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Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16873890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23132852"}],"value":"Its proteolytic activity is blocked by a signal peptide peptidase (SPP) inhibitor, (ZLL)2-ketone (ZLL) or a gamma-secretase inhibitor, LY411,575 (PubMed:16873890). However, is not inhibited by ZLL and LY411,575 for activity on simian foamy virus envelope glycoprotein gp130 (PubMed:23132852)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CUS9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15998642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16873890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23132852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25384971"}],"value":"Monomer (PubMed:15385547, PubMed:15998642, PubMed:16873890). Homodimer (PubMed:15385547, PubMed:15998642, PubMed:16873890). Interacts with STIM1 (via the transmembrane region and the SOAR/CAD domain); the interaction promotes the binding of STIM1 to ORAI1 (PubMed:25384971). 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