{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8R0J4","secondaryAccessions":["Q3TLG9","Q8C1M3","Q9CR66"],"uniProtkbId":"TM134_MOUSE","entryAudit":{"firstPublicDate":"2007-03-06","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2002-06-01","entryVersion":115,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transmembrane protein 134"}}},"genes":[{"geneName":{"value":"Tmem134"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H6X4"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8R0J4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8R0J4-2"],"sequenceIds":["VSP_023456"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8R0J4-3"],"sequenceIds":["VSP_023455"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TMEM134/TMEM230 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Transmembrane protein 134","featureId":"PRO_0000279486"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Alternative sequence","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_023455","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_023456","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"in Ref. 1; BAE38823","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Embryonic stem cell","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Mammary gland","type":"TISSUE"},{"value":"Tongue","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Salivary gland","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK002220","properties":[{"key":"ProteinId","value":"BAB21944.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK009745","properties":[{"key":"ProteinId","value":"BAB26475.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK010323","properties":[{"key":"ProteinId","value":"BAC25290.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK166519","properties":[{"key":"ProteinId","value":"BAE38823.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC026765","properties":[{"key":"ProteinId","value":"AAH26765.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001072117.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001078649.1"}],"isoformId":"Q8R0J4-1"},{"database":"RefSeq","id":"NP_080165.1","properties":[{"key":"NucleotideSequenceId","value":"NM_025889.2"}],"isoformId":"Q8R0J4-2"},{"database":"AlphaFoldDB","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8R0J4","properties":[{"key":"Number of interactors","value":"492"}]},{"database":"STRING","id":"10090.ENSMUSP00000158987","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000158987","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"260675","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8R0J4-1"},{"database":"ProteomicsDB","id":"260676","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8R0J4-2"},{"database":"ProteomicsDB","id":"260677","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8R0J4-3"},{"database":"Pumba","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"30426","properties":[{"key":"antibodies","value":"65 antibodies from 13 providers"}]},{"database":"DNASU","id":"66990","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000139987.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000159417.2"},{"key":"GeneId","value":"ENSMUSG00000024845.20"}],"isoformId":"Q8R0J4-3"},{"database":"Ensembl","id":"ENSMUST00000140267.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000159415.2"},{"key":"GeneId","value":"ENSMUSG00000024845.20"}],"isoformId":"Q8R0J4-1"},{"database":"Ensembl","id":"ENSMUST00000150627.11","properties":[{"key":"ProteinId","value":"ENSMUSP00000158987.4"},{"key":"GeneId","value":"ENSMUSG00000024845.20"}],"isoformId":"Q8R0J4-2"},{"database":"Ensembl","id":"ENSMUST00000169055.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000159412.2"},{"key":"GeneId","value":"ENSMUSG00000024845.20"}],"isoformId":"Q8R0J4-2"},{"database":"GeneID","id":"66990","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:66990","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008fyr.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8R0J4-1"},{"database":"UCSC","id":"uc008fys.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8R0J4-2"},{"database":"AGR","id":"MGI:1914240","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"80194","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1914240","properties":[{"key":"GeneName","value":"Tmem134"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000024845","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000011766","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"82048at9989","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"66990","properties":[{"key":"hits","value":"0 hits in 17 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8R0J4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"Q8R0J4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000024845","properties":[{"key":"ExpressionPatterns","value":"Expressed in lip and 175 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8R0J4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"InterPro","id":"IPR039714","properties":[{"key":"EntryName","value":"TMEM134"}]},{"database":"InterPro","id":"IPR008590","properties":[{"key":"EntryName","value":"TMEM_230/134"}]},{"database":"PANTHER","id":"PTHR13558","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 134"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13558:SF1","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 134"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05915","properties":[{"key":"EntryName","value":"TMEM_230_134"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSAARPQFSIDDAFELTLEDAGPEPESSGVARFGPLHFERRARFEVADEDKQSRLRYQNLENDEDGAQASPEPDGGVSTRDSGHMSVRSSQWSFSTISSSTQRSYNACCSWTQHPLIQKNRRVVLASFLLLLLGLVLILVGVGLEVAPSPGVSSAIFFVPGILLLVPGVYHVIFIYCAVKGRRGFQFFYLPYFEK","length":195,"molWeight":21637,"crc64":"D34CCCC924937662","md5":"CA981DFDECF7D9F2A2F8444262BAFA2F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":2,"Region":2,"Compositional bias":1,"Modified residue":1,"Alternative sequence":2,"Sequence conflict":1},"uniParcId":"UPI00000E82C2"}}