{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8N584","secondaryAccessions":["B7WP63","J3QRR1","Q0VAJ2","Q8N284"],"uniProtkbId":"TT39C_HUMAN","entryAudit":{"firstPublicDate":"2007-02-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-02-06","entryVersion":159,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tetratricopeptide repeat protein 39C"},"shortNames":[{"value":"TPR repeat protein 39C"}]}},"genes":[{"geneName":{"value":"TTC39C"},"synonyms":[{"value":"C18orf17"}]}],"comments":[{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8N584-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8N584-2"],"sequenceIds":["VSP_022720"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8N584-3"],"sequenceIds":["VSP_046039","VSP_046040"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TTC39 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH32684.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"Tetratricopeptide repeat protein 39C","featureId":"PRO_0000274352"},{"type":"Repeat","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"TPR 1"},{"type":"Repeat","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"TPR 2"},{"type":"Repeat","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"TPR 3"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_022720","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_046039","alternativeSequence":{"originalSequence":"NHSPLMSFGASFVSFLNAMM","alternativeSequences":["KSFLTSEKTSALPGETQRRL"]}},{"type":"Alternative sequence","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_046040","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in Ref. 1; BAC03578","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"in Ref. 1; BAC03578","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0802","category":"Domain","name":"TPR repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Corpus callosum","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16177791","citationType":"journal article","authors":["Nusbaum C.","Zody M.C.","Borowsky M.L.","Kamal M.","Kodira C.D.","Taylor T.D.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Abouelleil A.","Allen N.R.","Anderson S.","Bloom T.","Bugalter B.","Butler J.","Cook A.","DeCaprio D.","Engels R.","Garber M.","Gnirke A.","Hafez N.","Hall J.L.","Norman C.H.","Itoh T.","Jaffe D.B.","Kuroki Y.","Lehoczky J.","Lui A.","Macdonald P.","Mauceli E.","Mikkelsen T.S.","Naylor J.W.","Nicol R.","Nguyen C.","Noguchi H.","O'Leary S.B.","Piqani B.","Smith C.L.","Talamas J.A.","Topham K.","Totoki Y.","Toyoda A.","Wain H.M.","Young S.K.","Zeng Q.","Zimmer A.R.","Fujiyama A.","Hattori M.","Birren B.W.","Sakaki Y.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16177791"},{"database":"DOI","id":"10.1038/nature03983"}],"title":"DNA sequence and analysis of human chromosome 18.","publicationDate":"2005","journal":"Nature","firstPage":"551","lastPage":"555","volume":"437"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-583 (ISOFORM 1)"],"referenceComments":[{"value":"Ovarian adenocarcinoma","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK091080","properties":[{"key":"ProteinId","value":"BAC03578.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC010754","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC090772","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC016833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC032684","properties":[{"key":"ProteinId","value":"AAH32684.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC121034","properties":[{"key":"ProteinId","value":"AAI21035.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC121035","properties":[{"key":"ProteinId","value":"AAI21036.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS32804.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N584-2"},{"database":"CCDS","id":"CCDS45839.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N584-1"},{"database":"CCDS","id":"CCDS58616.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N584-3"},{"database":"RefSeq","id":"NP_001129465.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001135993.2"}],"isoformId":"Q8N584-1"},{"database":"RefSeq","id":"NP_001230354.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001243425.2"}],"isoformId":"Q8N584-3"},{"database":"RefSeq","id":"NP_001278959.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001292030.2"}]},{"database":"RefSeq","id":"NP_694943.2","properties":[{"key":"NucleotideSequenceId","value":"NM_153211.4"}],"isoformId":"Q8N584-2"},{"database":"RefSeq","id":"XP_047293253.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047437297.1"}],"isoformId":"Q8N584-2"},{"database":"RefSeq","id":"XP_047293254.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047437298.1"}],"isoformId":"Q8N584-2"},{"database":"RefSeq","id":"XP_054174172.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054318197.1"}],"isoformId":"Q8N584-2"},{"database":"RefSeq","id":"XP_054174173.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054318198.1"}],"isoformId":"Q8N584-2"},{"database":"AlphaFoldDB","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"125929","properties":[{"key":"Interactions","value":"15"}]},{"database":"FunCoup","id":"Q8N584","properties":[{"key":"Number of interactors","value":"52"}]},{"database":"IntAct","id":"Q8N584","properties":[{"key":"Interactions","value":"4"}]},{"database":"STRING","id":"9606.ENSP00000323645","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8N584","properties":[{"key":"glycosylation","value":"1 site, 1 N-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TTC39C","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"125863935","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000323645","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"72019","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N584-1"},{"database":"ProteomicsDB","id":"72020","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N584-2"},{"database":"Pumba","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"70687","properties":[{"key":"antibodies","value":"20 antibodies from 9 providers"}]},{"database":"DNASU","id":"125488","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000304621.10","properties":[{"key":"ProteinId","value":"ENSP00000306598.6"},{"key":"GeneId","value":"ENSG00000168234.15"}],"isoformId":"Q8N584-2"},{"database":"Ensembl","id":"ENST00000317571.8","properties":[{"key":"ProteinId","value":"ENSP00000323645.3"},{"key":"GeneId","value":"ENSG00000168234.15"}],"isoformId":"Q8N584-1"},{"database":"Ensembl","id":"ENST00000584250.2","properties":[{"key":"ProteinId","value":"ENSP00000464344.1"},{"key":"GeneId","value":"ENSG00000168234.15"}],"isoformId":"Q8N584-3"},{"database":"GeneID","id":"125488","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:125488","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000317571.8","properties":[{"key":"ProteinId","value":"ENSP00000323645.3"},{"key":"RefSeqNucleotideId","value":"NM_001135993.2"},{"key":"RefSeqProteinId","value":"NP_001129465.1"}]},{"database":"UCSC","id":"uc002kuu.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8N584-1"},{"database":"AGR","id":"HGNC:26595","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162407262","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"125488","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"125488","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TTC39C","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:26595","properties":[{"key":"GeneName","value":"TTC39C"}]},{"database":"HPA","id":"ENSG00000168234","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (liver, retina)"}]},{"database":"OpenTargets","id":"ENSG00000168234","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000168234","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3783","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000182917","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_010086_4_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YNIAMKQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2154985at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8N584","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000168234","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"125488","properties":[{"key":"hits","value":"13 hits in 1138 CRISPR screens"}]},{"database":"ChiTaRS","id":"TTC39C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"125488","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8N584","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8N584","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 18"}]},{"database":"RNAct","id":"Q8N584","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000168234","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lobe of liver and 165 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8N584","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0060271","properties":[{"key":"GoTerm","value":"P:cilium assembly"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032474","properties":[{"key":"GoTerm","value":"P:otolith morphogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"Gene3D","id":"1.25.40.10","properties":[{"key":"EntryName","value":"Tetratricopeptide repeat domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019412","properties":[{"key":"EntryName","value":"IML2/TPR_39"}]},{"database":"InterPro","id":"IPR011990","properties":[{"key":"EntryName","value":"TPR-like_helical_dom_sf"}]},{"database":"PANTHER","id":"PTHR31859","properties":[{"key":"EntryName","value":"TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31859:SF1","properties":[{"key":"EntryName","value":"TETRATRICOPEPTIDE REPEAT PROTEIN 39C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10300","properties":[{"key":"EntryName","value":"Iml2-TPR_39"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48452","properties":[{"key":"EntryName","value":"TPR-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGSEQQRPRRRDDGDSDAAAAAAAPLQDAELALAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCESEEAGVIETIKNKIKKNVDVRKSAPSMVDRLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKAWKIYNKCYLDINALQELYQKKLTEESLTSDAANDNHIVAEGVSEESLNRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLMYASESKDMKAPLATLALLWYHTVVRPFFALDGSDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLECQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQKLFKRKNNQIEQFSVKKAERFRKQTPTKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAVQYFQRAVKDELCRQNNLYVQPYACYELGCLLLDKPETVGRGRALLLQAKEDFSGYDFENRLHVRIHAALASLRELVPQ","length":583,"molWeight":65870,"crc64":"438BF2F476F533AD","md5":"45B77E47796B8F2751F116E1180BDBBB"},"extraAttributes":{"countByCommentType":{"ALTERNATIVE PRODUCTS":3,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Repeat":3,"Region":1,"Alternative sequence":3,"Sequence conflict":2},"uniParcId":"UPI0000EF8875"}}