{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8NDD1","secondaryAccessions":["Q5TBI0","Q5TBI1","Q6P6B4","Q7Z6H5","Q8N432","Q96NM6"],"uniProtkbId":"FSAF1_HUMAN","entryAudit":{"firstPublicDate":"2007-05-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2018-03-28","entryVersion":145,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25332"}],"value":"40S small subunit processome assembly factor 1"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25332"}],"value":"FSAF1"},"synonyms":[{"value":"C1orf131"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20813266"}],"value":"cPERP-A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34516797"}],"value":"Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Prevents helicase DHX37 to be recruited before post-A1 state"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34516797"}],"value":"Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8NDD1-6","intActId":"EBI-17761821"},"interactantTwo":{"uniProtKBAccession":"P55040","geneName":"GEM","intActId":"EBI-744104"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8NDD1-6","intActId":"EBI-17761821"},"interactantTwo":{"uniProtKBAccession":"Q92993","geneName":"KAT5","intActId":"EBI-399080"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8NDD1-6","intActId":"EBI-17761821"},"interactantTwo":{"uniProtKBAccession":"Q9NQZ2","geneName":"UTP3","intActId":"EBI-714067"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20813266"}],"value":"Chromosome","id":"SL-0468"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34516797"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8NDD1-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8NDD1-5"],"sequenceIds":["VSP_059469"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8NDD1-6"],"sequenceIds":["VSP_059467"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8NDD1-7"],"sequenceIds":["VSP_059466","VSP_059468"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"It is uncertain whether Met-1 or Met-11 is the initiator"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"40S small subunit processome assembly factor 1","featureId":"PRO_0000285029"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17525332"}]},{"type":"Modified residue","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_059466","alternativeSequence":{"originalSequence":"QANPSVLERDVDTQEF","alternativeSequences":["VMSWLAYIYVVNPLVL"]}},{"type":"Alternative sequence","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_059467","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_059468","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_059469","alternativeSequence":{"originalSequence":"D","alternativeSequences":["DR"]}},{"type":"Natural variant","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"in dbSNP:rs2274067","featureCrossReferences":[{"database":"dbSNP","id":"rs2274067"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17974005"}],"featureId":"VAR_031906","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"in Ref. 1; BAB70857","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","VARIANT VAL-28"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)","VARIANT VAL-28"],"referenceComments":[{"value":"Eye","type":"TISSUE"},{"value":"Ovary","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-163","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-185","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"20813266","citationType":"journal article","authors":["Ohta S.","Bukowski-Wills J.C.","Sanchez-Pulido L.","Alves Fde L.","Wood L.","Chen Z.A.","Platani M.","Fischer L.","Hudson D.F.","Ponting C.P.","Fukagawa T.","Earnshaw W.C.","Rappsilber J."],"citationCrossReferences":[{"database":"PubMed","id":"20813266"},{"database":"DOI","id":"10.1016/j.cell.2010.07.047"}],"title":"The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.","publicationDate":"2010","journal":"Cell","firstPage":"810","lastPage":"821","volume":"142"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":9,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-78 AND SER-279","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-279","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"34516797","citationType":"journal article","authors":["Singh S.","Vanden Broeck A.","Miller L.","Chaker-Margot M.","Klinge S."],"citationCrossReferences":[{"database":"PubMed","id":"34516797"},{"database":"DOI","id":"10.1126/science.abj5338"}],"title":"Nucleolar maturation of the human small subunit processome.","publicationDate":"2021","journal":"Science","firstPage":"eabj5338","lastPage":"eabj5338","volume":"373"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS)","FUNCTION","SUBUNIT","SUBCELLULAR LOCATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7MQ8"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7MQ9"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK055124","properties":[{"key":"ProteinId","value":"BAB70857.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL834274","properties":[{"key":"ProteinId","value":"CAD38949.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Transcribed_RNA"}]},{"database":"EMBL","id":"AL137801","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC036800","properties":[{"key":"ProteinId","value":"AAH36800.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC053609","properties":[{"key":"ProteinId","value":"AAH53609.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC062353","properties":[{"key":"ProteinId","value":"AAH62353.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1591.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8NDD1-1"},{"database":"CCDS","id":"CCDS73049.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8NDD1-6"},{"database":"RefSeq","id":"NP_001287759.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001300830.2"}],"isoformId":"Q8NDD1-6"},{"database":"RefSeq","id":"NP_689592.2","properties":[{"key":"NucleotideSequenceId","value":"NM_152379.4"}],"isoformId":"Q8NDD1-1"},{"database":"PDB","id":"7MQ8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"NE=1-293"}]},{"database":"PDB","id":"7MQ9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.87 A"},{"key":"Chains","value":"NE=1-293"}]},{"database":"PDBsum","id":"7MQ8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MQ9","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23936","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23937","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"126091","properties":[{"key":"Interactions","value":"69"}]},{"database":"ComplexPortal","id":"CPX-2511","properties":[{"key":"EntryName","value":"Small ribosomal subunit processome"}]},{"database":"FunCoup","id":"Q8NDD1","properties":[{"key":"Number of interactors","value":"1096"}]},{"database":"IntAct","id":"Q8NDD1","properties":[{"key":"Interactions","value":"25"}]},{"database":"MINT","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000355609","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q8NDD1","properties":[{"key":"glycosylation","value":"2 sites, 1 glycan"}]},{"database":"GlyGen","id":"Q8NDD1","properties":[{"key":"glycosylation","value":"4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)"}]},{"database":"iPTMnet","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C1orf131","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"146286060","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000355609","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"73015","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8NDD1-1"},{"database":"Pumba","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34684","properties":[{"key":"antibodies","value":"62 antibodies from 14 providers"}]},{"database":"DNASU","id":"128061","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000366649.7","properties":[{"key":"ProteinId","value":"ENSP00000355609.2"},{"key":"GeneId","value":"ENSG00000143633.14"}],"isoformId":"Q8NDD1-1"},{"database":"Ensembl","id":"ENST00000366651.7","properties":[{"key":"ProteinId","value":"ENSP00000355611.3"},{"key":"GeneId","value":"ENSG00000143633.14"}],"isoformId":"Q8NDD1-6"},{"database":"GeneID","id":"128061","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:128061","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000366649.7","properties":[{"key":"ProteinId","value":"ENSP00000355609.2"},{"key":"RefSeqNucleotideId","value":"NM_152379.4"},{"key":"RefSeqProteinId","value":"NP_689592.2"}]},{"database":"UCSC","id":"uc001hul.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8NDD1-1"},{"database":"AGR","id":"HGNC:25332","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142672449","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"128061","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FSAF1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:25332","properties":[{"key":"GeneName","value":"FSAF1"}]},{"database":"HPA","id":"ENSG00000143633","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"OpenTargets","id":"ENSG00000143633","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000143633","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S2E3","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000017022","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EVVQFHS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10067479at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8NDD1","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000143633","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"128061","properties":[{"key":"hits","value":"419 hits in 1131 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"C1orf131","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"128061","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8NDD1","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8NDD1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q8NDD1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000143633","properties":[{"key":"ExpressionPatterns","value":"Expressed in ileal mucosa and 173 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8NDD1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20813266"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34516797"}]},{"database":"GO","id":"GO:0032040","properties":[{"key":"GoTerm","value":"C:small-subunit processome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34516797"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0030490","properties":[{"key":"GoTerm","value":"P:maturation of SSU-rRNA"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34516797"}]},{"database":"GO","id":"GO:0042274","properties":[{"key":"GoTerm","value":"P:ribosomal small subunit biogenesis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34516797"}]},{"database":"InterPro","id":"IPR027973","properties":[{"key":"EntryName","value":"FSAF1-like"}]},{"database":"InterPro","id":"IPR052852","properties":[{"key":"EntryName","value":"SSU_Processome_Comp"}]},{"database":"PANTHER","id":"PTHR28366","properties":[{"key":"EntryName","value":"CHROMOSOME 1 OPEN READING FRAME 131"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28366:SF1","properties":[{"key":"EntryName","value":"CHROMOSOME 1 OPEN READING FRAME 131"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15375","properties":[{"key":"EntryName","value":"FSAF1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVDSSADPTMSQEQGPGSSTPPSSPTLLDALLQNLYDFGGTEGETEQKKIIKKRENKKRDVMASAALAAEPSPLPGSLIRGQRKSASSFFKELREERHCAPSGTPTGPEILAAAVPPSSLKNNREQVEVVEFHSNKKRKLTPDHNKNTKQANPSVLERDVDTQEFNLEKARLEVHRFGITGYGKGKERILEQERAIMLGAKPPKKSYVNYKVLQEQIKEKKAAKEEEKRLAQETDIFKKKKRKGQEDRKSKKKSAPSILSNGRIGQVGKFKNGTLILSPVDIKKINSSRVAK","length":293,"molWeight":32610,"crc64":"D045FE659BA8C659","md5":"DC43B7C2332103845B740ECD049A4D2D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"CAUTION":1},"countByFeatureType":{"Chain":1,"Region":5,"Compositional bias":3,"Modified residue":6,"Alternative sequence":4,"Natural variant":1,"Sequence conflict":1},"uniParcId":"UPI000013E1F8"}}