{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8L5T5","secondaryAccessions":["A0MES9","B7XG65","O22888","Q1PEV4"],"uniProtkbId":"LBD15_ARATH","entryAudit":{"firstPublicDate":"2003-03-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-28","entryVersion":118,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"LOB domain-containing protein 15"}},"alternativeNames":[{"fullName":{"value":"ASYMMETRIC LEAVES 2-like protein 11"},"shortNames":[{"value":"AS2-like protein 11"}]}]},"genes":[{"geneName":{"value":"LBD15"},"synonyms":[{"value":"ASL11"}],"orderedLocusNames":[{"value":"At2g40470"}],"orfNames":[{"value":"T2P4.18"}]}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8L5T5","intActId":"EBI-2356227"},"interactantTwo":{"uniProtKBAccession":"Q9C9L2","geneName":"TCP15","intActId":"EBI-4426144"},"numberOfExperiments":3,"organismDiffer":false}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12068116"}],"value":"Expressed in young shoots, roots, stems, leaves and flowers"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the LOB domain-containing protein family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous termination","sequence":"ABK28530.1","note":"Extended C-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"LOB domain-containing protein 15","featureId":"PRO_0000132266"},{"type":"Domain","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"LOB","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00291"}]},{"type":"Region","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"in Ref. 6; AAM67163","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"12068116","citationType":"journal article","authors":["Shuai B.","Reynaga-Pena C.G.","Springer P.S."],"citationCrossReferences":[{"database":"PubMed","id":"12068116"},{"database":"DOI","id":"10.1104/pp.010926"}],"title":"The LATERAL ORGAN BOUNDARIES gene defines a novel, plant-specific gene family.","publicationDate":"2002","journal":"Plant Physiol.","firstPage":"747","lastPage":"761","volume":"129"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY","GENE FAMILY","NOMENCLATURE"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"19154202","citationType":"journal article","authors":["Matsumura Y.","Iwakawa H.","Machida Y.","Machida C."],"citationCrossReferences":[{"database":"PubMed","id":"19154202"},{"database":"DOI","id":"10.1111/j.1365-313x.2009.03797.x"}],"title":"Characterization of genes in the ASYMMETRIC LEAVES2/LATERAL ORGAN BOUNDARIES (AS2/LOB) family in Arabidopsis thaliana, and functional and molecular comparisons between AS2 and other family members.","publicationDate":"2009","journal":"Plant J.","firstPage":"525","lastPage":"537","volume":"58"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"10617197","citationType":"journal article","authors":["Lin X.","Kaul S.","Rounsley S.D.","Shea T.P.","Benito M.-I.","Town C.D.","Fujii C.Y.","Mason T.M.","Bowman C.L.","Barnstead M.E.","Feldblyum T.V.","Buell C.R.","Ketchum K.A.","Lee J.J.","Ronning C.M.","Koo H.L.","Moffat K.S.","Cronin L.A.","Shen M.","Pai G.","Van Aken S.","Umayam L.","Tallon L.J.","Gill J.E.","Adams M.D.","Carrera A.J.","Creasy T.H.","Goodman H.M.","Somerville C.R.","Copenhaver G.P.","Preuss D.","Nierman W.C.","White O.","Eisen J.A.","Salzberg S.L.","Fraser C.M.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10617197"},{"database":"DOI","id":"10.1038/45471"}],"title":"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.","publicationDate":"1999","journal":"Nature","firstPage":"761","lastPage":"768","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"CI-3TH3AFLAVIRO9","citationType":"submission","authors":["Brover V.V.","Troukhan M.E.","Alexandrov N.A.","Lu Y.-P.","Flavell R.B.","Feldmann K.A."],"title":"Full-length cDNA from Arabidopsis thaliana.","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":7,"citation":{"id":"17147637","citationType":"journal article","authors":["Underwood B.A.","Vanderhaeghen R.","Whitford R.","Town C.D.","Hilson P."],"citationCrossReferences":[{"database":"PubMed","id":"17147637"},{"database":"DOI","id":"10.1111/j.1467-7652.2006.00183.x"}],"title":"Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.","publicationDate":"2006","journal":"Plant Biotechnol. J.","firstPage":"317","lastPage":"324","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":8,"citation":{"id":"CI-E4RG8NF34GSF7","citationType":"submission","authors":["Shinn P.","Chen H.","Kim C.J.","Ecker J.R."],"title":"Arabidopsis ORF clones.","publicationDate":"APR-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":9,"citation":{"id":"12040093","citationType":"journal article","authors":["Iwakawa H.","Ueno Y.","Semiarti E.","Onouchi H.","Kojima S.","Tsukaya H.","Hasebe M.","Soma T.","Ikezaki M.","Machida C.","Machida Y."],"citationCrossReferences":[{"database":"PubMed","id":"12040093"},{"database":"DOI","id":"10.1093/pcp/pcf077"}],"title":"The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana, required for formation of a symmetric flat leaf lamina, encodes a member of a novel family of proteins characterized by cysteine repeats and a leucine zipper.","publicationDate":"2002","journal":"Plant Cell Physiol.","firstPage":"467","lastPage":"478","volume":"43"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF447889","properties":[{"key":"ProteinId","value":"AAL38034.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB473844","properties":[{"key":"ProteinId","value":"BAH10555.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC002336","properties":[{"key":"ProteinId","value":"AAB87589.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002685","properties":[{"key":"ProteinId","value":"AEC09834.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408684","properties":[{"key":"ProteinId","value":"CAO7038200.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY088856","properties":[{"key":"ProteinId","value":"AAM67163.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ446613","properties":[{"key":"ProteinId","value":"ABE65897.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ653051","properties":[{"key":"ProteinId","value":"ABK28530.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT025288","properties":[{"key":"ProteinId","value":"ABF19041.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"H84829","properties":[{"key":"EntryName","value":"H84829"}]},{"database":"RefSeq","id":"NP_565933.1","properties":[{"key":"NucleotideSequenceId","value":"NM_129608.3"}]},{"database":"AlphaFoldDB","id":"Q8L5T5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8L5T5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"3979","properties":[{"key":"Interactions","value":"10"}]},{"database":"FunCoup","id":"Q8L5T5","properties":[{"key":"Number of interactors","value":"40"}]},{"database":"IntAct","id":"Q8L5T5","properties":[{"key":"Interactions","value":"18"}]},{"database":"STRING","id":"3702.Q8L5T5","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8L5T5","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"PaxDb","id":"3702-Q8L5T5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"250733","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"818641","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT2G40470","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT2G40470","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT2G40470","properties":[{"key":"GeneName","value":"LBD15"}]},{"database":"eggNOG","id":"ENOG502QUQH","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_058353_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8L5T5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RMGRRQI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1927167at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8L5T5","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q8L5T5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"ExpressionAtlas","id":"Q8L5T5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20306306"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IPI:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25533953"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29444288"}]},{"database":"GO","id":"GO:1905177","properties":[{"key":"GoTerm","value":"P:tracheary element differentiation"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29444288"}]},{"database":"InterPro","id":"IPR004883","properties":[{"key":"EntryName","value":"LOB"}]},{"database":"PANTHER","id":"PTHR31301:SF87","properties":[{"key":"EntryName","value":"LOB DOMAIN-CONTAINING PROTEIN 15"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31301","properties":[{"key":"EntryName","value":"LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03195","properties":[{"key":"EntryName","value":"LOB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50891","properties":[{"key":"EntryName","value":"LOB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSRERERFEEIGKKIKREADAWPHQMAGIRRPMSGPPGTLNTITPCAACKLLRRRCAQECPFSPYFSPHEPHKFASVHKVFGASNVSKMLMEVPESQRADAANSLVYEANVRLRDPVYGCMGAISALQQQVQALQAELTAVRSEILKYKQREAVATLIVPSNSQVAGFHNSGGVSVIAPPPQRPTTPPQPTTAHPPSPSSCVFSQPTTRDLEYGNIESENNYFG","length":224,"molWeight":24660,"crc64":"2458B44E0CFDDAC2","md5":"93D06BF0F8B68E47C944CCFCFFF6B064"},"extraAttributes":{"countByCommentType":{"INTERACTION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":1,"Compositional bias":1,"Sequence conflict":1},"uniParcId":"UPI00000A101A"}}