{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8TAF3","secondaryAccessions":["B4DM86","B4DQI2","B4DY84","Q63HJ2","Q658Y1","Q8N3Z1","Q9NSK8","Q9P279"],"uniProtkbId":"WDR48_HUMAN","entryAudit":{"firstPublicDate":"2005-12-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-06-01","entryVersion":195,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24145035"}],"value":"WD repeat-containing protein 48"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18082604"}],"value":"USP1-associated factor 1"}},{"fullName":{"value":"WD repeat endosomal protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12196293"}],"value":"p80"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24145035"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:30914"}],"value":"WDR48"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10819331"}],"value":"KIAA1449"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18082604"}],"value":"UAF1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18082604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19075014"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20147293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24145035"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26388029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27239033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27373336"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27463890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27650958"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31844045"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32350107"}],"value":"Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032488"}],"value":"(Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18082604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19075014"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20147293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22778262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24145035"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26388029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27239033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27373336"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27463890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27650958"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31844045"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33844468"}],"value":"Interacts with USP46 (PubMed:19075014, PubMed:26388029). Interacts with USP1 (PubMed:18082604, PubMed:26388029). Interacts with USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). Component of the USP12-WDR20-WDR48 deubiquitinating complex (PubMed:27373336). Component of the USP12-DMWD-WDR48 deubiquitinating complex (PubMed:33844468). Interacts with PHLPP1 (PubMed:24145035). Interacts with RAD51AP1; the interaction is direct and promotes formation of a trimeric complex with RAD51 via RAD51AP1 (PubMed:27239033, PubMed:27463890). Interacts with ATAD5; the interaction regulates USP1-mediated PCNA deubiquitination (PubMed:20147293). Interacts with RAD51; the interaction is enhanced under replication stress (PubMed:31844045). Interacts with ITCH; the interaction is more efficient when both USP12 and WDR48/UAF1 are involved and may facilitate recruitment of the USP12 deubiquitinating complex to Notch (PubMed:22778262)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032488"}],"value":"(Microbial infection) Interacts with papillomavirus HPV11 E1 protein"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12885920"}],"value":"(Microbial infection) Interacts with Saimiriine herpesvirus TIP protein"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37289831"}],"value":"(Microbial infection) Interacts with human cytomegalovirus protein UL138"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032488"}],"value":"(Microbial infection) Interacts with Epstein-Barr virus protein EBNA3"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8TAF3","intActId":"EBI-1045469"},"interactantTwo":{"uniProtKBAccession":"O94782","geneName":"USP1","intActId":"EBI-2513396"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8TAF3-1","intActId":"EBI-16178048"},"interactantTwo":{"uniProtKBAccession":"O94782","geneName":"USP1","intActId":"EBI-2513396"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032488"}],"value":"Mainly in cytoplasmic compartments (PubMed:12196293, PubMed:18032488). In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11 (PubMed:18032488)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032488"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032488"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"}],"value":"Lysosome","id":"SL-0158"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"}],"value":"Late endosome","id":"SL-0152"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8TAF3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8TAF3-2"],"sequenceIds":["VSP_016776","VSP_016777"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8TAF3-3"],"sequenceIds":["VSP_037625"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8TAF3-4"],"sequenceIds":["VSP_037623"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q8TAF3-5"],"sequenceIds":["VSP_037624","VSP_037626"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"}],"value":"Ubiquitous"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26388029"},{"evidenceCode":"ECO:0000305"}],"value":"N-terminal WD region interacts with TIP and C-terminal region mediates lysosomal localization (Probable). The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24145035"}],"value":"Knockdown of WDR48 increases Akt activation"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the WD repeat WDR48 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH37168.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA95973.2","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAH56182.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAH56300.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":677,"modifier":"EXACT"}},"description":"WD repeat-containing protein 48","featureId":"PRO_0000051399"},{"type":"Repeat","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"WD 7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"WD 8","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":609,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BH57"}]},{"type":"Modified residue","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":578,"modifier":"EXACT"},"end":{"value":578,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BH57"}]},{"type":"Modified residue","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":613,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_016776","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_037623","alternativeSequence":{"originalSequence":"MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTL","alternativeSequences":["MECQSAQV"]}},{"type":"Alternative sequence","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_037624","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_037625","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_037626","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":645,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_016777","alternativeSequence":{"originalSequence":"D","alternativeSequences":["DQV"]}},{"type":"Natural variant","location":{"start":{"value":628,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"found in a patient with spastic paraplegia; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24482476"}],"featureId":"VAR_077846","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"In UAF1(3A); impaired DNA-binding; when associated with A-50 and A-168. In UAF1(3A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-50 and A-168. In UAF1(11A); impaired DNA-binding; when associated with A-50, A-117, A-161, A-168, A-230, A-272, A-274, A-275, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-50, A-117, A-161, A-168, A-230, A-272, A-274, A-275, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"In UAF1(3A); impaired DNA-binding; when associated with A-30 and A-168. In UAF1(3A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30 and A-168. In UAF1(11A); impaired DNA-binding; when associated with A-30, A-117, A-161, A-168, A-230, A-272, A-274, A-275, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-117, A-161, A-168, A-230, A-272, A-274, A-275, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Impaired binding to USP12; when associated with Ala-256.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27373336"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-161, A-168, A-230, A-272, A-274, A-275, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-161, A-168, A-230, A-272, A-274, A-275, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Impaired binding to USP12; when associated with Ala-172.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27373336"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-117, A-168, A-230, A-272, A-274, A-275, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-117, A-168, A-230, A-272, A-274, A-275, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"In UAF1(3A); impaired DNA-binding; when associated with A-30 and A-50. In UAF1(3A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30 and A-50. In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-117, A-161, A-230, A-272, A-274, A-275, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-117, A-161, A-230, A-272, A-274, A-275, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Strongly reduces interaction with USP46 and abolishes stimulation of USP46 enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26388029"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Impaired binding to USP12; when associated with Ala-119.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27373336"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"Strongly reduces interaction with USP12 or USP46 and abolishes stimulation of their enzyme activity; when associated with A-256 and D-272.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26388029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27650958"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-117, A-161, A-168, A-272, A-274, A-275, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-117, A-161, A-168, A-272, A-274, A-275, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Strongly reduces interaction with USP12 or USP46 and abolishes stimulation of their enzyme activity; when associated with E-214 and D-272. Impaired binding to USP12; when associated with Ala-77.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26388029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27373336"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27650958"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-274, A-275, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-274, A-275, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Strongly reduces interaction with USP12 or USP46 and abolishes stimulation of their enzyme activity; when associated with E-214 and A-256.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26388029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27650958"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-272, A-275, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-272, A-275, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-272, A-274, A-318 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-272, A-274, A-318 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-272, A-274, A-275 and A-363. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-272, A-274, A-275 and A-363.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"In UAF1(11A); impaired DNA-binding; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-272, A-274, A-275 and A-318. In UAF1(11A); does not affect ability to promote USP1-mediated deubiquitination of FANCD2 and stimulate RAD51-mediated homologous recombination, because of DNA-binding mediated by RAD51AP1; when associated with A-30, A-50, A-117, A-161, A-168, A-230, A-272, A-274, A-275 and A-318.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31253762"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"Decreased interaction with RAD51AP1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27239033"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"Impaired binding to PHLPP1. Defective in stabilizing PHLPP1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24145035"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"Decreased interaction with RAD51AP1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27239033"}],"alternativeSequence":{"originalSequence":"KVMEH","alternativeSequences":["EVMEA"]}},{"type":"Mutagenesis","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":595,"modifier":"EXACT"}},"description":"Does not affect interaction with RAD51AP1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27239033"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"Does not affect interaction with RAD51AP1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27239033"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in Ref. 6; AAH37168","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in Ref. 4; BAG63646","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"in Ref. 4; BAG63646","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"in Ref. 4; BAG63646","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":585,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"in Ref. 4; BAG63646","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Beta strand","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8A9J"}]},{"type":"Beta strand","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HNW"}]},{"type":"Beta strand","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L8E"}]},{"type":"Beta strand","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JLQ"}]},{"type":"Beta strand","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CVL"}]},{"type":"Helix","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HNW"}]},{"type":"Beta strand","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L8E"}]},{"type":"Beta strand","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EBS"}]},{"type":"Beta strand","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":393,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L8E"}]},{"type":"Beta strand","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":514,"modifier":"EXACT"},"end":{"value":522,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":536,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":548,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":558,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":564,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Turn","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":575,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HNW"}]},{"type":"Helix","location":{"start":{"value":577,"modifier":"EXACT"},"end":{"value":581,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HNW"}]},{"type":"Beta strand","location":{"start":{"value":583,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":603,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":631,"modifier":"EXACT"},"end":{"value":638,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":643,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Helix","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]},{"type":"Beta strand","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5K1A"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"12196293","citationType":"journal article","authors":["Park J.","Lee B.-S.","Choi J.-K.","Means R.E.","Choe J.","Jung J.U."],"citationCrossReferences":[{"database":"PubMed","id":"12196293"},{"database":"DOI","id":"10.1016/s1074-7613(02)00368-0"}],"title":"Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression.","publicationDate":"2002","journal":"Immunity","firstPage":"221","lastPage":"233","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION (MICROBIAL INFECTION)","TISSUE SPECIFICITY","SUBCELLULAR LOCATION","INTERACTION WITH HERPESVIRUS SAIMIRI TIP (MICROBIAL INFECTION)"]},{"referenceNumber":2,"citation":{"id":"10819331","citationType":"journal article","authors":["Nagase T.","Kikuno R.","Ishikawa K.","Hirosawa M.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"10819331"},{"database":"DOI","id":"10.1093/dnares/7.2.143"}],"title":"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"2000","journal":"DNA Res.","firstPage":"143","lastPage":"150","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"12168954","citationType":"journal article","authors":["Nakajima D.","Okazaki N.","Yamakawa H.","Kikuno R.","Ohara O.","Nagase T."],"citationCrossReferences":[{"database":"PubMed","id":"12168954"},{"database":"DOI","id":"10.1093/dnares/9.3.99"}],"title":"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.","publicationDate":"2002","journal":"DNA Res.","firstPage":"99","lastPage":"106","volume":"9"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Teratocarcinoma","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-677 (ISOFORM 1)"],"referenceComments":[{"value":"Melanoma","type":"TISSUE"},{"value":"Retina","type":"TISSUE"},{"value":"Stomach","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"12885920","citationType":"journal article","authors":["Park J.","Cho N.-H.","Choi J.-K.","Feng P.","Choe J.","Jung J.U."],"citationCrossReferences":[{"database":"PubMed","id":"12885920"},{"database":"DOI","id":"10.1128/jvi.77.16.9041-9051.2003"}],"title":"Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts.","publicationDate":"2003","journal":"J. Virol.","firstPage":"9041","lastPage":"9051","volume":"77"},"referencePositions":["INTERACTION WITH HERPESVIRUS SAIMIRI TIP (MICROBIAL INFECTION)"]},{"referenceNumber":8,"citation":{"id":"18082604","citationType":"journal article","authors":["Cohn M.A.","Kowal P.","Yang K.","Haas W.","Huang T.T.","Gygi S.P.","D'Andrea A.D."],"citationCrossReferences":[{"database":"PubMed","id":"18082604"},{"database":"DOI","id":"10.1016/j.molcel.2007.09.031"}],"title":"A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.","publicationDate":"2007","journal":"Mol. Cell","firstPage":"786","lastPage":"797","volume":"28"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH USP1"]},{"referenceNumber":9,"citation":{"id":"18032488","citationType":"journal article","authors":["Cote-Martin A.","Moody C.","Fradet-Turcotte A.","D'Abramo C.M.","Lehoux M.","Joubert S.","Poirier G.G.","Coulombe B.","Laimins L.A.","Archambault J."],"citationCrossReferences":[{"database":"PubMed","id":"18032488"},{"database":"DOI","id":"10.1128/jvi.01405-07"}],"title":"Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes.","publicationDate":"2008","journal":"J. Virol.","firstPage":"1271","lastPage":"1283","volume":"82"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","SUBCELLULAR LOCATION","INTERACTION WITH HPV11 E1 (MICROBIAL INFECTION)"]},{"referenceNumber":10,"citation":{"id":"19075014","citationType":"journal article","authors":["Cohn M.A.","Kee Y.","Haas W.","Gygi S.P.","D'Andrea A.D."],"citationCrossReferences":[{"database":"PubMed","id":"19075014"},{"database":"DOI","id":"10.1074/jbc.m808430200"}],"title":"UAF1 is a subunit of multiple deubiquitinating enzyme complexes.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"5343","lastPage":"5351","volume":"284"},"referencePositions":["FUNCTION","INTERACTION WITH USP12 AND USP46"]},{"referenceNumber":11,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-214","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"20147293","citationType":"journal article","authors":["Lee K.Y.","Yang K.","Cohn M.A.","Sikdar N.","D'Andrea A.D.","Myung K."],"citationCrossReferences":[{"database":"PubMed","id":"20147293"},{"database":"DOI","id":"10.1074/jbc.m109.092544"}],"title":"Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"10362","lastPage":"10369","volume":"285"},"referencePositions":["FUNCTION","INTERACTION WITH ATAD5"]},{"referenceNumber":13,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":14,"citation":{"id":"22778262","citationType":"journal article","authors":["Moretti J.","Chastagner P.","Liang C.C.","Cohn M.A.","Israel A.","Brou C."],"citationCrossReferences":[{"database":"PubMed","id":"22778262"},{"database":"DOI","id":"10.1074/jbc.m112.366807"}],"title":"The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"29429","lastPage":"29441","volume":"287"},"referencePositions":["INTERACTION WITH ITCH AND USP12"]},{"referenceNumber":15,"citation":{"id":"24145035","citationType":"journal article","authors":["Gangula N.R.","Maddika S."],"citationCrossReferences":[{"database":"PubMed","id":"24145035"},{"database":"DOI","id":"10.1074/jbc.m113.503383"}],"title":"WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1).","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"34545","lastPage":"34554","volume":"288"},"referencePositions":["FUNCTION","MUTAGENESIS OF LEU-580","INTERACTION WITH PHLPP1"]},{"referenceNumber":16,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-613","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"25855980","citationType":"journal article","authors":["Ohashi M.","Holthaus A.M.","Calderwood M.A.","Lai C.Y.","Krastins B.","Sarracino D.","Johannsen E."],"citationCrossReferences":[{"database":"PubMed","id":"25855980"},{"database":"DOI","id":"10.1371/journal.ppat.1004822"}],"title":"The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.","publicationDate":"2015","journal":"PLoS Pathog.","firstPage":"e1004822","lastPage":"e1004822","volume":"11"},"referencePositions":["INTERACTION WITH EPSTEIN-BARR VIRUS PROTEINS EBNA3 (MICROBIAL INFECTION)"]},{"referenceNumber":18,"citation":{"id":"27463890","citationType":"journal article","authors":["Cukras S.","Lee E.","Palumbo E.","Benavidez P.","Moldovan G.L.","Kee Y."],"citationCrossReferences":[{"database":"PubMed","id":"27463890"},{"database":"DOI","id":"10.1080/15384101.2016.1209613"}],"title":"The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.","publicationDate":"2016","journal":"Cell Cycle","firstPage":"2636","lastPage":"2646","volume":"15"},"referencePositions":["FUNCTION","INTERACTION WITH RAD51AP1"]},{"referenceNumber":19,"citation":{"id":"27239033","citationType":"journal article","authors":["Liang F.","Longerich S.","Miller A.S.","Tang C.","Buzovetsky O.","Xiong Y.","Maranon D.G.","Wiese C.","Kupfer G.M.","Sung P."],"citationCrossReferences":[{"database":"PubMed","id":"27239033"},{"database":"DOI","id":"10.1016/j.celrep.2016.05.007"}],"title":"Promotion of RAD51-mediated homologous DNA pairing by the RAD51AP1-UAF1 complex.","publicationDate":"2016","journal":"Cell Rep.","firstPage":"2118","lastPage":"2126","volume":"15"},"referencePositions":["FUNCTION","DNA-BINDING","INTERACTION WITH RAD51AP1","MUTAGENESIS OF LYS-459; 595-LYS--HIS-599; LYS-595 AND HIS-599"]},{"referenceNumber":20,"citation":{"id":"31844045","citationType":"journal article","authors":["Park S.H.","Kang N.","Song E.","Wie M.","Lee E.A.","Hwang S.","Lee D.","Ra J.S.","Park I.B.","Park J.","Kang S.","Park J.H.","Hohng S.","Lee K.Y.","Myung K."],"citationCrossReferences":[{"database":"PubMed","id":"31844045"},{"database":"DOI","id":"10.1038/s41467-019-13667-4"}],"title":"ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress.","publicationDate":"2019","journal":"Nat. Commun.","firstPage":"5718","lastPage":"5718","volume":"10"},"referencePositions":["FUNCTION","INTERACTION WITH RAD51 AND ATAD5"]},{"referenceNumber":21,"citation":{"id":"31253762","citationType":"journal article","authors":["Liang F.","Miller A.S.","Longerich S.","Tang C.","Maranon D.","Williamson E.A.","Hromas R.","Wiese C.","Kupfer G.M.","Sung P."],"citationCrossReferences":[{"database":"PubMed","id":"31253762"},{"database":"DOI","id":"10.1038/s41467-019-10408-5"}],"title":"DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response.","publicationDate":"2019","journal":"Nat. Commun.","firstPage":"2849","lastPage":"2849","volume":"10"},"referencePositions":["FUNCTION","DNA-BINDING","MUTAGENESIS OF ARG-30; ARG-50; LYS-117; THR-161; LYS-168; SER-230; ARG-272; ARG-274; LYS-275; LYS-318 AND ILE-363"]},{"referenceNumber":22,"citation":{"id":"32350107","citationType":"journal article","authors":["Liang F.","Miller A.S.","Tang C.","Maranon D.","Williamson E.A.","Hromas R.","Wiese C.","Zhao W.","Sung P.","Kupfer G.M."],"citationCrossReferences":[{"database":"PubMed","id":"32350107"},{"database":"DOI","id":"10.1074/jbc.ra120.013714"}],"title":"The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair.","publicationDate":"2020","journal":"J. Biol. Chem.","firstPage":"8186","lastPage":"8194","volume":"295"},"referencePositions":["FUNCTION","DNA-BINDING","MUTAGENESIS OF ARG-30; ARG-50; LYS-117; THR-161; LYS-168; SER-230; ARG-272; ARG-274; LYS-275; LYS-318 AND ILE-363"]},{"referenceNumber":23,"citation":{"id":"33844468","citationType":"journal article","authors":["Olazabal-Herrero A.","Bilbao-Arribas M.","Carlevaris O.","Sendino M.","Varela-Martinez E.","Jugo B.M.","Berra E.","Rodriguez J.A."],"citationCrossReferences":[{"database":"PubMed","id":"33844468"},{"database":"DOI","id":"10.1111/febs.15875"}],"title":"The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase.","publicationDate":"2021","journal":"FEBS J.","firstPage":"5943","lastPage":"5963","volume":"288"},"referencePositions":["SUBUNIT"]},{"referenceNumber":24,"citation":{"id":"37289831","citationType":"journal article","authors":["Zarrella K.","Longmire P.","Zeltzer S.","Collins-McMillen D.","Hancock M.","Buehler J.","Reitsma J.M.","Terhune S.S.","Nelson J.A.","Goodrum F."],"citationCrossReferences":[{"database":"PubMed","id":"37289831"},{"database":"DOI","id":"10.1371/journal.ppat.1011185"}],"title":"Human Cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection.","publicationDate":"2023","journal":"PLoS Pathog.","firstPage":"e1011185","lastPage":"e1011185","volume":"19"},"referencePositions":["INTERACTION WITH HUMAN CYTOMEGALOVIRUS PROTEIN UL138 (MICROBIAL INFECTION)"]},{"referenceNumber":25,"citation":{"id":"26388029","citationType":"journal article","authors":["Yin J.","Schoeffler A.J.","Wickliffe K.","Newton K.","Starovasnik M.A.","Dueber E.C.","Harris S.F."],"citationCrossReferences":[{"database":"PubMed","id":"26388029"},{"database":"DOI","id":"10.1016/j.str.2015.08.010"}],"title":"Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46.","publicationDate":"2015","journal":"Structure","firstPage":"2043","lastPage":"2054","volume":"23"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 2-580 IN COMPLEX WITH USP46 AND UBIQUITIN","INTERACTION WITH USP46 AND USP1","FUNCTION","MUTAGENESIS OF SER-170; LYS-214; TRP-256 AND ARG-272"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CVL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CVN"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CVO"}]},{"referenceNumber":26,"citation":{"id":"27650958","citationType":"journal article","authors":["Dharadhar S.","Clerici M.","van Dijk W.J.","Fish A.","Sixma T.K."],"citationCrossReferences":[{"database":"PubMed","id":"27650958"},{"database":"DOI","id":"10.1016/j.jsb.2016.09.011"}],"title":"A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.","publicationDate":"2016","journal":"J. Struct. Biol.","firstPage":"437","lastPage":"447","volume":"196"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 9-580","X-RAY CRYSTALLOGRAPHY (2.79 ANGSTROMS) OF 9-580 IN COMPLEX WITH USP12 AND UBIQUITIN","INTERACTION WITH USP12","FUNCTION","MUTAGENESIS OF LYS-214; TRP-256 AND ARG-272"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5L8E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5L8W"}]},{"referenceNumber":27,"citation":{"id":"27373336","citationType":"journal article","authors":["Li H.","Lim K.S.","Kim H.","Hinds T.R.","Jo U.","Mao H.","Weller C.E.","Sun J.","Chatterjee C.","D'Andrea A.D.","Zheng N."],"citationCrossReferences":[{"database":"PubMed","id":"27373336"},{"database":"DOI","id":"10.1016/j.molcel.2016.05.031"}],"title":"Allosteric activation of ubiquitin-specific proteases by beta-propeller proteins UAF1 and WDR20.","publicationDate":"2016","journal":"Mol. Cell","firstPage":"249","lastPage":"260","volume":"63"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH USP12 AND WDR20","INTERACTION WITH USP12","FUNCTION","MUTAGENESIS OF TRP-77; TYR-119; TYR-172 AND TRP-256"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5K1A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5K1B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5K1C"}]},{"referenceNumber":28,"citation":{"id":"24482476","citationType":"journal article","authors":["Novarino G.","Fenstermaker A.G.","Zaki M.S.","Hofree M.","Silhavy J.L.","Heiberg A.D.","Abdellateef M.","Rosti B.","Scott E.","Mansour L.","Masri A.","Kayserili H.","Al-Aama J.Y.","Abdel-Salam G.M.","Karminejad A.","Kara M.","Kara B.","Bozorgmehri B.","Ben-Omran T.","Mojahedi F.","Mahmoud I.G.","Bouslam N.","Bouhouche A.","Benomar A.","Hanein S.","Raymond L.","Forlani S.","Mascaro M.","Selim L.","Shehata N.","Al-Allawi N.","Bindu P.S.","Azam M.","Gunel M.","Caglayan A.","Bilguvar K.","Tolun A.","Issa M.Y.","Schroth J.","Spencer E.G.","Rosti R.O.","Akizu N.","Vaux K.K.","Johansen A.","Koh A.A.","Megahed H.","Durr A.","Brice A.","Stevanin G.","Gabriel S.B.","Ideker T.","Gleeson J.G."],"citationCrossReferences":[{"database":"PubMed","id":"24482476"},{"database":"DOI","id":"10.1126/science.1247363"}],"title":"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.","publicationDate":"2014","journal":"Science","firstPage":"506","lastPage":"511","volume":"343"},"referencePositions":["VARIANT GLU-628 DEL"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF468833","properties":[{"key":"ProteinId","value":"AAL78650.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB040882","properties":[{"key":"ProteinId","value":"BAA95973.2"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK297349","properties":[{"key":"ProteinId","value":"BAG59798.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK298810","properties":[{"key":"ProteinId","value":"BAG60944.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK302307","properties":[{"key":"ProteinId","value":"BAG63646.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL162064","properties":[{"key":"ProteinId","value":"CAB82402.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL832926","properties":[{"key":"ProteinId","value":"CAH56300.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX649170","properties":[{"key":"ProteinId","value":"CAH56182.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC026353","properties":[{"key":"ProteinId","value":"AAH26353.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC037168","properties":[{"key":"ProteinId","value":"AAH37168.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS33738.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TAF3-1"},{"database":"PIR","id":"T47168","properties":[{"key":"EntryName","value":"T47168"}]},{"database":"RefSeq","id":"NP_001290331.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001303402.2"}],"isoformId":"Q8TAF3-4"},{"database":"RefSeq","id":"NP_001290332.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001303403.2"}],"isoformId":"Q8TAF3-3"},{"database":"RefSeq","id":"NP_001333156.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001346227.2"}]},{"database":"RefSeq","id":"NP_001333157.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001346228.2"}]},{"database":"RefSeq","id":"NP_065890.1","properties":[{"key":"NucleotideSequenceId","value":"NM_020839.4"}],"isoformId":"Q8TAF3-1"},{"database":"PDB","id":"5CVL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=2-580"}]},{"database":"PDB","id":"5CVN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.36 A"},{"key":"Chains","value":"A=2-580"}]},{"database":"PDB","id":"5CVO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.88 A"},{"key":"Chains","value":"A/D=1-562"}]},{"database":"PDB","id":"5K1A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D/F/H=1-677"}]},{"database":"PDB","id":"5K1B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"B=1-677"}]},{"database":"PDB","id":"5K1C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"B=1-563"}]},{"database":"PDB","id":"5L8E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B=9-580"}]},{"database":"PDB","id":"5L8W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.79 A"},{"key":"Chains","value":"B=9-580"}]},{"database":"PDB","id":"6JLQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"B=1-580"}]},{"database":"PDB","id":"7AY0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/C=1-563"}]},{"database":"PDB","id":"7AY1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"E=1-677"}]},{"database":"PDB","id":"7AY2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/D=1-563"}]},{"database":"PDB","id":"8A9J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"E=1-677"}]},{"database":"PDB","id":"8A9K","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"E=1-677"}]},{"database":"PDB","id":"9DI1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=1-677"}]},{"database":"PDB","id":"9DI2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1-677"}]},{"database":"PDB","id":"9EBS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"D=1-677"}]},{"database":"PDB","id":"9HNW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.04 A"},{"key":"Chains","value":"B=1-672"}]},{"database":"PDB","id":"9N9Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.15 A"},{"key":"Chains","value":"A=1-563"}]},{"database":"PDBsum","id":"5CVL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CVN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CVO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5K1A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5K1B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5K1C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5L8E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5L8W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6JLQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7AY0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7AY1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7AY2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A9J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A9K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DI1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DI2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EBS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HNW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9N9Y","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11934","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14722","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-15284","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-46895","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-46896","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47889","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52316","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"121649","properties":[{"key":"Interactions","value":"180"}]},{"database":"ComplexPortal","id":"CPX-9281","properties":[{"key":"EntryName","value":"USP46 deubiquitinase complex"}]},{"database":"ComplexPortal","id":"CPX-9361","properties":[{"key":"EntryName","value":"USP12-WDR20 deubiquitinase complex"}]},{"database":"ComplexPortal","id":"CPX-9381","properties":[{"key":"EntryName","value":"USP12-DMWD deubiquitinase complex"}]},{"database":"ComplexPortal","id":"CPX-9442","properties":[{"key":"EntryName","value":"USP1-UAF1 deubiquitinase complex"}]},{"database":"CORUM","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-50841N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8TAF3","properties":[{"key":"Number of interactors","value":"5826"}]},{"database":"IntAct","id":"Q8TAF3","properties":[{"key":"Interactions","value":"119"}]},{"database":"MINT","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-WDR48","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000307491","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3351203","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8TAF3","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"WDR48","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74760390","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000307491","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"73870","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TAF3-1"},{"database":"ProteomicsDB","id":"73871","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TAF3-2"},{"database":"ProteomicsDB","id":"73872","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TAF3-3"},{"database":"ProteomicsDB","id":"73873","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TAF3-4"},{"database":"ProteomicsDB","id":"73874","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8TAF3-5"},{"database":"Pumba","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"50460","properties":[{"key":"antibodies","value":"125 antibodies from 26 providers"}]},{"database":"DNASU","id":"57599","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000302313.10","properties":[{"key":"ProteinId","value":"ENSP00000307491.5"},{"key":"GeneId","value":"ENSG00000114742.15"}],"isoformId":"Q8TAF3-1"},{"database":"Ensembl","id":"ENST00000881529.1","properties":[{"key":"ProteinId","value":"ENSP00000551588.1"},{"key":"GeneId","value":"ENSG00000114742.15"}],"isoformId":"Q8TAF3-3"},{"database":"GeneID","id":"57599","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:57599","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000302313.10","properties":[{"key":"ProteinId","value":"ENSP00000307491.5"},{"key":"RefSeqNucleotideId","value":"NM_020839.4"},{"key":"RefSeqProteinId","value":"NP_065890.1"}]},{"database":"UCSC","id":"uc003cit.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8TAF3-1"},{"database":"AGR","id":"HGNC:30914","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134956949","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"57599","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"57599","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"WDR48","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:30914","properties":[{"key":"GeneName","value":"WDR48"}]},{"database":"HPA","id":"ENSG00000114742","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"WDR48","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"612167","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000114742","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"401800","properties":[{"key":"Disease","value":"Autosomal recessive spastic paraplegia type 60"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000114742","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0308","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00920000149157","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_014960_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IRHYHIL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2421129at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8TAF3","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-110314","properties":[{"key":"PathwayName","value":"Recognition of DNA damage by PCNA-containing replication complex"}]},{"database":"Reactome","id":"R-HSA-5689880","properties":[{"key":"PathwayName","value":"Ub-specific processing proteases"}]},{"database":"Reactome","id":"R-HSA-6783310","properties":[{"key":"PathwayName","value":"Fanconi Anemia Pathway"}]},{"database":"Reactome","id":"R-HSA-9673766","properties":[{"key":"PathwayName","value":"Signaling by cytosolic PDGFRA and PDGFRB fusion proteins"}]},{"database":"SignaLink","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000114742","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"57599","properties":[{"key":"hits","value":"261 hits in 1171 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"WDR48","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"57599","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8TAF3","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8TAF3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q8TAF3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000114742","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 212 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8TAF3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18032488"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005770","properties":[{"key":"GoTerm","value":"C:late endosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196293"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18082604"}]},{"database":"GO","id":"GO:1905368","properties":[{"key":"GoTerm","value":"C:peptidase complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20147737"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"31632687"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"33795880"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30466959"}]},{"database":"GO","id":"GO:0035800","properties":[{"key":"GoTerm","value":"F:deubiquitinase activator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18082604"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19075014"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24145035"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31253762"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31253762"}]},{"database":"GO","id":"GO:0003690","properties":[{"key":"GoTerm","value":"F:double-stranded DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27239033"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27239033"}]},{"database":"GO","id":"GO:0043130","properties":[{"key":"GoTerm","value":"F:ubiquitin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27239033"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27463890"}]},{"database":"GO","id":"GO:0000724","properties":[{"key":"GoTerm","value":"P:double-strand break repair via homologous recombination"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0090263","properties":[{"key":"GoTerm","value":"P:positive regulation of canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37798301"}]},{"database":"GO","id":"GO:1905168","properties":[{"key":"GoTerm","value":"P:positive regulation of double-strand break repair via homologous recombination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27239033"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27463890"}]},{"database":"GO","id":"GO:0046427","properties":[{"key":"GoTerm","value":"P:positive regulation of receptor signaling pathway via JAK-STAT"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37289831"}]},{"database":"CDD","id":"cd17041","properties":[{"key":"EntryName","value":"Ubl_WDR48"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000054","properties":[{"key":"EntryName","value":"Putative WD repeat-containing protein 48"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:002031","properties":[{"key":"EntryName","value":"WD repeat domain 48b"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR051246","properties":[{"key":"EntryName","value":"WDR48"}]},{"database":"InterPro","id":"IPR021772","properties":[{"key":"EntryName","value":"WDR48/Bun107_Ubl"}]},{"database":"PANTHER","id":"PTHR19862","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN 48"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19862:SF14","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN 48"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11816","properties":[{"key":"EntryName","value":"Ubl_WDR48-Bun107"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"7"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVNPMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST","length":677,"molWeight":76210,"crc64":"20FDA620E02696E0","md5":"9668E5EB547D4B047BB5B81207E4A4E7"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":5,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":5,"TISSUE SPECIFICITY":1,"DOMAIN":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":4},"countByFeatureType":{"Chain":1,"Repeat":8,"Region":1,"Compositional bias":1,"Modified residue":4,"Alternative sequence":6,"Natural variant":1,"Mutagenesis":23,"Sequence conflict":5,"Beta strand":49,"Turn":12,"Helix":16},"uniParcId":"UPI000006FF8C"}}