{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8NFR3","secondaryAccessions":["B2R5D3","D3DNM8","Q0P5S6"],"uniProtkbId":"SPTSB_HUMAN","entryAudit":{"firstPublicDate":"2006-06-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":142,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Serine palmitoyltransferase small subunit B"}},"alternativeNames":[{"fullName":{"value":"Protein ADMP"}},{"fullName":{"value":"Small subunit of serine palmitoyltransferase B"},"shortNames":[{"value":"ssSPTb"}]}]},"genes":[{"geneName":{"value":"SPTSSB"},"synonyms":[{"value":"ADMP"},{"value":"C3orf57"},{"value":"SSSPTB"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19416851"}],"value":"Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core (PubMed:19416851). Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851)"}],"commentType":"FUNCTION"},{"texts":[{"value":"Lipid metabolism; sphingolipid metabolism"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q969W0"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19416851"}],"value":"Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity (PubMed:19416851). SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15777716"}],"value":"Expression is seen predominantly in the prostate epithelium with weaker expression in the fibroblasts and endothelial cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15777716"}],"value":"Expression is suppressed by androgens in the androgen-sensitive LNCaP cell line"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SPTSS family. SPTSSB subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Serine palmitoyltransferase small subunit B","featureId":"PRO_0000239719"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0746","category":"Biological process","name":"Sphingolipid metabolism"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-B84QOFV96F1A5","citationType":"submission","authors":["Zan Q.","Guo J.H.","Yu L."],"publicationDate":"DEC-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":3,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lung","type":"TISSUE"},{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15777716","citationType":"journal article","authors":["Singh J.","Young L.","Handelsman D.J.","Dong Q."],"citationCrossReferences":[{"database":"PubMed","id":"15777716"},{"database":"DOI","id":"10.1016/j.gene.2004.12.047"}],"title":"Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium.","publicationDate":"2005","journal":"Gene","firstPage":"55","lastPage":"63","volume":"348"},"referencePositions":["INDUCTION","TISSUE SPECIFICITY"]},{"referenceNumber":6,"citation":{"id":"19416851","citationType":"journal article","authors":["Han G.","Gupta S.D.","Gable K.","Niranjanakumari S.","Moitra P.","Eichler F.","Brown R.H. Jr.","Harmon J.M.","Dunn T.M."],"citationCrossReferences":[{"database":"PubMed","id":"19416851"},{"database":"DOI","id":"10.1073/pnas.0811269106"}],"title":"Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"8186","lastPage":"8191","volume":"106"},"referencePositions":["FUNCTION","TOPOLOGY","IDENTIFICATION IN THE SPT COMPLEX","INTERACTION WITH SPTLC1"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF458592","properties":[{"key":"ProteinId","value":"AAM49720.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK312144","properties":[{"key":"ProteinId","value":"BAG35080.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471052","properties":[{"key":"ProteinId","value":"EAW78616.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471052","properties":[{"key":"ProteinId","value":"EAW78617.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC065208","properties":[{"key":"ProteinId","value":"AAH65208.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC071875","properties":[{"key":"ProteinId","value":"AAH71875.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC107756","properties":[{"key":"ProteinId","value":"AAI07757.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS33887.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001035189.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001040100.2"}]},{"database":"RefSeq","id":"NP_001307608.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001320679.2"}]},{"database":"RefSeq","id":"XP_024309147.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024453379.2"}]},{"database":"RefSeq","id":"XP_024309148.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024453380.2"}]},{"database":"RefSeq","id":"XP_054201454.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054345479.1"}]},{"database":"RefSeq","id":"XP_054201455.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054345480.1"}]},{"database":"AlphaFoldDB","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"ComplexPortal","id":"CPX-6664","properties":[{"key":"EntryName","value":"Serine palmitoyltransferase complex, SPTLC1-SPTLC2-SPTSSB variant"}]},{"database":"ComplexPortal","id":"CPX-6681","properties":[{"key":"EntryName","value":"Serine palmitoyltransferase complex, SPTLC1-SPTLC3-SPTSSB variant"}]},{"database":"CORUM","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-60755N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8NFR3","properties":[{"key":"Number of interactors","value":"356"}]},{"database":"IntAct","id":"Q8NFR3","properties":[{"key":"Interactions","value":"3"}]},{"database":"STRING","id":"9606.ENSP00000352097","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6067597","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"2513","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SPTSSB","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74730296","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000352097","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"73338","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"77962","properties":[{"key":"antibodies","value":"3 antibodies from 3 providers"}]},{"database":"DNASU","id":"165679","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000359175.9","properties":[{"key":"ProteinId","value":"ENSP00000352097.4"},{"key":"GeneId","value":"ENSG00000196542.10"}]},{"database":"Ensembl","id":"ENST00000497137.1","properties":[{"key":"ProteinId","value":"ENSP00000420115.1"},{"key":"GeneId","value":"ENSG00000196542.10"}]},{"database":"Ensembl","id":"ENST00000620149.2","properties":[{"key":"ProteinId","value":"ENSP00000480827.1"},{"key":"GeneId","value":"ENSG00000196542.10"}]},{"database":"Ensembl","id":"ENST00000886301.1","properties":[{"key":"ProteinId","value":"ENSP00000556360.1"},{"key":"GeneId","value":"ENSG00000196542.10"}]},{"database":"Ensembl","id":"ENST00000935638.1","properties":[{"key":"ProteinId","value":"ENSP00000605697.1"},{"key":"GeneId","value":"ENSG00000196542.10"}]},{"database":"Ensembl","id":"ENST00000941699.1","properties":[{"key":"ProteinId","value":"ENSP00000611758.1"},{"key":"GeneId","value":"ENSG00000196542.10"}]},{"database":"Ensembl","id":"ENST00000941700.1","properties":[{"key":"ProteinId","value":"ENSP00000611759.1"},{"key":"GeneId","value":"ENSG00000196542.10"}]},{"database":"GeneID","id":"165679","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:165679","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000620149.2","properties":[{"key":"ProteinId","value":"ENSP00000480827.1"},{"key":"RefSeqNucleotideId","value":"NM_001040100.2"},{"key":"RefSeqProteinId","value":"NP_001035189.1"}]},{"database":"UCSC","id":"uc003fee.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:24045","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA143485333","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"165679","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"165679","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SPTSSB","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:24045","properties":[{"key":"GeneName","value":"SPTSSB"}]},{"database":"HPA","id":"ENSG00000196542","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (skin, stomach, urinary bladder)"}]},{"database":"MIM","id":"610412","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000196542","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000196542","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S4Q9","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002766","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_187811_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WEFFSEI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10341425at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8NFR3","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:MONOMER66-34372","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1660661","properties":[{"key":"PathwayName","value":"Sphingolipid de novo biosynthesis"}]},{"database":"SignaLink","id":"Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00222","properties":[{"key":"RectionId","value":"-"}]},{"database":"Agora","id":"ENSG00000196542","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"165679","properties":[{"key":"hits","value":"8 hits in 1105 CRISPR screens"}]},{"database":"GenomeRNAi","id":"165679","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8NFR3","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8NFR3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q8NFR3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000196542","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 139 other cell types or tissues"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0017059","properties":[{"key":"GoTerm","value":"C:serine palmitoyltransferase complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19416851"}]},{"database":"GO","id":"GO:0004758","properties":[{"key":"GoTerm","value":"F:serine C-palmitoyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046513","properties":[{"key":"GoTerm","value":"P:ceramide biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007029","properties":[{"key":"GoTerm","value":"P:endoplasmic reticulum organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030148","properties":[{"key":"GoTerm","value":"P:sphingolipid biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046512","properties":[{"key":"GoTerm","value":"P:sphingosine biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19416851"}]},{"database":"InterPro","id":"IPR024512","properties":[{"key":"EntryName","value":"Ser_palmitoyltrfase_ssu-like"}]},{"database":"PANTHER","id":"PTHR28612","properties":[{"key":"EntryName","value":"SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28612:SF1","properties":[{"key":"EntryName","value":"SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11779","properties":[{"key":"EntryName","value":"SPT_ssu-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDLRRVKEYFSWLYYQYQIISCCAVLEPWERSMFNTILLTIIAMVVYTAYVFIPIHIRLAWEFFSKICGYHSTISN","length":76,"molWeight":9198,"crc64":"F43280DBC07B5A0E","md5":"694F71284CFA64979238E754A44A9AEE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":2},"uniParcId":"UPI000006E72B"}}