{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8N3U4","secondaryAccessions":["B1AMT5","D3DTF5","O00540","Q5JTI6","Q68DE9","Q9H1N8"],"uniProtkbId":"STAG2_HUMAN","entryAudit":{"firstPublicDate":"2003-03-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-08-16","entryVersion":203,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cohesin subunit SA-2"}},"alternativeNames":[{"fullName":{"value":"SCC3 homolog 2"}},{"fullName":{"value":"Stromal antigen 2"}}]},"genes":[{"geneName":{"value":"STAG2"},"synonyms":[{"value":"SA2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12034751"}],"value":"Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11076961"}],"value":"Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"P31749","geneName":"AKT1","intActId":"EBI-296087"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"Q29RF7","geneName":"PDS5A","intActId":"EBI-1175454"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"Q9NTI5","geneName":"PDS5B","intActId":"EBI-1175604"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"O60216","geneName":"RAD21","intActId":"EBI-80739"},"numberOfExperiments":23,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"Q5FBB7","geneName":"SGO1","intActId":"EBI-989069"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"Q14683","geneName":"SMC1A","intActId":"EBI-80690"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"Q9UQE7","geneName":"SMC3","intActId":"EBI-80718"},"numberOfExperiments":18,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"Q9NP77","geneName":"SSU72","intActId":"EBI-2515416"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"Q8WVM7","geneName":"STAG1","intActId":"EBI-1175097"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N3U4","intActId":"EBI-1057252"},"interactantTwo":{"uniProtKBAccession":"Q7Z5K2","geneName":"WAPL","intActId":"EBI-1022242"},"numberOfExperiments":14,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Chromosome","id":"SL-0468"}},{"location":{"value":"Chromosome, centromere","id":"SL-0047"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8N3U4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8N3U4-2"],"sequenceIds":["VSP_041119"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity)"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Mullegama-Klein-Martinez syndrome","diseaseAccession":"DI-05502","acronym":"MKMS","description":"An X-linked neurodevelopmental disorder with variable features including intellectual deficiency, microcephaly, microtia, hearing loss, developmental delay, dysmorphic features, language delay, congenital heart defect, and clinodactyly of the 5th finger.","diseaseCrossReference":{"database":"MIM","id":"301022"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28296084"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29263825"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30158690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30447054"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Holoprosencephaly 13, X-linked","diseaseAccession":"DI-05801","acronym":"HPE13","description":"An X-linked form of holoprosencephaly, a structural anomaly of the brain in which the developing forebrain fails to correctly separate into right and left hemispheres. It is a genetically and clinically heterogeneous disorder with a wide spectrum of severity, ranging from alobar holoprosencephaly with severe facial abnormalities, such as cyclopia and proboscis, to mild forms that include lobar or microform holoprosencephaly, without cerebral malformations and with mild craniofacial defects. HPE13 features range from full alobar holoprosencephaly with cyclopia to semilobar holoprosencephaly or septooptic dysplasia. Dysmorphic features include microcephaly, hypotelorism, low-set ears, micrognathia, and cleft lip/palate. Patients with a more severe phenotype may die in the newborn period, whereas those with a less severe phenotype show global developmental delay.","diseaseCrossReference":{"database":"MIM","id":"301043"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31334757"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SCC3 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30765867"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32536687"}],"value":"Variants MKMS 743-Trp--Phe-1231 DEL and HPE13 1033-Arg--Phe-1231 DEL were previously described; however, the corresponding paper has been retracted as Case 1's sex was incorrectly reported invalidating the conclusions"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA99732.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"Cohesin subunit SA-2","featureId":"PRO_0000120185"},{"type":"Domain","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"SCD","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00750"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1064,"modifier":"EXACT"},"end":{"value":1083,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1071,"modifier":"EXACT"},"end":{"value":1082,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1058,"modifier":"EXACT"},"end":{"value":1058,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1061,"modifier":"EXACT"},"end":{"value":1061,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1064,"modifier":"EXACT"},"end":{"value":1064,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35638"}]},{"type":"Modified residue","location":{"start":{"value":1065,"modifier":"EXACT"},"end":{"value":1065,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35638"}]},{"type":"Modified residue","location":{"start":{"value":1112,"modifier":"EXACT"},"end":{"value":1112,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":1177,"modifier":"EXACT"},"end":{"value":1177,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1178,"modifier":"EXACT"},"end":{"value":1178,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Alternative sequence","location":{"start":{"value":1156,"modifier":"EXACT"},"end":{"value":1156,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_041119","alternativeSequence":{"originalSequence":"N","alternativeSequences":["NTQVTWMLAQRQQEEARQQQERAAMSYVKLRTNLQHAI"]}},{"type":"Natural variant","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"in HPE13 and MKMS; patient cells show decreased protein abundance; increased sister chromatid cohesion","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28296084"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31334757"}],"featureId":"VAR_083967","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"in MKMS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30158690"}],"featureId":"VAR_082294","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"in HPE13","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31334757"}],"featureId":"VAR_083968","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in MKMS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30158690"}],"featureId":"VAR_082295","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"in HPE13","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31334757"}],"featureId":"VAR_083969","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"in MKMS; loss of interaction with RAD21; loss of interaction with cohesin complex","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29263825"}],"featureId":"VAR_082296","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"in MKMS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30158690"}],"featureId":"VAR_082297","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":604,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"in MKMS; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28296084"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30158690"}],"featureId":"VAR_082298","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":699,"modifier":"EXACT"},"end":{"value":699,"modifier":"EXACT"}},"description":"in dbSNP:rs6655782","featureCrossReferences":[{"database":"dbSNP","id":"rs6655782"}],"featureId":"VAR_060114","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":1009,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"in MKMS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30447054"}],"featureId":"VAR_082300","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":1012,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"in HPE13","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31334757"}],"featureId":"VAR_083970","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"in Ref. 1; CAD38591","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"in Ref. 5; CAA99732","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"in Ref. 1; CAD38591","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":608,"modifier":"EXACT"}},"description":"in Ref. 5; CAA99732","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"KH","alternativeSequences":["ND"]}},{"type":"Sequence conflict","location":{"start":{"value":706,"modifier":"EXACT"},"end":{"value":706,"modifier":"EXACT"}},"description":"in Ref. 5; CAA99732","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"in Ref. 1; CAD38591","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":835,"modifier":"EXACT"},"end":{"value":835,"modifier":"EXACT"}},"description":"in Ref. 1; CAD38591","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":971,"modifier":"EXACT"},"end":{"value":971,"modifier":"EXACT"}},"description":"in Ref. 1; CAH18271","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":992,"modifier":"EXACT"},"end":{"value":992,"modifier":"EXACT"}},"description":"in Ref. 1; CAD38591","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Sequence conflict","location":{"start":{"value":1105,"modifier":"EXACT"},"end":{"value":1105,"modifier":"EXACT"}},"description":"in Ref. 5; CAA99732","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":1144,"modifier":"EXACT"},"end":{"value":1144,"modifier":"EXACT"}},"description":"in Ref. 5; CAA99732","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Helix","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMS"}]},{"type":"Beta strand","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4PJW"}]},{"type":"Helix","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4PJW"}]},{"type":"Helix","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMV"}]},{"type":"Helix","location":{"start":{"value":458,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":507,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMV"}]},{"type":"Helix","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMV"}]},{"type":"Helix","location":{"start":{"value":515,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":546,"modifier":"EXACT"},"end":{"value":549,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZJS"}]},{"type":"Helix","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":578,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":592,"modifier":"EXACT"},"end":{"value":594,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":606,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":639,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":675,"modifier":"EXACT"},"end":{"value":677,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMV"}]},{"type":"Helix","location":{"start":{"value":681,"modifier":"EXACT"},"end":{"value":700,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":704,"modifier":"EXACT"},"end":{"value":706,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":722,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":727,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":753,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":757,"modifier":"EXACT"},"end":{"value":775,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":777,"modifier":"EXACT"},"end":{"value":779,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZJS"}]},{"type":"Helix","location":{"start":{"value":781,"modifier":"EXACT"},"end":{"value":797,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":800,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":808,"modifier":"EXACT"},"end":{"value":810,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":811,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4PK7"}]},{"type":"Helix","location":{"start":{"value":816,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":832,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":851,"modifier":"EXACT"},"end":{"value":873,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":879,"modifier":"EXACT"},"end":{"value":882,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":883,"modifier":"EXACT"},"end":{"value":886,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":892,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":912,"modifier":"EXACT"},"end":{"value":933,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":940,"modifier":"EXACT"},"end":{"value":942,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMS"}]},{"type":"Helix","location":{"start":{"value":943,"modifier":"EXACT"},"end":{"value":957,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Turn","location":{"start":{"value":963,"modifier":"EXACT"},"end":{"value":965,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMV"}]},{"type":"Helix","location":{"start":{"value":967,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":982,"modifier":"EXACT"},"end":{"value":984,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":987,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4PJW"}]},{"type":"Beta strand","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":992,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMV"}]},{"type":"Helix","location":{"start":{"value":995,"modifier":"EXACT"},"end":{"value":998,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4PK7"}]},{"type":"Helix","location":{"start":{"value":999,"modifier":"EXACT"},"end":{"value":1003,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":1004,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":1014,"modifier":"EXACT"},"end":{"value":1025,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Helix","location":{"start":{"value":1028,"modifier":"EXACT"},"end":{"value":1032,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]},{"type":"Beta strand","location":{"start":{"value":1035,"modifier":"EXACT"},"end":{"value":1037,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HMV"}]},{"type":"Helix","location":{"start":{"value":1039,"modifier":"EXACT"},"end":{"value":1045,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6QNX"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0137","category":"Cellular component","name":"Centromere"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0159","category":"Biological process","name":"Chromosome partition"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0370","category":"Disease","name":"Holoprosencephaly"},{"id":"KW-0469","category":"Biological process","name":"Meiosis"},{"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Retina","type":"TISSUE"},{"value":"Spinal cord","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15772651","citationType":"journal article","authors":["Ross M.T.","Grafham D.V.","Coffey A.J.","Scherer S.","McLay K.","Muzny D.","Platzer M.","Howell G.R.","Burrows C.","Bird C.P.","Frankish A.","Lovell F.L.","Howe K.L.","Ashurst J.L.","Fulton R.S.","Sudbrak R.","Wen G.","Jones M.C.","Hurles M.E.","Andrews T.D.","Scott C.E.","Searle S.","Ramser J.","Whittaker A.","Deadman R.","Carter N.P.","Hunt S.E.","Chen R.","Cree A.","Gunaratne P.","Havlak P.","Hodgson A.","Metzker M.L.","Richards S.","Scott G.","Steffen D.","Sodergren E.","Wheeler D.A.","Worley K.C.","Ainscough R.","Ambrose K.D.","Ansari-Lari M.A.","Aradhya S.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Ballabio A.","Banerjee R.","Barker G.E.","Barlow K.F.","Barrett I.P.","Bates K.N.","Beare D.M.","Beasley H.","Beasley O.","Beck A.","Bethel G.","Blechschmidt K.","Brady N.","Bray-Allen S.","Bridgeman A.M.","Brown A.J.","Brown M.J.","Bonnin D.","Bruford E.A.","Buhay C.","Burch P.","Burford D.","Burgess J.","Burrill W.","Burton J.","Bye J.M.","Carder C.","Carrel L.","Chako J.","Chapman J.C.","Chavez D.","Chen E.","Chen G.","Chen Y.","Chen Z.","Chinault C.","Ciccodicola A.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Clerc-Blankenburg K.","Clifford K.","Cobley V.","Cole C.G.","Conquer J.S.","Corby N.","Connor R.E.","David R.","Davies J.","Davis C.","Davis J.","Delgado O.","Deshazo D.","Dhami P.","Ding Y.","Dinh H.","Dodsworth S.","Draper H.","Dugan-Rocha S.","Dunham A.","Dunn M.","Durbin K.J.","Dutta I.","Eades T.","Ellwood M.","Emery-Cohen A.","Errington H.","Evans K.L.","Faulkner L.","Francis F.","Frankland J.","Fraser A.E.","Galgoczy P.","Gilbert J.","Gill R.","Gloeckner G.","Gregory S.G.","Gribble S.","Griffiths C.","Grocock R.","Gu Y.","Gwilliam R.","Hamilton C.","Hart E.A.","Hawes A.","Heath P.D.","Heitmann K.","Hennig S.","Hernandez J.","Hinzmann B.","Ho S.","Hoffs M.","Howden P.J.","Huckle E.J.","Hume J.","Hunt P.J.","Hunt A.R.","Isherwood J.","Jacob L.","Johnson D.","Jones S.","de Jong P.J.","Joseph S.S.","Keenan S.","Kelly S.","Kershaw J.K.","Khan Z.","Kioschis P.","Klages S.","Knights A.J.","Kosiura A.","Kovar-Smith C.","Laird G.K.","Langford C.","Lawlor S.","Leversha M.","Lewis L.","Liu W.","Lloyd C.","Lloyd D.M.","Loulseged H.","Loveland J.E.","Lovell J.D.","Lozado R.","Lu J.","Lyne R.","Ma J.","Maheshwari M.","Matthews L.H.","McDowall J.","McLaren S.","McMurray A.","Meidl P.","Meitinger T.","Milne S.","Miner G.","Mistry S.L.","Morgan M.","Morris S.","Mueller I.","Mullikin J.C.","Nguyen N.","Nordsiek G.","Nyakatura G.","O'dell C.N.","Okwuonu G.","Palmer S.","Pandian R.","Parker D.","Parrish J.","Pasternak S.","Patel D.","Pearce A.V.","Pearson D.M.","Pelan S.E.","Perez L.","Porter K.M.","Ramsey Y.","Reichwald K.","Rhodes S.","Ridler K.A.","Schlessinger D.","Schueler M.G.","Sehra H.K.","Shaw-Smith C.","Shen H.","Sheridan E.M.","Shownkeen R.","Skuce C.D.","Smith M.L.","Sotheran E.C.","Steingruber H.E.","Steward C.A.","Storey R.","Swann R.M.","Swarbreck D.","Tabor P.E.","Taudien S.","Taylor T.","Teague B.","Thomas K.","Thorpe A.","Timms K.","Tracey A.","Trevanion S.","Tromans A.C.","d'Urso M.","Verduzco D.","Villasana D.","Waldron L.","Wall M.","Wang Q.","Warren J.","Warry G.L.","Wei X.","West A.","Whitehead S.L.","Whiteley M.N.","Wilkinson J.E.","Willey D.L.","Williams G.","Williams L.","Williamson A.","Williamson H.","Wilming L.","Woodmansey R.L.","Wray P.W.","Yen J.","Zhang J.","Zhou J.","Zoghbi H.","Zorilla S.","Buck D.","Reinhardt R.","Poustka A.","Rosenthal A.","Lehrach H.","Meindl A.","Minx P.J.","Hillier L.W.","Willard H.F.","Wilson R.K.","Waterston R.H.","Rice C.M.","Vaudin M.","Coulson A.","Nelson D.L.","Weinstock G.","Sulston J.E.","Durbin R.M.","Hubbard T.","Gibbs R.A.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"15772651"},{"database":"DOI","id":"10.1038/nature03440"}],"title":"The DNA sequence of the human X chromosome.","publicationDate":"2005","journal":"Nature","firstPage":"325","lastPage":"337","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"9305759","citationType":"journal article","authors":["Carramolino L.","Lee B.C.","Zaballos A.","Peled A.","Barthelemy I.","Shav-Tal Y.","Prieto I.","Carmi P.","Gothelf Y.","Gonzalez de Buitrago G.","Aracil M.","Marquez G.","Barbero J.L.","Zipori D."],"citationCrossReferences":[{"database":"PubMed","id":"9305759"},{"database":"DOI","id":"10.1016/s0378-1119(97)00121-2"}],"title":"SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs.","publicationDate":"1997","journal":"Gene","firstPage":"151","lastPage":"159","volume":"195"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 48-1231 (ISOFORM 1)"],"referenceComments":[{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-FRQPII3CHT2BU","citationType":"journal article","authors":["Carramolino L.","Lee B.C.","Zaballos A.","Peled A.","Barthelemy I.","Shav-Tal Y.","Prieto I.","Carmi P.","Gothelf Y.","Gonzalez de Buitrago G.","Aracil M.","Marquez G.","Barbero J.L.","Zipori D."],"publicationDate":"1998","journal":"Gene","firstPage":"283","lastPage":"286","volume":"206"},"referencePositions":["ERRATUM OF PUBMED:9305759"]},{"referenceNumber":7,"citation":{"id":"11076961","citationType":"journal article","authors":["Sumara I.","Vorlaufer E.","Gieffers C.","Peters B.H.","Peters J.-M."],"citationCrossReferences":[{"database":"PubMed","id":"11076961"},{"database":"DOI","id":"10.1083/jcb.151.4.749"}],"title":"Characterization of vertebrate cohesin complexes and their regulation in prophase.","publicationDate":"2000","journal":"J. Cell Biol.","firstPage":"749","lastPage":"762","volume":"151"},"referencePositions":["IDENTIFICATION IN A COHESIN COMPLEX WITH SMC1A AND SMC3"]},{"referenceNumber":8,"citation":{"id":"12034751","citationType":"journal article","authors":["Prieto I.","Pezzi N.","Buesa J.M.","Kremer L.","Barthelemy I.","Carreiro C.","Roncal F.","Martinez A.","Gomez L.","Fernandez R.","Martinez-A C.","Barbero J.L."],"citationCrossReferences":[{"database":"PubMed","id":"12034751"},{"database":"DOI","id":"10.1093/embo-reports/kvf108"}],"title":"STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.","publicationDate":"2002","journal":"EMBO Rep.","firstPage":"543","lastPage":"550","volume":"3"},"referencePositions":["FUNCTION IN EARLY STEPS OF MEIOSIS"]},{"referenceNumber":9,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1061","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1058 AND SER-1061","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1058; SER-1061 AND THR-1112","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-607","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1061; SER-1177 AND SER-1178","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1061","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":16,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1058 AND SER-1061","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"28296084","citationType":"journal article","authoringGroup":["UCLA Clinical Genomics Center"],"authors":["Mullegama S.V.","Klein S.D.","Mulatinho M.V.","Senaratne T.N.","Singh K.","Nguyen D.C.","Gallant N.M.","Strom S.P.","Ghahremani S.","Rao N.P.","Martinez-Agosto J.A."],"citationCrossReferences":[{"database":"PubMed","id":"28296084"},{"database":"DOI","id":"10.1002/ajmg.a.38207"}],"title":"De novo loss-of-function variants in STAG2 are associated with developmental delay, microcephaly, and congenital anomalies.","publicationDate":"2017","journal":"Am. J. Med. Genet. A","firstPage":"1319","lastPage":"1327","volume":"173"},"referencePositions":["FUNCTION","INVOLVEMENT IN MKMS","VARIANTS MKMS 69-ARG--PHE-1231 DEL AND GLN-604","CHARACTERIZATION OF VARIANT MKMS 69-ARG--PHE-1231 DEL"]},{"referenceNumber":19,"citation":{"id":"29263825","citationType":"journal article","authors":["Soardi F.C.","Machado-Silva A.","Linhares N.D.","Zheng G.","Qu Q.","Pena H.B.","Martins T.M.M.","Vieira H.G.S.","Pereira N.B.","Melo-Minardi R.C.","Gomes C.C.","Gomez R.S.","Gomes D.A.","Pires D.E.V.","Ascher D.B.","Yu H.","Pena S.D.J."],"citationCrossReferences":[{"database":"PubMed","id":"29263825"},{"database":"DOI","id":"10.1038/s41525-017-0009-4"}],"title":"Familial STAG2 germline mutation defines a new human cohesinopathy.","publicationDate":"2017","journal":"NPJ Genom. Med.","firstPage":"7","lastPage":"7","volume":"2"},"referencePositions":["FUNCTION","IDENTIFICATION IN COHESIN COMPLEX","INVOLVEMENT IN MKMS","VARIANT MKMS ASN-327","CHARACTERIZATION OF VARIANT MKMS ASN-327"]},{"referenceNumber":20,"citation":{"id":"31334757","citationType":"journal article","authors":["Kruszka P.","Berger S.I.","Casa V.","Dekker M.R.","Gaesser J.","Weiss K.","Martinez A.F.","Murdock D.R.","Louie R.J.","Prijoles E.J.","Lichty A.W.","Brouwer O.F.","Zonneveld-Huijssoon E.","Stephan M.J.","Hogue J.","Hu P.","Tanima-Nagai M.","Everson J.L.","Prasad C.","Cereda A.","Iascone M.","Schreiber A.","Zurcher V.","Corsten-Janssen N.","Escobar L.","Clegg N.J.","Delgado M.R.","Hajirnis O.","Balasubramanian M.","Kayserili H.","Deardorff M.","Poot R.A.","Wendt K.S.","Lipinski R.J.","Muenke M."],"citationCrossReferences":[{"database":"PubMed","id":"31334757"},{"database":"DOI","id":"10.1093/brain/awz210"}],"title":"Cohesin complex-associated holoprosencephaly.","publicationDate":"2019","journal":"Brain","firstPage":"2631","lastPage":"2643","volume":"142"},"referencePositions":["INVOLVEMENT IN HPE13","VARIANTS HPE13 69-ARG--PHE-1231 DEL; 146-ARG--PHE-1231 DEL; 259-ARG--PHE-1231 DEL AND 1012-ARG--PHE-1231 DEL"]},{"referenceNumber":21,"citation":{"id":"30158690","citationType":"journal article","authoringGroup":["DDD Study"],"authors":["Yuan B.","Neira J.","Pehlivan D.","Santiago-Sim T.","Song X.","Rosenfeld J.","Posey J.E.","Patel V.","Jin W.","Adam M.P.","Baple E.L.","Dean J.","Fong C.T.","Hickey S.E.","Hudgins L.","Leon E.","Madan-Khetarpal S.","Rawlins L.","Rustad C.F.","Stray-Pedersen A.","Tveten K.","Wenger O.","Diaz J.","Jenkins L.","Martin L.","McGuire M.","Pietryga M.","Ramsdell L.","Slattery L.","Abid F.","Bertuch A.A.","Grange D.","Immken L.","Schaaf C.P.","Van Esch H.","Bi W.","Cheung S.W.","Breman A.M.","Smith J.L.","Shaw C.","Crosby A.H.","Eng C.","Yang Y.","Lupski J.R.","Xiao R.","Liu P."],"citationCrossReferences":[{"database":"PubMed","id":"30158690"},{"database":"DOI","id":"10.1038/s41436-018-0085-6"}],"title":"Clinical exome sequencing reveals locus heterogeneity and phenotypic variability of cohesinopathies.","publicationDate":"2019","journal":"Genet. Med.","firstPage":"663","lastPage":"675","volume":"21"},"referencePositions":["VARIANTS MKMS 140-GLN--PHE-1231 DEL; CYS-159; 535-CYS--PHE-1231 DEL AND GLN-604"]},{"referenceNumber":22,"citation":{"id":"30765867","citationType":"journal article","authors":["Aoi H.","Lei M.","Mizuguchi T.","Nishioka N.","Goto T.","Miyama S.","Suzuki T.","Iwama K.","Uchiyama Y.","Mitsuhashi S.","Itakura A.","Takeda S.","Matsumoto N."],"citationCrossReferences":[{"database":"PubMed","id":"30765867"},{"database":"DOI","id":"10.1038/s10038-019-0571-y"}],"title":"Nonsense variants in STAG2 result in distinct sex-dependent phenotypes.","publicationDate":"2019","journal":"J. Hum. Genet.","firstPage":"487","lastPage":"492","volume":"64"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":23,"citation":{"id":"32536687","citationType":"journal article","authors":["Aoi H.","Lei M.","Mizuguchi T.","Nishioka N.","Goto T.","Miyama S.","Suzuki T.","Iwama K.","Uchiyama Y.","Mitsuhashi S.","Itakura A.","Takeda S.","Matsumoto N."],"citationCrossReferences":[{"database":"PubMed","id":"32536687"},{"database":"DOI","id":"10.1038/s10038-020-0782-2"}],"publicationDate":"2020","journal":"J. Hum. Genet.","firstPage":"811","lastPage":"811","volume":"65"},"referencePositions":["RETRACTION NOTICE OF PUBMED:30765867"]},{"referenceNumber":24,"citation":{"id":"30447054","citationType":"journal article","authoringGroup":["UCLA Clinical Genomics Center"],"authors":["Mullegama S.V.","Klein S.D.","Signer R.H.","Vilain E.","Martinez-Agosto J.A."],"citationCrossReferences":[{"database":"PubMed","id":"30447054"},{"database":"DOI","id":"10.1002/mgg3.501"}],"title":"Mutations in STAG2 cause an X-linked cohesinopathy associated with undergrowth, developmental delay, and dysmorphia: Expanding the phenotype in males.","publicationDate":"2019","journal":"Mol. Genet. Genomic Med.","firstPage":"E00501","lastPage":"E00501","volume":"7"},"referencePositions":["VARIANT MKMS ASN-1009"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL831939","properties":[{"key":"ProteinId","value":"CAD38591.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR749433","properties":[{"key":"ProteinId","value":"CAH18271.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL355476","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471107","properties":[{"key":"ProteinId","value":"EAX11853.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471107","properties":[{"key":"ProteinId","value":"EAX11854.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471107","properties":[{"key":"ProteinId","value":"EAX11855.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471107","properties":[{"key":"ProteinId","value":"EAX11856.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471107","properties":[{"key":"ProteinId","value":"EAX11857.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC001765","properties":[{"key":"ProteinId","value":"AAH01765.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Z75331","properties":[{"key":"ProteinId","value":"CAA99732.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS14607.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N3U4-1"},{"database":"CCDS","id":"CCDS43990.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001036214.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001042749.2"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001036215.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001042750.2"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001036216.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001042751.2"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001269347.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001282418.2"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001362295.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375366.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001362296.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375367.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001362297.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375368.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001362298.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375369.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001362299.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375370.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001362300.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375371.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001362301.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375372.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001362302.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375373.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001362303.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375374.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001362304.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375375.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001362305.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375376.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001362306.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001375377.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001428006.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441077.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001428007.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441078.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001428008.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441079.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001428009.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441080.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001428010.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441081.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001428011.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441082.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001428012.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441083.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001428013.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441084.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_001428014.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441085.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"NP_001428015.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001441086.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"NP_006594.3","properties":[{"key":"NucleotideSequenceId","value":"NM_006603.5"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"XP_006724790.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006724727.2"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"XP_047297732.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047441776.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"XP_047297735.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047441779.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"XP_047297736.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047441780.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"XP_047297737.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047441781.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"XP_047297739.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047441783.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"XP_047297742.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047441786.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"XP_054182355.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054326380.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"XP_054182356.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054326381.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"XP_054182359.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054326384.1"}],"isoformId":"Q8N3U4-2"},{"database":"RefSeq","id":"XP_054182360.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054326385.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"XP_054182362.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054326387.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"XP_054182364.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054326389.1"}],"isoformId":"Q8N3U4-1"},{"database":"RefSeq","id":"XP_054182367.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054326392.1"}],"isoformId":"Q8N3U4-1"},{"database":"PDB","id":"4PJU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"A=80-1060"}]},{"database":"PDB","id":"4PJW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"A=80-1060"}]},{"database":"PDB","id":"4PK7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"A=80-1060"}]},{"database":"PDB","id":"6QNX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=80-1060"}]},{"database":"PDB","id":"7ZJS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.24 A"},{"key":"Chains","value":"A/C=1-1231"}]},{"database":"PDB","id":"8K4D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.52 A"},{"key":"Chains","value":"A=81-1060"}]},{"database":"PDB","id":"9EP3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.08 A"},{"key":"Chains","value":"A=80-1060"}]},{"database":"PDB","id":"9HMS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A=1-1231"}]},{"database":"PDB","id":"9HMV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-1231"}]},{"database":"PDBsum","id":"4PJU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4PJW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4PK7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6QNX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZJS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8K4D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EP3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HMS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HMV","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52297","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52298","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115958","properties":[{"key":"Interactions","value":"252"}]},{"database":"ComplexPortal","id":"CPX-5991","properties":[{"key":"EntryName","value":"Nuclear mitotic cohesin complex, STAG2 variant"}]},{"database":"CORUM","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-35418N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8N3U4","properties":[{"key":"Number of interactors","value":"4336"}]},{"database":"IntAct","id":"Q8N3U4","properties":[{"key":"Interactions","value":"96"}]},{"database":"MINT","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-STAG2","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000218089","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8N3U4","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"STAG2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"73621291","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000218089","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"71836","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N3U4-1"},{"database":"ProteomicsDB","id":"71837","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N3U4-2"},{"database":"Pumba","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"500","properties":[{"key":"antibodies","value":"337 antibodies from 39 providers"}]},{"database":"DNASU","id":"10735","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000218089.13","properties":[{"key":"ProteinId","value":"ENSP00000218089.9"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000371144.7","properties":[{"key":"ProteinId","value":"ENSP00000360186.3"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000371145.8","properties":[{"key":"ProteinId","value":"ENSP00000360187.4"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000371157.7","properties":[{"key":"ProteinId","value":"ENSP00000360199.3"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000371160.5","properties":[{"key":"ProteinId","value":"ENSP00000360202.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000455404.6","properties":[{"key":"ProteinId","value":"ENSP00000397265.2"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000687852.1","properties":[{"key":"ProteinId","value":"ENSP00000509048.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000899964.1","properties":[{"key":"ProteinId","value":"ENSP00000570023.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000899965.1","properties":[{"key":"ProteinId","value":"ENSP00000570024.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000899967.1","properties":[{"key":"ProteinId","value":"ENSP00000570026.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000899968.1","properties":[{"key":"ProteinId","value":"ENSP00000570027.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000899969.1","properties":[{"key":"ProteinId","value":"ENSP00000570028.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000899970.1","properties":[{"key":"ProteinId","value":"ENSP00000570029.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000899971.1","properties":[{"key":"ProteinId","value":"ENSP00000570030.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000899972.1","properties":[{"key":"ProteinId","value":"ENSP00000570031.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000899973.1","properties":[{"key":"ProteinId","value":"ENSP00000570032.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000899975.1","properties":[{"key":"ProteinId","value":"ENSP00000570034.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000899978.1","properties":[{"key":"ProteinId","value":"ENSP00000570037.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000940154.1","properties":[{"key":"ProteinId","value":"ENSP00000610213.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000940156.1","properties":[{"key":"ProteinId","value":"ENSP00000610215.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-1"},{"database":"Ensembl","id":"ENST00000940157.1","properties":[{"key":"ProteinId","value":"ENSP00000610216.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"Ensembl","id":"ENST00000940158.1","properties":[{"key":"ProteinId","value":"ENSP00000610217.1"},{"key":"GeneId","value":"ENSG00000101972.21"}],"isoformId":"Q8N3U4-2"},{"database":"GeneID","id":"10735","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10735","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000371145.8","properties":[{"key":"ProteinId","value":"ENSP00000360187.4"},{"key":"RefSeqNucleotideId","value":"NM_001042750.2"},{"key":"RefSeqProteinId","value":"NP_001036215.1"}],"isoformId":"Q8N3U4-2"},{"database":"UCSC","id":"uc004eua.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8N3U4-1"},{"database":"AGR","id":"HGNC:11355","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"10735","properties":[{"key":"Number of evidences","value":"6 evidence items across 3 molecular profiles"}]},{"database":"ClinPGx","id":"PA36177","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10735","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10735","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"STAG2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11355","properties":[{"key":"GeneName","value":"STAG2"}]},{"database":"HPA","id":"ENSG00000101972","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"STAG2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"300826","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"301022","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"301043","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000101972","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"93925","properties":[{"key":"Disease","value":"Alobar holoprosencephaly"}]},{"database":"Orphanet","id":"220386","properties":[{"key":"Disease","value":"Semilobar holoprosencephaly"}]},{"database":"Orphanet","id":"521258","properties":[{"key":"Disease","value":"Xq25 microduplication syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000101972","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2011","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000182972","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_005067_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FGWMLND","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"498590at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8N3U4","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1221632","properties":[{"key":"PathwayName","value":"Meiotic synapsis"}]},{"database":"Reactome","id":"R-HSA-2467813","properties":[{"key":"PathwayName","value":"Separation of Sister Chromatids"}]},{"database":"Reactome","id":"R-HSA-2468052","properties":[{"key":"PathwayName","value":"Establishment of Sister Chromatid Cohesion"}]},{"database":"Reactome","id":"R-HSA-2470946","properties":[{"key":"PathwayName","value":"Cohesin Loading onto Chromatin"}]},{"database":"Reactome","id":"R-HSA-2500257","properties":[{"key":"PathwayName","value":"Resolution of Sister Chromatid Cohesion"}]},{"database":"Reactome","id":"R-HSA-3108214","properties":[{"key":"PathwayName","value":"SUMOylation of DNA damage response and repair proteins"}]},{"database":"Reactome","id":"R-HSA-9018519","properties":[{"key":"PathwayName","value":"Estrogen-dependent gene expression"}]},{"database":"SignaLink","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000101972","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"10735","properties":[{"key":"hits","value":"148 hits in 808 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"STAG2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"STAG2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"10735","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8N3U4","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8N3U4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"RNAct","id":"Q8N3U4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000101972","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of paranasal sinus and 217 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8N3U4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16682347"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0000775","properties":[{"key":"GoTerm","value":"C:chromosome, centromeric region"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0008278","properties":[{"key":"GoTerm","value":"C:cohesin complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11590136"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0001650","properties":[{"key":"GoTerm","value":"C:fibrillar center"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0030892","properties":[{"key":"GoTerm","value":"C:mitotic cohesin complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23242214"}]},{"database":"GO","id":"GO:0097431","properties":[{"key":"GoTerm","value":"C:mitotic spindle pole"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11590136"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11590136"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9305759"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0034087","properties":[{"key":"GoTerm","value":"P:establishment of mitotic sister chromatid cohesion"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32409525"}]},{"database":"GO","id":"GO:0090307","properties":[{"key":"GoTerm","value":"P:mitotic spindle assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11590136"}]},{"database":"GO","id":"GO:0007062","properties":[{"key":"GoTerm","value":"P:sister chromatid cohesion"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28296084"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29263825"}]},{"database":"IDEAL","id":"IID00674","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR039662","properties":[{"key":"EntryName","value":"Cohesin_Scc3/SA"}]},{"database":"InterPro","id":"IPR056396","properties":[{"key":"EntryName","value":"HEAT_SCC3-SA"}]},{"database":"InterPro","id":"IPR020839","properties":[{"key":"EntryName","value":"SCD"}]},{"database":"InterPro","id":"IPR013721","properties":[{"key":"EntryName","value":"STAG"}]},{"database":"InterPro","id":"IPR063293","properties":[{"key":"EntryName","value":"STAG_C"}]},{"database":"PANTHER","id":"PTHR11199:SF3","properties":[{"key":"EntryName","value":"COHESIN SUBUNIT SA-2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11199","properties":[{"key":"EntryName","value":"STROMAL ANTIGEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24571","properties":[{"key":"EntryName","value":"HEAT_SCC3-SA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21581","properties":[{"key":"EntryName","value":"SCD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08514","properties":[{"key":"EntryName","value":"STAG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF31007","properties":[{"key":"EntryName","value":"STAG_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51425","properties":[{"key":"EntryName","value":"SCD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCKKGKKGPAEKGKGGNGGGKPPSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSRRDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMNSLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIVEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEPDEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCTHYVILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIFSHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDNNSADGQQEDEASKIEALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGSTVRSKKSKPSTGKRKVVEGMQLSLTEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMSVYPMQTEHHQTPLDYNRRGTSLMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPPSKNRRERTELKPDFFDPASIMDESVLGVSMF","length":1231,"molWeight":141326,"crc64":"692358EFFFF61BB9","md5":"4585069CD71C7F8FCA5D55D26FCBBEEC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":10,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"PTM":1,"DISEASE":2,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":2,"Compositional bias":2,"Modified residue":9,"Alternative sequence":1,"Natural variant":11,"Sequence conflict":11,"Helix":62,"Beta strand":15,"Turn":8},"uniParcId":"UPI00001A8BFE"}}