{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8N357","secondaryAccessions":["D6W543","Q53GK2","Q8NBX6","Q9NWX0"],"uniProtkbId":"S35F6_HUMAN","entryAudit":{"firstPublicDate":"2006-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":164,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Solute carrier family 35 member F6"}},"alternativeNames":[{"fullName":{"value":"ANT2-binding protein"},"shortNames":[{"value":"ANT2BP"}]},{"fullName":{"value":"Transport and Golgi organization 9 homolog"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"SLC35F6"},"synonyms":[{"value":"C2orf18"}],"orfNames":[{"value":"UNQ3047/PRO9863"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19154410"}],"value":"Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19154410"}],"value":"Interacts with SLC25A5"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"Q13520","geneName":"AQP6","intActId":"EBI-13059134"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"Q8N350-4","geneName":"CBARP","intActId":"EBI-19051169"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"Q9HA82","geneName":"CERS4","intActId":"EBI-2622997"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"P15328","geneName":"FOLR1","intActId":"EBI-2556557"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"P48165","geneName":"GJA8","intActId":"EBI-17458373"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"Q8TDT2","geneName":"GPR152","intActId":"EBI-13345167"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"P05141","geneName":"SLC25A5","intActId":"EBI-355133"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"Q9NPL8","geneName":"TIMMDC1","intActId":"EBI-6268651"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N357","intActId":"EBI-713484"},"interactantTwo":{"uniProtKBAccession":"Q9NUH8","geneName":"TMEM14B","intActId":"EBI-8638294"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Mitochondrion","id":"SL-0173"}},{"location":{"value":"Lysosome membrane","id":"SL-0157"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19154410"}],"value":"Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SLC35F solute transporter family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"Solute carrier family 35 member F6","featureId":"PRO_0000232514"},{"type":"Transmembrane","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"EamA"},{"type":"Region","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Glycosylation","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Sequence conflict","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"in Ref. 5; BAD96649","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in Ref. 5; BAD96649","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in Ref. 2; BAA91255","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"in Ref. 5; BAD96649","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"in Ref. 3; BAC11445","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"12975309","citationType":"journal article","authors":["Clark H.F.","Gurney A.L.","Abaya E.","Baker K.","Baldwin D.T.","Brush J.","Chen J.","Chow B.","Chui C.","Crowley C.","Currell B.","Deuel B.","Dowd P.","Eaton D.","Foster J.S.","Grimaldi C.","Gu Q.","Hass P.E.","Heldens S.","Huang A.","Kim H.S.","Klimowski L.","Jin Y.","Johnson S.","Lee J.","Lewis L.","Liao D.","Mark M.R.","Robbie E.","Sanchez C.","Schoenfeld J.","Seshagiri S.","Simmons L.","Singh J.","Smith V.","Stinson J.","Vagts A.","Vandlen R.L.","Watanabe C.","Wieand D.","Woods K.","Xie M.-H.","Yansura D.G.","Yi S.","Yu G.","Yuan J.","Zhang M.","Zhang Z.","Goddard A.D.","Wood W.I.","Godowski P.J.","Gray A.M."],"citationCrossReferences":[{"database":"PubMed","id":"12975309"},{"database":"DOI","id":"10.1101/gr.1293003"}],"title":"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2265","lastPage":"2270","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":3,"citation":{"id":"16303743","citationType":"journal article","authors":["Otsuki T.","Ota T.","Nishikawa T.","Hayashi K.","Suzuki Y.","Yamamoto J.","Wakamatsu A.","Kimura K.","Sakamoto K.","Hatano N.","Kawai Y.","Ishii S.","Saito K.","Kojima S.","Sugiyama T.","Ono T.","Okano K.","Yoshikawa Y.","Aotsuka S.","Sasaki N.","Hattori A.","Okumura K.","Nagai K.","Sugano S.","Isogai T."],"citationCrossReferences":[{"database":"PubMed","id":"16303743"},{"database":"DOI","id":"10.1093/dnares/12.2.117"}],"title":"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.","publicationDate":"2005","journal":"DNA Res.","firstPage":"117","lastPage":"126","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":5,"citation":{"id":"CI-5AVBODINQ93DF","citationType":"submission","authors":["Suzuki Y.","Sugano S.","Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S."],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"19154410","citationType":"journal article","authors":["Kashiwaya K.","Hosokawa M.","Eguchi H.","Ohigashi H.","Ishikawa O.","Shinomura Y.","Nakamura Y.","Nakagawa H."],"citationCrossReferences":[{"database":"PubMed","id":"19154410"},{"database":"DOI","id":"10.1111/j.1349-7006.2008.01058.x"}],"title":"Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis.","publicationDate":"2009","journal":"Cancer Sci.","firstPage":"457","lastPage":"464","volume":"100"},"referencePositions":["FUNCTION","INTERACTION WITH SLC25A5","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":12,"citation":{"id":"20957757","citationType":"journal article","authors":["Schroeder B.A.","Wrocklage C.","Hasilik A.","Saftig P."],"citationCrossReferences":[{"database":"PubMed","id":"20957757"},{"database":"DOI","id":"10.1002/pmic.201000196"}],"title":"The proteome of lysosomes.","publicationDate":"2010","journal":"Proteomics","firstPage":"4053","lastPage":"4076","volume":"10"},"referencePositions":["REVIEW","SUBCELLULAR LOCATION"]},{"referenceNumber":13,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY358820","properties":[{"key":"ProteinId","value":"AAQ89179.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK000562","properties":[{"key":"ProteinId","value":"BAA91255.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK075164","properties":[{"key":"ProteinId","value":"BAC11445.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR457243","properties":[{"key":"ProteinId","value":"CAG33524.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK222929","properties":[{"key":"ProteinId","value":"BAD96649.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC011740","properties":[{"key":"ProteinId","value":"AAX93265.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471053","properties":[{"key":"ProteinId","value":"EAX00673.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471053","properties":[{"key":"ProteinId","value":"EAX00676.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC028081","properties":[{"key":"ProteinId","value":"AAH28081.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1728.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_060347.2","properties":[{"key":"NucleotideSequenceId","value":"NM_017877.4"}]},{"database":"AlphaFoldDB","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"120314","properties":[{"key":"Interactions","value":"135"}]},{"database":"FunCoup","id":"Q8N357","properties":[{"key":"Number of interactors","value":"2332"}]},{"database":"IntAct","id":"Q8N357","properties":[{"key":"Interactions","value":"105"}]},{"database":"MINT","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"MUSIC2-C5367-SLC35F6","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - C5367 (4 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000345528","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"2.A.7.12.13","properties":[{"key":"FamilyName","value":"the drug/metabolite transporter (dmt) superfamily"}]},{"database":"GlyCosmos","id":"Q8N357","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"Q8N357","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SLC35F6","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74728772","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000345528","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"71766","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28001","properties":[{"key":"antibodies","value":"132 antibodies from 20 providers"}]},{"database":"DNASU","id":"54978","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000344420.10","properties":[{"key":"ProteinId","value":"ENSP00000345528.5"},{"key":"GeneId","value":"ENSG00000213699.10"}]},{"database":"GeneID","id":"54978","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:54978","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000344420.10","properties":[{"key":"ProteinId","value":"ENSP00000345528.5"},{"key":"RefSeqNucleotideId","value":"NM_017877.4"},{"key":"RefSeqProteinId","value":"NP_060347.2"}]},{"database":"UCSC","id":"uc002rhp.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:26055","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134913368","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"54978","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"54978","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SLC35F6","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:26055","properties":[{"key":"GeneName","value":"SLC35F6"}]},{"database":"HPA","id":"ENSG00000213699","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"619667","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000213699","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000213699","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3912","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000017237","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_025028_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FIYKHNV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"29773at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8N357","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000213699","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"54978","properties":[{"key":"hits","value":"12 hits in 1161 CRISPR screens"}]},{"database":"ChiTaRS","id":"SLC35F6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"C2orf18","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"54978","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8N357","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8N357","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"Q8N357","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000213699","properties":[{"key":"ExpressionPatterns","value":"Expressed in nipple and 182 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8N357","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0005765","properties":[{"key":"GoTerm","value":"C:lysosomal membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20957757"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19154410"}]},{"database":"GO","id":"GO:0022857","properties":[{"key":"GoTerm","value":"F:transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:1901029","properties":[{"key":"GoTerm","value":"P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19154410"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19154410"}]},{"database":"InterPro","id":"IPR037185","properties":[{"key":"EntryName","value":"EmrE-like"}]},{"database":"InterPro","id":"IPR009262","properties":[{"key":"EntryName","value":"SLC35_F1/F2/F6"}]},{"database":"InterPro","id":"IPR012404","properties":[{"key":"EntryName","value":"UCP036436"}]},{"database":"PANTHER","id":"PTHR13146","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13146:SF0","properties":[{"key":"EntryName","value":"SOLUTE CARRIER FAMILY 35 MEMBER F6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06027","properties":[{"key":"EntryName","value":"SLC35F"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF036436","properties":[{"key":"EntryName","value":"UCP036436"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF103481","properties":[{"key":"EntryName","value":"Multidrug resistance efflux transporter EmrE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAWTKYQLFLAGLMLVTGSINTLSAKWADNFMAEGCGGSKEHSFQHPFLQAVGMFLGEFSCLAAFYLLRCRAAGQSDSSVDPQQPFNPLLFLPPALCDMTGTSLMYVALNMTSASSFQMLRGAVIIFTGLFSVAFLGRRLVLSQWLGILATIAGLVVVGLADLLSKHDSQHKLSEVITGDLLIIMAQIIVAIQMVLEEKFVYKHNVHPLRAVGTEGLFGFVILSLLLVPMYYIPAGSFSGNPRGTLEDALDAFCQVGQQPLIAVALLGNISSIAFFNFAGISVTKELSATTRMVLDSLRTVVIWALSLALGWEAFHALQILGFLILLIGTALYNGLHRPLLGRLSRGRPLAEESEQERLLGGTRTPINDAS","length":371,"molWeight":40214,"crc64":"225AFE41FA555B12","md5":"B6F25D719FEA012DD0CA02347AF071DE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":9,"Domain":1,"Region":1,"Modified residue":1,"Glycosylation":1,"Sequence conflict":5},"uniParcId":"UPI0000071B52"}}