{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8K2W9","uniProtkbId":"CN093_MOUSE","entryAudit":{"firstPublicDate":"2003-07-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":120,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C14orf93 homolog"}},"flag":"Precursor"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"Uncharacterized protein C14orf93 homolog","featureId":"PRO_0000020951"},{"type":"Region","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H972"}]},{"type":"Modified residue","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Cross-link","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H972"}]},{"type":"Cross-link","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H972"}]}],"keywords":[{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Mammary tumor","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118; SER-286 AND SER-429","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Lung","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC029624","properties":[{"key":"ProteinId","value":"AAH29624.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS27094.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_083166.1","properties":[{"key":"NucleotideSequenceId","value":"NM_028890.2"}]},{"database":"RefSeq","id":"XP_006519681.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006519618.5"}]},{"database":"RefSeq","id":"XP_006519683.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006519620.5"}]},{"database":"RefSeq","id":"XP_011243512.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011245210.4"}]},{"database":"RefSeq","id":"XP_036014772.1","properties":[{"key":"NucleotideSequenceId","value":"XM_036158879.1"}]},{"database":"AlphaFoldDB","id":"Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8K2W9","properties":[{"key":"Number of interactors","value":"63"}]},{"database":"STRING","id":"10090.ENSMUSP00000022786","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000022786","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"120","properties":[{"key":"antibodies","value":"16 antibodies from 11 providers"}]},{"database":"DNASU","id":"74359","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000022786.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000022786.5"},{"key":"GeneId","value":"ENSMUSG00000022179.6"}]},{"database":"GeneID","id":"74359","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:74359","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007twk.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1921609","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1921609","properties":[{"key":"GeneName","value":"4931414P19Rik"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000022179","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QR1B","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000012708","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_037858_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FDQSHKT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9426338at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"74359","properties":[{"key":"hits","value":"2 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8K2W9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"RNAct","id":"Q8K2W9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000022179","properties":[{"key":"ExpressionPatterns","value":"Expressed in interventricular septum and 168 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8K2W9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28230092"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28230092"}]},{"database":"InterPro","id":"IPR028101","properties":[{"key":"EntryName","value":"DUF4616"}]},{"database":"PANTHER","id":"PTHR14375","properties":[{"key":"EntryName","value":"SIMILAR TO RIKEN CDNA 4931414P19"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14375:SF2","properties":[{"key":"EntryName","value":"SIMILAR TO RIKEN CDNA 4931414P19"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15394","properties":[{"key":"EntryName","value":"DUF4616"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSFSATILFSPPSGSEARCCCCACKSETSQGSTGSQGGNPPASTPITVTGHGLAVQSSEQLLHIIYQRVDKAVGLAEAALGLARANNELLKQLQEEVGELRQGKVCTADEDRESRARTPPPEEPGVLKGSPGEASNSLPAMEEECDSVGSGVQVVIEELRQLGAASTVGQGPLGFFAAPQRDARLPGCTLAAVEGAPLLNPMADDYVASEGSIQRVLVPAYAKQLSPATQLAIQRASSETGPESGTKLPATRPEGVLGSAALDSALDESGAGGAGELSRSLGFVGSPCRIRGTGQKNSRRKRDLVLSKLVHNVHNHITNDKRFNGSESIKSSWNISVVKFLLEKLKQELMVSPHNYTDKELKGACVAYFLTKRREYRNSLNPFKGLKEKEEKKLRSRRYRLFANRSSIMRHFGPEDQHLWKDVTEELMSDEEDSLNEPGVWVARSPRFRAQRLTELCYHLDANSKHGTKANRVYGPPSDRLPSVEAQLLPPELYNPNFQEDEGGGNEKGPVSPSYDQPHKTSCPDLNSFIEIKVEKDEYTL","length":541,"molWeight":58780,"crc64":"D738EBF0BF6E304E","md5":"0D49AC2BF23D68F5F865471D6E4F11E0"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":4,"Compositional bias":2,"Modified residue":4,"Cross-link":2},"uniParcId":"UPI000002885F"}}