{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8LEF3","secondaryAccessions":["Q9FNL9"],"uniProtkbId":"ELOF1_ARATH","entryAudit":{"firstPublicDate":"2002-11-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":131,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transcription elongation factor 1 homolog"}}},"genes":[{"orderedLocusNames":[{"value":"At5g46030"}],"orfNames":[{"value":"MCL19.8"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ELOF1 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"BAB08248.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Transcription elongation factor 1 homolog","featureId":"PRO_0000120946"},{"type":"Region","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P60003"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P60003"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P60003"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P60003"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}}],"keywords":[{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"9405937","citationType":"journal article","authors":["Kotani H.","Nakamura Y.","Sato S.","Kaneko T.","Asamizu E.","Miyajima N.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"9405937"},{"database":"DOI","id":"10.1093/dnares/4.4.291"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence features of the regions of 1,044,062 bp covered by thirteen physically assigned P1 clones.","publicationDate":"1997","journal":"DNA Res.","firstPage":"291","lastPage":"300","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-3TH3AFLAVIRO9","citationType":"submission","authors":["Brover V.V.","Troukhan M.E.","Alexandrov N.A.","Lu Y.-P.","Flavell R.B.","Feldmann K.A."],"title":"Full-length cDNA from Arabidopsis thaliana.","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB006698","properties":[{"key":"ProteinId","value":"BAB08248.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED95330.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"ANM68284.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"ANM68285.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"CAO7055373.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT002010","properties":[{"key":"ProteinId","value":"AAN72021.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT006515","properties":[{"key":"ProteinId","value":"AAP21323.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY085452","properties":[{"key":"ProteinId","value":"AAM62678.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001330049.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001344655.1"}]},{"database":"RefSeq","id":"NP_001330050.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001344654.1"}]},{"database":"RefSeq","id":"NP_568654.1","properties":[{"key":"NucleotideSequenceId","value":"NM_123971.3"}]},{"database":"AlphaFoldDB","id":"Q8LEF3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8LEF3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"19893","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q8LEF3","properties":[{"key":"Number of interactors","value":"3754"}]},{"database":"IntAct","id":"Q8LEF3","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"3702.Q8LEF3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q8LEF3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"220659","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"834644","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT5G46030","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT5G46030","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT5G46030","properties":[{"key":"GeneName","value":"-"}]},{"database":"eggNOG","id":"KOG3214","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_105983_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8LEF3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CLDANKK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"445983at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8LEF3","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q8LEF3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"ExpressionAtlas","id":"Q8LEF3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0008023","properties":[{"key":"GoTerm","value":"C:transcription elongation factor complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36627730"}]},{"database":"GO","id":"GO:0042393","properties":[{"key":"GoTerm","value":"F:histone binding"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36627730"}]},{"database":"GO","id":"GO:0000993","properties":[{"key":"GoTerm","value":"F:RNA polymerase II complex binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006368","properties":[{"key":"GoTerm","value":"P:transcription elongation by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36627730"}]},{"database":"FunFam","id":"2.20.25.190:FF:000001","properties":[{"key":"EntryName","value":"Transcription elongation factor 1 homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.190","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007808","properties":[{"key":"EntryName","value":"Elf1"}]},{"database":"InterPro","id":"IPR038567","properties":[{"key":"EntryName","value":"T_Elf1_sf"}]},{"database":"PANTHER","id":"PTHR20934","properties":[{"key":"EntryName","value":"TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR20934:SF24","properties":[{"key":"EntryName","value":"TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05129","properties":[{"key":"EntryName","value":"Zn_ribbon_Elf1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57783","properties":[{"key":"EntryName","value":"Zinc beta-ribbon"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKRKSRAKPAPTKRMDKLDTIFSCPFCNHGSSVECIIDMKHLIGKAACRICEESFSTTITALTEAIDIYSEWIDECERVNTAEDDVVQEEEEEVEEEEEEEEEEDDEDDHVSVKRKYNF","length":120,"molWeight":13885,"crc64":"DDAF1CD76316BA1F","md5":"0ACB3148AAD51822F18393798D884328"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Binding site":4},"uniParcId":"UPI0000001B11"}}