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In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-methionyl-[F-actin] + NADPH + O2 + H(+) = L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:51308"},{"database":"Rhea","id":"RHEA-COMP:12953"},{"database":"Rhea","id":"RHEA-COMP:12956"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16044"},{"database":"ChEBI","id":"CHEBI:45764"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.14.13.225","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29343822"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"NADPH + O2 + H(+) = H2O2 + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11260"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16240"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.6.3.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21864500"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845023"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29343822"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"FAD","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21864500"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57692"}}]},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":4.7,"unit":"uM","substrate":"F-actin (at saturating NADPH concentration)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21864500"}]},{"constant":375.0,"unit":"uM","substrate":"NADPH (for the NADPH oxidase reaction)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845023"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845023"}],"value":"kcat is 0.28 sec(-1) for NADPH for the NADPH oxidase reaction."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11827972"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12110185"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12788069"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15694364"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27552051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30905672"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32344433"}],"value":"Interacts with STK38 and STK38L (By similarity). Interacts with RAB1B, RAB8A, RAB10, RAB13, RAB15 and RAB35 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously; ternary complex formation of RAB8A, RAB13 and MICAL1 is possible. Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with GRAF1/ARHGAP26, GRAF2/ARHGAP10, RAB8A, RAB8B and RAB10; may bind simultaneously to GRAFs and Rabs and connects GRAFs to Rabs (PubMed:32344433). Does not interact with RAB1 and RAB11A (PubMed:32344433)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8TDZ2","intActId":"EBI-7153876"},"interactantTwo":{"uniProtKBAccession":"Q9NQ75-2","geneName":"CASS4","intActId":"EBI-12270182"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28230050"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32344433"}],"value":"Accumulates transiently at the abscission site before abscission occurs. Colocalized with GRAF1/ARHGAP26 and GRAF2/ARHGAP10, RAB8A, RAB8B and RAB10 on endosomal tubules (PubMed:32344433)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32344433"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32344433"}],"value":"Endosome membrane","id":"SL-0100"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28230050"}],"value":"Midbody","id":"SL-0469"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"MICAL-1a"}],"isoformIds":["Q8TDZ2-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"MICAL-1b"}],"isoformIds":["Q8TDZ2-2"],"sequenceIds":["VSP_009639"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8TDZ2-3"],"sequenceIds":["VSP_009637","VSP_009638"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8TDZ2-4"],"sequenceIds":["VSP_042590"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11827972"}],"value":"Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27552051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32344433"}],"value":"The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab13 and Rab15 (in their GTP-bound forms)"}],"commentType":"DOMAIN"},{"texts":[{"value":"The C-terminal coiled coil part contains the plexin-interacting region"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Mical family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q86BA1"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VDP3"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21864500"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845023"}],"value":"The reaction mechanism is subject to discussion. 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