{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8N129","secondaryAccessions":["Q8WUN9"],"uniProtkbId":"CNPY4_HUMAN","entryAudit":{"firstPublicDate":"2008-01-15","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2002-10-01","entryVersion":150,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein canopy homolog 4"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"CNPY4"},"orfNames":[{"value":"PSEC0237"},{"value":"UNQ1909/PRO4354"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16338228"}],"value":"Plays a role in the regulation of the cell surface expression of TLR4"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Interacts with TLR4"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8N129","intActId":"EBI-723824"},"interactantTwo":{"uniProtKBAccession":"Q9BRQ8","geneName":"AIFM2","intActId":"EBI-3956936"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8N129","intActId":"EBI-723824"},"interactantTwo":{"uniProtKBAccession":"O15335","geneName":"CHAD","intActId":"EBI-21895311"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the canopy family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Protein canopy homolog 4","featureId":"PRO_0000314018"},{"type":"Region","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Natural variant","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in dbSNP:rs60551236","featureCrossReferences":[{"database":"dbSNP","id":"rs60551236"}],"featureId":"VAR_062216","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"12975309","citationType":"journal article","authors":["Clark H.F.","Gurney A.L.","Abaya E.","Baker K.","Baldwin D.T.","Brush J.","Chen J.","Chow B.","Chui C.","Crowley C.","Currell B.","Deuel B.","Dowd P.","Eaton D.","Foster J.S.","Grimaldi C.","Gu Q.","Hass P.E.","Heldens S.","Huang A.","Kim H.S.","Klimowski L.","Jin Y.","Johnson S.","Lee J.","Lewis L.","Liao D.","Mark M.R.","Robbie E.","Sanchez C.","Schoenfeld J.","Seshagiri S.","Simmons L.","Singh J.","Smith V.","Stinson J.","Vagts A.","Vandlen R.L.","Watanabe C.","Wieand D.","Woods K.","Xie M.-H.","Yansura D.G.","Yi S.","Yu G.","Yuan J.","Zhang M.","Zhang Z.","Goddard A.D.","Wood W.I.","Godowski P.J.","Gray A.M."],"citationCrossReferences":[{"database":"PubMed","id":"12975309"},{"database":"DOI","id":"10.1101/gr.1293003"}],"title":"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2265","lastPage":"2270","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":2,"citation":{"id":"16303743","citationType":"journal article","authors":["Otsuki T.","Ota T.","Nishikawa T.","Hayashi K.","Suzuki Y.","Yamamoto J.","Wakamatsu A.","Kimura K.","Sakamoto K.","Hatano N.","Kawai Y.","Ishii S.","Saito K.","Kojima S.","Sugiyama T.","Ono T.","Okano K.","Yoshikawa Y.","Aotsuka S.","Sasaki N.","Hattori A.","Okumura K.","Nagai K.","Sugano S.","Isogai T."],"citationCrossReferences":[{"database":"PubMed","id":"16303743"},{"database":"DOI","id":"10.1093/dnares/12.2.117"}],"title":"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.","publicationDate":"2005","journal":"DNA Res.","firstPage":"117","lastPage":"126","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Embryo","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"12690205","citationType":"journal article","authors":["Scherer S.W.","Cheung J.","MacDonald J.R.","Osborne L.R.","Nakabayashi K.","Herbrick J.-A.","Carson A.R.","Parker-Katiraee L.","Skaug J.","Khaja R.","Zhang J.","Hudek A.K.","Li M.","Haddad M.","Duggan G.E.","Fernandez B.A.","Kanematsu E.","Gentles S.","Christopoulos C.C.","Choufani S.","Kwasnicka D.","Zheng X.H.","Lai Z.","Nusskern D.R.","Zhang Q.","Gu Z.","Lu F.","Zeesman S.","Nowaczyk M.J.","Teshima I.","Chitayat D.","Shuman C.","Weksberg R.","Zackai E.H.","Grebe T.A.","Cox S.R.","Kirkpatrick S.J.","Rahman N.","Friedman J.M.","Heng H.H.Q.","Pelicci P.G.","Lo-Coco F.","Belloni E.","Shaffer L.G.","Pober B.","Morton C.C.","Gusella J.F.","Bruns G.A.P.","Korf B.R.","Quade B.J.","Ligon A.H.","Ferguson H.","Higgins A.W.","Leach N.T.","Herrick S.R.","Lemyre E.","Farra C.G.","Kim H.-G.","Summers A.M.","Gripp K.W.","Roberts W.","Szatmari P.","Winsor E.J.T.","Grzeschik K.-H.","Teebi A.","Minassian B.A.","Kere J.","Armengol L.","Pujana M.A.","Estivill X.","Wilson M.D.","Koop B.F.","Tosi S.","Moore G.E.","Boright A.P.","Zlotorynski E.","Kerem B.","Kroisel P.M.","Petek E.","Oscier D.G.","Mould S.J.","Doehner H.","Doehner K.","Rommens J.M.","Vincent J.B.","Venter J.C.","Li P.W.","Mural R.J.","Adams M.D.","Tsui L.-C."],"citationCrossReferences":[{"database":"PubMed","id":"12690205"},{"database":"DOI","id":"10.1126/science.1083423"}],"title":"Human chromosome 7: DNA sequence and biology.","publicationDate":"2003","journal":"Science","firstPage":"767","lastPage":"772","volume":"300"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"16338228","citationType":"journal article","authors":["Konno K.","Wakabayashi Y.","Akashi-Takamura S.","Ishii T.","Kobayashi M.","Takahashi K.","Kusumoto Y.","Saitoh S.","Yoshizawa Y.","Miyake K."],"citationCrossReferences":[{"database":"PubMed","id":"16338228"},{"database":"DOI","id":"10.1016/j.bbrc.2005.11.123"}],"title":"A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression.","publicationDate":"2006","journal":"Biochem. Biophys. Res. Commun.","firstPage":"1076","lastPage":"1082","volume":"339"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY359100","properties":[{"key":"ProteinId","value":"AAQ89458.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK075537","properties":[{"key":"ProteinId","value":"BAC11680.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH236956","properties":[{"key":"ProteinId","value":"EAL23850.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC019903","properties":[{"key":"ProteinId","value":"AAH19903.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC032339","properties":[{"key":"ProteinId","value":"AAH32339.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS34701.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_689968.1","properties":[{"key":"NucleotideSequenceId","value":"NM_152755.2"}]},{"database":"AlphaFoldDB","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"128831","properties":[{"key":"Interactions","value":"21"}]},{"database":"FunCoup","id":"Q8N129","properties":[{"key":"Number of interactors","value":"696"}]},{"database":"IntAct","id":"Q8N129","properties":[{"key":"Interactions","value":"21"}]},{"database":"STRING","id":"9606.ENSP00000262932","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CNPY4","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74728482","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000262932","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"71530","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"2588","properties":[{"key":"antibodies","value":"51 antibodies from 17 providers"}]},{"database":"DNASU","id":"245812","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000262932.5","properties":[{"key":"ProteinId","value":"ENSP00000262932.3"},{"key":"GeneId","value":"ENSG00000166997.9"}]},{"database":"GeneID","id":"245812","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:245812","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000262932.5","properties":[{"key":"ProteinId","value":"ENSP00000262932.3"},{"key":"RefSeqNucleotideId","value":"NM_152755.2"},{"key":"RefSeqProteinId","value":"NP_689968.1"}]},{"database":"UCSC","id":"uc003uto.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:28631","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162382618","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"245812","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"245812","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CNPY4","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:28631","properties":[{"key":"GeneName","value":"CNPY4"}]},{"database":"HPA","id":"ENSG00000166997","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"610047","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000166997","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000166997","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4052","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000014072","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_078068_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CKFLTME","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6020060at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8N129","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000166997","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"245812","properties":[{"key":"hits","value":"7 hits in 1152 CRISPR screens"}]},{"database":"ChiTaRS","id":"CNPY4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"245812","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8N129","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8N129","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q8N129","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000166997","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 182 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8N129","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:1903078","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to plasma membrane"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16338228"}]},{"database":"InterPro","id":"IPR021852","properties":[{"key":"EntryName","value":"DUF3456"}]},{"database":"PANTHER","id":"PTHR15382","properties":[{"key":"EntryName","value":"CTG4A-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15382:SF3","properties":[{"key":"EntryName","value":"PROTEIN CANOPY HOMOLOG 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11938","properties":[{"key":"EntryName","value":"DUF3456"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGPVRLGILLFLFLAVHEAWAGMLKEEDDDTERLPSKCEVCKLLSTELQAELSRTGRSREVLELGQVLDTGKRKRHVPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQCETMLEEFEDIVGDWYFHHQEQPLQNFLCEGHVLPAAETACLQETWTGKEITDGEEKTEGEEEQEEEEEEEEEEGGDKMTKTGSHPKLDREDL","length":248,"molWeight":28310,"crc64":"561CAEB4A0D7B833","md5":"15ACC723B1110C8D3C2F57AA20A8CE1B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Compositional bias":2,"Disulfide bond":3,"Natural variant":1},"uniParcId":"UPI000003B115"}}