],"isoformId":"Q8TEW8-2"},{"database":"RefSeq","id":"NP_995585.2","properties":[{"key":"NucleotideSequenceId","value":"NM_205863.4"}],"isoformId":"Q8TEW8-5"},{"database":"AlphaFoldDB","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"125592","properties":[{"key":"Interactions","value":"52"}]},{"database":"CORUM","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-42276N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8TEW8","properties":[{"key":"Number of interactors","value":"339"}]},{"database":"IntAct","id":"Q8TEW8","properties":[{"key":"Interactions","value":"380"}]},{"database":"MINT","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000385848","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8TEW8","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"iPTMnet","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PARD3B","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"30913163","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000385848","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"19836","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"74517","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-1"},{"database":"ProteomicsDB","id":"74518","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-2"},{"database":"ProteomicsDB","id":"74519","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-3"},{"database":"ProteomicsDB","id":"74520","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-4"},{"database":"ProteomicsDB","id":"74521","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TEW8-5"},{"database":"Antibodypedia","id":"34169","properties":[{"key":"antibodies","value":"41 antibodies from 18 providers"}]},{"database":"DNASU","id":"117583","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000349953.7","properties":[{"key":"ProteinId","value":"ENSP00000340280.3"},{"key":"GeneId","value":"ENSG00000116117.20"}],"isoformId":"Q8TEW8-5"},{"database":"Ensembl","id":"ENST00000351153.5","properties":[{"key":"ProteinId","value":"ENSP00000317261.2"},{"key":"GeneId","value":"ENSG00000116117.20"}],"isoformId":"Q8TEW8-6"},{"database":"Ensembl","id":"ENST00000358768.6","properties":[{"key":"ProteinId","value":"ENSP00000351618.2"},{"key":"GeneId","value":"ENSG00000116117.20"}],"isoformId":"Q8TEW8-2"},{"database":"Ensembl","id":"ENST00000406610.7","properties":[{"key":"ProteinId","value":"ENSP00000385848.2"},{"key":"GeneId","value":"ENSG00000116117.20"}],"isoformId":"Q8TEW8-1"},{"database":"Ensembl","id":"ENST00000415947.1","properties":[{"key":"ProteinId","value":"ENSP00000407718.1"},{"key":"GeneId","value":"ENSG00000116117.20"}],"isoformId":"Q8TEW8-4"},{"database":"GeneID","id":"117583","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:117583","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000406610.7","properties":[{"key":"ProteinId","value":"ENSP00000385848.2"},{"key":"RefSeqNucleotideId","value":"NM_001302769.2"},{"key":"RefSeqProteinId","value":"NP_001289698.1"}]},{"database":"UCSC","id":"uc002vao.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8TEW8-1"},{"database":"AGR","id":"HGNC:14446","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162398721","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"117583","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"117583","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PARD3B","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:14446","properties":[{"key":"GeneName","value":"PARD3B"}]},{"database":"HPA","id":"ENSG00000116117","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"619353","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000116117","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000116117","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3528","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183214","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2605385_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QFQHIKA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6264899at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8TEW8","properties":[{"key":"Number of GO annotations","value":"10 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000116117","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"117583","properties":[{"key":"hits","value":"9 hits in 1155 CRISPR screens"}]},{"database":"ChiTaRS","id":"PARD3B","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"PARD3B","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"117583","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8TEW8","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8TEW8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"Q8TEW8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000116117","properties":[{"key":"ExpressionPatterns","value":"Expressed in sural nerve and 149 other cell types or tissues"}]},{"database":"GO","id":"GO:0005912","properties":[{"key":"GoTerm","value":"C:adherens junction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043296","properties":[{"key":"GoTerm","value":"C:apical junction complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016324","properties":[{"key":"GoTerm","value":"C:apical plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005923","properties":[{"key":"GoTerm","value":"C:bicellular tight junction"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16458856"}]},{"database":"GO","id":"GO:0035091","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030010","properties":[{"key":"GoTerm","value":"P:establishment of cell polarity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0045197","properties":[{"key":"GoTerm","value":"P:establishment or maintenance of epithelial cell apical/basal polarity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008104","properties":[{"key":"GoTerm","value":"P:intracellular protein localization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd06691","properties":[{"key":"EntryName","value":"PDZ1_Par3-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd23058","properties":[{"key":"EntryName","value":"PDZ2_Par3-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd23059","properties":[{"key":"EntryName","value":"PDZ3_Par3-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.42.10:FF:000078","properties":[{"key":"EntryName","value":"Partitioning defective 3 homolog B"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.42.10:FF:000117","properties":[{"key":"EntryName","value":"partitioning defective 3 homolog B isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.42.10:FF:000011","properties":[{"key":"EntryName","value":"partitioning defective 3 homolog isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000017","properties":[{"key":"EntryName","value":"partitioning defective 3 homolog isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.42.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR052213","properties":[{"key":"EntryName","value":"PAR3"}]},{"database":"InterPro","id":"IPR021922","properties":[{"key":"EntryName","value":"Par3/HAL_N"}]},{"database":"InterPro","id":"IPR001478","properties":[{"key":"EntryName","value":"PDZ"}]},{"database":"InterPro","id":"IPR036034","properties":[{"key":"EntryName","value":"PDZ_sf"}]},{"database":"PANTHER","id":"PTHR16484:SF4","properties":[{"key":"EntryName","value":"PARTITIONING DEFECTIVE 3 HOMOLOG B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16484","properties":[{"key":"EntryName","value":"PARTITIONING DEFECTIVE 3 RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12053","properties":[{"key":"EntryName","value":"Par3_HAL_N_term"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00595","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00228","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF50156","properties":[{"key":"EntryName","value":"PDZ domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50106","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMTAAV","length":1205,"molWeight":132494,"crc64":"26E6704CCDCE8CD8","md5":"454B745927053EF0E290F22F49256498"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":29,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":6,"TISSUE SPECIFICITY":1,"DOMAIN":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Domain":3,"Region":6,"Compositional bias":5,"Modified residue":12,"Alternative sequence":6,"Natural variant":4,"Sequence conflict":1},"uniParcId":"UPI0000070178"}}