ID FIBIN_HUMAN Reviewed; 211 AA. AC Q8TAL6; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 27-NOV-2024, entry version 135. DE RecName: Full=Fin bud initiation factor homolog; DE Flags: Precursor; GN Name=FIBIN; ORFNames=PSEC0235; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Placenta; RX PubMed=17196583; DOI=10.1016/j.ydbio.2006.11.041; RA Wakahara T., Kusu N., Yamauchi H., Kimura I., Konishi M., Miyake A., RA Itoh N.; RT "Fibin, a novel secreted lateral plate mesoderm signal, is essential for RT pectoral fin bud initiation in zebrafish."; RL Dev. Biol. 303:527-535(2007). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo; RX PubMed=16303743; DOI=10.1093/dnares/12.2.117; RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y., RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., RA Isogai T.; RT "Signal sequence and keyword trap in silico for selection of full-length RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA RT libraries."; RL DNA Res. 12:117-126(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PROTEIN SEQUENCE OF 19-21, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-30, RP SUBUNIT, AND DISULFIDE BONDS. RX PubMed=21615908; DOI=10.1186/1471-2091-12-26; RA Lakner J., Seyer C., Hermsdorf T., Schoneberg T.; RT "Characterization of the expression, promoter activity and molecular RT architecture of fibin."; RL BMC Biochem. 12:26-26(2011). CC -!- SUBUNIT: Homodimer; disulfide-linked. Seems to also exist as monomers. CC {ECO:0000269|PubMed:21615908}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Golgi apparatus CC {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:21615908}. CC -!- SIMILARITY: Belongs to the FIBIN family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB236892; BAF42654.1; -; mRNA. DR EMBL; AK075535; BAC11678.1; -; mRNA. DR EMBL; CH471064; EAW68292.1; -; Genomic_DNA. DR EMBL; BC026873; AAH26873.1; -; mRNA. DR CCDS; CCDS7861.1; -. DR RefSeq; NP_976249.1; NM_203371.1. DR AlphaFoldDB; Q8TAL6; -. DR BioGRID; 132428; 84. DR IntAct; Q8TAL6; 68. DR STRING; 9606.ENSP00000321962; -. DR GlyCosmos; Q8TAL6; 1 site, No reported glycans. DR GlyGen; Q8TAL6; 1 site. DR iPTMnet; Q8TAL6; -. DR PhosphoSitePlus; Q8TAL6; -. DR BioMuta; FIBIN; -. DR DMDM; 74730366; -. DR jPOST; Q8TAL6; -. DR MassIVE; Q8TAL6; -. DR PaxDb; 9606-ENSP00000321962; -. DR PeptideAtlas; Q8TAL6; -. DR ProteomicsDB; 73891; -. DR Antibodypedia; 25393; 58 antibodies from 16 providers. DR DNASU; 387758; -. DR Ensembl; ENST00000318627.4; ENSP00000321962.2; ENSG00000176971.4. DR GeneID; 387758; -. DR KEGG; hsa:387758; -. DR MANE-Select; ENST00000318627.4; ENSP00000321962.2; NM_203371.2; NP_976249.1. DR UCSC; uc001mrd.4; human. DR AGR; HGNC:33747; -. DR CTD; 387758; -. DR DisGeNET; 387758; -. DR GeneCards; FIBIN; -. DR HGNC; HGNC:33747; FIBIN. DR HPA; ENSG00000176971; Low tissue specificity. DR neXtProt; NX_Q8TAL6; -. DR OpenTargets; ENSG00000176971; -. DR PharmGKB; PA164720070; -. DR VEuPathDB; HostDB:ENSG00000176971; -. DR eggNOG; ENOG502QSW0; Eukaryota. DR GeneTree; ENSGT00390000007623; -. DR HOGENOM; CLU_1323584_0_0_1; -. DR InParanoid; Q8TAL6; -. DR OMA; GFFCHLC; -. DR OrthoDB; 4475554at2759; -. DR PhylomeDB; Q8TAL6; -. DR TreeFam; TF331989; -. DR PathwayCommons; Q8TAL6; -. DR SignaLink; Q8TAL6; -. DR BioGRID-ORCS; 387758; 9 hits in 1147 CRISPR screens. DR ChiTaRS; FIBIN; human. DR GenomeRNAi; 387758; -. DR Pharos; Q8TAL6; Tbio. DR PRO; PR:Q8TAL6; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q8TAL6; protein. DR Bgee; ENSG00000176971; Expressed in calcaneal tendon and 167 other cell types or tissues. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR InterPro; IPR026772; Fibin. DR PANTHER; PTHR31185; FIN BUD INITIATION FACTOR FIBIN; 1. DR PANTHER; PTHR31185:SF0; FIN BUD INITIATION FACTOR HOMOLOG; 1. DR Pfam; PF15819; Fibin; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; KW Glycoprotein; Golgi apparatus; Proteomics identification; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..18 FT /evidence="ECO:0000269|PubMed:21615908" FT CHAIN 19..211 FT /note="Fin bud initiation factor homolog" FT /id="PRO_0000349211" FT CARBOHYD 30 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:21615908" FT DISULFID 52 FT /note="Interchain" FT /evidence="ECO:0000269|PubMed:21615908" FT DISULFID 64 FT /note="Interchain" FT /evidence="ECO:0000269|PubMed:21615908" SQ SEQUENCE 211 AA; 24273 MW; A808B3D2E23E732D CRC64; MVFLKFFCMS FFCHLCQGYF DGPLYPEMSN GTLHHYFVPD GDYEENDDPE KCQLLFRVSD HRRCSQGEGS QVGSLLSLTL REEFTVLGRQ VEDAGRVLEG ISKSISYDLD GEESYGKYLR RESHQIGDAY SNSDKSLTEL ESKFKQGQEQ DSRQESRLNE DFLGMLVHTR SLLKETLDIS VGLRDKYELL ALTIRSHGTR LGRLKNDYLK V //