{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8N0T1","secondaryAccessions":["B2RXE7","E5RFW5"],"uniProtkbId":"RBIS_HUMAN","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-05-14","entryVersion":145,"sequenceVersion":4},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Ribosomal biogenesis factor"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:32235"}],"value":"RBIS"},"synonyms":[{"value":"C8orf59"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26711351"}],"value":"Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26711351"}],"value":"Associates with the pre-60S ribosomal particles"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8N0T1-2","intActId":"EBI-13380894"},"interactantTwo":{"uniProtKBAccession":"P62508-3","geneName":"ESRRG","intActId":"EBI-12001340"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26711351"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8N0T1-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8N0T1-2"],"sequenceIds":["VSP_032304"],"isoformSequenceStatus":"Described"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Ribosomal biogenesis factor","featureId":"PRO_0000324604"},{"type":"Modified residue","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_032304","alternativeSequence":{"originalSequence":"INIMNEEKVNRVNKAFVNVQKELAHFAKSISLEPLQKELIPQQRHESKPVNVDEATRLMALL","alternativeSequences":["VLHFS"]}},{"type":"Sequence conflict","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"in Ref. 3; BC062221","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L. III","Engels R.","Gloeckner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.J.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-21","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-69","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"26711351","citationType":"journal article","authors":["Badertscher L.","Wild T.","Montellese C.","Alexander L.T.","Bammert L.","Sarazova M.","Stebler M.","Csucs G.","Mayer T.U.","Zamboni N.","Zemp I.","Horvath P.","Kutay U."],"citationCrossReferences":[{"database":"PubMed","id":"26711351"},{"database":"DOI","id":"10.1016/j.celrep.2015.11.061"}],"title":"Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"2879","lastPage":"2891","volume":"13"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","SUBUNIT"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011773","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471068","properties":[{"key":"ProteinId","value":"EAW87124.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC032347","properties":[{"key":"ProteinId","value":"AAH32347.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC146983","properties":[{"key":"ProteinId","value":"AAI46984.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC146988","properties":[{"key":"ProteinId","value":"AAI46989.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC157825","properties":[{"key":"ProteinId","value":"AAI57826.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC062221","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS55255.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N0T1-1"},{"database":"RefSeq","id":"NP_001093140.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001099670.3"}],"isoformId":"Q8N0T1-1"},{"database":"RefSeq","id":"NP_001093141.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001099671.3"}],"isoformId":"Q8N0T1-1"},{"database":"RefSeq","id":"NP_001093142.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001099672.3"}],"isoformId":"Q8N0T1-1"},{"database":"RefSeq","id":"NP_001093143.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001099673.3"}],"isoformId":"Q8N0T1-1"},{"database":"RefSeq","id":"XP_011515830.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011517528.4"}],"isoformId":"Q8N0T1-1"},{"database":"RefSeq","id":"XP_054216445.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054360470.1"}],"isoformId":"Q8N0T1-1"},{"database":"AlphaFoldDB","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"135095","properties":[{"key":"Interactions","value":"29"}]},{"database":"FunCoup","id":"Q8N0T1","properties":[{"key":"Number of interactors","value":"2344"}]},{"database":"IntAct","id":"Q8N0T1","properties":[{"key":"Interactions","value":"7"}]},{"database":"MINT","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000484492","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8N0T1","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C8orf59","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"519668681","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000484492","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"15478","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"71453","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N0T1-1"},{"database":"ProteomicsDB","id":"71454","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N0T1-2"},{"database":"Pumba","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"Q8N0T1-1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8N0T1-1"},{"database":"Antibodypedia","id":"59064","properties":[{"key":"antibodies","value":"30 antibodies from 8 providers"}]},{"database":"DNASU","id":"401466","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000321777.5","properties":[{"key":"ProteinId","value":"ENSP00000319020.5"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-2"},{"database":"Ensembl","id":"ENST00000611854.4","properties":[{"key":"ProteinId","value":"ENSP00000484811.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000612809.4","properties":[{"key":"ProteinId","value":"ENSP00000481745.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000612977.4","properties":[{"key":"ProteinId","value":"ENSP00000484101.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000615697.4","properties":[{"key":"ProteinId","value":"ENSP00000482944.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000619594.5","properties":[{"key":"ProteinId","value":"ENSP00000484492.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000864766.1","properties":[{"key":"ProteinId","value":"ENSP00000534825.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000864768.1","properties":[{"key":"ProteinId","value":"ENSP00000534827.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929980.1","properties":[{"key":"ProteinId","value":"ENSP00000600039.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929981.1","properties":[{"key":"ProteinId","value":"ENSP00000600040.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929982.1","properties":[{"key":"ProteinId","value":"ENSP00000600041.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929983.1","properties":[{"key":"ProteinId","value":"ENSP00000600042.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929984.1","properties":[{"key":"ProteinId","value":"ENSP00000600043.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929988.1","properties":[{"key":"ProteinId","value":"ENSP00000600047.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929989.1","properties":[{"key":"ProteinId","value":"ENSP00000600048.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929990.1","properties":[{"key":"ProteinId","value":"ENSP00000600049.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929991.1","properties":[{"key":"ProteinId","value":"ENSP00000600050.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929992.1","properties":[{"key":"ProteinId","value":"ENSP00000600051.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929994.1","properties":[{"key":"ProteinId","value":"ENSP00000600053.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929995.1","properties":[{"key":"ProteinId","value":"ENSP00000600054.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929996.1","properties":[{"key":"ProteinId","value":"ENSP00000600055.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929997.1","properties":[{"key":"ProteinId","value":"ENSP00000600056.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000929998.1","properties":[{"key":"ProteinId","value":"ENSP00000600057.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"Ensembl","id":"ENST00000956034.1","properties":[{"key":"ProteinId","value":"ENSP00000626093.1"},{"key":"GeneId","value":"ENSG00000176731.13"}],"isoformId":"Q8N0T1-1"},{"database":"GeneID","id":"401466","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:401466","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000619594.5","properties":[{"key":"ProteinId","value":"ENSP00000484492.1"},{"key":"RefSeqNucleotideId","value":"NM_001099673.3"},{"key":"RefSeqProteinId","value":"NP_001093143.1"}]},{"database":"UCSC","id":"uc033bru.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8N0T1-1"},{"database":"AGR","id":"HGNC:32235","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142672322","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"401466","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"401466","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"RBIS","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:32235","properties":[{"key":"GeneName","value":"RBIS"}]},{"database":"HPA","id":"ENSG00000176731","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"OpenTargets","id":"ENSG00000176731","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000176731","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S982","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000015564","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_152931_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FQVANRH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9520891at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8N0T1","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000176731","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"401466","properties":[{"key":"hits","value":"49 hits in 721 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"C8orf59","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"401466","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8N0T1","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8N0T1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"Q8N0T1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000176731","properties":[{"key":"ExpressionPatterns","value":"Expressed in epithelial cell of pancreas and 187 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8N0T1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26711351"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0042254","properties":[{"key":"GoTerm","value":"P:ribosome biogenesis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26711351"}]},{"database":"InterPro","id":"IPR031389","properties":[{"key":"EntryName","value":"RBIS"}]},{"database":"PANTHER","id":"PTHR35544","properties":[{"key":"EntryName","value":"RIBOSOMAL BIOGENESIS FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR35544:SF4","properties":[{"key":"EntryName","value":"RIBOSOMAL BIOGENESIS FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15679","properties":[{"key":"EntryName","value":"DUF4665"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAKNKLRGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKINIMNEEKVNRVNKAFVNVQKELAHFAKSISLEPLQKELIPQQRHESKPVNVDEATRLMALL","length":100,"molWeight":11456,"crc64":"37D727E9E8A27034","md5":"390D994AC08578BE0C14FBF18FD7CD0D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2},"countByFeatureType":{"Chain":1,"Modified residue":3,"Alternative sequence":1,"Sequence conflict":1},"uniParcId":"UPI000049275D"}}