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Expressed in the ovaries, Fallopian tubes and uterus (PubMed:30388401)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"J3QMY9"}],"value":"Despite a weak sequence similarity, retains most of the structural features of the ancestral archaeal Top6B subunit (AC O05207), including the transducer domain that interacts with the SPO11 subunit and the ATP-binding fold, also named GHKL fold"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Hydatidiform mole, recurrent, 4","diseaseAccession":"DI-05568","acronym":"HYDM4","description":"A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. 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The disease is caused by variants affecting the gene represented in this entry (PubMed:36732965, PubMed:41211863)"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18160775"}],"value":"Expansion of a polymorphic CGG repeat within the 5'-UTR of this gene may be the cause of folate-sensitive fragile site FRA11A. 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