{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8TDM6","secondaryAccessions":["A6H8Y3","Q149N1","Q5T1H7","Q5T1H8","Q6DKG3","Q86WC0","Q8TDM7","Q9UE73","Q9Y4E3"],"uniProtkbId":"DLG5_HUMAN","entryAudit":{"firstPublicDate":"2003-01-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-07-24","entryVersion":222,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Disks large homolog 5"}},"alternativeNames":[{"fullName":{"value":"Discs large protein P-dlg"}},{"fullName":{"value":"Placenta and prostate DLG"}}]},"genes":[{"geneName":{"value":"DLG5"},"synonyms":[{"value":"KIAA0583"},{"value":"PDLG"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"E9Q9R9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28087714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28169360"}],"value":"Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). 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Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"E9Q9R9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12657639"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28087714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28169360"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9738934"}],"value":"Interacts with MPP1 (PubMed:9738934). Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex (PubMed:12657639). Interacts (via coiled-coil domain) with MARK3. Interacts (via PDZ domain 3) with STK3/MST2 and STK4/MST1 (PubMed:28087714). Interacts with SCRIB (PubMed:28169360). 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