ID   LRC17_HUMAN             Reviewed;         441 AA.
AC   Q8N6Y2; Q13288; Q6UWA7; Q75MG5;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=Leucine-rich repeat-containing protein 17;
DE   AltName: Full=p37NB;
DE   Flags: Precursor;
GN   Name=LRRC17; Synonyms=P37NB; ORFNames=UNQ3076/PRO9909;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND VARIANT
RP   ALA-187.
RX   PubMed=8982252; DOI=10.1016/s0167-4781(96)00158-3;
RA   Kim D., LaQuaglia M.P., Yang S.Y.;
RT   "A cDNA encoding a putative 37 kDa leucine-rich repeat (LRR) protein,
RT   p37NB, isolated from S-type neuroblastoma cell has a differential tissue
RT   distribution.";
RL   Biochim. Biophys. Acta 1309:183-188(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=19336404; DOI=10.1074/jbc.m807722200;
RA   Kim T., Kim K., Lee S.H., So H.-S., Lee J., Kim N., Choi Y.;
RT   "Identification of LRRc17 as a negative regulator of receptor activator of
RT   NF-kappaB ligand (RANKL)-induced osteoclast differentiation.";
RL   J. Biol. Chem. 284:15308-15316(2009).
CC   -!- FUNCTION: Involved in bone homeostasis. Acts as a negative regulator of
CC       RANKL-induced osteoclast precursor differentiation from bone marrow
CC       precursors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N6Y2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N6Y2-2; Sequence=VSP_011424, VSP_011425;
CC   -!- TISSUE SPECIFICITY: Expressed in osteoblast cell lines. Well expressed
CC       in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and
CC       lung and only at the basal levels in the other tissues examined
CC       including adult kidney. More expressed in S-type neuroblastoma cells
CC       than in N-type neuroblastoma cells. {ECO:0000269|PubMed:19336404,
CC       ECO:0000269|PubMed:8982252}.
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DR   EMBL; U32907; AAB41565.1; -; mRNA.
DR   EMBL; AY358889; AAQ89248.1; -; mRNA.
DR   EMBL; AC073127; AAS07483.1; -; Genomic_DNA.
DR   EMBL; BC027903; AAH27903.1; -; mRNA.
DR   CCDS; CCDS34721.1; -. [Q8N6Y2-1]
DR   CCDS; CCDS5727.1; -. [Q8N6Y2-2]
DR   PIR; G02020; G02020.
DR   RefSeq; NP_001026862.1; NM_001031692.2. [Q8N6Y2-1]
DR   RefSeq; NP_005815.2; NM_005824.2. [Q8N6Y2-2]
DR   RefSeq; XP_005250165.1; XM_005250108.1. [Q8N6Y2-1]
DR   AlphaFoldDB; Q8N6Y2; -.
DR   SMR; Q8N6Y2; -.
DR   BioGRID; 115528; 23.
DR   IntAct; Q8N6Y2; 1.
DR   STRING; 9606.ENSP00000344242; -.
DR   GlyCosmos; Q8N6Y2; 1 site, 1 glycan.
DR   GlyGen; Q8N6Y2; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8N6Y2; -.
DR   PhosphoSitePlus; Q8N6Y2; -.
DR   BioMuta; LRRC17; -.
DR   DMDM; 51701682; -.
DR   jPOST; Q8N6Y2; -.
DR   MassIVE; Q8N6Y2; -.
DR   MaxQB; Q8N6Y2; -.
DR   PaxDb; 9606-ENSP00000344242; -.
DR   PeptideAtlas; Q8N6Y2; -.
DR   ProteomicsDB; 72249; -. [Q8N6Y2-1]
DR   ProteomicsDB; 72250; -. [Q8N6Y2-2]
DR   Antibodypedia; 31152; 69 antibodies from 16 providers.
DR   DNASU; 10234; -.
DR   Ensembl; ENST00000249377.4; ENSP00000249377.4; ENSG00000128606.13. [Q8N6Y2-2]
DR   Ensembl; ENST00000339431.9; ENSP00000344242.4; ENSG00000128606.13. [Q8N6Y2-1]
DR   GeneID; 10234; -.
DR   KEGG; hsa:10234; -.
DR   MANE-Select; ENST00000339431.9; ENSP00000344242.4; NM_001031692.3; NP_001026862.1.
DR   UCSC; uc003vat.4; human. [Q8N6Y2-1]
DR   AGR; HGNC:16895; -.
DR   CTD; 10234; -.
DR   DisGeNET; 10234; -.
DR   GeneCards; LRRC17; -.
DR   HGNC; HGNC:16895; LRRC17.
DR   HPA; ENSG00000128606; Tissue enhanced (ovary).
DR   MIM; 618749; gene.
DR   neXtProt; NX_Q8N6Y2; -.
DR   OpenTargets; ENSG00000128606; -.
DR   PharmGKB; PA134866295; -.
DR   VEuPathDB; HostDB:ENSG00000128606; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000156400; -.
DR   HOGENOM; CLU_049990_0_0_1; -.
DR   InParanoid; Q8N6Y2; -.
DR   OMA; RQTQECK; -.
DR   OrthoDB; 5397338at2759; -.
DR   PhylomeDB; Q8N6Y2; -.
DR   PathwayCommons; Q8N6Y2; -.
DR   BioGRID-ORCS; 10234; 13 hits in 1139 CRISPR screens.
DR   ChiTaRS; LRRC17; human.
DR   GeneWiki; LRRC17; -.
DR   GenomeRNAi; 10234; -.
DR   Pharos; Q8N6Y2; Tdark.
DR   PRO; PR:Q8N6Y2; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q8N6Y2; Protein.
DR   Bgee; ENSG00000128606; Expressed in secondary oocyte and 164 other cell types or tissues.
DR   ExpressionAtlas; Q8N6Y2; baseline and differential.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0048539; P:bone marrow development; ISS:UniProtKB.
DR   GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR24369:SF9; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00365; LRR_SD22; 3.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SMART; SM00082; LRRCT; 2.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 6.
DR   Genevisible; Q8N6Y2; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Leucine-rich repeat; Osteogenesis;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..441
FT                   /note="Leucine-rich repeat-containing protein 17"
FT                   /id="PRO_0000021608"
FT   REPEAT          82..103
FT                   /note="LRR 1"
FT   REPEAT          106..127
FT                   /note="LRR 2"
FT   REPEAT          130..151
FT                   /note="LRR 3"
FT   DOMAIN          163..214
FT                   /note="LRRCT 1"
FT   DOMAIN          225..268
FT                   /note="LRRNT"
FT   REPEAT          269..290
FT                   /note="LRR 4"
FT   REPEAT          293..314
FT                   /note="LRR 5"
FT   REPEAT          317..340
FT                   /note="LRR 6"
FT   DOMAIN          350..402
FT                   /note="LRRCT 2"
FT   VAR_SEQ         310..313
FT                   /note="AAFL -> GSLR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:8982252"
FT                   /id="VSP_011424"
FT   VAR_SEQ         314..441
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:8982252"
FT                   /id="VSP_011425"
FT   VARIANT         95
FT                   /note="T -> I (in dbSNP:rs34613342)"
FT                   /id="VAR_051103"
FT   VARIANT         119
FT                   /note="K -> E (in dbSNP:rs3800939)"
FT                   /id="VAR_051104"
FT   VARIANT         187
FT                   /note="G -> A (in dbSNP:rs1057066)"
FT                   /evidence="ECO:0000269|PubMed:8982252"
FT                   /id="VAR_051105"
FT   CONFLICT        214
FT                   /note="Missing (in Ref. 2; AAQ89248)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   441 AA;  51800 MW;  F629666C807A4254 CRC64;
     MRVVTIVILL CFCKAAELRK ASPGSVRSRV NHGRAGGGRR GSNPVKRYAP GLPCDVYTYL
     HEKYLDCQER KLVYVLPGWP QDLLHMLLAR NKIRTLKNNM FSKFKKLKSL DLQQNEISKI
     ESEAFFGLNK LTTLLLQHNQ IKVLTEEVFI YTPLLSYLRL YDNPWHCTCE IETLISMLQI
     PRNRNLGNYA KCESPQEQKN KKLRQIKSEQ LCNEEEKEQL DPKPQVSGRP PVIKPEVDST
     FCHNYVFPIQ TLDCKRKELK KVPNNIPPDI VKLDLSYNKI NQLRPKEFED VHELKKLNLS
     SNGIEFIDPA AFLGLTHLEE LDLSNNSLQN FDYGVLEDLY FLKLLWLRDN PWRCDYNIHY
     LYYWLKHHYN VHFNGLECKT PEEYKGWSVG KYIRSYYEEC PKDKLPAYPE SFDQDTEDDE
     WEKKHRDHTA KKQSVIITIV G
//